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The map label for this gene is eryA [H]

Identifier: 86360745

GI number: 86360745

Start: 10694

End: 11662

Strand: Reverse

Name: eryA [H]

Synonym: RHE_PF00011

Alternate gene names: 86360745

Gene position: 11662-10694 (Counterclockwise)

Preceding gene: 86360749

Following gene: 86360742

Centisome position: 1.82

GC content: 65.22

Gene sequence:

>969_bases
ATGCAATATCAGGCGGTCGTGCGAAAATTCGGGCCGGCCGAAGAGGTCGTCGGGATCGAACGGGCCGAACTGGCGCCGCT
GCGGCGCGACCAAGTTCGCGTCCGCCTGCTGGCGCGCTCGATCAATCCCTCCGATATCATCACCATCTCAGGCGCCTATA
AGGGCCGCACGACCCTGCCCTTCATCCCCGGCTTCGAAGCCTTAGGCGTGGTCGAAACGTGCGGCGAGGAGGTCCACGGG
CTGGTGCCGGGAGCCCGCGTGCTGCCGGTGCGTAGCGCCGGCGGATGGCAGGAATTCAAGGATACCGATCCCTCTTGGTG
CCTTCGTGTGCCTGACGCCCTTTCCGATTTCGAGGCGGCGACCAGCTACGTCAACCCGATGACGGCCTGGCTGATGCTGC
ATAAGAAGATCGGGCTGAGACCCGGGATGCGCATAGCCCTCAACGCCGCCGCCTCTTCGATCGGGTCAATCCTGATCGGC
ATGGCGAACGCCGTTGGCGTGGAACCGATCGCAATCGTCCGCAGCGAAGAATCCCTCGCGCGTCTGCGTGGCCGGCTGGA
GGCCGTTATCGTCGACAGAGCGGATGGCAACGTCGCCGCCGGCCTGGCCGGCCGGCATGGGCTCGATGCAGTGCTCGATT
GCGTCGGCGGCGCGTGCGCCTCGATCCTTGCCGATGCGCTGAGGCCCGGCGGGCATTTCCTGCATTACGGCCTGCTTTCG
GGAGAGAGCATCCCGCCGTCATTCTGGGCCTCCCACCCCGACATTGCCTTTTCATTCTGCCACCTCAGGGAGTGGGTTCA
TTCCGAGACGATGGGCGACGTCCAGCGCGCCTATGCAGAGGTGGCGGCGATGATCGCCTCCAAGGTGATCGCGACTGAGG
TGCGGGAGGTATTTCCTCTGGAAAAGATCGGCGAGGCGCTGCACGCCGCCCTGCCCTTCCGGACGGGTGGCAAGGTGTTG
CTGGCGTGA

Upstream 100 bases:

>100_bases
CGCATCGAGACCCGGAACGATGCTAAAGGCCTGTCGTCAACGCTCATTCGATCACCGAAAATTCGACGGCGTGTTCTAAC
CGACTGTGTGGGGGATGCAA

Downstream 100 bases:

>100_bases
CAACAGCGCGTGCCGCACCTGGCAGTTTAAACTGATACCGCTGAGCGGATTCCGGCATAGCTTCATCGGCTTTCCGGTCT
GCCGCGCCCGGCTGTGACTT

Product: zinc-dependent oxidoreductase protein

Products: NA

Alternate protein names: 6-deoxyerythronolide B synthase II; DEBS 2; ORF 2 [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MQYQAVVRKFGPAEEVVGIERAELAPLRRDQVRVRLLARSINPSDIITISGAYKGRTTLPFIPGFEALGVVETCGEEVHG
LVPGARVLPVRSAGGWQEFKDTDPSWCLRVPDALSDFEAATSYVNPMTAWLMLHKKIGLRPGMRIALNAAASSIGSILIG
MANAVGVEPIAIVRSEESLARLRGRLEAVIVDRADGNVAAGLAGRHGLDAVLDCVGGACASILADALRPGGHFLHYGLLS
GESIPPSFWASHPDIAFSFCHLREWVHSETMGDVQRAYAEVAAMIASKVIATEVREVFPLEKIGEALHAALPFRTGGKVL
LA

Sequences:

>Translated_322_residues
MQYQAVVRKFGPAEEVVGIERAELAPLRRDQVRVRLLARSINPSDIITISGAYKGRTTLPFIPGFEALGVVETCGEEVHG
LVPGARVLPVRSAGGWQEFKDTDPSWCLRVPDALSDFEAATSYVNPMTAWLMLHKKIGLRPGMRIALNAAASSIGSILIG
MANAVGVEPIAIVRSEESLARLRGRLEAVIVDRADGNVAAGLAGRHGLDAVLDCVGGACASILADALRPGGHFLHYGLLS
GESIPPSFWASHPDIAFSFCHLREWVHSETMGDVQRAYAEVAAMIASKVIATEVREVFPLEKIGEALHAALPFRTGGKVL
LA
>Mature_322_residues
MQYQAVVRKFGPAEEVVGIERAELAPLRRDQVRVRLLARSINPSDIITISGAYKGRTTLPFIPGFEALGVVETCGEEVHG
LVPGARVLPVRSAGGWQEFKDTDPSWCLRVPDALSDFEAATSYVNPMTAWLMLHKKIGLRPGMRIALNAAASSIGSILIG
MANAVGVEPIAIVRSEESLARLRGRLEAVIVDRADGNVAAGLAGRHGLDAVLDCVGGACASILADALRPGGHFLHYGLLS
GESIPPSFWASHPDIAFSFCHLREWVHSETMGDVQRAYAEVAAMIASKVIATEVREVFPLEKIGEALHAALPFRTGGKVL
LA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI67078404, Length=320, Percent_Identity=28.75, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI67078406, Length=295, Percent_Identity=27.7966101694915, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI24308257, Length=312, Percent_Identity=25, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI18379349, Length=310, Percent_Identity=25.4838709677419, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17536829, Length=293, Percent_Identity=30.0341296928328, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17556000, Length=253, Percent_Identity=30.8300395256917, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17507255, Length=175, Percent_Identity=29.7142857142857, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45550423, Length=330, Percent_Identity=30.3030303030303, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR009081
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR000794
- InterPro:   IPR002198
- InterPro:   IPR015357
- InterPro:   IPR011032
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016036
- InterPro:   IPR016040
- InterPro:   IPR006163
- InterPro:   IPR020842
- InterPro:   IPR020801
- InterPro:   IPR020841
- InterPro:   IPR020807
- InterPro:   IPR020843
- InterPro:   IPR020806
- InterPro:   IPR015083
- InterPro:   IPR006162
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00698 Acyl_transf_1; PF08240 ADH_N; PF00106 adh_short; PF00107 ADH_zinc_N; PF08990 Docking; PF09277 Erythro-docking; PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; PF00550 PP-binding [H]

EC number: =2.3.1.94 [H]

Molecular weight: Translated: 34459; Mature: 34459

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYQAVVRKFGPAEEVVGIERAELAPLRRDQVRVRLLARSINPSDIITISGAYKGRTTLP
CCHHHHHHHCCCHHHHHCCCHHHHCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCC
FIPGFEALGVVETCGEEVHGLVPGARVLPVRSAGGWQEFKDTDPSWCLRVPDALSDFEAA
CCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHCCCCCHHEEECCHHHHHHHHH
TSYVNPMTAWLMLHKKIGLRPGMRIALNAAASSIGSILIGMANAVGVEPIAIVRSEESLA
HHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHH
RLRGRLEAVIVDRADGNVAAGLAGRHGLDAVLDCVGGACASILADALRPGGHFLHYGLLS
HHHCCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
GESIPPSFWASHPDIAFSFCHLREWVHSETMGDVQRAYAEVAAMIASKVIATEVREVFPL
CCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
EKIGEALHAALPFRTGGKVLLA
HHHHHHHHHHCCCCCCCCEEEC
>Mature Secondary Structure
MQYQAVVRKFGPAEEVVGIERAELAPLRRDQVRVRLLARSINPSDIITISGAYKGRTTLP
CCHHHHHHHCCCHHHHHCCCHHHHCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCC
FIPGFEALGVVETCGEEVHGLVPGARVLPVRSAGGWQEFKDTDPSWCLRVPDALSDFEAA
CCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHCCCCCHHEEECCHHHHHHHHH
TSYVNPMTAWLMLHKKIGLRPGMRIALNAAASSIGSILIGMANAVGVEPIAIVRSEESLA
HHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHH
RLRGRLEAVIVDRADGNVAAGLAGRHGLDAVLDCVGGACASILADALRPGGHFLHYGLLS
HHHCCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
GESIPPSFWASHPDIAFSFCHLREWVHSETMGDVQRAYAEVAAMIASKVIATEVREVFPL
CCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
EKIGEALHAALPFRTGGKVLLA
HHHHHHHHHHCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2024119; 1740151 [H]