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The map label for this gene is pncB [H]

Identifier: 86608574

GI number: 86608574

Start: 1130673

End: 1132055

Strand: Reverse

Name: pncB [H]

Synonym: CYB_1096

Alternate gene names: 86608574

Gene position: 1132055-1130673 (Counterclockwise)

Preceding gene: 86608575

Following gene: 86608573

Centisome position: 37.16

GC content: 61.68

Gene sequence:

>1383_bases
ATGTTGAGCCCTGATTTCTCGTCGTTGCGGCCCCAAGACTATGGCCTGCTAACCGACCTGTACCAGTTCACCATGGCCGC
CTGCTACGTGGGGGAAGGGCTAGAGTCTCAGCCCGCTGCCTTTGAGCTGTTTGTGCGGCGGCTGCCCACCGACTATGGCT
ACCTAATCGCCATGGGGCTCACCCAGGCAGTGGACTATCTGCAGCAACTGAGCTTCGCCCCCGAGGCTTTGCGAGCGCTG
CGGGAAACGGGCATTTTCGCCGATGCGCCGGAGCGCTTTTGGGAGCTGCTGGCCCGCTGCCGGTTTGAGGGGGATGTGTG
GGCGGTGCCGGAAGGAACCGCCATTTTCGCCAACCAGCCCCTGTTGCGGGTGGAAGCCCCCCTCTGGCAAGCCCAACTGG
TGGAAACTTACTTGCTGTCCACCTTTAACTACCAGACCCTGATCGCCACCAAGGCGGCCCGTATGCGAGATGCAGCAGGG
GATGAGGCCATTTTGTTGGAGTTCGGCACCCGGCGAGCTTTTGGTCCCCAGGCGGGGCTGTGGGCAGCCCGGGCGGCTCT
GGCGGCAGGGTTCAATGCCACCTCCAACGTCTTGGCAGCCCTGAAATTGGGGCGCAAGCCGGCAGGAACCATGGCCCATT
CCCTAGTGATGGCCATTGCTGCTCTCTCGGGAGACGAAACCCGCGCCTTTCAATCCTTTCGGCGCTACTTTCCCCAAGCT
GCGCTTCTAATCGATACCTACGATCCCATCCAAGGGGCGCGCACAGCAGCCCAGCTCTTTGCGGCCAGAAGCCCAGATCA
ACTGGGATCCCAGGGGGAAATCGGCGGGGTGCGCATCGACTCGGGAGATTTGGAAGATCTCTCTCGCCGGGTGAAACAAA
TTTTGCCTCAAGGCGCCCCGGTGTTCGTCAGTGGGGATTTGGACGAATACGAGATCGAGCGCCTGCATCGCTCCCAAGCC
CCCATCAGCGGTTATGGGGTGGGCACCCGCCTGGTAACTGGAGAAGGCGTAAACGGGGTGTACAAATTGGTGGAAATCAA
TGGGATCCCAGTGGCCAAAGCTTCCTTTGCCAAAGCCACCCTTCCCGGTCGCAAGCAGATCTTTCGCGGCCCTGAAGGAG
ACTTGTTGGGCCATGCTGACGAGCCCCCGCCTCCTGGCTACGAACCGCTCTTGCGCAAAGTTATGGAAAAAGGGCTGCTG
CTGGATCCCTTGCCGGATCTGGAAGCCATTGCCCGCACCAGCCGCGCCTCTGTGCTGTGCCTGCCCCAGGGAGTGCGACA
ACTGCGCCAGCCGGATCCCTGGCCCACAGCCCTGACTGCCGCTTTGCAACGGTTGAAAGACCACACCCTTGGCCAGGAAT
GTGCCTCGGCGGGCCCTGCCTGA

Upstream 100 bases:

>100_bases
CTACAAGCAGCCTTACTTATGGTAAGTTTCACTATAACCTTCGCAACAGCCCTCTGCTCGATCCCGCCGTTCCCCACTGG
CTTCTGCCCCGAGGTTTTTC

Downstream 100 bases:

>100_bases
GGAGAAGGAGTCCCGCTGCACTATAATGTTCTAGCTTCAAGGTCTCCGCTTTGAGGTTTGAGTTTTGCCATTGGACTTGA
GCCTCAGGCCATTTTGATTT

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MLSPDFSSLRPQDYGLLTDLYQFTMAACYVGEGLESQPAAFELFVRRLPTDYGYLIAMGLTQAVDYLQQLSFAPEALRAL
RETGIFADAPERFWELLARCRFEGDVWAVPEGTAIFANQPLLRVEAPLWQAQLVETYLLSTFNYQTLIATKAARMRDAAG
DEAILLEFGTRRAFGPQAGLWAARAALAAGFNATSNVLAALKLGRKPAGTMAHSLVMAIAALSGDETRAFQSFRRYFPQA
ALLIDTYDPIQGARTAAQLFAARSPDQLGSQGEIGGVRIDSGDLEDLSRRVKQILPQGAPVFVSGDLDEYEIERLHRSQA
PISGYGVGTRLVTGEGVNGVYKLVEINGIPVAKASFAKATLPGRKQIFRGPEGDLLGHADEPPPPGYEPLLRKVMEKGLL
LDPLPDLEAIARTSRASVLCLPQGVRQLRQPDPWPTALTAALQRLKDHTLGQECASAGPA

Sequences:

>Translated_460_residues
MLSPDFSSLRPQDYGLLTDLYQFTMAACYVGEGLESQPAAFELFVRRLPTDYGYLIAMGLTQAVDYLQQLSFAPEALRAL
RETGIFADAPERFWELLARCRFEGDVWAVPEGTAIFANQPLLRVEAPLWQAQLVETYLLSTFNYQTLIATKAARMRDAAG
DEAILLEFGTRRAFGPQAGLWAARAALAAGFNATSNVLAALKLGRKPAGTMAHSLVMAIAALSGDETRAFQSFRRYFPQA
ALLIDTYDPIQGARTAAQLFAARSPDQLGSQGEIGGVRIDSGDLEDLSRRVKQILPQGAPVFVSGDLDEYEIERLHRSQA
PISGYGVGTRLVTGEGVNGVYKLVEINGIPVAKASFAKATLPGRKQIFRGPEGDLLGHADEPPPPGYEPLLRKVMEKGLL
LDPLPDLEAIARTSRASVLCLPQGVRQLRQPDPWPTALTAALQRLKDHTLGQECASAGPA
>Mature_460_residues
MLSPDFSSLRPQDYGLLTDLYQFTMAACYVGEGLESQPAAFELFVRRLPTDYGYLIAMGLTQAVDYLQQLSFAPEALRAL
RETGIFADAPERFWELLARCRFEGDVWAVPEGTAIFANQPLLRVEAPLWQAQLVETYLLSTFNYQTLIATKAARMRDAAG
DEAILLEFGTRRAFGPQAGLWAARAALAAGFNATSNVLAALKLGRKPAGTMAHSLVMAIAALSGDETRAFQSFRRYFPQA
ALLIDTYDPIQGARTAAQLFAARSPDQLGSQGEIGGVRIDSGDLEDLSRRVKQILPQGAPVFVSGDLDEYEIERLHRSQA
PISGYGVGTRLVTGEGVNGVYKLVEINGIPVAKASFAKATLPGRKQIFRGPEGDLLGHADEPPPPGYEPLLRKVMEKGLL
LDPLPDLEAIARTSRASVLCLPQGVRQLRQPDPWPTALTAALQRLKDHTLGQECASAGPA

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=537, Percent_Identity=32.5884543761639, Blast_Score=184, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71997947, Length=537, Percent_Identity=30.9124767225326, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI71997952, Length=537, Percent_Identity=30.9124767225326, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI71997955, Length=207, Percent_Identity=37.1980676328502, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24581587, Length=518, Percent_Identity=31.2741312741313, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI161076680, Length=216, Percent_Identity=37.962962962963, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24581595, Length=216, Percent_Identity=37.962962962963, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI28574709, Length=216, Percent_Identity=37.962962962963, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24581593, Length=216, Percent_Identity=37.962962962963, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24581591, Length=216, Percent_Identity=37.962962962963, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 49958; Mature: 49958

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSPDFSSLRPQDYGLLTDLYQFTMAACYVGEGLESQPAAFELFVRRLPTDYGYLIAMGL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
TQAVDYLQQLSFAPEALRALRETGIFADAPERFWELLARCRFEGDVWAVPEGTAIFANQP
HHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCEEECCCC
LLRVEAPLWQAQLVETYLLSTFNYQTLIATKAARMRDAAGDEAILLEFGTRRAFGPQAGL
CEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHH
WAARAALAAGFNATSNVLAALKLGRKPAGTMAHSLVMAIAALSGDETRAFQSFRRYFPQA
HHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
ALLIDTYDPIQGARTAAQLFAARSPDQLGSQGEIGGVRIDSGDLEDLSRRVKQILPQGAP
EEEEECCCCHHHHHHHHHHHHCCCHHHCCCCCCCCCEEECCCCHHHHHHHHHHHCCCCCC
VFVSGDLDEYEIERLHRSQAPISGYGVGTRLVTGEGVNGVYKLVEINGIPVAKASFAKAT
EEEECCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCHHHHHHHC
LPGRKQIFRGPEGDLLGHADEPPPPGYEPLLRKVMEKGLLLDPLPDLEAIARTSRASVLC
CCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEE
LPQGVRQLRQPDPWPTALTAALQRLKDHTLGQECASAGPA
CHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLSPDFSSLRPQDYGLLTDLYQFTMAACYVGEGLESQPAAFELFVRRLPTDYGYLIAMGL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
TQAVDYLQQLSFAPEALRALRETGIFADAPERFWELLARCRFEGDVWAVPEGTAIFANQP
HHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCEEECCCC
LLRVEAPLWQAQLVETYLLSTFNYQTLIATKAARMRDAAGDEAILLEFGTRRAFGPQAGL
CEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHH
WAARAALAAGFNATSNVLAALKLGRKPAGTMAHSLVMAIAALSGDETRAFQSFRRYFPQA
HHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
ALLIDTYDPIQGARTAAQLFAARSPDQLGSQGEIGGVRIDSGDLEDLSRRVKQILPQGAP
EEEEECCCCHHHHHHHHHHHHCCCHHHCCCCCCCCCEEECCCCHHHHHHHHHHHCCCCCC
VFVSGDLDEYEIERLHRSQAPISGYGVGTRLVTGEGVNGVYKLVEINGIPVAKASFAKAT
EEEECCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCHHHHHHHC
LPGRKQIFRGPEGDLLGHADEPPPPGYEPLLRKVMEKGLLLDPLPDLEAIARTSRASVLC
CCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCEEEE
LPQGVRQLRQPDPWPTALTAALQRLKDHTLGQECASAGPA
CHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]