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The map label for this gene is fabG [H]

Identifier: 86608464

GI number: 86608464

Start: 1020247

End: 1020951

Strand: Reverse

Name: fabG [H]

Synonym: CYB_0985

Alternate gene names: 86608464

Gene position: 1020951-1020247 (Counterclockwise)

Preceding gene: 86608465

Following gene: 86608463

Centisome position: 33.51

GC content: 62.13

Gene sequence:

>705_bases
ATGCAGGGCAACCAAGGCAAGCAAATCCTCTTGACCGGCGGCACAGGCGGGCTGGGTTTGGGGGTGGTTCCCGTGGTGCT
GGCCAGCGGAGCAGAGCTGACCTTGACCTATCGCCAAGAGAAAGATCTTGCCATTTTGCGGGAGCGCCTGCCGGCCAATG
CTCTGGATCGGGTTCGCTTTGTGCAAGTGGATTTAACAGATGAGGCGGCGGTTGCCCGCGTCATTGCCGACCTACCCCGC
GTGGATGGGCTGATCCACCTGGTGGGGGGCTTTGCCATGGGCCCCACCCACGAGTACAGCTTGGCGGACTGGTATCGCGA
CTTCGACCTCAACCTCACCACCACTTTTCTGACCTGCAAGCACAGCCTGCGCAGAATGTGGCAACAGGGCTATGGGCGGA
TTGTAACGGTGGGATCCCGCGGAGCGGTGGAGCCGGGCCCGCAATTGGCTGCCTACTGCGCTTCCAAAGCGGGGGTGGTG
GCCCTGACCCGTACCATTGCCGCCGAAACCAAAGGCACAGACATCACAGCCAACGTCATCCTGCCCAGCCTCATCGACAC
GCCGGCCAACCGAGCTGCCATGGGATCCGAGCAAGCCGAGCTGTGGGTAAAGCCAGAGTCCATCGGGCAGGTGATCGCCT
TTTTGGTCTCAGAAGCAGCGCGGGATCTGCGAGGGGCGGTGATCCCGGTGTATGGCAACGTCTAG

Upstream 100 bases:

>100_bases
GAGAGGGAAGCTCAGTTGGGCGAACCCAAACATCCTCTGGGGTTTTTGAAGTCCCTTCCCGATCTTGTTCTGGATCCCTT
TCGTCAATGCAGGTGCATCC

Downstream 100 bases:

>100_bases
GCAACTGGTTGACCAAGCCATGAGCCGCCATTCATGATACAGAATATGCACTTATCCCTATCCAGTTCTTTTCCATGCTG
AAGCGATTATTCTTGGGTGG

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MQGNQGKQILLTGGTGGLGLGVVPVVLASGAELTLTYRQEKDLAILRERLPANALDRVRFVQVDLTDEAAVARVIADLPR
VDGLIHLVGGFAMGPTHEYSLADWYRDFDLNLTTTFLTCKHSLRRMWQQGYGRIVTVGSRGAVEPGPQLAAYCASKAGVV
ALTRTIAAETKGTDITANVILPSLIDTPANRAAMGSEQAELWVKPESIGQVIAFLVSEAARDLRGAVIPVYGNV

Sequences:

>Translated_234_residues
MQGNQGKQILLTGGTGGLGLGVVPVVLASGAELTLTYRQEKDLAILRERLPANALDRVRFVQVDLTDEAAVARVIADLPR
VDGLIHLVGGFAMGPTHEYSLADWYRDFDLNLTTTFLTCKHSLRRMWQQGYGRIVTVGSRGAVEPGPQLAAYCASKAGVV
ALTRTIAAETKGTDITANVILPSLIDTPANRAAMGSEQAELWVKPESIGQVIAFLVSEAARDLRGAVIPVYGNV
>Mature_234_residues
MQGNQGKQILLTGGTGGLGLGVVPVVLASGAELTLTYRQEKDLAILRERLPANALDRVRFVQVDLTDEAAVARVIADLPR
VDGLIHLVGGFAMGPTHEYSLADWYRDFDLNLTTTFLTCKHSLRRMWQQGYGRIVTVGSRGAVEPGPQLAAYCASKAGVV
ALTRTIAAETKGTDITANVILPSLIDTPANRAAMGSEQAELWVKPESIGQVIAFLVSEAARDLRGAVIPVYGNV

Specific function: Part of the bacABCDE operon responsible for the biosynthesis of bacilysin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI19923817, Length=249, Percent_Identity=25.7028112449799, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI32483357, Length=242, Percent_Identity=26.0330578512397, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI7705925, Length=238, Percent_Identity=25.2100840336134, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787335, Length=241, Percent_Identity=27.8008298755187, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1786812, Length=242, Percent_Identity=28.099173553719, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788459, Length=242, Percent_Identity=26.0330578512397, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI2367365, Length=236, Percent_Identity=29.6610169491525, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1789208, Length=245, Percent_Identity=27.3469387755102, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1787820, Length=182, Percent_Identity=26.3736263736264, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082160, Length=242, Percent_Identity=25.2066115702479, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI87082100, Length=247, Percent_Identity=28.7449392712551, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI1790717, Length=241, Percent_Identity=24.0663900414938, Blast_Score=60, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17560676, Length=250, Percent_Identity=24.4, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=248, Percent_Identity=25.4032258064516, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24643142, Length=210, Percent_Identity=27.6190476190476, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639444, Length=242, Percent_Identity=28.9256198347107, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 24996; Mature: 24996

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGNQGKQILLTGGTGGLGLGVVPVVLASGAELTLTYRQEKDLAILRERLPANALDRVRF
CCCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHCCCCCCCCEEE
VQVDLTDEAAVARVIADLPRVDGLIHLVGGFAMGPTHEYSLADWYRDFDLNLTTTFLTCK
EEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHH
HSLRRMWQQGYGRIVTVGSRGAVEPGPQLAAYCASKAGVVALTRTIAAETKGTDITANVI
HHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEHHEE
LPSLIDTPANRAAMGSEQAELWVKPESIGQVIAFLVSEAARDLRGAVIPVYGNV
HHHHHCCCCCHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
>Mature Secondary Structure
MQGNQGKQILLTGGTGGLGLGVVPVVLASGAELTLTYRQEKDLAILRERLPANALDRVRF
CCCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHCCCCCCCCEEE
VQVDLTDEAAVARVIADLPRVDGLIHLVGGFAMGPTHEYSLADWYRDFDLNLTTTFLTCK
EEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHH
HSLRRMWQQGYGRIVTVGSRGAVEPGPQLAAYCASKAGVVALTRTIAAETKGTDITANVI
HHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEHHEE
LPSLIDTPANRAAMGSEQAELWVKPESIGQVIAFLVSEAARDLRGAVIPVYGNV
HHHHHCCCCCHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA