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The map label for this gene is mprA [H]

Identifier: 86608487

GI number: 86608487

Start: 1047612

End: 1048967

Strand: Reverse

Name: mprA [H]

Synonym: CYB_1008

Alternate gene names: 86608487

Gene position: 1048967-1047612 (Counterclockwise)

Preceding gene: 86608488

Following gene: 86608486

Centisome position: 34.43

GC content: 58.85

Gene sequence:

>1356_bases
TTGCGGGTAGTTTGCTTTCCCGCGCCACCCTGCCTCGGTTTATCTATGGATCCCAGACCGGAGAGCGCTAGTGCAGCTCC
TGCGCCTGAGAAGGCGAAACTCGTCTCTGGCAGAAGTCAAGACGGCAGTCTGCAAGCCCGTGTACTGATTGTGGATGATA
GCTACATGGTGGCAGAGATGCTGTCCAACTTTTTGGGCAAGCAGGGCTGCAGTATTTCTTATGCTTTGGATGGCCTCTCC
GCGCTGGAGCAAATTCGCCGCCAACCCCCAGACCTCATCATTGCCGACTGGGTCATGCCCTCTCTGAACGGCCTAGACCT
GTGCCGCCAACTGCGGCAATTGCCGGAATATGCCTGGGTGTACTACATCATCATGACTGCCCGCGAGGGCAACGATAGCA
TGGAGCGGGCTTTGGAGGCAGGTGCCGATGAGTTTCTTTCCAAACCCTTTCAGGCTGCAGAGCTGCTGACGCGGGTGCGG
GCAGGGCTGCGCATTGTAGAAAGTCGCCGCCAGCAATATCTGCTCAAAACTGGGCAAAAATCTCCTCCCTCTCCCCCCAA
GTCGATTGGTTTGGAGGTGGGTAACCGTCAGGATTTGGTGGCTCGTTTGCCGCTGCGGGTGGCCCAGGCCCGTGCCCAAT
CGGAACCCCTCAGCTTGTTTGTGCTGCGCTTGGCCAACCTCGGTTCTCTGGCACAAGGGCTGGATGCTGACGGTCGGGCT
GATCTGCTCAAACTGTTTAGGGAGCGTTTGGCCAATAACCTGCGCGATGGAGACGACCTGTTTTGCTACGACGAGGGGCA
GTTTATCATTCTGCTCTCCGGGAGCACCTTGGCTGCTGCGCAAATTGCTGCCGAACGCTGCTGCCAGCGAATGATTCAGG
ATCCCTTTGTGGTGAATGGACGGGCGCTGCCGGTACAGCTCCAGTTTGGAGCGGCCAGCCTCATGGACAGCGATGACCCC
AAGGGGGTGGCTCTGTTGCGTCGGGCTGCCCAGGCTATGCGAGATAGCAGGAATGTGCACAGCTCGGTGGTGACTGCTCC
CCATCCCATCCCAGTTTCCGACCGCGTCAGCGGAACGGAGTCCTCAGAGCTGCTGAAACGCCTGCAGCGTCTGGAAAAAG
AAAACGCCGAACTGCGCCGAGAGCTGGAGACTCGCCTCAAGCAGATTGAGGATCTCCGCCAACACCATCAAGAGCTCAGC
CAAAAAATGCAGGCTTCTGCACCGGAACTGTCCACAGCGGGATCCCTGGCCCATAGACCCTTCCGCTTGCGGCGGCGAAA
ACTCCGGCAGCTTTGTCTGAAGCGTCAACTGAGCCGTAGAAGACCGCGCCTGGCCTTGGGGCGGCTGAGCAGGTAG

Upstream 100 bases:

>100_bases
AATCCATCTAACCAACTCGGCAAAGTGGAAGCGGCTGCTGTTCGCTACCGCATCAGAATAACGATGGAGATACCACATTC
ATTAGAATAGCGATGGAAAG

Downstream 100 bases:

>100_bases
CGATGGGCTGAGCGAACGGGAGAGACGGAAGGGAGGTGCAAAAGGCTATGATGGGCATTCTTCAGGGTCAAGTGGCCGGA
TCTGGGATCTGGAGACCAGC

Product: response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MRVVCFPAPPCLGLSMDPRPESASAAPAPEKAKLVSGRSQDGSLQARVLIVDDSYMVAEMLSNFLGKQGCSISYALDGLS
ALEQIRRQPPDLIIADWVMPSLNGLDLCRQLRQLPEYAWVYYIIMTAREGNDSMERALEAGADEFLSKPFQAAELLTRVR
AGLRIVESRRQQYLLKTGQKSPPSPPKSIGLEVGNRQDLVARLPLRVAQARAQSEPLSLFVLRLANLGSLAQGLDADGRA
DLLKLFRERLANNLRDGDDLFCYDEGQFIILLSGSTLAAAQIAAERCCQRMIQDPFVVNGRALPVQLQFGAASLMDSDDP
KGVALLRRAAQAMRDSRNVHSSVVTAPHPIPVSDRVSGTESSELLKRLQRLEKENAELRRELETRLKQIEDLRQHHQELS
QKMQASAPELSTAGSLAHRPFRLRRRKLRQLCLKRQLSRRRPRLALGRLSR

Sequences:

>Translated_451_residues
MRVVCFPAPPCLGLSMDPRPESASAAPAPEKAKLVSGRSQDGSLQARVLIVDDSYMVAEMLSNFLGKQGCSISYALDGLS
ALEQIRRQPPDLIIADWVMPSLNGLDLCRQLRQLPEYAWVYYIIMTAREGNDSMERALEAGADEFLSKPFQAAELLTRVR
AGLRIVESRRQQYLLKTGQKSPPSPPKSIGLEVGNRQDLVARLPLRVAQARAQSEPLSLFVLRLANLGSLAQGLDADGRA
DLLKLFRERLANNLRDGDDLFCYDEGQFIILLSGSTLAAAQIAAERCCQRMIQDPFVVNGRALPVQLQFGAASLMDSDDP
KGVALLRRAAQAMRDSRNVHSSVVTAPHPIPVSDRVSGTESSELLKRLQRLEKENAELRRELETRLKQIEDLRQHHQELS
QKMQASAPELSTAGSLAHRPFRLRRRKLRQLCLKRQLSRRRPRLALGRLSR
>Mature_451_residues
MRVVCFPAPPCLGLSMDPRPESASAAPAPEKAKLVSGRSQDGSLQARVLIVDDSYMVAEMLSNFLGKQGCSISYALDGLS
ALEQIRRQPPDLIIADWVMPSLNGLDLCRQLRQLPEYAWVYYIIMTAREGNDSMERALEAGADEFLSKPFQAAELLTRVR
AGLRIVESRRQQYLLKTGQKSPPSPPKSIGLEVGNRQDLVARLPLRVAQARAQSEPLSLFVLRLANLGSLAQGLDADGRA
DLLKLFRERLANNLRDGDDLFCYDEGQFIILLSGSTLAAAQIAAERCCQRMIQDPFVVNGRALPVQLQFGAASLMDSDDP
KGVALLRRAAQAMRDSRNVHSSVVTAPHPIPVSDRVSGTESSELLKRLQRLEKENAELRRELETRLKQIEDLRQHHQELS
QKMQASAPELSTAGSLAHRPFRLRRRKLRQLCLKRQLSRRRPRLALGRLSR

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=118, Percent_Identity=33.0508474576271, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790860, Length=143, Percent_Identity=33.5664335664336, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786784, Length=130, Percent_Identity=36.1538461538462, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788394, Length=125, Percent_Identity=30.4, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786911, Length=117, Percent_Identity=36.7521367521368, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI87082012, Length=118, Percent_Identity=33.0508474576271, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789402, Length=118, Percent_Identity=29.6610169491525, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1789809, Length=124, Percent_Identity=32.258064516129, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1787229, Length=126, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 50280; Mature: 50280

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVCFPAPPCLGLSMDPRPESASAAPAPEKAKLVSGRSQDGSLQARVLIVDDSYMVAEM
CEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEEEECCHHHHHH
LSNFLGKQGCSISYALDGLSALEQIRRQPPDLIIADWVMPSLNGLDLCRQLRQLPEYAWV
HHHHHCCCCCEEHHHHHHHHHHHHHHCCCCCEEEECHHCCCCCHHHHHHHHHHCHHHHEE
YYIIMTAREGNDSMERALEAGADEFLSKPFQAAELLTRVRAGLRIVESRRQQYLLKTGQK
HHEEEEECCCCHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SPPSPPKSIGLEVGNRQDLVARLPLRVAQARAQSEPLSLFVLRLANLGSLAQGLDADGRA
CCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHH
DLLKLFRERLANNLRDGDDLFCYDEGQFIILLSGSTLAAAQIAAERCCQRMIQDPFVVNG
HHHHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEEECC
RALPVQLQFGAASLMDSDDPKGVALLRRAAQAMRDSRNVHSSVVTAPHPIPVSDRVSGTE
EEEEEEEECCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
SSELLKRLQRLEKENAELRRELETRLKQIEDLRQHHQELSQKMQASAPELSTAGSLAHRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
FRLRRRKLRQLCLKRQLSRRRPRLALGRLSR
HHHHHHHHHHHHHHHHHHHCCCCHHHCCCCC
>Mature Secondary Structure
MRVVCFPAPPCLGLSMDPRPESASAAPAPEKAKLVSGRSQDGSLQARVLIVDDSYMVAEM
CEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEEEECCHHHHHH
LSNFLGKQGCSISYALDGLSALEQIRRQPPDLIIADWVMPSLNGLDLCRQLRQLPEYAWV
HHHHHCCCCCEEHHHHHHHHHHHHHHCCCCCEEEECHHCCCCCHHHHHHHHHHCHHHHEE
YYIIMTAREGNDSMERALEAGADEFLSKPFQAAELLTRVRAGLRIVESRRQQYLLKTGQK
HHEEEEECCCCHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SPPSPPKSIGLEVGNRQDLVARLPLRVAQARAQSEPLSLFVLRLANLGSLAQGLDADGRA
CCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHH
DLLKLFRERLANNLRDGDDLFCYDEGQFIILLSGSTLAAAQIAAERCCQRMIQDPFVVNG
HHHHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEEECC
RALPVQLQFGAASLMDSDDPKGVALLRRAAQAMRDSRNVHSSVVTAPHPIPVSDRVSGTE
EEEEEEEECCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
SSELLKRLQRLEKENAELRRELETRLKQIEDLRQHHQELSQKMQASAPELSTAGSLAHRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
FRLRRRKLRQLCLKRQLSRRRPRLALGRLSR
HHHHHHHHHHHHHHHHHHHCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA