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The map label for this gene is dapA

Identifier: 86607550

GI number: 86607550

Start: 61302

End: 62222

Strand: Reverse

Name: dapA

Synonym: CYB_0048

Alternate gene names: 86607550

Gene position: 62222-61302 (Counterclockwise)

Preceding gene: 86607552

Following gene: 86607549

Centisome position: 2.04

GC content: 56.79

Gene sequence:

>921_bases
GTGAACTTCGGTCGAGTGCTGACGGCCATGGTTACCCCCTTTACTGATGAGGGGGAGCTTAACTACGATGAGGCCGCTCG
TTTGGCCGATTACTTGGCAACCCACGGCAGTGACGGCTTGGTGGTCTGTGGCACCACAGGCGAATCTCCCACCCTAACCT
GGCAAGAGGAGTATGAGCTGTTCCGCGTGGTGCGAGATGCCGTAGCCGGTCGGGCTAAGGTGATCGCCGGGACGGGATCC
AACTCCACCCGTGAGGCCATTGAAGCCACAAAAAAGGCCGCTCAACTCGGTTTGGATGGCTCTCTGCAGGTGGTGCCCTA
CTACAACAAGCCTACCCAGGCCGGCCTTTATGAGCACTTCAAGGCCATCGCCCAAGCCAGTGACCTGCCCATCTTGCTCT
ACAACATTCCCAGTCGGACAGGGGCCAGTTTACAGCCGGAGACTGTAGCCCAATTAGCAGAATTGGAAACGGTTGTCGCC
ATCAAAGAAGCCAGTGGTATGATGGATGTAGCTTCGGAAATTCGGCGACTCACTCCCTCGCGTTTCGCCATCTATTCAGG
GGATGACTCTCTGACGTTGCCGCTCCTATCTTTGGGGGGGAGCGGGGTGGTCAGTGTAGCCAGCCACCTGGTTGGGTTGC
AGTTGCAGGAGCTGATCCAGAGCTACATCAGGGGGCAACACGATCAAGCTTTGGCCCACCACCTGCGCCTGTTTCCGTTG
TTCAAGGTTTTATTCATCGAGACCAACCCAGTTCCGATTAAGGCCGCATTGGAGATGCAGGGTTGGCGAGTGGGTCGGGC
GCGCCTTCCCCTAGCGCCTCTACAGCCCAGTTCTCTGCAGGTTTTGCGACAGGTGCTTGAAGAGATGGGCCTACTGGCTG
AATCGAAGGGATCCGAACAAATGGCGACAAAAGTTTCATGA

Upstream 100 bases:

>100_bases
TCCCTAACGCAAAGGCAGGTATGATGGAAAAACAAACTGGTCTCATCTGGGTCGCCCGGTCGATTGTTGGATTGGTGTGG
TTGATGGGGAGAAGCAATCG

Downstream 100 bases:

>100_bases
TTGCATTTTTAGACTTTGCTTCTGCCATGACCACGGTTTTCAGGGGTTTGCAAGGGGCTCTTTTGTGGCGTTTGACCTGT
GGGTAGGTAGCTTTTTCCCT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MNFGRVLTAMVTPFTDEGELNYDEAARLADYLATHGSDGLVVCGTTGESPTLTWQEEYELFRVVRDAVAGRAKVIAGTGS
NSTREAIEATKKAAQLGLDGSLQVVPYYNKPTQAGLYEHFKAIAQASDLPILLYNIPSRTGASLQPETVAQLAELETVVA
IKEASGMMDVASEIRRLTPSRFAIYSGDDSLTLPLLSLGGSGVVSVASHLVGLQLQELIQSYIRGQHDQALAHHLRLFPL
FKVLFIETNPVPIKAALEMQGWRVGRARLPLAPLQPSSLQVLRQVLEEMGLLAESKGSEQMATKVS

Sequences:

>Translated_306_residues
MNFGRVLTAMVTPFTDEGELNYDEAARLADYLATHGSDGLVVCGTTGESPTLTWQEEYELFRVVRDAVAGRAKVIAGTGS
NSTREAIEATKKAAQLGLDGSLQVVPYYNKPTQAGLYEHFKAIAQASDLPILLYNIPSRTGASLQPETVAQLAELETVVA
IKEASGMMDVASEIRRLTPSRFAIYSGDDSLTLPLLSLGGSGVVSVASHLVGLQLQELIQSYIRGQHDQALAHHLRLFPL
FKVLFIETNPVPIKAALEMQGWRVGRARLPLAPLQPSSLQVLRQVLEEMGLLAESKGSEQMATKVS
>Mature_306_residues
MNFGRVLTAMVTPFTDEGELNYDEAARLADYLATHGSDGLVVCGTTGESPTLTWQEEYELFRVVRDAVAGRAKVIAGTGS
NSTREAIEATKKAAQLGLDGSLQVVPYYNKPTQAGLYEHFKAIAQASDLPILLYNIPSRTGASLQPETVAQLAELETVVA
IKEASGMMDVASEIRRLTPSRFAIYSGDDSLTLPLLSLGGSGVVSVASHLVGLQLQELIQSYIRGQHDQALAHHLRLFPL
FKVLFIETNPVPIKAALEMQGWRVGRARLPLAPLQPSSLQVLRQVLEEMGLLAESKGSEQMATKVS

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=286, Percent_Identity=27.6223776223776, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI13540533, Length=241, Percent_Identity=26.9709543568465, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1788823, Length=291, Percent_Identity=40.2061855670103, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1786463, Length=278, Percent_Identity=30.5755395683453, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI87082415, Length=274, Percent_Identity=29.1970802919708, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1789620, Length=225, Percent_Identity=29.3333333333333, Blast_Score=104, Evalue=8e-24,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_SYNJB (Q2JQ67)

Other databases:

- EMBL:   CP000240
- RefSeq:   YP_476312.1
- HSSP:   Q9X1K9
- ProteinModelPortal:   Q2JQ67
- SMR:   Q2JQ67
- STRING:   Q2JQ67
- GeneID:   3899973
- GenomeReviews:   CP000240_GR
- KEGG:   cyb:CYB_0048
- TIGR:   CYB_0048
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   LFITTNP
- PhylomeDB:   Q2JQ67
- ProtClustDB:   PRK03170
- BioCyc:   SSP321332:CYB_0048-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 33103; Mature: 33103

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 162-162 BINDING 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFGRVLTAMVTPFTDEGELNYDEAARLADYLATHGSDGLVVCGTTGESPTLTWQEEYEL
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEHHHHHHH
FRVVRDAVAGRAKVIAGTGSNSTREAIEATKKAAQLGLDGSLQVVPYYNKPTQAGLYEHF
HHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHH
KAIAQASDLPILLYNIPSRTGASLQPETVAQLAELETVVAIKEASGMMDVASEIRRLTPS
HHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
RFAIYSGDDSLTLPLLSLGGSGVVSVASHLVGLQLQELIQSYIRGQHDQALAHHLRLFPL
CEEEEECCCCEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
FKVLFIETNPVPIKAALEMQGWRVGRARLPLAPLQPSSLQVLRQVLEEMGLLAESKGSEQ
HHHHEEECCCCCEEEEEECCCCEECCCCCCCCCCCCHHHHHHHHHHHHHCHHHCCCCCHH
MATKVS
HHHCCC
>Mature Secondary Structure
MNFGRVLTAMVTPFTDEGELNYDEAARLADYLATHGSDGLVVCGTTGESPTLTWQEEYEL
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEHHHHHHH
FRVVRDAVAGRAKVIAGTGSNSTREAIEATKKAAQLGLDGSLQVVPYYNKPTQAGLYEHF
HHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHH
KAIAQASDLPILLYNIPSRTGASLQPETVAQLAELETVVAIKEASGMMDVASEIRRLTPS
HHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
RFAIYSGDDSLTLPLLSLGGSGVVSVASHLVGLQLQELIQSYIRGQHDQALAHHLRLFPL
CEEEEECCCCEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
FKVLFIETNPVPIKAALEMQGWRVGRARLPLAPLQPSSLQVLRQVLEEMGLLAESKGSEQ
HHHHEEECCCCCEEEEEECCCCEECCCCCCCCCCCCHHHHHHHHHHHHHCHHHCCCCCHH
MATKVS
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA