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The map label for this gene is ribD [H]

Identifier: 85860188

GI number: 85860188

Start: 2389377

End: 2390519

Strand: Direct

Name: ribD [H]

Synonym: SYN_00578

Alternate gene names: 85860188

Gene position: 2389377-2390519 (Clockwise)

Preceding gene: 85860187

Following gene: 85860190

Centisome position: 75.15

GC content: 58.71

Gene sequence:

>1143_bases
TTGAACGATGAATTCTATATGAAGCGAGCCCTTCAGCTTGCCCGGAAAGGGGAAGGGTGGGTCAGTCCCAACCCGATGGT
GGGCTCGGTCATCGTCAAAAACGACCGTATCATCGGAGAGGGCTATCATCGAAAATTCGGAGAGGCTCATGCGGAGATCA
ATGCCCTGAACGGGGCAAAGGAATCGGCCGAGGGCTCGACCATCTATGTGTCCCTCGAACCCTGCAGCCACTACGGCAAA
ACGCCGCCCTGCGTTGAACGTCTCGTCGCCTGCCGGCCGAAGCGGGTCGTCATCGGCACGACGGACCCCAACCCCCTCGT
AGCGGGCCGGGGAATCGGGATTTTGAAACGCAACGGCATCGAAGTCACCGTCGGGGTTCTCGAAGAGGTCTGCCGGGAAA
TCAACGAATCCTTCCTGAAATTCATCCAGTTCCGAATCCCCTTCGTGACCCTGAAATACGCCCAGACCCTGGACGGCAGG
ATCGCGACGTCAACCGGCCATTCCCGCTGGATCAGTTCACCCCCTTCAAGACGGTTCGCTCACCGTCTGCGCCATGCCCA
CGATGCAATCCTGGTCGGCATCGGCACGGTTCTGTCGGATGACCCGGAGCTGACCGTCCGCCTGGTTCGGGGGAAAAATC
CCCTGCGGATCGTTCTGGACAGCCGCCTCCGGATACCCCTGACGGCGCGCATTCTTCAGGAGCAGGATCAGGCAAAAACC
CTGATGGTGACAACCGATCACGCGGACAGGAAAAAGCTTTCCCAATTGAACGACCGCGGCATCGAAACGCTCATTCTGCC
TGTAGAGTCATCAGGAAGAATTGACCTGAACCGGCTTCTCCGGGAACTGGGAAGCCGCGGCATCGCTTCGGTGCTGGTCG
AAGGCGGCTCCGGAATTCTCACCGCCCTGATGGCTCAAGACCTTGCCGATCGCCTGATTGCCATCATCGCCCCCAAGATT
TCAGGCCGGGGGATCGAAGCCGTCGGGCAACTGAACATAACCAGCATGGGAAAGGCCATCGGGTTGGTTTTCAGGAAAAT
TTACCGCAAAGGCGATGACCTCATCATTGACAGCCGTTTCCGCAGGCCGGCAGAAACGTCACATCCTGCACCCCCCGATA
AACCGATCATCCCCCTCCGGTAA

Upstream 100 bases:

>100_bases
TTCATCGGCGGGTTAGCCTATAAAACTGAGGAAAATCAACGGGACATAAGATTTTGTTATGTCGTGCGAAGCAAGATGAG
AATCGCGGGGGAAAACCGGT

Downstream 100 bases:

>100_bases
ATTCACCCCCCGAGAGAACCACTTTTTAAGGTAAGGAACGCAGCAGCATTTCCGCCGCCCGGATGCCATCCAGCGCCGAG
CTGACAATGCCGCCCGCGTA

Product: diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MNDEFYMKRALQLARKGEGWVSPNPMVGSVIVKNDRIIGEGYHRKFGEAHAEINALNGAKESAEGSTIYVSLEPCSHYGK
TPPCVERLVACRPKRVVIGTTDPNPLVAGRGIGILKRNGIEVTVGVLEEVCREINESFLKFIQFRIPFVTLKYAQTLDGR
IATSTGHSRWISSPPSRRFAHRLRHAHDAILVGIGTVLSDDPELTVRLVRGKNPLRIVLDSRLRIPLTARILQEQDQAKT
LMVTTDHADRKKLSQLNDRGIETLILPVESSGRIDLNRLLRELGSRGIASVLVEGGSGILTALMAQDLADRLIAIIAPKI
SGRGIEAVGQLNITSMGKAIGLVFRKIYRKGDDLIIDSRFRRPAETSHPAPPDKPIIPLR

Sequences:

>Translated_380_residues
MNDEFYMKRALQLARKGEGWVSPNPMVGSVIVKNDRIIGEGYHRKFGEAHAEINALNGAKESAEGSTIYVSLEPCSHYGK
TPPCVERLVACRPKRVVIGTTDPNPLVAGRGIGILKRNGIEVTVGVLEEVCREINESFLKFIQFRIPFVTLKYAQTLDGR
IATSTGHSRWISSPPSRRFAHRLRHAHDAILVGIGTVLSDDPELTVRLVRGKNPLRIVLDSRLRIPLTARILQEQDQAKT
LMVTTDHADRKKLSQLNDRGIETLILPVESSGRIDLNRLLRELGSRGIASVLVEGGSGILTALMAQDLADRLIAIIAPKI
SGRGIEAVGQLNITSMGKAIGLVFRKIYRKGDDLIIDSRFRRPAETSHPAPPDKPIIPLR
>Mature_380_residues
MNDEFYMKRALQLARKGEGWVSPNPMVGSVIVKNDRIIGEGYHRKFGEAHAEINALNGAKESAEGSTIYVSLEPCSHYGK
TPPCVERLVACRPKRVVIGTTDPNPLVAGRGIGILKRNGIEVTVGVLEEVCREINESFLKFIQFRIPFVTLKYAQTLDGR
IATSTGHSRWISSPPSRRFAHRLRHAHDAILVGIGTVLSDDPELTVRLVRGKNPLRIVLDSRLRIPLTARILQEQDQAKT
LMVTTDHADRKKLSQLNDRGIETLILPVESSGRIDLNRLLRELGSRGIASVLVEGGSGILTALMAQDLADRLIAIIAPKI
SGRGIEAVGQLNITSMGKAIGLVFRKIYRKGDDLIIDSRFRRPAETSHPAPPDKPIIPLR

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG0117

COG function: function code H; Pyrimidine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=370, Percent_Identity=41.0810810810811, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI145693172, Length=154, Percent_Identity=32.4675324675325, Blast_Score=75, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319629, Length=211, Percent_Identity=29.3838862559242, Blast_Score=88, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 41906; Mature: 41906

Theoretical pI: Translated: 10.43; Mature: 10.43

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDEFYMKRALQLARKGEGWVSPNPMVGSVIVKNDRIIGEGYHRKFGEAHAEINALNGAK
CCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCEEECCCHHHHHHHHHHHHHHCCCCC
ESAEGSTIYVSLEPCSHYGKTPPCVERLVACRPKRVVIGTTDPNPLVAGRGIGILKRNGI
CCCCCCEEEEEECCHHCCCCCCHHHHHHHHCCCCEEEEECCCCCCEEECCCCEEEECCCC
EVTVGVLEEVCREINESFLKFIQFRIPFVTLKYAQTLDGRIATSTGHSRWISSPPSRRFA
EEEHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHCCCEEEECCCCCCCCCCCCHHHHH
HRLRHAHDAILVGIGTVLSDDPELTVRLVRGKNPLRIVLDSRLRIPLTARILQEQDQAKT
HHHHHHHCEEEEEEHHHHCCCCCEEEEEEECCCCEEEEECCCCCCCHHHHHHHHCCCCCE
LMVTTDHADRKKLSQLNDRGIETLILPVESSGRIDLNRLLRELGSRGIASVLVEGGSGIL
EEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHCCCCHHHHEEECCCHHH
TALMAQDLADRLIAIIAPKISGRGIEAVGQLNITSMGKAIGLVFRKIYRKGDDLIIDSRF
HHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCEEEECCC
RRPAETSHPAPPDKPIIPLR
CCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNDEFYMKRALQLARKGEGWVSPNPMVGSVIVKNDRIIGEGYHRKFGEAHAEINALNGAK
CCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCEEECCCHHHHHHHHHHHHHHCCCCC
ESAEGSTIYVSLEPCSHYGKTPPCVERLVACRPKRVVIGTTDPNPLVAGRGIGILKRNGI
CCCCCCEEEEEECCHHCCCCCCHHHHHHHHCCCCEEEEECCCCCCEEECCCCEEEECCCC
EVTVGVLEEVCREINESFLKFIQFRIPFVTLKYAQTLDGRIATSTGHSRWISSPPSRRFA
EEEHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHCCCEEEECCCCCCCCCCCCHHHHH
HRLRHAHDAILVGIGTVLSDDPELTVRLVRGKNPLRIVLDSRLRIPLTARILQEQDQAKT
HHHHHHHCEEEEEEHHHHCCCCCEEEEEEECCCCEEEEECCCCCCCHHHHHHHHCCCCCE
LMVTTDHADRKKLSQLNDRGIETLILPVESSGRIDLNRLLRELGSRGIASVLVEGGSGIL
EEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHCCCCHHHHEEECCCHHH
TALMAQDLADRLIAIIAPKISGRGIEAVGQLNITSMGKAIGLVFRKIYRKGDDLIIDSRF
HHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCEEEECCC
RRPAETSHPAPPDKPIIPLR
CCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]