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The map label for this gene is guaC [C]

Identifier: 86609078

GI number: 86609078

Start: 1688132

End: 1689295

Strand: Reverse

Name: guaC [C]

Synonym: CYB_1616

Alternate gene names: 86609078

Gene position: 1689295-1688132 (Counterclockwise)

Preceding gene: 86609079

Following gene: 86609077

Centisome position: 55.45

GC content: 62.8

Gene sequence:

>1164_bases
ATGGACGTGCAACTGGGCCGCAATCGGCAGGCAAGACGCGCTTACGGGCTGGATGAAATCGCGCTGGCCCCAGGCAGACG
AACGCTGGATCCCAGCCTGGTGGATACCCACTTCACCCTGGGAGGGATCCAACGGCAAATCCCCATCATCGCCAGCGCTA
TGGACGGCGTGGTGGATGTGCGAATGGCCATTTTGCTCTCGGAGCTGGGGGCCTTCGGGGTGTTGAACCTGGATGGCATC
CAAACCCGCTACGCCGATCCCGATGAGGTTTTGGCTCAGATCGCGTCGGTGGGCAAAGACGAGTTTGTGCCTCTGATGCA
GCGCCTCTACAGCGAACCTGTAAAGCCGGATCTGATTCAAGAGCGCATCCGCCAAATCAAGGCCGGTGGCGCCATTGCAG
CAGCCAGCAGTGTGCCCGCCCACGCCGCCCAATACGGCCCCCTGGTGGCTGAAGCCGGGGGGGATCTGTTTTTCGTCCAG
GCCACGGTGGTTTCCGTTCACCACAAGGTTCCCGAAGGCATGGAACTGCTGGATCTGGCCCAATTTTGCCGGTCGATGTC
CATTCCTGTTGTGGTGGGCAACTGCGTTACCTACGATGTCGCTCTGGAGCTGATGCAGGCCGGAGCTGCCGGTGTCTTGG
TGGGGATCGGCCCTGGCGCTGCCTGTACTTCCCGAGGCGTGTTGGGGGTGGGAGTGCCGCAGGCTACAGCGATTGCCGAC
TGTGCCGCTGCACGGGAGCAGTTTTTGGCGGAAACCGGCGCCTATGTCCCTGTGATTGCCGATGGGGGATTGGTGACCGG
TGGCGACATTTGCAAGGCCATCGCTTGTGGAGCCGATGCAGTGATGATCGGATCCCCCCTGGCCCGCGCCTATGAGGCCC
CCGGTCGCGGCTTTCATTGGGGCATGGCTACCCCCAGCCCCATCTTGCCCCGCGGCACCCGCATCCGCGTGGGATCCACC
GGCACCTTGGAAGAAATCTTGCGCGGCCCCGCCCGCCTGGACGACGGTACCCACAACCTCTTGGGCGCCCTGCGCACCAG
CATGGCCACCTTGGGGGCTGCCAATCTTCGAGAAATGCAGCAGGTGGAGATCTGCATTGCCCCTTCCCTCCTGACCGAGG
GCAAGGTGTACCAGAAGGCGCAGAGCTTGGGTATGGGGAAATAG

Upstream 100 bases:

>100_bases
ACCCGCTCCGGGATCGCAGCCAAGAGAACAAGACTCTCGCTGGCCTTGGATCCCCCCTTGGCGGCATGATAAGAACAAGG
ATCCGCAGAACAGGGGAAAA

Downstream 100 bases:

>100_bases
TCCTTTGGGAATGCTAAACTCGGTGGACTGGGATCCCTCGGGGGCGGTTAGCTCAGCGGTAGAGCGCCTGCCTTACAAGC
AGGATGTCACTGGTTCGAGT

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MDVQLGRNRQARRAYGLDEIALAPGRRTLDPSLVDTHFTLGGIQRQIPIIASAMDGVVDVRMAILLSELGAFGVLNLDGI
QTRYADPDEVLAQIASVGKDEFVPLMQRLYSEPVKPDLIQERIRQIKAGGAIAAASSVPAHAAQYGPLVAEAGGDLFFVQ
ATVVSVHHKVPEGMELLDLAQFCRSMSIPVVVGNCVTYDVALELMQAGAAGVLVGIGPGAACTSRGVLGVGVPQATAIAD
CAAAREQFLAETGAYVPVIADGGLVTGGDICKAIACGADAVMIGSPLARAYEAPGRGFHWGMATPSPILPRGTRIRVGST
GTLEEILRGPARLDDGTHNLLGALRTSMATLGAANLREMQQVEICIAPSLLTEGKVYQKAQSLGMGK

Sequences:

>Translated_387_residues
MDVQLGRNRQARRAYGLDEIALAPGRRTLDPSLVDTHFTLGGIQRQIPIIASAMDGVVDVRMAILLSELGAFGVLNLDGI
QTRYADPDEVLAQIASVGKDEFVPLMQRLYSEPVKPDLIQERIRQIKAGGAIAAASSVPAHAAQYGPLVAEAGGDLFFVQ
ATVVSVHHKVPEGMELLDLAQFCRSMSIPVVVGNCVTYDVALELMQAGAAGVLVGIGPGAACTSRGVLGVGVPQATAIAD
CAAAREQFLAETGAYVPVIADGGLVTGGDICKAIACGADAVMIGSPLARAYEAPGRGFHWGMATPSPILPRGTRIRVGST
GTLEEILRGPARLDDGTHNLLGALRTSMATLGAANLREMQQVEICIAPSLLTEGKVYQKAQSLGMGK
>Mature_387_residues
MDVQLGRNRQARRAYGLDEIALAPGRRTLDPSLVDTHFTLGGIQRQIPIIASAMDGVVDVRMAILLSELGAFGVLNLDGI
QTRYADPDEVLAQIASVGKDEFVPLMQRLYSEPVKPDLIQERIRQIKAGGAIAAASSVPAHAAQYGPLVAEAGGDLFFVQ
ATVVSVHHKVPEGMELLDLAQFCRSMSIPVVVGNCVTYDVALELMQAGAAGVLVGIGPGAACTSRGVLGVGVPQATAIAD
CAAAREQFLAETGAYVPVIADGGLVTGGDICKAIACGADAVMIGSPLARAYEAPGRGFHWGMATPSPILPRGTRIRVGST
GTLEEILRGPARLDDGTHNLLGALRTSMATLGAANLREMQQVEICIAPSLLTEGKVYQKAQSLGMGK

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. [C

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family [H]

Homologues:

Organism=Homo sapiens, GI50541956, Length=370, Percent_Identity=27.2972972972973, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI50541954, Length=370, Percent_Identity=27.2972972972973, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI50541952, Length=370, Percent_Identity=27.2972972972973, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI50541948, Length=370, Percent_Identity=27.2972972972973, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI156104880, Length=368, Percent_Identity=25.2717391304348, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI66933016, Length=112, Percent_Identity=43.75, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI217035150, Length=111, Percent_Identity=43.2432432432432, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI217035148, Length=111, Percent_Identity=43.2432432432432, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI217035152, Length=111, Percent_Identity=43.2432432432432, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI217035146, Length=111, Percent_Identity=43.2432432432432, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI34328930, Length=111, Percent_Identity=43.2432432432432, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI34328928, Length=111, Percent_Identity=43.2432432432432, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI156616279, Length=111, Percent_Identity=43.2432432432432, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1786293, Length=370, Percent_Identity=27.5675675675676, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1788855, Length=200, Percent_Identity=37.5, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17560440, Length=188, Percent_Identity=34.5744680851064, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71994385, Length=170, Percent_Identity=33.5294117647059, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71994389, Length=170, Percent_Identity=33.5294117647059, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322012, Length=112, Percent_Identity=39.2857142857143, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323585, Length=112, Percent_Identity=37.5, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6323464, Length=112, Percent_Identity=36.6071428571429, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI28571163, Length=244, Percent_Identity=30.7377049180328, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24641071, Length=244, Percent_Identity=30.7377049180328, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24641073, Length=244, Percent_Identity=30.7377049180328, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001093
- InterPro:   IPR005992 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 40385; Mature: 40385

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVQLGRNRQARRAYGLDEIALAPGRRTLDPSLVDTHFTLGGIQRQIPIIASAMDGVVDV
CCCCCCCCCHHHHHCCCCHHEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
RMAILLSELGAFGVLNLDGIQTRYADPDEVLAQIASVGKDEFVPLMQRLYSEPVKPDLIQ
HHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHH
ERIRQIKAGGAIAAASSVPAHAAQYGPLVAEAGGDLFFVQATVVSVHHKVPEGMELLDLA
HHHHHHHCCCCEEECCCCCHHHHHHCCEEEECCCCEEEEHHHHHHHHHCCCCCHHHHHHH
QFCRSMSIPVVVGNCVTYDVALELMQAGAAGVLVGIGPGAACTSRGVLGVGVPQATAIAD
HHHHHCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCEEEECCCCHHHHHH
CAAAREQFLAETGAYVPVIADGGLVTGGDICKAIACGADAVMIGSPLARAYEAPGRGFHW
HHHHHHHHHHHCCCEEEEEECCCEEECHHHHHHHHCCCCEEECCCHHHHHHCCCCCCEEC
GMATPSPILPRGTRIRVGSTGTLEEILRGPARLDDGTHNLLGALRTSMATLGAANLREMQ
CCCCCCCCCCCCCEEEECCCCCHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QVEICIAPSLLTEGKVYQKAQSLGMGK
HHHHEECCHHHHCCHHHHHHHHCCCCC
>Mature Secondary Structure
MDVQLGRNRQARRAYGLDEIALAPGRRTLDPSLVDTHFTLGGIQRQIPIIASAMDGVVDV
CCCCCCCCCHHHHHCCCCHHEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
RMAILLSELGAFGVLNLDGIQTRYADPDEVLAQIASVGKDEFVPLMQRLYSEPVKPDLIQ
HHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHH
ERIRQIKAGGAIAAASSVPAHAAQYGPLVAEAGGDLFFVQATVVSVHHKVPEGMELLDLA
HHHHHHHCCCCEEECCCCCHHHHHHCCEEEECCCCEEEEHHHHHHHHHCCCCCHHHHHHH
QFCRSMSIPVVVGNCVTYDVALELMQAGAAGVLVGIGPGAACTSRGVLGVGVPQATAIAD
HHHHHCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCEEEECCCCHHHHHH
CAAAREQFLAETGAYVPVIADGGLVTGGDICKAIACGADAVMIGSPLARAYEAPGRGFHW
HHHHHHHHHHHCCCEEEEEECCCEEECHHHHHHHHCCCCEEECCCHHHHHHCCCCCCEEC
GMATPSPILPRGTRIRVGSTGTLEEILRGPARLDDGTHNLLGALRTSMATLGAANLREMQ
CCCCCCCCCCCCCEEEECCCCCHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QVEICIAPSLLTEGKVYQKAQSLGMGK
HHHHEECCHHHHCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA