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The map label for this gene is aroE

Identifier: 86608485

GI number: 86608485

Start: 1046132

End: 1046998

Strand: Reverse

Name: aroE

Synonym: CYB_1006

Alternate gene names: 86608485

Gene position: 1046998-1046132 (Counterclockwise)

Preceding gene: 86608486

Following gene: 86608482

Centisome position: 34.37

GC content: 61.59

Gene sequence:

>867_bases
GTGGACGGTCGGATTTCGGGAAGCACCCAATTGCTCGGTCTAATCGGGGATCCGGTGGCCCACAGCTTATCCCCAGCCAT
GCACAATGCTGCTTTGGCAGCTATGGGGGAAAACTATTGCTATGTGCCGTTTCCGGTGGCTCCAAAACACTTGGCGGCGG
CGGTGGCAGGGCTGGCGGCCATTGGGGTGCGGGGGTTTAATGTGACGATTCCTCACAAACAGGCCATTCTCCCTTTGCTC
GATCAGATTGAATCGCGGGCAGCAGCGGTGGGGGCGGTGAATACGGTTTACCCCTTGCCAGAGGGCGGGTGGGCGGGCAC
CAATACCGATATCGATGGCTTTGTGCAGCCTTTGCTGGGTCTGGAAAAAGGGATCCCTACTCTCATTCTGGGATCCGGGG
GGGCAGCGCGGGCGGCCATCCAAGGCTGTTTGGAGTTGGGGCTGGGGCCGGTGCGGGTGGCGGGGCGATCCCCCAACTCA
TTGCTGGCCTTGCAACAGACCTGGCCTCAGGTGGAGACGGTGAACTGGGCGGAGTTGAATTGCTACCTGTCTCAGACGCG
GCTTTTGGTCAACACCACCCCCGTGGGCATGCACAAGCCGGGATCCCCCGCCGGTCAAGGGCTTTCCCCCCTGAGCCGAG
AGCAACTGGGCCTGCTGTCTCCGGGTGCCATCGTGTACGACCTGATCTATGTGCCGGATCCCACTCCTCTGCTGCGGATG
GCCGCCGAGTTGGGACATACCCCCATCAGTGGACTAGAGATGCTGGTTCACCAGGGGGCCAAGGCTCTATCGCTTTGGCT
GGGAGGCAAGCCTGTACCGGTGGAGGTGATGCGGCAGGCAGCTCAACACCAGTTGGCCCAGGTTTAG

Upstream 100 bases:

>100_bases
GGCAGACTCTGCAGCGGGTTGAGTCGGAGTCTCAGTAGTTTTTAAATCGTCTTTAAATCTTGAGTGGCTTAAGGGATCCC
TTGAGGAGTTGGCTGAGCCG

Downstream 100 bases:

>100_bases
GGTCACTCCAGGCCAGTTGGAAGCCCTCTCTCAAGATGTAATGAGATAACAACAACTACCGGGCTAGCAATCCAAGGTTG
TTTCCCGCTCCCAGGGCGTG

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MDGRISGSTQLLGLIGDPVAHSLSPAMHNAALAAMGENYCYVPFPVAPKHLAAAVAGLAAIGVRGFNVTIPHKQAILPLL
DQIESRAAAVGAVNTVYPLPEGGWAGTNTDIDGFVQPLLGLEKGIPTLILGSGGAARAAIQGCLELGLGPVRVAGRSPNS
LLALQQTWPQVETVNWAELNCYLSQTRLLVNTTPVGMHKPGSPAGQGLSPLSREQLGLLSPGAIVYDLIYVPDPTPLLRM
AAELGHTPISGLEMLVHQGAKALSLWLGGKPVPVEVMRQAAQHQLAQV

Sequences:

>Translated_288_residues
MDGRISGSTQLLGLIGDPVAHSLSPAMHNAALAAMGENYCYVPFPVAPKHLAAAVAGLAAIGVRGFNVTIPHKQAILPLL
DQIESRAAAVGAVNTVYPLPEGGWAGTNTDIDGFVQPLLGLEKGIPTLILGSGGAARAAIQGCLELGLGPVRVAGRSPNS
LLALQQTWPQVETVNWAELNCYLSQTRLLVNTTPVGMHKPGSPAGQGLSPLSREQLGLLSPGAIVYDLIYVPDPTPLLRM
AAELGHTPISGLEMLVHQGAKALSLWLGGKPVPVEVMRQAAQHQLAQV
>Mature_288_residues
MDGRISGSTQLLGLIGDPVAHSLSPAMHNAALAAMGENYCYVPFPVAPKHLAAAVAGLAAIGVRGFNVTIPHKQAILPLL
DQIESRAAAVGAVNTVYPLPEGGWAGTNTDIDGFVQPLLGLEKGIPTLILGSGGAARAAIQGCLELGLGPVRVAGRSPNS
LLALQQTWPQVETVNWAELNCYLSQTRLLVNTTPVGMHKPGSPAGQGLSPLSREQLGLLSPGAIVYDLIYVPDPTPLLRM
AAELGHTPISGLEMLVHQGAKALSLWLGGKPVPVEVMRQAAQHQLAQV

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=294, Percent_Identity=32.9931972789116, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1789675, Length=279, Percent_Identity=27.9569892473118, Blast_Score=91, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6320332, Length=277, Percent_Identity=27.7978339350181, Blast_Score=86, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_SYNJB (Q2JMQ3)

Other databases:

- EMBL:   CP000240
- RefSeq:   YP_477247.1
- HSSP:   Q9SQT8
- ProteinModelPortal:   Q2JMQ3
- SMR:   Q2JMQ3
- STRING:   Q2JMQ3
- GeneID:   3900378
- GenomeReviews:   CP000240_GR
- KEGG:   cyb:CYB_1006
- TIGR:   CYB_1006
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   CALRSIN
- PhylomeDB:   Q2JMQ3
- ProtClustDB:   PRK00258
- BioCyc:   SSP321332:CYB_1006-MONOMER
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 29952; Mature: 29952

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: ACT_SITE 73-73

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGRISGSTQLLGLIGDPVAHSLSPAMHNAALAAMGENYCYVPFPVAPKHLAAAVAGLAA
CCCCCCCCCEEEEECCCHHHHHCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHH
IGVRGFNVTIPHKQAILPLLDQIESRAAAVGAVNTVYPLPEGGWAGTNTDIDGFVQPLLG
HCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCHHHHHHHHHH
LEKGIPTLILGSGGAARAAIQGCLELGLGPVRVAGRSPNSLLALQQTWPQVETVNWAELN
HHCCCCEEEEECCCHHHHHHHHHHHHCCCCEEECCCCCCCEEEEHHHCCCCCCCCHHHEE
CYLSQTRLLVNTTPVGMHKPGSPAGQGLSPLSREQLGLLSPGAIVYDLIYVPDPTPLLRM
EEEECCEEEEECCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCEEEEEEECCCCCHHHHH
AAELGHTPISGLEMLVHQGAKALSLWLGGKPVPVEVMRQAAQHQLAQV
HHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDGRISGSTQLLGLIGDPVAHSLSPAMHNAALAAMGENYCYVPFPVAPKHLAAAVAGLAA
CCCCCCCCCEEEEECCCHHHHHCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHH
IGVRGFNVTIPHKQAILPLLDQIESRAAAVGAVNTVYPLPEGGWAGTNTDIDGFVQPLLG
HCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCHHHHHHHHHH
LEKGIPTLILGSGGAARAAIQGCLELGLGPVRVAGRSPNSLLALQQTWPQVETVNWAELN
HHCCCCEEEEECCCHHHHHHHHHHHHCCCCEEECCCCCCCEEEEHHHCCCCCCCCHHHEE
CYLSQTRLLVNTTPVGMHKPGSPAGQGLSPLSREQLGLLSPGAIVYDLIYVPDPTPLLRM
EEEECCEEEEECCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCEEEEEEECCCCCHHHHH
AAELGHTPISGLEMLVHQGAKALSLWLGGKPVPVEVMRQAAQHQLAQV
HHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA