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The map label for this gene is htrA [H]

Identifier: 86608070

GI number: 86608070

Start: 584583

End: 585827

Strand: Direct

Name: htrA [H]

Synonym: CYB_0578

Alternate gene names: 86608070

Gene position: 584583-585827 (Clockwise)

Preceding gene: 86608068

Following gene: 86608071

Centisome position: 19.19

GC content: 62.09

Gene sequence:

>1245_bases
ATGAAGCGCAGCACATCCATGCCGGGCCAGCCCTCTCCCGGGTCAGAAGCTTCCGCCCAACCTGCTCAATCCTCTTTCCA
GCCTTTTGCCATCTCCACTTGGAAGTCTCTTCTCTCGTCAGTGCTGCTGGTGCTGCTGGGCATTGGGCTGGGAGCGGCTC
TGGTGGGGGGCAAGGGGGTATCTGCCCAGACGACGGCAACCCCGCCCCAACTGAACCTGAATTTCATCGCCGATGTGGCG
CAAAAGGTGGGGCCGGCGGTGGTTCGCATCGATGCTGAGCGGACGGTGCGCGCCCCTGCCCCTTTTCCGGAGGAGTTTTT
CAGCGATCCCTTTTTCCGGGATTTCTTTGGCCAAGCGATCCCTTCCATCCCTCGGCAGCGGCGACAGCAGGGAACCGGCT
CTGGGTTCATCATCAGCCCAGACGGCCAGATCATCACCAATGCCCATGTGGTCGAGGGATCCGACAAGGTAACGGTGACG
CTCAAGGATACCCGCAGCTTTGATGGGCAGGTCATCGGTTCGGATCCGGTTACGGACATCGCCGTGGTGAAGATCAACGC
CCAGAACCTGCCGACCGTGAAGCTGGGGCGCTCGGAAACCCTGGAGCCGGGCCAGTGGGCCATTGCCATCGGCAACCCCC
TGGGTTTGGATAACACCGTTACGGCTGGGATCATCAGCGCTTTGGGCCGTTCCAGCGGGGAGATTCGGGTGCCTGACAAG
CGGGTATCTTTTATCCAAACGGATGCGGCCATCAACCCCGGCAACTCCGGCGGGCCGCTGCTCAACGCCCAAGGGGAGGT
GATCGGGGTGAACACCGCCATCATCCAGGGAGCGCAAGGGTTGGGCTTCGCCATCCCCATTGAGACGGCCCAGCGGGTGG
CCAATCAGTTGATTACTCGCGGCAAGGTGGATCACCCCTACCTGGGCATCCGCATGCTGACGCTGACTCCAGAGCTGAAG
GAGCGCCTCAACCAGGATCCCAATAGCCGCATTTTGATAACGGTGGATCAGGGTGTACTGATCGGCGAAGTCATCCAGGG
ATCCCCGGCGGAACGGGCAGGGCTGCGGTCTGGGGATGTCATTCTCTCCATCAATGGTCGTGCCGTAACCACAGCCGATC
AGGTGCAACAGGAGGTGGAGCGCACTGAGGTGGGCAGCACCCTGGAGCTGGAGATCGAGCGAGCCGGGCGGCGACAGAAG
ATCCGCGCGGTAACAGGCTCTTTCCCGGCCCCCAGCGGAGGCTGA

Upstream 100 bases:

>100_bases
CCACTCTGGGATCCCTGCTGTCCATGTTAGATTAGGCTCTAGGTTTCTTCCCCTGCGTGGGGCCGAAGTCTTGCAGCATC
CCAACCCTCTTCTTGTAGCT

Downstream 100 bases:

>100_bases
TTGGGCATGGTTGACCGCCCCTCAAGTATCAACCAGACCCCAGCGACACAGCAGGGTTGTTCTCAATGGGGGTGAACTTC
CCTCTTCCCCTGGGAGAGGG

Product: S1C family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MKRSTSMPGQPSPGSEASAQPAQSSFQPFAISTWKSLLSSVLLVLLGIGLGAALVGGKGVSAQTTATPPQLNLNFIADVA
QKVGPAVVRIDAERTVRAPAPFPEEFFSDPFFRDFFGQAIPSIPRQRRQQGTGSGFIISPDGQIITNAHVVEGSDKVTVT
LKDTRSFDGQVIGSDPVTDIAVVKINAQNLPTVKLGRSETLEPGQWAIAIGNPLGLDNTVTAGIISALGRSSGEIRVPDK
RVSFIQTDAAINPGNSGGPLLNAQGEVIGVNTAIIQGAQGLGFAIPIETAQRVANQLITRGKVDHPYLGIRMLTLTPELK
ERLNQDPNSRILITVDQGVLIGEVIQGSPAERAGLRSGDVILSINGRAVTTADQVQQEVERTEVGSTLELEIERAGRRQK
IRAVTGSFPAPSGG

Sequences:

>Translated_414_residues
MKRSTSMPGQPSPGSEASAQPAQSSFQPFAISTWKSLLSSVLLVLLGIGLGAALVGGKGVSAQTTATPPQLNLNFIADVA
QKVGPAVVRIDAERTVRAPAPFPEEFFSDPFFRDFFGQAIPSIPRQRRQQGTGSGFIISPDGQIITNAHVVEGSDKVTVT
LKDTRSFDGQVIGSDPVTDIAVVKINAQNLPTVKLGRSETLEPGQWAIAIGNPLGLDNTVTAGIISALGRSSGEIRVPDK
RVSFIQTDAAINPGNSGGPLLNAQGEVIGVNTAIIQGAQGLGFAIPIETAQRVANQLITRGKVDHPYLGIRMLTLTPELK
ERLNQDPNSRILITVDQGVLIGEVIQGSPAERAGLRSGDVILSINGRAVTTADQVQQEVERTEVGSTLELEIERAGRRQK
IRAVTGSFPAPSGG
>Mature_414_residues
MKRSTSMPGQPSPGSEASAQPAQSSFQPFAISTWKSLLSSVLLVLLGIGLGAALVGGKGVSAQTTATPPQLNLNFIADVA
QKVGPAVVRIDAERTVRAPAPFPEEFFSDPFFRDFFGQAIPSIPRQRRQQGTGSGFIISPDGQIITNAHVVEGSDKVTVT
LKDTRSFDGQVIGSDPVTDIAVVKINAQNLPTVKLGRSETLEPGQWAIAIGNPLGLDNTVTAGIISALGRSSGEIRVPDK
RVSFIQTDAAINPGNSGGPLLNAQGEVIGVNTAIIQGAQGLGFAIPIETAQRVANQLITRGKVDHPYLGIRMLTLTPELK
ERLNQDPNSRILITVDQGVLIGEVIQGSPAERAGLRSGDVILSINGRAVTTADQVQQEVERTEVGSTLELEIERAGRRQK
IRAVTGSFPAPSGG

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=349, Percent_Identity=39.541547277937, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI22129776, Length=336, Percent_Identity=38.3928571428571, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI7019477, Length=334, Percent_Identity=40.1197604790419, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI24308541, Length=332, Percent_Identity=35.8433734939759, Blast_Score=186, Evalue=4e-47,
Organism=Escherichia coli, GI1789629, Length=365, Percent_Identity=37.5342465753425, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1786356, Length=366, Percent_Identity=36.8852459016393, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI1789630, Length=285, Percent_Identity=35.7894736842105, Blast_Score=164, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6324206, Length=298, Percent_Identity=26.8456375838926, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24646839, Length=386, Percent_Identity=35.2331606217617, Blast_Score=197, Evalue=8e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 43565; Mature: 43565

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRSTSMPGQPSPGSEASAQPAQSSFQPFAISTWKSLLSSVLLVLLGIGLGAALVGGKGV
CCCCCCCCCCCCCCCCCCCCCHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHEEECCCCC
SAQTTATPPQLNLNFIADVAQKVGPAVVRIDAERTVRAPAPFPEEFFSDPFFRDFFGQAI
CCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCEECCCCCCHHHHCCCHHHHHHHHHH
PSIPRQRRQQGTGSGFIISPDGQIITNAHVVEGSDKVTVTLKDTRSFDGQVIGSDPVTDI
HHHHHHHHHCCCCCEEEECCCCCEEEEEEEEECCCEEEEEEECCCCCCCEEECCCCCCEE
AVVKINAQNLPTVKLGRSETLEPGQWAIAIGNPLGLDNTVTAGIISALGRSSGEIRVPDK
EEEEEECCCCCEEECCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCEECCHH
RVSFIQTDAAINPGNSGGPLLNAQGEVIGVNTAIIQGAQGLGFAIPIETAQRVANQLITR
HEEEEEECCCCCCCCCCCCEEECCCCEEEEEHHEEECCCCCEEEEEHHHHHHHHHHHHHC
GKVDHPYLGIRMLTLTPELKERLNQDPNSRILITVDQGVLIGEVIQGSPAERAGLRSGDV
CCCCCCEECEEEEEECHHHHHHHCCCCCCEEEEEECCCEEEEHHHCCCCHHHCCCCCCCE
ILSINGRAVTTADQVQQEVERTEVGSTLELEIERAGRRQKIRAVTGSFPAPSGG
EEEECCCEEECHHHHHHHHHHHHCCCEEEEEEHHCCCHHEEHHHCCCCCCCCCC
>Mature Secondary Structure
MKRSTSMPGQPSPGSEASAQPAQSSFQPFAISTWKSLLSSVLLVLLGIGLGAALVGGKGV
CCCCCCCCCCCCCCCCCCCCCHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHEEECCCCC
SAQTTATPPQLNLNFIADVAQKVGPAVVRIDAERTVRAPAPFPEEFFSDPFFRDFFGQAI
CCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCEECCCCCCHHHHCCCHHHHHHHHHH
PSIPRQRRQQGTGSGFIISPDGQIITNAHVVEGSDKVTVTLKDTRSFDGQVIGSDPVTDI
HHHHHHHHHCCCCCEEEECCCCCEEEEEEEEECCCEEEEEEECCCCCCCEEECCCCCCEE
AVVKINAQNLPTVKLGRSETLEPGQWAIAIGNPLGLDNTVTAGIISALGRSSGEIRVPDK
EEEEEECCCCCEEECCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCEECCHH
RVSFIQTDAAINPGNSGGPLLNAQGEVIGVNTAIIQGAQGLGFAIPIETAQRVANQLITR
HEEEEEECCCCCCCCCCCCEEECCCCEEEEEHHEEECCCCCEEEEEHHHHHHHHHHHHHC
GKVDHPYLGIRMLTLTPELKERLNQDPNSRILITVDQGVLIGEVIQGSPAERAGLRSGDV
CCCCCCEECEEEEEECHHHHHHHCCCCCCEEEEEECCCEEEEHHHCCCCHHHCCCCCCCE
ILSINGRAVTTADQVQQEVERTEVGSTLELEIERAGRRQKIRAVTGSFPAPSGG
EEEECCCEEECHHHHHHHHHHHHCCCEEEEEEHHCCCHHEEHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]