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The map label for this gene is atpB

Identifier: 85860198

GI number: 85860198

Start: 2397976

End: 2398629

Strand: Direct

Name: atpB

Synonym: SYN_00588

Alternate gene names: 85860198

Gene position: 2397976-2398629 (Clockwise)

Preceding gene: 85860197

Following gene: 85860203

Centisome position: 75.42

GC content: 52.45

Gene sequence:

>654_bases
ATGCATTCTCTGTCGTTTCTTGCAAATCCCTACGTACCATCGCACGTGGTGTATGCCTGGTTTATCATGGCTTTGCTGAT
CCTGTGCGGCCTGCTTTTAAGGCGCGGCATGGAGATACTGCCCGGTTCATTCCAGAGCTTCATGGAAGTGGTTATTGGCG
GGTTTGATTCCCTGGTGACGGATACCATGGGCCATGAAGGCAAGAAGTTCTTCCCCCTTATTGCCACCATCGGCCTCTTC
ATTCTCGTATCCAACCTTCTTGGTCTTGTCCCCGGCTTTGAATCCCCCACGGCGAATCTGAACACCAACGCCGCCATGGC
GGTTGTGGTCTTCATTCTGACGCACTATGTGGGAATCAAGGTTCATGGCGGAAAATATATCAAGCAGTTCATGGGACCCG
TATGGTGGCTGGTCCCCCTGATGATCCCCATCGAACTCATCAGCCATCTTGTTCGTCCCTTGTCACTCTCCATTCGACTC
TTCGGAAATATCGAGGGTGGACATATTGTCGTCGCCGTGCTGTTCCTGCTGGCACCCTTTCTGGTTCCCGTGCCCATTCT
GTTCCTGAAAGTCTTCATTTCCCTCATCCAGACCCTGGTCTTCATGCTCCTGTCCATGATGTATATCGCCGGAGCCATGG
AGGAAGCGCACTAA

Upstream 100 bases:

>100_bases
CATCGGTCTGCTTTTAGGTCTTTCCATCGTGGTTATCAATATCGTGTTCACCGTCATCATGGCGTTTCATAAAAAAAATT
TTATGGAGGTTAGTTAAACA

Downstream 100 bases:

>100_bases
GACCTCGTCGATCCAACCATCGATACAACTCTGTAAAATTTTCATCAAGAAAGGGACAGGCCCCCAAGCCTGTCCCTTTC
ACTTTTTTAAAGCCGATCTG

Product: ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MHSLSFLANPYVPSHVVYAWFIMALLILCGLLLRRGMEILPGSFQSFMEVVIGGFDSLVTDTMGHEGKKFFPLIATIGLF
ILVSNLLGLVPGFESPTANLNTNAAMAVVVFILTHYVGIKVHGGKYIKQFMGPVWWLVPLMIPIELISHLVRPLSLSIRL
FGNIEGGHIVVAVLFLLAPFLVPVPILFLKVFISLIQTLVFMLLSMMYIAGAMEEAH

Sequences:

>Translated_217_residues
MHSLSFLANPYVPSHVVYAWFIMALLILCGLLLRRGMEILPGSFQSFMEVVIGGFDSLVTDTMGHEGKKFFPLIATIGLF
ILVSNLLGLVPGFESPTANLNTNAAMAVVVFILTHYVGIKVHGGKYIKQFMGPVWWLVPLMIPIELISHLVRPLSLSIRL
FGNIEGGHIVVAVLFLLAPFLVPVPILFLKVFISLIQTLVFMLLSMMYIAGAMEEAH
>Mature_217_residues
MHSLSFLANPYVPSHVVYAWFIMALLILCGLLLRRGMEILPGSFQSFMEVVIGGFDSLVTDTMGHEGKKFFPLIATIGLF
ILVSNLLGLVPGFESPTANLNTNAAMAVVVFILTHYVGIKVHGGKYIKQFMGPVWWLVPLMIPIELISHLVRPLSLSIRL
FGNIEGGHIVVAVLFLLAPFLVPVPILFLKVFISLIQTLVFMLLSMMYIAGAMEEAH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=206, Percent_Identity=30.0970873786408, Blast_Score=83, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6226527, Length=180, Percent_Identity=27.7777777777778, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_SYNAS (Q2LVX0)

Other databases:

- EMBL:   CP000252
- RefSeq:   YP_462400.1
- ProteinModelPortal:   Q2LVX0
- SMR:   Q2LVX0
- STRING:   Q2LVX0
- GeneID:   3883633
- GenomeReviews:   CP000252_GR
- KEGG:   sat:SYN_00588
- NMPDR:   fig|56780.10.peg.2346
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   DAQKHLS
- PhylomeDB:   Q2LVX0
- BioCyc:   SACI56780:SYN_00588-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 23953; Mature: 23953

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x169424a0)-; HASH(0x16a46f34)-; HASH(0x169b383c)-; HASH(0x17601b58)-; HASH(0x177ed280)-; HASH(0x17b21914)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSLSFLANPYVPSHVVYAWFIMALLILCGLLLRRGMEILPGSFQSFMEVVIGGFDSLVT
CCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHH
DTMGHEGKKFFPLIATIGLFILVSNLLGLVPGFESPTANLNTNAAMAVVVFILTHYVGIK
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHE
VHGGKYIKQFMGPVWWLVPLMIPIELISHLVRPLSLSIRLFGNIEGGHIVVAVLFLLAPF
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHH
LVPVPILFLKVFISLIQTLVFMLLSMMYIAGAMEEAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MHSLSFLANPYVPSHVVYAWFIMALLILCGLLLRRGMEILPGSFQSFMEVVIGGFDSLVT
CCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHH
DTMGHEGKKFFPLIATIGLFILVSNLLGLVPGFESPTANLNTNAAMAVVVFILTHYVGIK
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHE
VHGGKYIKQFMGPVWWLVPLMIPIELISHLVRPLSLSIRLFGNIEGGHIVVAVLFLLAPF
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHH
LVPVPILFLKVFISLIQTLVFMLLSMMYIAGAMEEAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA