Click here to switch to the map view.

The map label for this gene is trpA [H]

Identifier: 86608417

GI number: 86608417

Start: 975617

End: 976432

Strand: Direct

Name: trpA [H]

Synonym: CYB_0937

Alternate gene names: 86608417

Gene position: 975617-976432 (Clockwise)

Preceding gene: 86608416

Following gene: 86608419

Centisome position: 32.02

GC content: 63.6

Gene sequence:

>816_bases
ATGCCCAGCCGGATCACAGCCTGTTTCCAGGCGCTGCGCAGCCGCGGTGAAGCAGCCCTCATCCCCTACCTCACCGCCGG
GGATCCCAACTTGGAAACCACCTTTGAGGCTTTGCAGGTTCTGGATCAGAGCGGCGCCGATCTTATCGAGCTGGGGGTAC
CCTACTCGGATCCCTTGGCCGATGGGCCGGTGATCCAAGCAGCAGCCACCCGCGCCCTCAGTCGGGGAGTCACTTTGGGC
GCCATTCTACAAGGCTTGCGCTGTCTCTCGCTGCAGGCCCCCCTGATCCTGTTCACCTACTACAACCCCATCCACCAGCT
CGGCATCCCCAACTTTCTGCATCAACTGCGGCAGGCCGGCTGTGCCGGCTTGGTCGTCCCCGATCTGCCTCTGGAAGAGG
CGGGATCCCTGCGACAAGCAGCCCAGGCCGAAGAGATCGACCTCATCCTGCTGGTGGCCCCCACCAGCCCCCCGGAGCGC
ATGCGCCGCATTGCCCAGCAGTCCAGTGGCTTTGTCTACTTGGTCAGCACCACCGGCGTTACCGGCGAACGGGCCACCCT
GGAAAAGCGGATCCCGGCTTTGCTGCAGCAACTGCGCCAACAAACCCCCCTGCCGATTGGGGTGGGCTTCGGCATCTCCA
CTCCCGACCAGGCCCGCCAGATCGCTCTCTGGGGAGCAGATGCAGCGATTGTGGGCAGCGCATTTGTGCAACGGCTGGCC
AAAGCCCCCACGCCTGAAGAAGGACTGCAGCAAATAGCCCACTTTTGTCGAGCCCTCAAAGCGGCTCTGCAAGAGGTGAC
CACTCCAGAGCGCTGA

Upstream 100 bases:

>100_bases
CGCTCCGGTACCGGCTACGATTTTGTGCCTCTCCCCTAGGGATCCCGGCAGACGCTACAGTGGGGGATGCTCTCAATCTC
CTCAGAATCGAATGGATCCC

Downstream 100 bases:

>100_bases
CCGAAGCGCGAGGAGCGTGGAGCGGCGGAAAAATCCCCCGGCTTTAGCCGTGGGGAGAACGTCAGTTCTGTTCAGGAGGG
CGCCAACTCAGGTTGCTTCC

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MPSRITACFQALRSRGEAALIPYLTAGDPNLETTFEALQVLDQSGADLIELGVPYSDPLADGPVIQAAATRALSRGVTLG
AILQGLRCLSLQAPLILFTYYNPIHQLGIPNFLHQLRQAGCAGLVVPDLPLEEAGSLRQAAQAEEIDLILLVAPTSPPER
MRRIAQQSSGFVYLVSTTGVTGERATLEKRIPALLQQLRQQTPLPIGVGFGISTPDQARQIALWGADAAIVGSAFVQRLA
KAPTPEEGLQQIAHFCRALKAALQEVTTPER

Sequences:

>Translated_271_residues
MPSRITACFQALRSRGEAALIPYLTAGDPNLETTFEALQVLDQSGADLIELGVPYSDPLADGPVIQAAATRALSRGVTLG
AILQGLRCLSLQAPLILFTYYNPIHQLGIPNFLHQLRQAGCAGLVVPDLPLEEAGSLRQAAQAEEIDLILLVAPTSPPER
MRRIAQQSSGFVYLVSTTGVTGERATLEKRIPALLQQLRQQTPLPIGVGFGISTPDQARQIALWGADAAIVGSAFVQRLA
KAPTPEEGLQQIAHFCRALKAALQEVTTPER
>Mature_270_residues
PSRITACFQALRSRGEAALIPYLTAGDPNLETTFEALQVLDQSGADLIELGVPYSDPLADGPVIQAAATRALSRGVTLGA
ILQGLRCLSLQAPLILFTYYNPIHQLGIPNFLHQLRQAGCAGLVVPDLPLEEAGSLRQAAQAEEIDLILLVAPTSPPERM
RRIAQQSSGFVYLVSTTGVTGERATLEKRIPALLQQLRQQTPLPIGVGFGISTPDQARQIALWGADAAIVGSAFVQRLAK
APTPEEGLQQIAHFCRALKAALQEVTTPER

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=263, Percent_Identity=36.1216730038023, Blast_Score=156, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6321412, Length=247, Percent_Identity=35.6275303643725, Blast_Score=157, Evalue=1e-39,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 29001; Mature: 28870

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSRITACFQALRSRGEAALIPYLTAGDPNLETTFEALQVLDQSGADLIELGVPYSDPLA
CCHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCC
DGPVIQAAATRALSRGVTLGAILQGLRCLSLQAPLILFTYYNPIHQLGIPNFLHQLRQAG
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCHHHHHHHHHCC
CAGLVVPDLPLEEAGSLRQAAQAEEIDLILLVAPTSPPERMRRIAQQSSGFVYLVSTTGV
CCCEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCC
TGERATLEKRIPALLQQLRQQTPLPIGVGFGISTPDQARQIALWGADAAIVGSAFVQRLA
CCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHEEEEECCCHHHHHHHHHHHHH
KAPTPEEGLQQIAHFCRALKAALQEVTTPER
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PSRITACFQALRSRGEAALIPYLTAGDPNLETTFEALQVLDQSGADLIELGVPYSDPLA
CHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCC
DGPVIQAAATRALSRGVTLGAILQGLRCLSLQAPLILFTYYNPIHQLGIPNFLHQLRQAG
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCHHHHHHHHHCC
CAGLVVPDLPLEEAGSLRQAAQAEEIDLILLVAPTSPPERMRRIAQQSSGFVYLVSTTGV
CCCEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCC
TGERATLEKRIPALLQQLRQQTPLPIGVGFGISTPDQARQIALWGADAAIVGSAFVQRLA
CCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHEEEEECCCHHHHHHHHHHHHH
KAPTPEEGLQQIAHFCRALKAALQEVTTPER
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA