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The map label for this gene is trx-2 [H]

Identifier: 86608440

GI number: 86608440

Start: 999058

End: 999534

Strand: Reverse

Name: trx-2 [H]

Synonym: CYB_0960

Alternate gene names: 86608440

Gene position: 999534-999058 (Counterclockwise)

Preceding gene: 86608441

Following gene: 86608433

Centisome position: 32.81

GC content: 54.93

Gene sequence:

>477_bases
ATGCTTTCCATCCCCAAATGGTTTCTGCAGCCAGCCGAGTTGCCTGGTAGCATGATCCCAAAGAACTTCTTTAGTTTGGG
AGTGATGGCCTTGCAAGTTGCTTTAGATGCTTTTAATCAAGAACTTTTGACAAGTGACGGGTTGGTTTTGGTGGATTTCG
GCGCCCCTTGGTGTGGCCTGTGTCGCTTCATTCAGCCGATTACCGACCGTCTCGTAGCCGAGTGGGGAGGAGCGGTCAAA
GTACTGCGGGTGAATGTAGACGACAATTTTTGGCTGCCGCGCCGCTATCGGGTGCGCTCTTTGCCAACCCTAATTTTGTT
TGAGAAAGGTCAAGAAGTGCAAAGGCTGGAGCACTTCGCCAGCCGCGATGAGGTGCTTCGCCGCTGCGAGCAGTTGTTTC
TTGACCACCTGCGCTACCTGGGTTCGGGAGCCTGCTCATCCTCGTTTGAGCCCCAAGCCCCGCCGCCCGGCGTGTAG

Upstream 100 bases:

>100_bases
ATCCCCGGCTTGGCCATTCTGCAGAAGCGACAGCAACTGCGCCCCCAAGAGTTTTTTCGCTGGGCCTATCTGGGGGTATT
CAGCTTTGTATTGATTCTTT

Downstream 100 bases:

>100_bases
AGGGTGATCACGTCGCCGGCTTTTAGGGAGCGGCTGATTTTGCCGGGTAGGGGATCCCCGTTGAGGAGGTTGATCCCCAC
CTGGCCTGGCCCACCCCCCT

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 158; Mature: 158

Protein sequence:

>158_residues
MLSIPKWFLQPAELPGSMIPKNFFSLGVMALQVALDAFNQELLTSDGLVLVDFGAPWCGLCRFIQPITDRLVAEWGGAVK
VLRVNVDDNFWLPRRYRVRSLPTLILFEKGQEVQRLEHFASRDEVLRRCEQLFLDHLRYLGSGACSSSFEPQAPPPGV

Sequences:

>Translated_158_residues
MLSIPKWFLQPAELPGSMIPKNFFSLGVMALQVALDAFNQELLTSDGLVLVDFGAPWCGLCRFIQPITDRLVAEWGGAVK
VLRVNVDDNFWLPRRYRVRSLPTLILFEKGQEVQRLEHFASRDEVLRRCEQLFLDHLRYLGSGACSSSFEPQAPPPGV
>Mature_158_residues
MLSIPKWFLQPAELPGSMIPKNFFSLGVMALQVALDAFNQELLTSDGLVLVDFGAPWCGLCRFIQPITDRLVAEWGGAVK
VLRVNVDDNFWLPRRYRVRSLPTLILFEKGQEVQRLEHFASRDEVLRRCEQLFLDHLRYLGSGACSSSFEPQAPPPGV

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI5031973, Length=110, Percent_Identity=29.0909090909091, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI87082331, Length=81, Percent_Identity=39.5061728395062, Blast_Score=78, Evalue=2e-16,
Organism=Escherichia coli, GI1788936, Length=78, Percent_Identity=39.7435897435897, Blast_Score=65, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639826, Length=77, Percent_Identity=41.5584415584416, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 17875; Mature: 17875

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSIPKWFLQPAELPGSMIPKNFFSLGVMALQVALDAFNQELLTSDGLVLVDFGAPWCGL
CCCCCHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHH
CRFIQPITDRLVAEWGGAVKVLRVNVDDNFWLPRRYRVRSLPTLILFEKGQEVQRLEHFA
HHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHCCCEEEEECCCHHHHHHHHHH
SRDEVLRRCEQLFLDHLRYLGSGACSSSFEPQAPPPGV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLSIPKWFLQPAELPGSMIPKNFFSLGVMALQVALDAFNQELLTSDGLVLVDFGAPWCGL
CCCCCHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHH
CRFIQPITDRLVAEWGGAVKVLRVNVDDNFWLPRRYRVRSLPTLILFEKGQEVQRLEHFA
HHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHCCCEEEEECCCHHHHHHHHHH
SRDEVLRRCEQLFLDHLRYLGSGACSSSFEPQAPPPGV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769 [H]