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The map label for this gene is ubiB [C]

Identifier: 86608111

GI number: 86608111

Start: 631292

End: 633211

Strand: Direct

Name: ubiB [C]

Synonym: CYB_0623

Alternate gene names: 86608111

Gene position: 631292-633211 (Clockwise)

Preceding gene: 86608108

Following gene: 86608113

Centisome position: 20.72

GC content: 59.06

Gene sequence:

>1920_bases
ATGGGCGCAACACCGGTAGTGACAATAGCAGCGAGGCAGGATGGCTTGGGTTCTGGGGCTGTCTCCATCCCTCCGGCAGA
TCTGGGGGTGGTTCCTGAGCCAAGCTTGCGTTACGACCCAGAGCAGTTGGCCAAGCAATATCGAGGGCGCTGGGATCTGG
TGGTGCGGCGCCTGTTTCAGTTGATCACCCCCTTTTTGGGCTTGTTGGCCTGGGTGTTTTGGGATCGCTGGCGGGGAGTA
GAACTGAAGAATCGCCCGAAACATGCGGCCCGGCTACGGGAGATCCTCACGGAATTGGGGCCGACAGCCATCAAAATCGG
CCAAGCCCTCTCCACCCGTCCCGATCTGGTTTCGCCCCTGTTTCTGGAGGAGCTGGCCAAACTGCAGGATGAGCTGCCCC
CCTTCGAGAATGCCATTGCTTTTGCCCTCATCGAGTCGGAGATCGGCAAACCCATAGACAAAATCTTTCGAGAGATCAGC
CCTGAACCGATTGCCGCCGCCAGCTTGGGGCAAGTGTACCAGGCCTACTTGCACAGCGGGGAGAAAGTCGCCGTCAAGGT
GCAGCGGCCCGACTTGATTGGGCGCATCTCTCTCGACATGTATATTGTCCGCAGCCTGGCCGCCTGGGCCAAACGCACTT
TCCGCCGCATCCGCAGCGACCTGGTGGGCATCGTCGATGAGTTTGCCGGGCGCCTCTACGAAGAAATGGACTACACGCAG
GAGGGCCGCAATGCCGAGCGGTTCCTGGCGCTGTACCGTCACCCCTCCATCTACGCTCCCAAAATTTACTGGGAGTACAC
CCGCACCAAGGTGCTGACGATGGAGTGGATTGATGGCATCAAGCTGACTCAGGTTGACAAAATCGCTGCTGCGGGGCTGG
ATGGACGGCACTTGATCGAGATCGGTGTCAATTGCTCCCTCAAGCAGCTTTTGGAAAATGGCTTTTTCCACGCCGATCCC
CACCCGGGCAACCTCTTGGCCATGTACGACGGGCGGCTGGCCTATATCGATTTCGGCATGATGAGCACCATCGCGCCCCA
TCAGCGCTACGGCCTGATCAAGGCGATTGTGCATTTGGTAAACCGAGACTTTGCCGGGCTGGCCCAAGACTACGTGGACT
TGGAGTTCCTGGATCCAGATACCGACCTGACTCCCATCATCCCTGCTCTGGAAGCTGTCTTCGCCGAAGCGATGGGCAAA
TCGGTCTCCGAACTGAATTTCAAGAGCATCACCGATCGGCTCTCGGGGGTGATGTACGACTTTCCCTTTCGAGTTCCCGC
CTACTACGCCTTGATCATCCGCTCTTTGCTCACCCTGGAAGGGATCGCCATCGGCCTGGATCCCAACTTTAAGGTGTTGA
GCGTGGCCTATCCCTACGTGGCTCAGCGCCTGCTCACCGACCCGGCCCCGGAGCTGCGCGTATCTCTGCGGGAGCTGCTG
TTTAACCAGGGGCAATTTCGCTGGAACCGCCTGGAGAACCTGCTGCGCAACGCCGTCAACAGCGAGGATTTTGACCTGCA
GGGATCCCTGGAAAAGGCCGTTGATTTTATCTTTTCTGAGCGGGGCGCTTTCCTGCGGGAGCGCCTAGTGGATGTGCTCT
TTTCCAGCTCCGGATCCCAGGGTGGCTCAGATGGCTTGGCTCATTTGCAGCGTCTGTGGGAACTCCTCAGCAGCAACCCG
AGCTTTCAGCCGCTGCAGCTTCTGCCGATTGTTGCCAAGGTGGCTGCCAAACCGGAAGCTCAACAACTGGGCCGTCAATT
GGCCTCCCGCTGGTTGCAACGCTCGGCAGCTCGCCTCATCCGCGACCTGCTATTGCCGGATACAGAAAAGCCCAGTTCAC
CCTCTTCCCTCAACGGGCGTGGCGGGATCCCTGGGCCAGCAACCTCTGCTTCTACCGCTCAACTTCCCCTTCCGGCCTAG

Upstream 100 bases:

>100_bases
GGCCTTTTCAAGCCCAATCGAGCAGGCTGGTGGCTGTCTCCGAGGGTCGCCAGGCTGAGCCAGCAAGTTAAGATGTGTTA
CGGAATCCGTTGGGGCATCT

Downstream 100 bases:

>100_bases
CTCAGGTGCTCTTGGGGGGCAGTATCGCTGTTGGGGTTAACAGAGGCCAGAGCCAGCGTAATCCACTCGGAAAATTCATC
GCGGCGGAAAACCTGGGGGC

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 639; Mature: 638

Protein sequence:

>639_residues
MGATPVVTIAARQDGLGSGAVSIPPADLGVVPEPSLRYDPEQLAKQYRGRWDLVVRRLFQLITPFLGLLAWVFWDRWRGV
ELKNRPKHAARLREILTELGPTAIKIGQALSTRPDLVSPLFLEELAKLQDELPPFENAIAFALIESEIGKPIDKIFREIS
PEPIAAASLGQVYQAYLHSGEKVAVKVQRPDLIGRISLDMYIVRSLAAWAKRTFRRIRSDLVGIVDEFAGRLYEEMDYTQ
EGRNAERFLALYRHPSIYAPKIYWEYTRTKVLTMEWIDGIKLTQVDKIAAAGLDGRHLIEIGVNCSLKQLLENGFFHADP
HPGNLLAMYDGRLAYIDFGMMSTIAPHQRYGLIKAIVHLVNRDFAGLAQDYVDLEFLDPDTDLTPIIPALEAVFAEAMGK
SVSELNFKSITDRLSGVMYDFPFRVPAYYALIIRSLLTLEGIAIGLDPNFKVLSVAYPYVAQRLLTDPAPELRVSLRELL
FNQGQFRWNRLENLLRNAVNSEDFDLQGSLEKAVDFIFSERGAFLRERLVDVLFSSSGSQGGSDGLAHLQRLWELLSSNP
SFQPLQLLPIVAKVAAKPEAQQLGRQLASRWLQRSAARLIRDLLLPDTEKPSSPSSLNGRGGIPGPATSASTAQLPLPA

Sequences:

>Translated_639_residues
MGATPVVTIAARQDGLGSGAVSIPPADLGVVPEPSLRYDPEQLAKQYRGRWDLVVRRLFQLITPFLGLLAWVFWDRWRGV
ELKNRPKHAARLREILTELGPTAIKIGQALSTRPDLVSPLFLEELAKLQDELPPFENAIAFALIESEIGKPIDKIFREIS
PEPIAAASLGQVYQAYLHSGEKVAVKVQRPDLIGRISLDMYIVRSLAAWAKRTFRRIRSDLVGIVDEFAGRLYEEMDYTQ
EGRNAERFLALYRHPSIYAPKIYWEYTRTKVLTMEWIDGIKLTQVDKIAAAGLDGRHLIEIGVNCSLKQLLENGFFHADP
HPGNLLAMYDGRLAYIDFGMMSTIAPHQRYGLIKAIVHLVNRDFAGLAQDYVDLEFLDPDTDLTPIIPALEAVFAEAMGK
SVSELNFKSITDRLSGVMYDFPFRVPAYYALIIRSLLTLEGIAIGLDPNFKVLSVAYPYVAQRLLTDPAPELRVSLRELL
FNQGQFRWNRLENLLRNAVNSEDFDLQGSLEKAVDFIFSERGAFLRERLVDVLFSSSGSQGGSDGLAHLQRLWELLSSNP
SFQPLQLLPIVAKVAAKPEAQQLGRQLASRWLQRSAARLIRDLLLPDTEKPSSPSSLNGRGGIPGPATSASTAQLPLPA
>Mature_638_residues
GATPVVTIAARQDGLGSGAVSIPPADLGVVPEPSLRYDPEQLAKQYRGRWDLVVRRLFQLITPFLGLLAWVFWDRWRGVE
LKNRPKHAARLREILTELGPTAIKIGQALSTRPDLVSPLFLEELAKLQDELPPFENAIAFALIESEIGKPIDKIFREISP
EPIAAASLGQVYQAYLHSGEKVAVKVQRPDLIGRISLDMYIVRSLAAWAKRTFRRIRSDLVGIVDEFAGRLYEEMDYTQE
GRNAERFLALYRHPSIYAPKIYWEYTRTKVLTMEWIDGIKLTQVDKIAAAGLDGRHLIEIGVNCSLKQLLENGFFHADPH
PGNLLAMYDGRLAYIDFGMMSTIAPHQRYGLIKAIVHLVNRDFAGLAQDYVDLEFLDPDTDLTPIIPALEAVFAEAMGKS
VSELNFKSITDRLSGVMYDFPFRVPAYYALIIRSLLTLEGIAIGLDPNFKVLSVAYPYVAQRLLTDPAPELRVSLRELLF
NQGQFRWNRLENLLRNAVNSEDFDLQGSLEKAVDFIFSERGAFLRERLVDVLFSSSGSQGGSDGLAHLQRLWELLSSNPS
FQPLQLLPIVAKVAAKPEAQQLGRQLASRWLQRSAARLIRDLLLPDTEKPSSPSSLNGRGGIPGPATSASTAQLPLPA

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=245, Percent_Identity=32.6530612244898, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI41393593, Length=270, Percent_Identity=31.1111111111111, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI217035081, Length=185, Percent_Identity=34.0540540540541, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI27363457, Length=302, Percent_Identity=27.1523178807947, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI34147522, Length=300, Percent_Identity=26, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI217416386, Length=243, Percent_Identity=27.9835390946502, Blast_Score=73, Evalue=8e-13,
Organism=Escherichia coli, GI2367309, Length=431, Percent_Identity=31.0904872389791, Blast_Score=190, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17559152, Length=274, Percent_Identity=31.7518248175182, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323282, Length=240, Percent_Identity=28.75, Blast_Score=91, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6321319, Length=293, Percent_Identity=26.962457337884, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6325148, Length=450, Percent_Identity=21.7777777777778, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24662575, Length=242, Percent_Identity=33.8842975206612, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI22024280, Length=269, Percent_Identity=29.368029739777, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI18859849, Length=266, Percent_Identity=28.9473684210526, Blast_Score=86, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 71348; Mature: 71217

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGATPVVTIAARQDGLGSGAVSIPPADLGVVPEPSLRYDPEQLAKQYRGRWDLVVRRLFQ
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHH
LITPFLGLLAWVFWDRWRGVELKNRPKHAARLREILTELGPTAIKIGQALSTRPDLVSPL
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHH
FLEELAKLQDELPPFENAIAFALIESEIGKPIDKIFREISPEPIAAASLGQVYQAYLHSG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
EKVAVKVQRPDLIGRISLDMYIVRSLAAWAKRTFRRIRSDLVGIVDEFAGRLYEEMDYTQ
CEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGRNAERFLALYRHPSIYAPKIYWEYTRTKVLTMEWIDGIKLTQVDKIAAAGLDGRHLIE
CCCCHHHHHHHHHCCCCCCCCEEEEEHHHEEEEHHHHCCCCHHHHHHHHHCCCCCCEEEE
IGVNCSLKQLLENGFFHADPHPGNLLAMYDGRLAYIDFGMMSTIAPHQRYGLIKAIVHLV
ECCCCCHHHHHHCCCEECCCCCCCEEEEECCEEEEEECHHHHHCCCHHHHHHHHHHHHHH
NRDFAGLAQDYVDLEFLDPDTDLTPIIPALEAVFAEAMGKSVSELNFKSITDRLSGVMYD
CCCHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
FPFRVPAYYALIIRSLLTLEGIAIGLDPNFKVLSVAYPYVAQRLLTDPAPELRVSLRELL
CCCHHHHHHHHHHHHHHHHHCEEEECCCCCEEEEEHHHHHHHHHHCCCCHHHHHHHHHHH
FNQGQFRWNRLENLLRNAVNSEDFDLQGSLEKAVDFIFSERGAFLRERLVDVLFSSSGSQ
HCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
GGSDGLAHLQRLWELLSSNPSFQPLQLLPIVAKVAAKPEAQQLGRQLASRWLQRSAARLI
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
RDLLLPDTEKPSSPSSLNGRGGIPGPATSASTAQLPLPA
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GATPVVTIAARQDGLGSGAVSIPPADLGVVPEPSLRYDPEQLAKQYRGRWDLVVRRLFQ
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHH
LITPFLGLLAWVFWDRWRGVELKNRPKHAARLREILTELGPTAIKIGQALSTRPDLVSPL
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHH
FLEELAKLQDELPPFENAIAFALIESEIGKPIDKIFREISPEPIAAASLGQVYQAYLHSG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
EKVAVKVQRPDLIGRISLDMYIVRSLAAWAKRTFRRIRSDLVGIVDEFAGRLYEEMDYTQ
CEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGRNAERFLALYRHPSIYAPKIYWEYTRTKVLTMEWIDGIKLTQVDKIAAAGLDGRHLIE
CCCCHHHHHHHHHCCCCCCCCEEEEEHHHEEEEHHHHCCCCHHHHHHHHHCCCCCCEEEE
IGVNCSLKQLLENGFFHADPHPGNLLAMYDGRLAYIDFGMMSTIAPHQRYGLIKAIVHLV
ECCCCCHHHHHHCCCEECCCCCCCEEEEECCEEEEEECHHHHHCCCHHHHHHHHHHHHHH
NRDFAGLAQDYVDLEFLDPDTDLTPIIPALEAVFAEAMGKSVSELNFKSITDRLSGVMYD
CCCHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
FPFRVPAYYALIIRSLLTLEGIAIGLDPNFKVLSVAYPYVAQRLLTDPAPELRVSLRELL
CCCHHHHHHHHHHHHHHHHHCEEEECCCCCEEEEEHHHHHHHHHHCCCCHHHHHHHHHHH
FNQGQFRWNRLENLLRNAVNSEDFDLQGSLEKAVDFIFSERGAFLRERLVDVLFSSSGSQ
HCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
GGSDGLAHLQRLWELLSSNPSFQPLQLLPIVAKVAAKPEAQQLGRQLASRWLQRSAARLI
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
RDLLLPDTEKPSSPSSLNGRGGIPGPATSASTAQLPLPA
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]