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The map label for this gene is hisB [H]

Identifier: 86608157

GI number: 86608157

Start: 684863

End: 685483

Strand: Direct

Name: hisB [H]

Synonym: CYB_0671

Alternate gene names: 86608157

Gene position: 684863-685483 (Clockwise)

Preceding gene: 86608156

Following gene: 86608158

Centisome position: 22.48

GC content: 59.74

Gene sequence:

>621_bases
ATGACTGCCCTCGACTCCTCGCGCCTGCTCCAGCCCAGAACGGCCTCTGTTCACCGTCGCACTGGAGAAACGGATGTCCA
AATTCATCTGAACCTGGATGGCAGCGGGCGCCATGAGATCGATACTGGGATCCCCTTTTTGGATCACATGCTGGCCCAGC
TCAGCACCCACGGGCTGATCGACCTGCAGATCAAGGCCATAGGGGATCTGCACATCGACGATCACCACACCAACGAAGAT
GTGGGCATCACGCTGGGACAAGCCCTGGCGCAGGCTCTGCAGGATCGGCGTGGCATTCATCGCTTCGGCCATTTTTGGGC
ACCTTTGGATGAAGCTTTGGTGCAGGTGGTGCTGGATTTCTCCGGGCGTCCTCACCTCAGCTATGGCCTGGAGCTGCCCA
CGGAGCGCATTGGCCGCTACGAAACCCAGTTGGTGCGGGAGTTTTATCAGGCGGTGGTCAACCACGCCCAGCTCACTTTG
CACATTCGCCAGGCTGCCGGCCTCAATGCCCACCATATTGTCGAGGCCAGTTTTAAGGCGTTTGCCCGCGCCCTGCGCAT
GGCCGTAGAACGGGATCCCCGCCGACAAGAAGGGATCCCCAGTTCGAAGGGAGTACTCTAG

Upstream 100 bases:

>100_bases
GAGAAGGGATTCTCACCTGCTGCATGGGTGAAGGTGTCGATGGCGGCGGGCTTGTGCGATCCTAGAGCTGGGACTTCCCG
CCTGCTTCGATACTTTTCCC

Downstream 100 bases:

>100_bases
GCATGAACTGGCCACGGAGACTGTTGGCCTTGGCTCTGGGATTGGGGACAGTTTTCTTCGGTCTGGGCCAGATGGGGGGT
GCAATTCTCAGTGTGGGCCT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MTALDSSRLLQPRTASVHRRTGETDVQIHLNLDGSGRHEIDTGIPFLDHMLAQLSTHGLIDLQIKAIGDLHIDDHHTNED
VGITLGQALAQALQDRRGIHRFGHFWAPLDEALVQVVLDFSGRPHLSYGLELPTERIGRYETQLVREFYQAVVNHAQLTL
HIRQAAGLNAHHIVEASFKAFARALRMAVERDPRRQEGIPSSKGVL

Sequences:

>Translated_206_residues
MTALDSSRLLQPRTASVHRRTGETDVQIHLNLDGSGRHEIDTGIPFLDHMLAQLSTHGLIDLQIKAIGDLHIDDHHTNED
VGITLGQALAQALQDRRGIHRFGHFWAPLDEALVQVVLDFSGRPHLSYGLELPTERIGRYETQLVREFYQAVVNHAQLTL
HIRQAAGLNAHHIVEASFKAFARALRMAVERDPRRQEGIPSSKGVL
>Mature_205_residues
TALDSSRLLQPRTASVHRRTGETDVQIHLNLDGSGRHEIDTGIPFLDHMLAQLSTHGLIDLQIKAIGDLHIDDHHTNEDV
GITLGQALAQALQDRRGIHRFGHFWAPLDEALVQVVLDFSGRPHLSYGLELPTERIGRYETQLVREFYQAVVNHAQLTLH
IRQAAGLNAHHIVEASFKAFARALRMAVERDPRRQEGIPSSKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=196, Percent_Identity=47.9591836734694, Blast_Score=175, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6324776, Length=221, Percent_Identity=39.3665158371041, Blast_Score=150, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 23053; Mature: 22922

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALDSSRLLQPRTASVHRRTGETDVQIHLNLDGSGRHEIDTGIPFLDHMLAQLSTHGLI
CCCCCCCCCCCCCHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCEE
DLQIKAIGDLHIDDHHTNEDVGITLGQALAQALQDRRGIHRFGHFWAPLDEALVQVVLDF
EEEEEEECCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
SGRPHLSYGLELPTERIGRYETQLVREFYQAVVNHAQLTLHIRQAAGLNAHHIVEASFKA
CCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHCCCCHHHHHHHHHHH
FARALRMAVERDPRRQEGIPSSKGVL
HHHHHHHHHHCCCCHHCCCCCCCCCC
>Mature Secondary Structure 
TALDSSRLLQPRTASVHRRTGETDVQIHLNLDGSGRHEIDTGIPFLDHMLAQLSTHGLI
CCCCCCCCCCCCHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCEE
DLQIKAIGDLHIDDHHTNEDVGITLGQALAQALQDRRGIHRFGHFWAPLDEALVQVVLDF
EEEEEEECCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
SGRPHLSYGLELPTERIGRYETQLVREFYQAVVNHAQLTLHIRQAAGLNAHHIVEASFKA
CCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHCCCCHHHHHHHHHHH
FARALRMAVERDPRRQEGIPSSKGVL
HHHHHHHHHHCCCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA