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The map label for this gene is lrp [H]

Identifier: 86361090

GI number: 86361090

Start: 405850

End: 406326

Strand: Reverse

Name: lrp [H]

Synonym: RHE_PF00360

Alternate gene names: 86361090

Gene position: 406326-405850 (Counterclockwise)

Preceding gene: 86361092

Following gene: 86361085

Centisome position: 63.24

GC content: 50.73

Gene sequence:

>477_bases
ATGAAACTCGACCGGATCGACATAAAAATTCTCTACGAACTGCAGAAGAATGGCCGCGTCACCAATGTGGAGCTCGCCGA
GTTGGTCAATCTGTCGCCGAGCCCCTGCCTGATGCGGGTGAAGAAGCTGCAGTCGGAAGGTTATATCGAAGGCTATTCTG
CTCAGATCAACGTCAGCAAACTCGGGCAGACGCTGACCGTATTTACCGAGATTACCTTGAAAAACCATCGGCAGATCGAT
TTCGCCCGTTTCCTCGCAGCGATCGAGAAGGTCGACCAGGTGATCGAATGCCATCTGGTTTCGGGCGGCTATGATTATTT
GCTGAAATTCGTCACCGCCGGAATAGACGAATACCAGACGATCATGGAACGACTCACCGACATGGACGTCGGCATTGATA
AATATTTCAGCTTCGTCGTTCTGAAATCACCGATCATTAAAGCGCACATGCCGCTGACCACTTTGTTCCCGCATTAG

Upstream 100 bases:

>100_bases
CCCGGTCGACACCTCCTTGCCATGTGTTAAGCTCGACGTTGGAAAAGCCGCAGCAGATTATGCTTCGTCACTGGCGATCT
CGAGCAAATGAAGGCATGTG

Downstream 100 bases:

>100_bases
AGAGCGCATCGCACCGGCTTGTGATCGGCATGGACGCCTCGGTGATAGCTGTCGCACCAGCCGGCAGGTTTGGCTGGGTC
GTGGAGAGATTTCCAAATAC

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 158; Mature: 158

Protein sequence:

>158_residues
MKLDRIDIKILYELQKNGRVTNVELAELVNLSPSPCLMRVKKLQSEGYIEGYSAQINVSKLGQTLTVFTEITLKNHRQID
FARFLAAIEKVDQVIECHLVSGGYDYLLKFVTAGIDEYQTIMERLTDMDVGIDKYFSFVVLKSPIIKAHMPLTTLFPH

Sequences:

>Translated_158_residues
MKLDRIDIKILYELQKNGRVTNVELAELVNLSPSPCLMRVKKLQSEGYIEGYSAQINVSKLGQTLTVFTEITLKNHRQID
FARFLAAIEKVDQVIECHLVSGGYDYLLKFVTAGIDEYQTIMERLTDMDVGIDKYFSFVVLKSPIIKAHMPLTTLFPH
>Mature_158_residues
MKLDRIDIKILYELQKNGRVTNVELAELVNLSPSPCLMRVKKLQSEGYIEGYSAQINVSKLGQTLTVFTEITLKNHRQID
FARFLAAIEKVDQVIECHLVSGGYDYLLKFVTAGIDEYQTIMERLTDMDVGIDKYFSFVVLKSPIIKAHMPLTTLFPH

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=140, Percent_Identity=43.5714285714286, Blast_Score=123, Evalue=5e-30,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=29.3333333333333, Blast_Score=79, Evalue=1e-16,
Organism=Escherichia coli, GI1790182, Length=150, Percent_Identity=29.3333333333333, Blast_Score=69, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18041; Mature: 18041

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDRIDIKILYELQKNGRVTNVELAELVNLSPSPCLMRVKKLQSEGYIEGYSAQINVSK
CCCCHHHHHEEEEECCCCCCCCCHHHHHHCCCCCHHHHHHHHHHCCCCEECCCCEEEHHH
LGQTLTVFTEITLKNHRQIDFARFLAAIEKVDQVIECHLVSGGYDYLLKFVTAGIDEYQT
HCCCCEEHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHH
IMERLTDMDVGIDKYFSFVVLKSPIIKAHMPLTTLFPH
HHHHHHHCCCCHHHHHHHHHHHCCHHHHCCCCHHCCCC
>Mature Secondary Structure
MKLDRIDIKILYELQKNGRVTNVELAELVNLSPSPCLMRVKKLQSEGYIEGYSAQINVSK
CCCCHHHHHEEEEECCCCCCCCCHHHHHHCCCCCHHHHHHHHHHCCCCEECCCCEEEHHH
LGQTLTVFTEITLKNHRQIDFARFLAAIEKVDQVIECHLVSGGYDYLLKFVTAGIDEYQT
HCCCCEEHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHH
IMERLTDMDVGIDKYFSFVVLKSPIIKAHMPLTTLFPH
HHHHHHHCCCCHHHHHHHHHHHCCHHHHCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]