Click here to switch to the map view.

The map label for this gene is folP [H]

Identifier: 85859373

GI number: 85859373

Start: 1573320

End: 1574567

Strand: Direct

Name: folP [H]

Synonym: SYN_02778

Alternate gene names: 85859373

Gene position: 1573320-1574567 (Clockwise)

Preceding gene: 85859372

Following gene: 85859374

Centisome position: 49.49

GC content: 49.84

Gene sequence:

>1248_bases
ATGGGTAAAATCAAAAGTTTATATATCCCTTGTTATCCCATGAGATCCCTTCATGTCCCTTTTCCTTCCGAGGCCGCTGC
GCTGTTGAAAGAAGTGGGCGTAGATCCCTATGGAATCGACGCCATGCTTCCCAAAATGAGTCACCTGAATGTTCTCATTG
AGGGACTTGAATGCAGAGTTGCCAATATCGTCAAACAGGAGATGCTTTCCGTCGGTGGAGATGCCGCCGTGGCCAGGGGG
TCCGTTGGATGTGCAATTGAAAGGACAGATGCCATCCTGATGGGAACGGCGAAACAGATTCAGCGTTTTGCGGAAAAGAT
TTCATGTCAGCCCTTAGGACTGAGGGTCATCGCAGAACGTCTCAGAGAGCTCCTCGCCAATATGGCGAAGGAATCAATTC
TTCTTCGGACGCCGAAACGGAAAATTGTCTTTGGCAAAAATACCCACATTATGGGAATTCTCAATGTTACACCGGATTCT
TTTTCAGATGGGGGAAGATATCTTCTTCCTGACCAGGCTGTTGCCCGCGGCATTCAACTTGCGGAGGAAGGCGCTGATAT
TCTTGACATCGGAGGTGAATCATCAAGACCGGGTTCCGATCCCGTTTCTTTGACGGAAGAGGCGAACCGGGTGCTGCCGG
TTATCAAAAGACTGGTCAGGGAAATCGACATTCCCGTTTCCATCGATACGACAAAAGCCGAAATCGCCCGTGAAGCTCTG
GCCGCCGGAGCAGAAATCATAAACGATATCAGTTCAATGAGCTTTGACGAGCATATGATGCAAACGGTAATCGATTCCGG
GGCGGCGGTTGTTCTCATGCATATGAGGGGAAAACCGAAGAACATGCAGAAAGGTGATCTGACATATCGCTCGGTGCGGG
GAGAAGTGATTCAGTCCCTTCGAGAAAGGATGAATCAGGCGGTTTCATCCGGCATCGAGGAAGAACGGATTCTTGTCGAT
CCCGGGTTCGGATTCGGGAAAAAGCCTGCGGATTCGCTTAAACTCCTCAAACACCTGTCGGAGTTTAAATCACTGGGACG
CCCGATTCTCGTCGGACCTTCCCGGAAGTATTTTATCGCTGCGGCTATGGCTGAAAAAGAAGCGATTCCCGATCCTCTGC
AAAGAATCGAGGGAACGGCAGCAGCCGTTGTCGCAGCAATTATGAATGGGGCTCACATTGTCCGTGTTCATGATGTCTCT
GTAATGAAAAAAACAGCGGCCGTAACTGACGCCATTCTTCATGCATAG

Upstream 100 bases:

>100_bases
AAGACCGTGGGCAGGAAAATCCCGTGAGTGTGGAAGCGTGAAAAATTATCATTTTTCTGCTTTCCCTGATTACCCGCAAC
AGGGGATCTGAGGGTAACTA

Downstream 100 bases:

>100_bases
AAATTCAAAATACCTCTCAAAAAAAGCGGAAATCTGATCATCATGGTTCATGGAACAGGGATTGATCTGGTTGATATAGA
CCGCCTCGAAAAAATTCTGA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MGKIKSLYIPCYPMRSLHVPFPSEAAALLKEVGVDPYGIDAMLPKMSHLNVLIEGLECRVANIVKQEMLSVGGDAAVARG
SVGCAIERTDAILMGTAKQIQRFAEKISCQPLGLRVIAERLRELLANMAKESILLRTPKRKIVFGKNTHIMGILNVTPDS
FSDGGRYLLPDQAVARGIQLAEEGADILDIGGESSRPGSDPVSLTEEANRVLPVIKRLVREIDIPVSIDTTKAEIAREAL
AAGAEIINDISSMSFDEHMMQTVIDSGAAVVLMHMRGKPKNMQKGDLTYRSVRGEVIQSLRERMNQAVSSGIEEERILVD
PGFGFGKKPADSLKLLKHLSEFKSLGRPILVGPSRKYFIAAAMAEKEAIPDPLQRIEGTAAAVVAAIMNGAHIVRVHDVS
VMKKTAAVTDAILHA

Sequences:

>Translated_415_residues
MGKIKSLYIPCYPMRSLHVPFPSEAAALLKEVGVDPYGIDAMLPKMSHLNVLIEGLECRVANIVKQEMLSVGGDAAVARG
SVGCAIERTDAILMGTAKQIQRFAEKISCQPLGLRVIAERLRELLANMAKESILLRTPKRKIVFGKNTHIMGILNVTPDS
FSDGGRYLLPDQAVARGIQLAEEGADILDIGGESSRPGSDPVSLTEEANRVLPVIKRLVREIDIPVSIDTTKAEIAREAL
AAGAEIINDISSMSFDEHMMQTVIDSGAAVVLMHMRGKPKNMQKGDLTYRSVRGEVIQSLRERMNQAVSSGIEEERILVD
PGFGFGKKPADSLKLLKHLSEFKSLGRPILVGPSRKYFIAAAMAEKEAIPDPLQRIEGTAAAVVAAIMNGAHIVRVHDVS
VMKKTAAVTDAILHA
>Mature_414_residues
GKIKSLYIPCYPMRSLHVPFPSEAAALLKEVGVDPYGIDAMLPKMSHLNVLIEGLECRVANIVKQEMLSVGGDAAVARGS
VGCAIERTDAILMGTAKQIQRFAEKISCQPLGLRVIAERLRELLANMAKESILLRTPKRKIVFGKNTHIMGILNVTPDSF
SDGGRYLLPDQAVARGIQLAEEGADILDIGGESSRPGSDPVSLTEEANRVLPVIKRLVREIDIPVSIDTTKAEIAREALA
AGAEIINDISSMSFDEHMMQTVIDSGAAVVLMHMRGKPKNMQKGDLTYRSVRGEVIQSLRERMNQAVSSGIEEERILVDP
GFGFGKKPADSLKLLKHLSEFKSLGRPILVGPSRKYFIAAAMAEKEAIPDPLQRIEGTAAAVVAAIMNGAHIVRVHDVSV
MKKTAAVTDAILHA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=267, Percent_Identity=42.6966292134831, Blast_Score=208, Evalue=7e-55,
Organism=Saccharomyces cerevisiae, GI6324073, Length=320, Percent_Identity=31.875, Blast_Score=143, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 44925; Mature: 44794

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKIKSLYIPCYPMRSLHVPFPSEAAALLKEVGVDPYGIDAMLPKMSHLNVLIEGLECRV
CCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHHH
ANIVKQEMLSVGGDAAVARGSVGCAIERTDAILMGTAKQIQRFAEKISCQPLGLRVIAER
HHHHHHHHHHCCCCHHHHCCCCCEEEECCCCCEECCHHHHHHHHHHHCCCCCHHHHHHHH
LRELLANMAKESILLRTPKRKIVFGKNTHIMGILNVTPDSFSDGGRYLLPDQAVARGIQL
HHHHHHHHHHHHEEEECCCCEEEECCCCEEEEEEECCCCCCCCCCCEECCCHHHHHHHHH
AEEGADILDIGGESSRPGSDPVSLTEEANRVLPVIKRLVREIDIPVSIDTTKAEIAREAL
HHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHH
AAGAEIINDISSMSFDEHMMQTVIDSGAAVVLMHMRGKPKNMQKGDLTYRSVRGEVIQSL
HHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
RERMNQAVSSGIEEERILVDPGFGFGKKPADSLKLLKHLSEFKSLGRPILVGPSRKYFIA
HHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCEEEE
AAMAEKEAIPDPLQRIEGTAAAVVAAIMNGAHIVRVHDVSVMKKTAAVTDAILHA
EHHHHHHCCCCHHHHHCCHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GKIKSLYIPCYPMRSLHVPFPSEAAALLKEVGVDPYGIDAMLPKMSHLNVLIEGLECRV
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHHH
ANIVKQEMLSVGGDAAVARGSVGCAIERTDAILMGTAKQIQRFAEKISCQPLGLRVIAER
HHHHHHHHHHCCCCHHHHCCCCCEEEECCCCCEECCHHHHHHHHHHHCCCCCHHHHHHHH
LRELLANMAKESILLRTPKRKIVFGKNTHIMGILNVTPDSFSDGGRYLLPDQAVARGIQL
HHHHHHHHHHHHEEEECCCCEEEECCCCEEEEEEECCCCCCCCCCCEECCCHHHHHHHHH
AEEGADILDIGGESSRPGSDPVSLTEEANRVLPVIKRLVREIDIPVSIDTTKAEIAREAL
HHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHH
AAGAEIINDISSMSFDEHMMQTVIDSGAAVVLMHMRGKPKNMQKGDLTYRSVRGEVIQSL
HHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
RERMNQAVSSGIEEERILVDPGFGFGKKPADSLKLLKHLSEFKSLGRPILVGPSRKYFIA
HHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCEEEE
AAMAEKEAIPDPLQRIEGTAAAVVAAIMNGAHIVRVHDVSVMKKTAAVTDAILHA
EHHHHHHCCCCHHHHHCCHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]