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The map label for this gene is tmk

Identifier: 86608314

GI number: 86608314

Start: 863963

End: 864583

Strand: Direct

Name: tmk

Synonym: CYB_0832

Alternate gene names: 86608314

Gene position: 863963-864583 (Clockwise)

Preceding gene: 86608313

Following gene: 86608315

Centisome position: 28.36

GC content: 65.22

Gene sequence:

>621_bases
GTGTTCATCACCCTAGAAGGCGGGGAAGGGGTGGGCAAAACCACCCAACAGGCCCTCTTGGTTGAGCGGCTGCGCCAAGA
AGGCTACGCTTGCCTGTGTACCCGCGAGCCGGGGGGCACGGCGCTGGGCAAAACGCTGCGGGAGCTGTTGCTGCACGGGG
ATCCCTTTAGTCCTCTGGCGGAGTTGCTCCTGTACGCGGCGGATCGGGCTGAACACGTGAGCAAAGTCATCGCGCCGGCT
CTGGCGGCAGGGCAGGTGGTGGTTTGTGACCGCTTTACCGATTCCACCCTGGCCTACCAGGGCTACGGTCGGGGGCTGGA
CTTGGAGAAGATCCGCCAGCTCAACCACTTAGCCACCGGCGGGTTGCAGCCGCACCTCACCCTGTGGCTGGATCTTCCAC
CAGAGGTGGGACTGGCGCGGGCAAAGGCTCGCGACAGGCTTGAACAAGAACGCCTGGAGTTCCACCGCCGCGTCTACCAA
GGGTTCCAGGCTCTGGCTGCCGCCGAACCACAGCGGATTGTCCGCATTTCAGCCCAGGGATCCCCCGCAGAGGTGGCTGC
CCGCCTCTGGTCAGTGGTCGAACCCCGCCTACCACTTGCGACAGCAGGCCGGGAGCCCTAG

Upstream 100 bases:

>100_bases
CCCACCAACATCCCCGACGTCTACGTGATGGTGCCGGGGCACTCCTTTAATTTGCAGCCCCAACTCAACCTGCGCTAACC
CTCCTGCAGAGGACGACGGT

Downstream 100 bases:

>100_bases
ACTGATACATTTACGCTGAACATTGCTGAACATCACTGTTCAACTATGCAGCGATAGCATTCTGTTTGTTTCCAAACAGA
ATGGCGGTATCCCGCAAAGC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MFITLEGGEGVGKTTQQALLVERLRQEGYACLCTREPGGTALGKTLRELLLHGDPFSPLAELLLYAADRAEHVSKVIAPA
LAAGQVVVCDRFTDSTLAYQGYGRGLDLEKIRQLNHLATGGLQPHLTLWLDLPPEVGLARAKARDRLEQERLEFHRRVYQ
GFQALAAAEPQRIVRISAQGSPAEVAARLWSVVEPRLPLATAGREP

Sequences:

>Translated_206_residues
MFITLEGGEGVGKTTQQALLVERLRQEGYACLCTREPGGTALGKTLRELLLHGDPFSPLAELLLYAADRAEHVSKVIAPA
LAAGQVVVCDRFTDSTLAYQGYGRGLDLEKIRQLNHLATGGLQPHLTLWLDLPPEVGLARAKARDRLEQERLEFHRRVYQ
GFQALAAAEPQRIVRISAQGSPAEVAARLWSVVEPRLPLATAGREP
>Mature_206_residues
MFITLEGGEGVGKTTQQALLVERLRQEGYACLCTREPGGTALGKTLRELLLHGDPFSPLAELLLYAADRAEHVSKVIAPA
LAAGQVVVCDRFTDSTLAYQGYGRGLDLEKIRQLNHLATGGLQPHLTLWLDLPPEVGLARAKARDRLEQERLEFHRRVYQ
GFQALAAAEPQRIVRISAQGSPAEVAARLWSVVEPRLPLATAGREP

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=177, Percent_Identity=45.7627118644068, Blast_Score=130, Evalue=6e-32,
Organism=Drosophila melanogaster, GI28573735, Length=198, Percent_Identity=28.2828282828283, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_SYNJB (Q2JN62)

Other databases:

- EMBL:   CP000240
- RefSeq:   YP_477076.1
- HSSP:   P65248
- ProteinModelPortal:   Q2JN62
- SMR:   Q2JN62
- STRING:   Q2JN62
- GeneID:   3902347
- GenomeReviews:   CP000240_GR
- KEGG:   cyb:CYB_0832
- TIGR:   CYB_0832
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- PhylomeDB:   Q2JN62
- ProtClustDB:   CLSK750787
- BioCyc:   SSP321332:CYB_0832-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 22537; Mature: 22537

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFITLEGGEGVGKTTQQALLVERLRQEGYACLCTREPGGTALGKTLRELLLHGDPFSPLA
CEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCHHHH
ELLLYAADRAEHVSKVIAPALAAGQVVVCDRFTDSTLAYQGYGRGLDLEKIRQLNHLATG
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCCCCHHHHHHHHHHHCC
GLQPHLTLWLDLPPEVGLARAKARDRLEQERLEFHRRVYQGFQALAAAEPQRIVRISAQG
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
SPAEVAARLWSVVEPRLPLATAGREP
CHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MFITLEGGEGVGKTTQQALLVERLRQEGYACLCTREPGGTALGKTLRELLLHGDPFSPLA
CEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCHHHH
ELLLYAADRAEHVSKVIAPALAAGQVVVCDRFTDSTLAYQGYGRGLDLEKIRQLNHLATG
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCCCCHHHHHHHHHHHCC
GLQPHLTLWLDLPPEVGLARAKARDRLEQERLEFHRRVYQGFQALAAAEPQRIVRISAQG
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
SPAEVAARLWSVVEPRLPLATAGREP
CHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA