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The map label for this gene is folE

Identifier: 86607689

GI number: 86607689

Start: 201389

End: 202078

Strand: Reverse

Name: folE

Synonym: CYB_0188

Alternate gene names: 86607689

Gene position: 202078-201389 (Counterclockwise)

Preceding gene: 86607690

Following gene: 86607688

Centisome position: 6.63

GC content: 56.96

Gene sequence:

>690_bases
ATGACCCTTGCGAAACCCGGATCTGGCTCGCAATCTCGAATGGATGACAAAGCCCATTTCAAGTCTCGGGTGATTCGAGA
TCGAGCCACTTTTGCGGAAGAAGAATTGGGTAGCTCGGATGTCTCAGATCCGGCTATGGTGGCGGCGGTGGAGACGCTGC
TGCGGGGGATCGGGGAGGATCCCCAACGGGAGGGGCTGCGAAAAACCCCGGAACGAGTGGTTGCGGCTTTGAAGTTTTTG
ACCAGTGGGTATCGGCAGTCTTTGGAGGAGCTACTGAACAGTGCCATCTTTGATGAGGGCCATGACGAGATGGTGCTGTT
GCGGGATGTGTCTCTGTTTAGCCTGTGCGAGCACCATCTGCTGCCCTTTATCGGCAAAGCCCATGTGGCCTACATCCCCA
AGCAAAAGGTGGTGGGCCTAAGCAAAATTGCCCGTATCGTCGAGATGTACTCCCGCCGCCTGCAGGTTCAGGAACGCCTG
ACACGGCAAATTGCTGAGGCCTTGATGGAGGTGCTGGATCCCTACGGGGTGGGGGTGGTTATCGAGGCTACCCACATGTG
CATGGTGATGCGGGGGGTACAAAAGGCCGGCTCCTGGACGGTCACCAGCTCGATGGTGGGGGTGTTTCAGGAGGATCCCC
GTACCCGCGAAGAGTTTCTGAGTCTCATTCGCCATCCGTCCAATTTTTAG

Upstream 100 bases:

>100_bases
CTGAGGATGGTCTTGGCTATCGCAGCTTTTGACTGGATGCCCCTTGAGCTGAGTTGCACTGAGTTCTCTTAGCCTTTCGT
TCAACAAGGAATATCCTGCT

Downstream 100 bases:

>100_bases
GGAGCTTCCCGGAGCTTTGTCGGTGAGTGGGTTAAGCCTCTGCTCAGGCGGGGAATGCTAGCCTAAGATCGACGCAAACC
CTGCCAGAAGCGAGGCTTGT

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MTLAKPGSGSQSRMDDKAHFKSRVIRDRATFAEEELGSSDVSDPAMVAAVETLLRGIGEDPQREGLRKTPERVVAALKFL
TSGYRQSLEELLNSAIFDEGHDEMVLLRDVSLFSLCEHHLLPFIGKAHVAYIPKQKVVGLSKIARIVEMYSRRLQVQERL
TRQIAEALMEVLDPYGVGVVIEATHMCMVMRGVQKAGSWTVTSSMVGVFQEDPRTREEFLSLIRHPSNF

Sequences:

>Translated_229_residues
MTLAKPGSGSQSRMDDKAHFKSRVIRDRATFAEEELGSSDVSDPAMVAAVETLLRGIGEDPQREGLRKTPERVVAALKFL
TSGYRQSLEELLNSAIFDEGHDEMVLLRDVSLFSLCEHHLLPFIGKAHVAYIPKQKVVGLSKIARIVEMYSRRLQVQERL
TRQIAEALMEVLDPYGVGVVIEATHMCMVMRGVQKAGSWTVTSSMVGVFQEDPRTREEFLSLIRHPSNF
>Mature_228_residues
TLAKPGSGSQSRMDDKAHFKSRVIRDRATFAEEELGSSDVSDPAMVAAVETLLRGIGEDPQREGLRKTPERVVAALKFLT
SGYRQSLEELLNSAIFDEGHDEMVLLRDVSLFSLCEHHLLPFIGKAHVAYIPKQKVVGLSKIARIVEMYSRRLQVQERLT
RQIAEALMEVLDPYGVGVVIEATHMCMVMRGVQKAGSWTVTSSMVGVFQEDPRTREEFLSLIRHPSNF

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family

Homologues:

Organism=Homo sapiens, GI66932968, Length=186, Percent_Identity=62.3655913978495, Blast_Score=265, Evalue=2e-71,
Organism=Homo sapiens, GI4503949, Length=186, Percent_Identity=62.3655913978495, Blast_Score=265, Evalue=2e-71,
Organism=Homo sapiens, GI66932970, Length=155, Percent_Identity=54.8387096774194, Blast_Score=198, Evalue=4e-51,
Organism=Homo sapiens, GI66932972, Length=146, Percent_Identity=57.5342465753425, Blast_Score=197, Evalue=8e-51,
Organism=Escherichia coli, GI1788476, Length=124, Percent_Identity=52.4193548387097, Blast_Score=122, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17560486, Length=210, Percent_Identity=56.6666666666667, Blast_Score=253, Evalue=6e-68,
Organism=Saccharomyces cerevisiae, GI6321706, Length=177, Percent_Identity=57.0621468926554, Blast_Score=222, Evalue=4e-59,
Organism=Drosophila melanogaster, GI24656782, Length=181, Percent_Identity=60.2209944751381, Blast_Score=234, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24656791, Length=181, Percent_Identity=60.2209944751381, Blast_Score=233, Evalue=6e-62,
Organism=Drosophila melanogaster, GI24656796, Length=181, Percent_Identity=60.2209944751381, Blast_Score=233, Evalue=7e-62,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): GCH1_SYNJB (Q2JPT8)

Other databases:

- EMBL:   CP000240
- RefSeq:   YP_476451.1
- ProteinModelPortal:   Q2JPT8
- SMR:   Q2JPT8
- STRING:   Q2JPT8
- GeneID:   3902229
- GenomeReviews:   CP000240_GR
- KEGG:   cyb:CYB_0188
- TIGR:   CYB_0188
- eggNOG:   COG0302
- HOGENOM:   HBG370191
- OMA:   ARIVEMF
- PhylomeDB:   Q2JPT8
- ProtClustDB:   PRK09347
- BioCyc:   SSP321332:CYB_0188-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00223
- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234
- TIGRFAMs:   TIGR00063

Pfam domain/function: PF01227 GTP_cyclohydroI

EC number: =3.5.4.16

Molecular weight: Translated: 25658; Mature: 25527

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLAKPGSGSQSRMDDKAHFKSRVIRDRATFAEEELGSSDVSDPAMVAAVETLLRGIGED
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCC
PQREGLRKTPERVVAALKFLTSGYRQSLEELLNSAIFDEGHDEMVLLRDVSLFSLCEHHL
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHH
LPFIGKAHVAYIPKQKVVGLSKIARIVEMYSRRLQVQERLTRQIAEALMEVLDPYGVGVV
HHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
IEATHMCMVMRGVQKAGSWTVTSSMVGVFQEDPRTREEFLSLIRHPSNF
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
TLAKPGSGSQSRMDDKAHFKSRVIRDRATFAEEELGSSDVSDPAMVAAVETLLRGIGED
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCC
PQREGLRKTPERVVAALKFLTSGYRQSLEELLNSAIFDEGHDEMVLLRDVSLFSLCEHHL
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHH
LPFIGKAHVAYIPKQKVVGLSKIARIVEMYSRRLQVQERLTRQIAEALMEVLDPYGVGVV
HHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
IEATHMCMVMRGVQKAGSWTVTSSMVGVFQEDPRTREEFLSLIRHPSNF
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA