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The map label for this gene is proA [H]

Identifier: 86608305

GI number: 86608305

Start: 853143

End: 854510

Strand: Direct

Name: proA [H]

Synonym: CYB_0823

Alternate gene names: 86608305

Gene position: 853143-854510 (Clockwise)

Preceding gene: 86608302

Following gene: 86608306

Centisome position: 28.0

GC content: 61.77

Gene sequence:

>1368_bases
ATGTCCCTTGCCACCGATTGCCCCAGCTCGCTTGCATCTGCCTCAGAGCGCCCGCTGCTGTCCCAAGTGCAGTTGGCCCG
CGCTGCTGCCCAACACACGGCCACCTTGCCCACGGCTATTAAGAATGCCGCTCTGGAGGCCATGGCCACTGCCTTGTTGG
AGCACCAAGAGCCTATCTTGGCCGCCAACCGGGCGGATTTGGAGCGGGCAGCAGAGATGGTGAAAGCCGGGGAGTTGTCG
GCATCTGCCTATGCCCGCCTGAAGCTGGATGCCCACAAACTGGCAGATATGGTGGCCGGAGTGCGGCAGGTGATCCGGCT
GGGGGATCCGGTGGGCCGAGCTTTGCTGATCCGGGAACTGGACGAGGGGCTAATTTTGGAACGGCGCACCTACCCTTTGG
GGGTGCTGGGGGTGATCTTCGAGTCGCGGCCCGATGCTTTGGTGCAAATTGCTGCCCTGGCGGTGAAAACCGGCAATAGC
GTCTTGCTCAAGGGGGGATCCGAAGCTTTGCTCTCCTGTCAAGCCTTGATGGCGGCCATCCAGGCGGGCCTGCAACAGAT
CCCGGAGTTCCCCCAGGGATCCCTGCAGTTGCTCACCAGCCGCGCCGAGGTCAAGGCCCTACTGCAACTGGAAGGGCTGG
TAGACCTGATCATCCCCCGCGGCTCCAGCAGCTTTGTCCGCTACATCCTGGAGAATACCCGCATCCCGGTATTGGGCCAT
GCCGATGGCCTGTGTCACCTGTACGTGGATCGGGCAGCGGATGTGGACATGGCGATCAAGCTGACGGTGGACAGCAAAAC
CCAGTACCCCGCCGCCTGCAATGCCATCGAGACCCTGTTGGTCCACAAGGCCATAGCCCCCCACTTTTTGCCTCTGGCGG
TCAAGGCCCTGCGGGAAAAGGGGGTGGAATTGCGGGGGGATCCCCTCTGCCGCGAGCTGGTGCCGGATCTGATCCCGGCC
ACCGAGGACGACTGGAGCACCGAGTATGCCGATTTGATCCTCTCTATTAAAGTGGTGGGCTCCCTTGACGAGGCCATTGC
CCACATCCAGCAGTACGGATCCCGCCATACCGAGGCGATTGTAACCGAGGATGCCGCTGCTGCCCGGCGATTTTTGGATG
AAGTGGATGCGGCAGGGGTCTTTCACAATGCTTCCACCCGCTTTGCCGACGGGTTTCGCTACGGCTTTGGGGCAGAAGTG
GGCATCAGCACCCAAAAACTGCCGCCGCGCGGCCCGGTGGGCTTAGAAGGCTTGGTGACCTACCGCTACCAACTGCGAGG
GCAAGGACATCTTGTAGCCGACTACACAGGCCCCCAGGCCCGACCTTTTCAACATCGGGATCGCCTGAACAACACCGGCT
TAGCTTAG

Upstream 100 bases:

>100_bases
CCGGGGGTGCTTCTAGGATCACAGTTCAACACAACTTTGTTACAACCTATCATCGCAACCCTTTTCTTCCAAATGGGCAC
TTTGCCCCCTTTCTGACTCT

Downstream 100 bases:

>100_bases
CTGCAAAAGCCGGCTGTACAAACCGGCTGTACAAAGCAGTCGTTCACAAAAACCGTTCTCCTCGTCTTCGCGGCTCCAGG
TTGAGGTAAATTAAAAAATA

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MSLATDCPSSLASASERPLLSQVQLARAAAQHTATLPTAIKNAALEAMATALLEHQEPILAANRADLERAAEMVKAGELS
ASAYARLKLDAHKLADMVAGVRQVIRLGDPVGRALLIRELDEGLILERRTYPLGVLGVIFESRPDALVQIAALAVKTGNS
VLLKGGSEALLSCQALMAAIQAGLQQIPEFPQGSLQLLTSRAEVKALLQLEGLVDLIIPRGSSSFVRYILENTRIPVLGH
ADGLCHLYVDRAADVDMAIKLTVDSKTQYPAACNAIETLLVHKAIAPHFLPLAVKALREKGVELRGDPLCRELVPDLIPA
TEDDWSTEYADLILSIKVVGSLDEAIAHIQQYGSRHTEAIVTEDAAAARRFLDEVDAAGVFHNASTRFADGFRYGFGAEV
GISTQKLPPRGPVGLEGLVTYRYQLRGQGHLVADYTGPQARPFQHRDRLNNTGLA

Sequences:

>Translated_455_residues
MSLATDCPSSLASASERPLLSQVQLARAAAQHTATLPTAIKNAALEAMATALLEHQEPILAANRADLERAAEMVKAGELS
ASAYARLKLDAHKLADMVAGVRQVIRLGDPVGRALLIRELDEGLILERRTYPLGVLGVIFESRPDALVQIAALAVKTGNS
VLLKGGSEALLSCQALMAAIQAGLQQIPEFPQGSLQLLTSRAEVKALLQLEGLVDLIIPRGSSSFVRYILENTRIPVLGH
ADGLCHLYVDRAADVDMAIKLTVDSKTQYPAACNAIETLLVHKAIAPHFLPLAVKALREKGVELRGDPLCRELVPDLIPA
TEDDWSTEYADLILSIKVVGSLDEAIAHIQQYGSRHTEAIVTEDAAAARRFLDEVDAAGVFHNASTRFADGFRYGFGAEV
GISTQKLPPRGPVGLEGLVTYRYQLRGQGHLVADYTGPQARPFQHRDRLNNTGLA
>Mature_454_residues
SLATDCPSSLASASERPLLSQVQLARAAAQHTATLPTAIKNAALEAMATALLEHQEPILAANRADLERAAEMVKAGELSA
SAYARLKLDAHKLADMVAGVRQVIRLGDPVGRALLIRELDEGLILERRTYPLGVLGVIFESRPDALVQIAALAVKTGNSV
LLKGGSEALLSCQALMAAIQAGLQQIPEFPQGSLQLLTSRAEVKALLQLEGLVDLIIPRGSSSFVRYILENTRIPVLGHA
DGLCHLYVDRAADVDMAIKLTVDSKTQYPAACNAIETLLVHKAIAPHFLPLAVKALREKGVELRGDPLCRELVPDLIPAT
EDDWSTEYADLILSIKVVGSLDEAIAHIQQYGSRHTEAIVTEDAAAARRFLDEVDAAGVFHNASTRFADGFRYGFGAEVG
ISTQKLPPRGPVGLEGLVTYRYQLRGQGHLVADYTGPQARPFQHRDRLNNTGLA

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361368, Length=430, Percent_Identity=43.953488372093, Blast_Score=328, Evalue=7e-90,
Organism=Homo sapiens, GI62912457, Length=430, Percent_Identity=43.953488372093, Blast_Score=328, Evalue=9e-90,
Organism=Escherichia coli, GI1786438, Length=412, Percent_Identity=41.2621359223301, Blast_Score=305, Evalue=6e-84,
Organism=Caenorhabditis elegans, GI17569969, Length=422, Percent_Identity=44.5497630331754, Blast_Score=332, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI17569967, Length=422, Percent_Identity=44.5497630331754, Blast_Score=332, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6324899, Length=447, Percent_Identity=42.0581655480984, Blast_Score=332, Evalue=6e-92,
Organism=Drosophila melanogaster, GI21357643, Length=436, Percent_Identity=44.0366972477064, Blast_Score=328, Evalue=6e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 48937; Mature: 48806

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLATDCPSSLASASERPLLSQVQLARAAAQHTATLPTAIKNAALEAMATALLEHQEPIL
CCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
AANRADLERAAEMVKAGELSASAYARLKLDAHKLADMVAGVRQVIRLGDPVGRALLIREL
HCCHHHHHHHHHHHHHCCCCHHHHHEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
DEGLILERRTYPLGVLGVIFESRPDALVQIAALAVKTGNSVLLKGGSEALLSCQALMAAI
CCCCEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHH
QAGLQQIPEFPQGSLQLLTSRAEVKALLQLEGLVDLIIPRGSSSFVRYILENTRIPVLGH
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHEEECCCCHHHHHHHHHCCCCCEEEC
ADGLCHLYVDRAADVDMAIKLTVDSKTQYPAACNAIETLLVHKAIAPHFLPLAVKALREK
CCCEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVELRGDPLCRELVPDLIPATEDDWSTEYADLILSIKVVGSLDEAIAHIQQYGSRHTEAI
CCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHE
VTEDAAAARRFLDEVDAAGVFHNASTRFADGFRYGFGAEVGISTQKLPPRGPVGLEGLVT
EECHHHHHHHHHHHHHHCCEECCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEE
YRYQLRGQGHLVADYTGPQARPFQHRDRLNNTGLA
EEEEECCCCCEEEECCCCCCCCCHHHHCCCCCCCC
>Mature Secondary Structure 
SLATDCPSSLASASERPLLSQVQLARAAAQHTATLPTAIKNAALEAMATALLEHQEPIL
CCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
AANRADLERAAEMVKAGELSASAYARLKLDAHKLADMVAGVRQVIRLGDPVGRALLIREL
HCCHHHHHHHHHHHHHCCCCHHHHHEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
DEGLILERRTYPLGVLGVIFESRPDALVQIAALAVKTGNSVLLKGGSEALLSCQALMAAI
CCCCEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHH
QAGLQQIPEFPQGSLQLLTSRAEVKALLQLEGLVDLIIPRGSSSFVRYILENTRIPVLGH
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHEEECCCCHHHHHHHHHCCCCCEEEC
ADGLCHLYVDRAADVDMAIKLTVDSKTQYPAACNAIETLLVHKAIAPHFLPLAVKALREK
CCCEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVELRGDPLCRELVPDLIPATEDDWSTEYADLILSIKVVGSLDEAIAHIQQYGSRHTEAI
CCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHE
VTEDAAAARRFLDEVDAAGVFHNASTRFADGFRYGFGAEVGISTQKLPPRGPVGLEGLVT
EECHHHHHHHHHHHHHHCCEECCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEE
YRYQLRGQGHLVADYTGPQARPFQHRDRLNNTGLA
EEEEECCCCCEEEECCCCCCCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA