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The map label for this gene is lysC [H]

Identifier: 85859376

GI number: 85859376

Start: 1575524

End: 1576744

Strand: Direct

Name: lysC [H]

Synonym: SYN_02781

Alternate gene names: 85859376

Gene position: 1575524-1576744 (Clockwise)

Preceding gene: 85859375

Following gene: 85859377

Centisome position: 49.56

GC content: 48.89

Gene sequence:

>1221_bases
ATGGCTTTAGTTGTTCAAAAATATGGTGGAACCTCTGTTGCCAATCTGGAGAAAATCGAAAATGTTGCCCGGAAAGTCAT
CAAAACAAAGAAAGAGGGAAACGACGTCGTGGTTGTGCTTTCAGCCATGGCGGGTGAAACTAATCGACTGATCGAACTGG
CCCGTCAAGCTGCCGAAGATTATGATGTTCGTGAGTATGACACCCTGATTTCAACTGGGGAGCAGGTTACAATTTCCCTG
CTTGCCATGGTTCTGAACCGGATGGGCTATCCCGCTCGATCCTTTCTGGGGCATCAAGTCAGAATCATGACTGATCAGGC
TTACACCCAGGCAAGAATTCTGGATGTGGAAGATCGGCTTTTGCGCGGTGAACTTGAAAAGGGAAAGATTGCGGTGGTGG
CGGGATTCCAGGGTGTGGATCAGGATAATAATATCACGACACTGGGACGGGGCGGTTCCGATACGAGTGCCGTCGCACTG
GCCGCTGCTCTTCATGCCGATGTTTGCGAAATTTACACGGACGTGGACGGAGTCTACACAACGGATCCGAATATCTGCAG
CAACGCACGACTGCTCGAGAAAATTTCCTATGACGAAATGCTTGAAATGGCACGGGCTGGCGCAAAGGTATTGCAGCCGC
GTTCCGTCGAACTGGCGAAAAAATATGAAGTTCCTGTTTATGTTAAATCTTCTTTTAAAGATGAAGTTGGAACGCTCGTG
ACAAAGGAGGATAAGGATATGGAGAGAGAAGTCGTATCGGGAGTTACATATGACCGGGATCAGGCAAAGATCACGGTGGT
TCATGTTCCCGACAAATCCGGCGTTGCTGCCCGGTTATTTACGCCTCTGGCTGAACATAACATCGTAGTCGATATGATCA
TTCAGAACGCCAGCCTTGAAGGCTATACCGATCTGAGTTTTACAGTGTCCAGGAAAGATATCAAGGAAACAAAGCGTTTG
ATTGAGGAGGCGGCGAAGGAAGTAGGCGCTTCCAAAGTTGAAGTGGATGAGCAGGTGGCCAAGGTATCCATCATTGGTGT
GGGAATGATCAGCCATTCCGGTGTAGCCGCCAGGATGTTCGCAGCCCTGGCCCAGGAGGGGATCAATATTATGATGATCA
GCACCTCTGAAATCAAAGTCTCCTGTGTTATTCAATCCAAATACACGGAACTGGCGGTCATGGTTCTGCATGAAGTCTTC
GGGCTGGATAAGAAATCCTGA

Upstream 100 bases:

>100_bases
CACATTTCTTGATGAAAACACACGCCGCATTGAAATTTCCGCCCCGGAAAAGCGTCTGGAAGAAATTTCATCGGCCCTCA
GTAAGGGAGGATTTTAGTAT

Downstream 100 bases:

>100_bases
TCCTGAATCTGAAAGGAGAATAAAAATTCAAAAGCAATGAAATGAAGCCAGGCTGCAGAAACAACAATCTGACCCGAAGC
CAGTTGGGCGGCGCTGTGCT

Product: aspartokinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MALVVQKYGGTSVANLEKIENVARKVIKTKKEGNDVVVVLSAMAGETNRLIELARQAAEDYDVREYDTLISTGEQVTISL
LAMVLNRMGYPARSFLGHQVRIMTDQAYTQARILDVEDRLLRGELEKGKIAVVAGFQGVDQDNNITTLGRGGSDTSAVAL
AAALHADVCEIYTDVDGVYTTDPNICSNARLLEKISYDEMLEMARAGAKVLQPRSVELAKKYEVPVYVKSSFKDEVGTLV
TKEDKDMEREVVSGVTYDRDQAKITVVHVPDKSGVAARLFTPLAEHNIVVDMIIQNASLEGYTDLSFTVSRKDIKETKRL
IEEAAKEVGASKVEVDEQVAKVSIIGVGMISHSGVAARMFAALAQEGINIMMISTSEIKVSCVIQSKYTELAVMVLHEVF
GLDKKS

Sequences:

>Translated_406_residues
MALVVQKYGGTSVANLEKIENVARKVIKTKKEGNDVVVVLSAMAGETNRLIELARQAAEDYDVREYDTLISTGEQVTISL
LAMVLNRMGYPARSFLGHQVRIMTDQAYTQARILDVEDRLLRGELEKGKIAVVAGFQGVDQDNNITTLGRGGSDTSAVAL
AAALHADVCEIYTDVDGVYTTDPNICSNARLLEKISYDEMLEMARAGAKVLQPRSVELAKKYEVPVYVKSSFKDEVGTLV
TKEDKDMEREVVSGVTYDRDQAKITVVHVPDKSGVAARLFTPLAEHNIVVDMIIQNASLEGYTDLSFTVSRKDIKETKRL
IEEAAKEVGASKVEVDEQVAKVSIIGVGMISHSGVAARMFAALAQEGINIMMISTSEIKVSCVIQSKYTELAVMVLHEVF
GLDKKS
>Mature_405_residues
ALVVQKYGGTSVANLEKIENVARKVIKTKKEGNDVVVVLSAMAGETNRLIELARQAAEDYDVREYDTLISTGEQVTISLL
AMVLNRMGYPARSFLGHQVRIMTDQAYTQARILDVEDRLLRGELEKGKIAVVAGFQGVDQDNNITTLGRGGSDTSAVALA
AALHADVCEIYTDVDGVYTTDPNICSNARLLEKISYDEMLEMARAGAKVLQPRSVELAKKYEVPVYVKSSFKDEVGTLVT
KEDKDMEREVVSGVTYDRDQAKITVVHVPDKSGVAARLFTPLAEHNIVVDMIIQNASLEGYTDLSFTVSRKDIKETKRLI
EEAAKEVGASKVEVDEQVAKVSIIGVGMISHSGVAARMFAALAQEGINIMMISTSEIKVSCVIQSKYTELAVMVLHEVFG
LDKKS

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=353, Percent_Identity=32.5779036827195, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1790455, Length=464, Percent_Identity=28.8793103448276, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790376, Length=472, Percent_Identity=23.9406779661017, Blast_Score=83, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320893, Length=490, Percent_Identity=24.6938775510204, Blast_Score=127, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44388; Mature: 44256

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVVQKYGGTSVANLEKIENVARKVIKTKKEGNDVVVVLSAMAGETNRLIELARQAAED
CEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHC
YDVREYDTLISTGEQVTISLLAMVLNRMGYPARSFLGHQVRIMTDQAYTQARILDVEDRL
CCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHCCCEEEEEECCCHHHEEEECHHHHH
LRGELEKGKIAVVAGFQGVDQDNNITTLGRGGSDTSAVALAAALHADVCEIYTDVDGVYT
HHCCCCCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
TDPNICSNARLLEKISYDEMLEMARAGAKVLQPRSVELAKKYEVPVYVKSSFKDEVGTLV
CCCCCCCCHHHHHHCCHHHHHHHHHCCHHHCCCCCHHHHHHCCCCEEEECCCHHHHCCEE
TKEDKDMEREVVSGVTYDRDQAKITVVHVPDKSGVAARLFTPLAEHNIVVDMIIQNASLE
ECCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCEEEEEEEECCCCC
GYTDLSFTVSRKDIKETKRLIEEAAKEVGASKVEVDEQVAKVSIIGVGMISHSGVAARMF
CCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHEEEEEEEEEECCCCHHHHHH
AALAQEGINIMMISTSEIKVSCVIQSKYTELAVMVLHEVFGLDKKS
HHHHHCCCEEEEEECCCEEEEEEEECHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ALVVQKYGGTSVANLEKIENVARKVIKTKKEGNDVVVVLSAMAGETNRLIELARQAAED
EEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHC
YDVREYDTLISTGEQVTISLLAMVLNRMGYPARSFLGHQVRIMTDQAYTQARILDVEDRL
CCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHCCCEEEEEECCCHHHEEEECHHHHH
LRGELEKGKIAVVAGFQGVDQDNNITTLGRGGSDTSAVALAAALHADVCEIYTDVDGVYT
HHCCCCCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
TDPNICSNARLLEKISYDEMLEMARAGAKVLQPRSVELAKKYEVPVYVKSSFKDEVGTLV
CCCCCCCCHHHHHHCCHHHHHHHHHCCHHHCCCCCHHHHHHCCCCEEEECCCHHHHCCEE
TKEDKDMEREVVSGVTYDRDQAKITVVHVPDKSGVAARLFTPLAEHNIVVDMIIQNASLE
ECCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCEEEEEEEECCCCC
GYTDLSFTVSRKDIKETKRLIEEAAKEVGASKVEVDEQVAKVSIIGVGMISHSGVAARMF
CCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHEEEEEEEEEECCCCHHHHHH
AALAQEGINIMMISTSEIKVSCVIQSKYTELAVMVLHEVFGLDKKS
HHHHHCCCEEEEEECCCEEEEEEEECHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]