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The map label for this gene is lysC [H]

Identifier: 86747204

GI number: 86747204

Start: 80003

End: 81256

Strand: Reverse

Name: lysC [H]

Synonym: RPB_0077

Alternate gene names: 86747204

Gene position: 81256-80003 (Counterclockwise)

Preceding gene: 86747207

Following gene: 86747203

Centisome position: 1.52

GC content: 65.23

Gene sequence:

>1254_bases
ATGGGCCGGCTGGTGATGAAATTCGGCGGCACGTCCGTCGCCAATATCGAGCGCATCCAGAACGTCGCGCGCCACGTCAA
GCGCGAGGTCGATGCCGGCCATGAGGTTGCCGTGGTGGTGTCGGCGATGGCCGGCAAGACCAACGAGCTGGTGGCCTGGT
GCACCGAAGCCTCGCCGATGCACGACGCCCGCGAATACGACGCCGTGGTGGCGTCCGGCGAGCAGGTGACGTCGGGGCTT
CTCGCGATCGCCTTGCAGGCGCTCGGCATCCAGGCGCGATCCTGGCAGGGCTGGCAGTTGCCGATCCGCACCAGCGACGC
CCATGCCTCGGCTCGGATCGTCGAGATCGACGGCAGCGAGATCGTCAAGCGCTTCGGCGACCGCAAGGAAGTCGCGGTGA
TCGCCGGCTTCCAGGGCATCAATCCCGAGACCGGCCGCATCACCACGCTCGGCCGCGGCGGCTCCGACACCTCGGCGGTG
GCGATCGCGGCGGCGCTGAAGGCCGACCGCTGCGACATCTATACCGACGTCGACGGCGTCTACACCACCGACCCCCGCGT
GGTGCCGAAGGCGAAACGGCTCGACAAGGTGGCGTTCGAGGAGATGTTGGAACTGGCGTCGCAGGGCGCCAAGGTGCTGC
AGGTCCGCTCGGTCGAGCTCGGCATGGTGCACAACATGCCGATCTTCGTGCGCTCTTCCTTCGACAAACCCGAAGATATC
GATCCGCACGGCACGCCGCCGGGCACGCTGATCTGCAGCGAGGAGAAAATCATGGAGAACCACGTCGTCACCGGCATCGC
CTTTTCCAAGGACGAAGCCCAGATCTCGGTGCGCCGGATCGAGGACAAGCCGGGCGTGGCGGCGTCGATCTTCGGGCCGC
TGGCCGACGCCAACATCAACGTCGACATGATCGTGCAGAACGTCTCGGAAGACGGCAAGACCACGGATCTCACCTTCACG
GTTCCGGCGTCGGATTTCGCCCGCGCCAAGCAGACGATTACTTCGGCGCAGGACAAGATCGGTTACGCCCGGTTCGACAG
CGAGACCGACGTCGCCAAGGTGTCGGTGATCGGCTCCGGGATGCGCAGCCATGCCGGCGTCGCCGCCCAGGCATTCGCCG
CTTTGGCCGCGCGCAACATCAATATTCGCGCGATCACGACCTCGGAGATCAAGTTCTCGGTGCTGATCGACGCCGCCTAC
ACCGAGCTCGCGGTGCGGACATTGCATACTTTGTACGGATTGGATCAAGTTTAG

Upstream 100 bases:

>100_bases
TGCCCGGAACAGCGCCGCTGTGTATACGCGCCTCGCGGCGCCTATCTCGCGAAGCCCGCGCCATCAATACTCGTTGTCTG
CAGGGATTGCACTATTCGTC

Downstream 100 bases:

>100_bases
AATAAATTCGGTGCGATTTCAGGCCGGGCGCGGCGCTTTTTGCCGTCGTCCGTGGCAGGCGTTTTGCTTGGCAAATCAAG
CGTCAATTCGCTATACGGCC

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MGRLVMKFGGTSVANIERIQNVARHVKREVDAGHEVAVVVSAMAGKTNELVAWCTEASPMHDAREYDAVVASGEQVTSGL
LAIALQALGIQARSWQGWQLPIRTSDAHASARIVEIDGSEIVKRFGDRKEVAVIAGFQGINPETGRITTLGRGGSDTSAV
AIAAALKADRCDIYTDVDGVYTTDPRVVPKAKRLDKVAFEEMLELASQGAKVLQVRSVELGMVHNMPIFVRSSFDKPEDI
DPHGTPPGTLICSEEKIMENHVVTGIAFSKDEAQISVRRIEDKPGVAASIFGPLADANINVDMIVQNVSEDGKTTDLTFT
VPASDFARAKQTITSAQDKIGYARFDSETDVAKVSVIGSGMRSHAGVAAQAFAALAARNINIRAITTSEIKFSVLIDAAY
TELAVRTLHTLYGLDQV

Sequences:

>Translated_417_residues
MGRLVMKFGGTSVANIERIQNVARHVKREVDAGHEVAVVVSAMAGKTNELVAWCTEASPMHDAREYDAVVASGEQVTSGL
LAIALQALGIQARSWQGWQLPIRTSDAHASARIVEIDGSEIVKRFGDRKEVAVIAGFQGINPETGRITTLGRGGSDTSAV
AIAAALKADRCDIYTDVDGVYTTDPRVVPKAKRLDKVAFEEMLELASQGAKVLQVRSVELGMVHNMPIFVRSSFDKPEDI
DPHGTPPGTLICSEEKIMENHVVTGIAFSKDEAQISVRRIEDKPGVAASIFGPLADANINVDMIVQNVSEDGKTTDLTFT
VPASDFARAKQTITSAQDKIGYARFDSETDVAKVSVIGSGMRSHAGVAAQAFAALAARNINIRAITTSEIKFSVLIDAAY
TELAVRTLHTLYGLDQV
>Mature_416_residues
GRLVMKFGGTSVANIERIQNVARHVKREVDAGHEVAVVVSAMAGKTNELVAWCTEASPMHDAREYDAVVASGEQVTSGLL
AIALQALGIQARSWQGWQLPIRTSDAHASARIVEIDGSEIVKRFGDRKEVAVIAGFQGINPETGRITTLGRGGSDTSAVA
IAAALKADRCDIYTDVDGVYTTDPRVVPKAKRLDKVAFEEMLELASQGAKVLQVRSVELGMVHNMPIFVRSSFDKPEDID
PHGTPPGTLICSEEKIMENHVVTGIAFSKDEAQISVRRIEDKPGVAASIFGPLADANINVDMIVQNVSEDGKTTDLTFTV
PASDFARAKQTITSAQDKIGYARFDSETDVAKVSVIGSGMRSHAGVAAQAFAALAARNINIRAITTSEIKFSVLIDAAYT
ELAVRTLHTLYGLDQV

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=484, Percent_Identity=31.198347107438, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1790455, Length=460, Percent_Identity=29.3478260869565, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1790376, Length=272, Percent_Identity=27.9411764705882, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320893, Length=504, Percent_Identity=25.9920634920635, Blast_Score=104, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44703; Mature: 44572

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRLVMKFGGTSVANIERIQNVARHVKREVDAGHEVAVVVSAMAGKTNELVAWCTEASPM
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCCCEEEEECCCCCC
HDAREYDAVVASGEQVTSGLLAIALQALGIQARSWQGWQLPIRTSDAHASARIVEIDGSE
CHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEECCCCCEEEEEECCCCCCCEEEEEECCHH
IVKRFGDRKEVAVIAGFQGINPETGRITTLGRGGSDTSAVAIAAALKADRCDIYTDVDGV
HHHHHCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCEEECCCCE
YTTDPRVVPKAKRLDKVAFEEMLELASQGAKVLQVRSVELGMVHNMPIFVRSSFDKPEDI
EECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEEECCCEEEECCCCCCCCC
DPHGTPPGTLICSEEKIMENHVVTGIAFSKDEAQISVRRIEDKPGVAASIFGPLADANIN
CCCCCCCCCEEECHHHHHHHHEEEEEEECCCCCEEEEEEECCCCCCEEEHHCCCCCCCCC
VDMIVQNVSEDGKTTDLTFTVPASDFARAKQTITSAQDKIGYARFDSETDVAKVSVIGSG
CEEEEEECCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEEEECCC
MRSHAGVAAQAFAALAARNINIRAITTSEIKFSVLIDAAYTELAVRTLHTLYGLDQV
HHHHCCHHHHHHHHHHHCCCEEEEEEECCEEEEEEEEHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GRLVMKFGGTSVANIERIQNVARHVKREVDAGHEVAVVVSAMAGKTNELVAWCTEASPM
CEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCCCEEEEECCCCCC
HDAREYDAVVASGEQVTSGLLAIALQALGIQARSWQGWQLPIRTSDAHASARIVEIDGSE
CHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEECCCCCEEEEEECCCCCCCEEEEEECCHH
IVKRFGDRKEVAVIAGFQGINPETGRITTLGRGGSDTSAVAIAAALKADRCDIYTDVDGV
HHHHHCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCEEECCCCE
YTTDPRVVPKAKRLDKVAFEEMLELASQGAKVLQVRSVELGMVHNMPIFVRSSFDKPEDI
EECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEEECCCEEEECCCCCCCCC
DPHGTPPGTLICSEEKIMENHVVTGIAFSKDEAQISVRRIEDKPGVAASIFGPLADANIN
CCCCCCCCCEEECHHHHHHHHEEEEEEECCCCCEEEEEEECCCCCCEEEHHCCCCCCCCC
VDMIVQNVSEDGKTTDLTFTVPASDFARAKQTITSAQDKIGYARFDSETDVAKVSVIGSG
CEEEEEECCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEEEECCC
MRSHAGVAAQAFAALAARNINIRAITTSEIKFSVLIDAAYTELAVRTLHTLYGLDQV
HHHHCCHHHHHHHHHHHCCCEEEEEEECCEEEEEEEEHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]