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The map label for this gene is fadE12 [H]

Identifier: 86747342

GI number: 86747342

Start: 243808

End: 244974

Strand: Reverse

Name: fadE12 [H]

Synonym: RPB_0216

Alternate gene names: 86747342

Gene position: 244974-243808 (Counterclockwise)

Preceding gene: 86747343

Following gene: 86747340

Centisome position: 4.59

GC content: 63.92

Gene sequence:

>1167_bases
ATGGACTTCGCCCTCACCGATCAGCAGCAAGCCATCCGCGACGCGGTGGCGAAGATCTGCGCCGATTTCGACGATGCTTA
TTGGTTGCGGAAGGATCGCGAGGGTGGCTTCCCGCACGACTTCCACAAAGCTTTGGCGGACGCCGGCTGGCTCGGCATCT
GCGTGCCTGAAGCGTATGGCGGCTCCGGCCTCGGCATCACCGAGGCCGCGATCATGATGCGGGCGATCTCCGAATCCGGC
GCCGGCATGTCGGGCGCCTCGGCGGTGCATATCAATGTGTTCGGGCTCAACCCGGTCGTGGTGTTCGGCACCGAAGAGCA
GCGCCGTCGGATGCTGCCGCCGATGGTGGAAGGGCGCGAGAAGGCGTGCTTCGCGGTGACCGAGCCGAACACCGGGCTCA
ACACCACCCAGCTCAAGACCCGCGCTGTGAGGAAAGGCGATCGCTACATCGTCAACGGCCAGAAGGTCTGGATCTCGACC
GCGCAGGTCGCGCATAAAATCTTGCTACTTGCGCGCACCACTCCGCTGGAGGACGTCAAGTCGCCGACCCACGGGCTCAG
CCTGTTCTACACCGATCTCGATCGCCGCAAGGTCGAAATCCACGAGATCGACAAGATGGGCCGCAAGATCGTCGACTCCA
ACGAATTGTTCTTCGCCGACTACGAGATCCCGGTCGAGGACCGGATCGGCGAGGAAGGAAGCGGCTTCCAGTACATTCTC
GAAGGCATGAACCCGGAGCGCATCCTGATCGCGGCCGAAGCCGTCGGGCTCGGAAAGCTGGCGCTGTCGCGGGCGTCGGA
CTACGCCAAGTCGCGGATCGTGTTCAATCGCCCGATCGGCCAGAACCAGGGGATCCAGCATCCCCTGGCGAAGAACTGGG
TCGAGCTGGAAGCCGCATGGCTGATGGTGATGTCGGCGGCGTGGCAATACGACAAGGGGATGCCGTGCGGCGCCGCCGCC
AATGCGGCGAAATATCTCGCCGGCGAAGCGGGCTTTTCGGCCTGCGAGCAGGCGGTGATGACGCATGGCGGCTTCGGCTA
CGCCAAGGAATATCACGTCGAGCGTTATCTGCGCGAAGTGCTGATCCCGCGCATCGCGCCGGTCAGCCCGCAGCTGGCGC
TCTCCTTCATCGCCGAGAAGGTGCTGGGGCTGGCGAAGTCGTACTGA

Upstream 100 bases:

>100_bases
AGGGTTGCGCTTGCCTGCGCGGCCGCAAATGGCATGGTGCGGCGACGCGCGACGCTCGCGCGCGGGAAACGCCCGACACC
AATCAACAAAGAGCCAGCTC

Downstream 100 bases:

>100_bases
TCGCGCACCGATCGCAGAAGGCCGCGCTCACGCCGCCTGATCGGCCTCGTCGTCGCTGAAATCCTCCAGCATCGGCAGCG
CCATGCCGTCGATCTCGCCC

Product: Acyl-CoA dehydrogenase-like

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MDFALTDQQQAIRDAVAKICADFDDAYWLRKDREGGFPHDFHKALADAGWLGICVPEAYGGSGLGITEAAIMMRAISESG
AGMSGASAVHINVFGLNPVVVFGTEEQRRRMLPPMVEGREKACFAVTEPNTGLNTTQLKTRAVRKGDRYIVNGQKVWIST
AQVAHKILLLARTTPLEDVKSPTHGLSLFYTDLDRRKVEIHEIDKMGRKIVDSNELFFADYEIPVEDRIGEEGSGFQYIL
EGMNPERILIAAEAVGLGKLALSRASDYAKSRIVFNRPIGQNQGIQHPLAKNWVELEAAWLMVMSAAWQYDKGMPCGAAA
NAAKYLAGEAGFSACEQAVMTHGGFGYAKEYHVERYLREVLIPRIAPVSPQLALSFIAEKVLGLAKSY

Sequences:

>Translated_388_residues
MDFALTDQQQAIRDAVAKICADFDDAYWLRKDREGGFPHDFHKALADAGWLGICVPEAYGGSGLGITEAAIMMRAISESG
AGMSGASAVHINVFGLNPVVVFGTEEQRRRMLPPMVEGREKACFAVTEPNTGLNTTQLKTRAVRKGDRYIVNGQKVWIST
AQVAHKILLLARTTPLEDVKSPTHGLSLFYTDLDRRKVEIHEIDKMGRKIVDSNELFFADYEIPVEDRIGEEGSGFQYIL
EGMNPERILIAAEAVGLGKLALSRASDYAKSRIVFNRPIGQNQGIQHPLAKNWVELEAAWLMVMSAAWQYDKGMPCGAAA
NAAKYLAGEAGFSACEQAVMTHGGFGYAKEYHVERYLREVLIPRIAPVSPQLALSFIAEKVLGLAKSY
>Mature_388_residues
MDFALTDQQQAIRDAVAKICADFDDAYWLRKDREGGFPHDFHKALADAGWLGICVPEAYGGSGLGITEAAIMMRAISESG
AGMSGASAVHINVFGLNPVVVFGTEEQRRRMLPPMVEGREKACFAVTEPNTGLNTTQLKTRAVRKGDRYIVNGQKVWIST
AQVAHKILLLARTTPLEDVKSPTHGLSLFYTDLDRRKVEIHEIDKMGRKIVDSNELFFADYEIPVEDRIGEEGSGFQYIL
EGMNPERILIAAEAVGLGKLALSRASDYAKSRIVFNRPIGQNQGIQHPLAKNWVELEAAWLMVMSAAWQYDKGMPCGAAA
NAAKYLAGEAGFSACEQAVMTHGGFGYAKEYHVERYLREVLIPRIAPVSPQLALSFIAEKVLGLAKSY

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557231, Length=382, Percent_Identity=29.3193717277487, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI187960098, Length=382, Percent_Identity=29.3193717277487, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI4557233, Length=353, Percent_Identity=32.2946175637394, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI4501859, Length=379, Percent_Identity=28.7598944591029, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI7656849, Length=361, Percent_Identity=29.9168975069252, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI226958412, Length=364, Percent_Identity=28.021978021978, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI21361497, Length=355, Percent_Identity=29.5774647887324, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4501857, Length=335, Percent_Identity=29.5522388059701, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI226958414, Length=328, Percent_Identity=28.6585365853659, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI4557235, Length=349, Percent_Identity=29.2263610315186, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI76496475, Length=349, Percent_Identity=29.2263610315186, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI7669494, Length=367, Percent_Identity=25.3405994550409, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI4503943, Length=367, Percent_Identity=25.3405994550409, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI48976061, Length=320, Percent_Identity=24.375, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI211971008, Length=320, Percent_Identity=24.375, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI38505218, Length=288, Percent_Identity=26.7361111111111, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI87081958, Length=384, Percent_Identity=28.90625, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1786223, Length=386, Percent_Identity=28.4974093264249, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=31.413612565445, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17569725, Length=389, Percent_Identity=30.0771208226221, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17570075, Length=388, Percent_Identity=30.1546391752577, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17538396, Length=373, Percent_Identity=28.686327077748, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17506239, Length=378, Percent_Identity=27.7777777777778, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17508101, Length=336, Percent_Identity=29.1666666666667, Blast_Score=151, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71985184, Length=382, Percent_Identity=27.7486910994764, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71990804, Length=283, Percent_Identity=32.1554770318021, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17533517, Length=354, Percent_Identity=27.683615819209, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17505929, Length=340, Percent_Identity=30.5882352941176, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71985192, Length=317, Percent_Identity=26.4984227129338, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17551932, Length=373, Percent_Identity=26.5415549597855, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI32563615, Length=228, Percent_Identity=27.6315789473684, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17531909, Length=243, Percent_Identity=28.8065843621399, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17534353, Length=303, Percent_Identity=23.7623762376238, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71982178, Length=246, Percent_Identity=27.2357723577236, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17562446, Length=298, Percent_Identity=25.503355704698, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17531913, Length=201, Percent_Identity=27.363184079602, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI21356377, Length=385, Percent_Identity=30.9090909090909, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24646207, Length=385, Percent_Identity=30.6493506493506, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24666513, Length=376, Percent_Identity=29.7872340425532, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24660351, Length=386, Percent_Identity=29.0155440414508, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI21355753, Length=344, Percent_Identity=27.906976744186, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI281363737, Length=383, Percent_Identity=27.4151436031332, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI19920834, Length=360, Percent_Identity=25.8333333333333, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42655; Mature: 42655

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFALTDQQQAIRDAVAKICADFDDAYWLRKDREGGFPHDFHKALADAGWLGICVPEAYG
CCCCCCCHHHHHHHHHHHHHHCCCHHHHHEECCCCCCCHHHHHHHHCCCEEEEECCCCCC
GSGLGITEAAIMMRAISESGAGMSGASAVHINVFGLNPVVVFGTEEQRRRMLPPMVEGRE
CCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCEEEEECCCHHHHHCCCCHHCCCC
KACFAVTEPNTGLNTTQLKTRAVRKGDRYIVNGQKVWISTAQVAHKILLLARTTPLEDVK
CEEEEEECCCCCCCHHHHHHHHHHCCCEEEECCCEEEEEHHHHHHHHHHHCCCCCHHHHC
SPTHGLSLFYTDLDRRKVEIHEIDKMGRKIVDSNELFFADYEIPVEDRIGEEGSGFQYIL
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHCCCCCCCHHHHC
EGMNPERILIAAEAVGLGKLALSRASDYAKSRIVFNRPIGQNQGIQHPLAKNWVELEAAW
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHHHH
LMVMSAAWQYDKGMPCGAAANAAKYLAGEAGFSACEQAVMTHGGFGYAKEYHVERYLREV
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LIPRIAPVSPQLALSFIAEKVLGLAKSY
HHHCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDFALTDQQQAIRDAVAKICADFDDAYWLRKDREGGFPHDFHKALADAGWLGICVPEAYG
CCCCCCCHHHHHHHHHHHHHHCCCHHHHHEECCCCCCCHHHHHHHHCCCEEEEECCCCCC
GSGLGITEAAIMMRAISESGAGMSGASAVHINVFGLNPVVVFGTEEQRRRMLPPMVEGRE
CCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCEEEEECCCHHHHHCCCCHHCCCC
KACFAVTEPNTGLNTTQLKTRAVRKGDRYIVNGQKVWISTAQVAHKILLLARTTPLEDVK
CEEEEEECCCCCCCHHHHHHHHHHCCCEEEECCCEEEEEHHHHHHHHHHHCCCCCHHHHC
SPTHGLSLFYTDLDRRKVEIHEIDKMGRKIVDSNELFFADYEIPVEDRIGEEGSGFQYIL
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHCCCCCCCHHHHC
EGMNPERILIAAEAVGLGKLALSRASDYAKSRIVFNRPIGQNQGIQHPLAKNWVELEAAW
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHHHH
LMVMSAAWQYDKGMPCGAAANAAKYLAGEAGFSACEQAVMTHGGFGYAKEYHVERYLREV
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LIPRIAPVSPQLALSFIAEKVLGLAKSY
HHHCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]