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The map label for this gene is clpP

Identifier: 85859380

GI number: 85859380

Start: 1580036

End: 1580620

Strand: Direct

Name: clpP

Synonym: SYN_02785

Alternate gene names: 85859380

Gene position: 1580036-1580620 (Clockwise)

Preceding gene: 85859379

Following gene: 85859381

Centisome position: 49.7

GC content: 46.67

Gene sequence:

>585_bases
ATGAATCTCATTCCGATGGTGGTTCAGCAGGATGGGCGCGGTGAACGGGCATATGATATTTATTCGCGATTACTCAAGGA
TCGGATTATCTTTCTTGGTACGCCAATCGATGATGAGGTGGCGAATCTGATCATCGCTCAGTTGCTTTTTCTTGAATCCG
AAGATCCGGATAAAGAAATTTTCTTTTATCTCAACACACCCGGAGGCCACATCAGTTCCGGCATGGCGATCTATGATACG
ATGCGCTATATCAAACCACCAGTCGCCACCGTCTGCGTGGGACAAGCGGCCAGTATGGGCGCTTTACTGCTTGCCGCTGG
AGAGCAGGGAAAAAGATCTGCTTTGCCTCACTCAAGGATATTGATCCATCAGCCCCTTGGCGGATTTCAAGGCCAGGCTA
CTGATATCGACATTCAGGCGCGGGAAATACTAAGACTGAAAGATGAATTAAGTCTTATTCTTGCAGATTTAACCAACCAG
CCTCTGGATAGAATCAAGACGGACACCGAACGTGATTATTATATGACCAGCCAGCAGGCCAAAGAATACGGAATTATCGA
TGAAATCATTGTTAAGCGGTCATAA

Upstream 100 bases:

>100_bases
GAAACGACATTCTGAATAAAAAGGTCTTTGACTTTATTGAATCAAAAGCATCCGTTTCAATGATCGAAAAAGAAAAGACC
TCACCTGAGGAGGCAAACTG

Downstream 100 bases:

>100_bases
TAAATTACAAAAAGAGGAAGAATGAATGGGTAGAAAAACAACCGATTATTCCAGGGGACAAGAAATGCTTTTTTGTTCAT
TCTGCGGAAAAACACAAAAT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MNLIPMVVQQDGRGERAYDIYSRLLKDRIIFLGTPIDDEVANLIIAQLLFLESEDPDKEIFFYLNTPGGHISSGMAIYDT
MRYIKPPVATVCVGQAASMGALLLAAGEQGKRSALPHSRILIHQPLGGFQGQATDIDIQAREILRLKDELSLILADLTNQ
PLDRIKTDTERDYYMTSQQAKEYGIIDEIIVKRS

Sequences:

>Translated_194_residues
MNLIPMVVQQDGRGERAYDIYSRLLKDRIIFLGTPIDDEVANLIIAQLLFLESEDPDKEIFFYLNTPGGHISSGMAIYDT
MRYIKPPVATVCVGQAASMGALLLAAGEQGKRSALPHSRILIHQPLGGFQGQATDIDIQAREILRLKDELSLILADLTNQ
PLDRIKTDTERDYYMTSQQAKEYGIIDEIIVKRS
>Mature_194_residues
MNLIPMVVQQDGRGERAYDIYSRLLKDRIIFLGTPIDDEVANLIIAQLLFLESEDPDKEIFFYLNTPGGHISSGMAIYDT
MRYIKPPVATVCVGQAASMGALLLAAGEQGKRSALPHSRILIHQPLGGFQGQATDIDIQAREILRLKDELSLILADLTNQ
PLDRIKTDTERDYYMTSQQAKEYGIIDEIIVKRS

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=191, Percent_Identity=60.2094240837696, Blast_Score=239, Evalue=1e-63,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=58.2474226804124, Blast_Score=258, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=53.2258064516129, Blast_Score=213, Evalue=4e-56,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=56.3157894736842, Blast_Score=231, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_SYNAS (Q2LTK5)

Other databases:

- EMBL:   CP000252
- RefSeq:   YP_461582.1
- ProteinModelPortal:   Q2LTK5
- SMR:   Q2LTK5
- STRING:   Q2LTK5
- MEROPS:   S14.001
- GeneID:   3882834
- GenomeReviews:   CP000252_GR
- KEGG:   sat:SYN_02785
- NMPDR:   fig|56780.10.peg.1527
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   KFGLVDN
- PhylomeDB:   Q2LTK5
- BioCyc:   SACI56780:SYN_02785-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21709; Mature: 21709

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 98-98 ACT_SITE 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLIPMVVQQDGRGERAYDIYSRLLKDRIIFLGTPIDDEVANLIIAQLLFLESEDPDKEI
CCCCCEEEECCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEE
FFYLNTPGGHISSGMAIYDTMRYIKPPVATVCVGQAASMGALLLAAGEQGKRSALPHSRI
EEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCEE
LIHQPLGGFQGQATDIDIQAREILRLKDELSLILADLTNQPLDRIKTDTERDYYMTSQQA
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEECHHHH
KEYGIIDEIIVKRS
HHHCCHHHHHHCCC
>Mature Secondary Structure
MNLIPMVVQQDGRGERAYDIYSRLLKDRIIFLGTPIDDEVANLIIAQLLFLESEDPDKEI
CCCCCEEEECCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEE
FFYLNTPGGHISSGMAIYDTMRYIKPPVATVCVGQAASMGALLLAAGEQGKRSALPHSRI
EEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCEE
LIHQPLGGFQGQATDIDIQAREILRLKDELSLILADLTNQPLDRIKTDTERDYYMTSQQA
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEECHHHH
KEYGIIDEIIVKRS
HHHCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA