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The map label for this gene is appB [H]

Identifier: 86360963

GI number: 86360963

Start: 247383

End: 248384

Strand: Reverse

Name: appB [H]

Synonym: RHE_PF00233

Alternate gene names: 86360963

Gene position: 248384-247383 (Counterclockwise)

Preceding gene: 86360964

Following gene: 86360962

Centisome position: 38.66

GC content: 58.48

Gene sequence:

>1002_bases
ATGCAAGAGGCGCCCATGCTGGTCTTTATCGCCAAACGACTGCTATGGATGATTCCATCGCTCTTTGCCGTCAGCTTTCT
CGCTTTCGTGCTGATCCAGCTGCCGCCGGGCGACTACGTCACGACCTATATTGCTACGCTGGCGGCCTCCAATGAAATCG
TCGATCAGAACACCGCTGCACAATTGCGCGAACGCTTCGGACTCGATGACCCCATGCTCATCCAATATTTCAAATGGATT
TGGGGCATCCTCTCGCGCGGCGATTTCGGCATCTCCTTCGAATGGCAGCAGCCGGTCTCCGACCTGATCTGGGAGCGAAT
GGCGCTGACCCTTGTTCTGGCTCTGGCGACATTGATTGCCACCTGGGCGATCGCGCTGCCCATCGGCGTCTATTCCGCCG
TGCGCAAATATTCGATCGGCGACTATTTCTTCACAGCCTTCACTTTCTTCGGTCTGGCCGTTCCGTCCTTCCTGCTGGCG
CTGGTGCTGATGTATGTCGCGGCGGTCGAATTCGGCCAGGATGTCGGCGGGCTGTTTTCTCCGCAATATGAGAATGCGCC
CTGGAGCTTCGCCAAGATGGTCGATCTGTTCTCGCATCTCTGGCTTCCGGTCATCATTCTGGCCGTGTCCTCGACGGCGA
GCCTCATCCGCGTGATGCGGGCCAACATGCTCGACGAACTGCCGAAGCCCTACGTGACGACGGCGCGGGCAAAGGGGCTC
TCGGAATTCCGGCTGCTGATGAAATACCCTTTGATGATCGCGCTCAACCCGTTCATCTCGACGATCGCCTGGCTGCTGCC
TAATCTCATCTCCGGCTCGGTCGTCGTCGCCATCGTACTCAATCTGCCGACGGCAGCCCCTTTGCTGCTGCAGGCATTGA
TGGCCCAGGACATGTATCTGGCGGGTGCCTTCGTTCTGCTGATCTGCGCGCTGACGCTGATAGGCTCTCTGATCAGCGAC
ATCCTGCTTGCGCTGGTCGATCCCCGCATCCGGTTGGAATAG

Upstream 100 bases:

>100_bases
TTTGATCGAGCGCCGTACCGACGGTACGGCGCTTTCTTCGGTTCGCCTTCCGATGCCTCGCCGGCGATGAGATCCGGCAA
GGCCCGGAGGGCGGGACTCA

Downstream 100 bases:

>100_bases
GAGCCTGATATGGCCGACATCGCCGTTACAAATATTCAGCCGGATCGCGCCGCCGTCGCATCGCAGTGGCAGCTGATCTG
GTGGGCCTTTCGCCGCCACA

Product: oligopeptide ABC transporter, permease protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MQEAPMLVFIAKRLLWMIPSLFAVSFLAFVLIQLPPGDYVTTYIATLAASNEIVDQNTAAQLRERFGLDDPMLIQYFKWI
WGILSRGDFGISFEWQQPVSDLIWERMALTLVLALATLIATWAIALPIGVYSAVRKYSIGDYFFTAFTFFGLAVPSFLLA
LVLMYVAAVEFGQDVGGLFSPQYENAPWSFAKMVDLFSHLWLPVIILAVSSTASLIRVMRANMLDELPKPYVTTARAKGL
SEFRLLMKYPLMIALNPFISTIAWLLPNLISGSVVVAIVLNLPTAAPLLLQALMAQDMYLAGAFVLLICALTLIGSLISD
ILLALVDPRIRLE

Sequences:

>Translated_333_residues
MQEAPMLVFIAKRLLWMIPSLFAVSFLAFVLIQLPPGDYVTTYIATLAASNEIVDQNTAAQLRERFGLDDPMLIQYFKWI
WGILSRGDFGISFEWQQPVSDLIWERMALTLVLALATLIATWAIALPIGVYSAVRKYSIGDYFFTAFTFFGLAVPSFLLA
LVLMYVAAVEFGQDVGGLFSPQYENAPWSFAKMVDLFSHLWLPVIILAVSSTASLIRVMRANMLDELPKPYVTTARAKGL
SEFRLLMKYPLMIALNPFISTIAWLLPNLISGSVVVAIVLNLPTAAPLLLQALMAQDMYLAGAFVLLICALTLIGSLISD
ILLALVDPRIRLE
>Mature_333_residues
MQEAPMLVFIAKRLLWMIPSLFAVSFLAFVLIQLPPGDYVTTYIATLAASNEIVDQNTAAQLRERFGLDDPMLIQYFKWI
WGILSRGDFGISFEWQQPVSDLIWERMALTLVLALATLIATWAIALPIGVYSAVRKYSIGDYFFTAFTFFGLAVPSFLLA
LVLMYVAAVEFGQDVGGLFSPQYENAPWSFAKMVDLFSHLWLPVIILAVSSTASLIRVMRANMLDELPKPYVTTARAKGL
SEFRLLMKYPLMIALNPFISTIAWLLPNLISGSVVVAIVLNLPTAAPLLLQALMAQDMYLAGAFVLLICALTLIGSLISD
ILLALVDPRIRLE

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG0601

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789965, Length=342, Percent_Identity=29.8245614035088, Blast_Score=157, Evalue=8e-40,
Organism=Escherichia coli, GI1787053, Length=330, Percent_Identity=31.2121212121212, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1787497, Length=327, Percent_Identity=28.1345565749235, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1788504, Length=364, Percent_Identity=28.5714285714286, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1789888, Length=326, Percent_Identity=29.7546012269939, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1787550, Length=257, Percent_Identity=27.2373540856031, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1787761, Length=322, Percent_Identity=26.0869565217391, Blast_Score=86, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 36982; Mature: 36982

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQEAPMLVFIAKRLLWMIPSLFAVSFLAFVLIQLPPGDYVTTYIATLAASNEIVDQNTAA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHCCHHHH
QLRERFGLDDPMLIQYFKWIWGILSRGDFGISFEWQQPVSDLIWERMALTLVLALATLIA
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEHHCHHHHHHHHHHHHHHHHHHHHHHH
TWAIALPIGVYSAVRKYSIGDYFFTAFTFFGLAVPSFLLALVLMYVAAVEFGQDVGGLFS
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PQYENAPWSFAKMVDLFSHLWLPVIILAVSSTASLIRVMRANMLDELPKPYVTTARAKGL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCH
SEFRLLMKYPLMIALNPFISTIAWLLPNLISGSVVVAIVLNLPTAAPLLLQALMAQDMYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AGAFVLLICALTLIGSLISDILLALVDPRIRLE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]