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The map label for this gene is hisIE [H]

Identifier: 86607659

GI number: 86607659

Start: 172007

End: 172630

Strand: Reverse

Name: hisIE [H]

Synonym: CYB_0157

Alternate gene names: 86607659

Gene position: 172630-172007 (Counterclockwise)

Preceding gene: 86607660

Following gene: 86607658

Centisome position: 5.67

GC content: 61.06

Gene sequence:

>624_bases
ATGGCTTGGTTAGGCAGCCTCACCTACAACGAACAGGGTTTGATCCCGGCCATCGTGCAGGACTACCTGGATGGGACGGT
GCTGATGATGGCCTGGATGAACCGGGAGTCCCTGCAAAAAACTTTGGAAACAGGCCGCACCTGGTTCTGGAGCCGCTCGC
GGCAGGCGCTGTGGCCCAAAGGGGAAACTTCTGGCCACGTCCAGTGGGTCAAGCAAATCCGCTACGACTGCGACGGCGAC
GCGCTGGTCATCCTGGTGGAGCAGGTGGGGGATGCGGCATGCCACACGGGGGCGCGGAGCTGCTTCTTCCGCCCTTTGCA
AGGGGATCCCATTCCGGCAGCCGATACCCTGTCGCAGGTGTTTGCCGTCGTCAAAGCCCGCCAGGCGGATCCCCGTCCCG
ATTCCTACACCAGCAGCTTGCTAGCCAAGGGGGAAAATGCCATTTTGAAGAAACTTGGCGAGGAGACGGCTGAGGTGGTG
ATGGCGGCTAAGGATCAAGACCGCGTGGCTTTGGCCCGTGAGATGGCCGACCTCTGGTACCACTGCCTCGTGGCCCTTGC
TCACTATCAGGTAGATGTTAGGGATGTCTATCGCCAGCTCCAAGCCCGCCGTTCCGCCAAGTGA

Upstream 100 bases:

>100_bases
CTGCTAATAATCTCGATTGGTTTTCTGCCAAACCCTTATGGCTGCTGCTGTGATCTCGGGCCTCTCTTGGCAGTCCCCCA
GAGCCCTTTCACCGGAGGAG

Downstream 100 bases:

>100_bases
AAGGGCCATGTCCCCCGAAGGCGGTGCTCCCGCAGATCCCTCTCCGTCCTCTTGGGATCCCTCCCTGGACAAAGCCCACC
TGGATTTACGAGCCGCGCGC

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MAWLGSLTYNEQGLIPAIVQDYLDGTVLMMAWMNRESLQKTLETGRTWFWSRSRQALWPKGETSGHVQWVKQIRYDCDGD
ALVILVEQVGDAACHTGARSCFFRPLQGDPIPAADTLSQVFAVVKARQADPRPDSYTSSLLAKGENAILKKLGEETAEVV
MAAKDQDRVALAREMADLWYHCLVALAHYQVDVRDVYRQLQARRSAK

Sequences:

>Translated_207_residues
MAWLGSLTYNEQGLIPAIVQDYLDGTVLMMAWMNRESLQKTLETGRTWFWSRSRQALWPKGETSGHVQWVKQIRYDCDGD
ALVILVEQVGDAACHTGARSCFFRPLQGDPIPAADTLSQVFAVVKARQADPRPDSYTSSLLAKGENAILKKLGEETAEVV
MAAKDQDRVALAREMADLWYHCLVALAHYQVDVRDVYRQLQARRSAK
>Mature_206_residues
AWLGSLTYNEQGLIPAIVQDYLDGTVLMMAWMNRESLQKTLETGRTWFWSRSRQALWPKGETSGHVQWVKQIRYDCDGDA
LVILVEQVGDAACHTGARSCFFRPLQGDPIPAADTLSQVFAVVKARQADPRPDSYTSSLLAKGENAILKKLGEETAEVVM
AAKDQDRVALAREMADLWYHCLVALAHYQVDVRDVYRQLQARRSAK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=193, Percent_Identity=43.0051813471503, Blast_Score=144, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6319819, Length=191, Percent_Identity=34.0314136125654, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 23302; Mature: 23171

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWLGSLTYNEQGLIPAIVQDYLDGTVLMMAWMNRESLQKTLETGRTWFWSRSRQALWPK
CCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHCCCEEECCCCCCCCCC
GETSGHVQWVKQIRYDCDGDALVILVEQVGDAACHTGARSCFFRPLQGDPIPAADTLSQV
CCCCHHHHHHHHHHCCCCCCEEEEEHHHHCCHHHHHCHHHHEECCCCCCCCCHHHHHHHH
FAVVKARQADPRPDSYTSSLLAKGENAILKKLGEETAEVVMAAKDQDRVALAREMADLWY
HHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
HCLVALAHYQVDVRDVYRQLQARRSAK
HHHHHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AWLGSLTYNEQGLIPAIVQDYLDGTVLMMAWMNRESLQKTLETGRTWFWSRSRQALWPK
CCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHCCCEEECCCCCCCCCC
GETSGHVQWVKQIRYDCDGDALVILVEQVGDAACHTGARSCFFRPLQGDPIPAADTLSQV
CCCCHHHHHHHHHHCCCCCCEEEEEHHHHCCHHHHHCHHHHEECCCCCCCCCHHHHHHHH
FAVVKARQADPRPDSYTSSLLAKGENAILKKLGEETAEVVMAAKDQDRVALAREMADLWY
HHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
HCLVALAHYQVDVRDVYRQLQARRSAK
HHHHHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]