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The map label for this gene is adk [H]

Identifier: 85859317

GI number: 85859317

Start: 1506838

End: 1507563

Strand: Direct

Name: adk [H]

Synonym: SYN_02538

Alternate gene names: 85859317

Gene position: 1506838-1507563 (Clockwise)

Preceding gene: 85859309

Following gene: 85859318

Centisome position: 47.4

GC content: 52.07

Gene sequence:

>726_bases
TTGACCCGGTGCCGGATTTTGCCTATAGTCCCAAAACTGCAAACGAAATTGAAAGTTAAGGAGGTTATCAGGAATATGAA
GATTATTCTTTTGGGAGCGCCGGGCGCCGGGAAGGGCACAGTGGCCAAACTGCTGACGGAGTATGATGGTTCCGTACAGA
TTTCCACGGGAGACATTCTGCGGGCGGCCGTCAAGGAAGGAACAGAGCTTGGACGGGAGGCCAAAGGCTACATGGATCGG
GGTGATCTGGTTCCCGATGCGCTGATCATGCGGATGATGGAAACCCGCCTTCAACAGCCGGATTGTGCAAACGGATTCAT
CCTGGACGGTTTTCCCAGAACGATTCCCCAGGCCGAGGCCTTGAAGAAGCTCCTGGAAAAACTGAATATTCGACTGAATT
TTGTCGTCAATCTGGAAGTTCCGCGGGATGTGATCCTGGATCGGCTGACCACTCGGAGAACCTGCTCCAATCCGGATTGT
CAGGAAATATACAATATCAAAAGCAATCCTCCCCTGCCCGATGGCCGCTGCAAGAAATGCGGCAGTCCGACGATTCAGCG
GGATGATGAGACCGAAGAAGCCATTCTGAACCGTCTGGAAACCTACAATGAGAAAACCGCGCCTCTGATTGGCTTTTATG
AAAGGGAAGGGCTGCTCAAGACATTTTCCTCAGTCAGCAGCGCCGAAACCGTGGAAGCCGTTAAAAAGGCCTTGAAGGAA
TGCTGA

Upstream 100 bases:

>100_bases
TGGGAAGTAAGCCTCTTCCCTGAGGCTGGCGGCGTTCCGTGACTATAAAAAAGTATTATGGATTTAGTCAAGAATTAATG
CCTTTCCGCCCTGTATTCGC

Downstream 100 bases:

>100_bases
TCAAAATACCGGGTCTGTTTCGCCATGATCGATTATGAGAAGGAACTGAACGAAGAGCAGTGTCACGTTGTGCTGGAAGC
GGGAGGGCCCATGCTGGTTC

Product: adenylate kinase / nucleoside-diphosphate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MTRCRILPIVPKLQTKLKVKEVIRNMKIILLGAPGAGKGTVAKLLTEYDGSVQISTGDILRAAVKEGTELGREAKGYMDR
GDLVPDALIMRMMETRLQQPDCANGFILDGFPRTIPQAEALKKLLEKLNIRLNFVVNLEVPRDVILDRLTTRRTCSNPDC
QEIYNIKSNPPLPDGRCKKCGSPTIQRDDETEEAILNRLETYNEKTAPLIGFYEREGLLKTFSSVSSAETVEAVKKALKE
C

Sequences:

>Translated_241_residues
MTRCRILPIVPKLQTKLKVKEVIRNMKIILLGAPGAGKGTVAKLLTEYDGSVQISTGDILRAAVKEGTELGREAKGYMDR
GDLVPDALIMRMMETRLQQPDCANGFILDGFPRTIPQAEALKKLLEKLNIRLNFVVNLEVPRDVILDRLTTRRTCSNPDC
QEIYNIKSNPPLPDGRCKKCGSPTIQRDDETEEAILNRLETYNEKTAPLIGFYEREGLLKTFSSVSSAETVEAVKKALKE
C
>Mature_240_residues
TRCRILPIVPKLQTKLKVKEVIRNMKIILLGAPGAGKGTVAKLLTEYDGSVQISTGDILRAAVKEGTELGREAKGYMDRG
DLVPDALIMRMMETRLQQPDCANGFILDGFPRTIPQAEALKKLLEKLNIRLNFVVNLEVPRDVILDRLTTRRTCSNPDCQ
EIYNIKSNPPLPDGRCKKCGSPTIQRDDETEEAILNRLETYNEKTAPLIGFYEREGLLKTFSSVSSAETVEAVKKALKEC

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=214, Percent_Identity=38.785046728972, Blast_Score=157, Evalue=6e-39,
Organism=Homo sapiens, GI4502013, Length=214, Percent_Identity=38.785046728972, Blast_Score=157, Evalue=6e-39,
Organism=Homo sapiens, GI19923437, Length=216, Percent_Identity=37.5, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI310110345, Length=202, Percent_Identity=36.1386138613861, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI53832003, Length=202, Percent_Identity=36.1386138613861, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI8051579, Length=202, Percent_Identity=36.1386138613861, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI53832001, Length=202, Percent_Identity=36.1386138613861, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI4502011, Length=215, Percent_Identity=28.3720930232558, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI22749187, Length=188, Percent_Identity=31.3829787234043, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI28144899, Length=213, Percent_Identity=27.2300469483568, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI28144897, Length=213, Percent_Identity=27.2300469483568, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI7706497, Length=245, Percent_Identity=25.7142857142857, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1786680, Length=191, Percent_Identity=48.6910994764398, Blast_Score=187, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17552384, Length=231, Percent_Identity=34.6320346320346, Blast_Score=150, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17537943, Length=216, Percent_Identity=30.0925925925926, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17550688, Length=198, Percent_Identity=29.2929292929293, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17533833, Length=207, Percent_Identity=27.536231884058, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17567503, Length=210, Percent_Identity=25.7142857142857, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320432, Length=210, Percent_Identity=38.0952380952381, Blast_Score=152, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6321018, Length=202, Percent_Identity=40.0990099009901, Blast_Score=138, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6322828, Length=190, Percent_Identity=27.3684210526316, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17737899, Length=206, Percent_Identity=40.2912621359223, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24645822, Length=206, Percent_Identity=40.2912621359223, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI22026816, Length=190, Percent_Identity=41.5789473684211, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24663208, Length=188, Percent_Identity=26.063829787234, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17647141, Length=188, Percent_Identity=26.063829787234, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221459597, Length=205, Percent_Identity=25.8536585365854, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21356893, Length=205, Percent_Identity=25.8536585365854, Blast_Score=74, Evalue=7e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 26892; Mature: 26761

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRCRILPIVPKLQTKLKVKEVIRNMKIILLGAPGAGKGTVAKLLTEYDGSVQISTGDIL
CCCCEEEECCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEHHHHH
RAAVKEGTELGREAKGYMDRGDLVPDALIMRMMETRLQQPDCANGFILDGFPRTIPQAEA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCHHHH
LKKLLEKLNIRLNFVVNLEVPRDVILDRLTTRRTCSNPDCQEIYNIKSNPPLPDGRCKKC
HHHHHHHHCCEEEEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCHHHHC
GSPTIQRDDETEEAILNRLETYNEKTAPLIGFYEREGLLKTFSSVSSAETVEAVKKALKE
CCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
C
C
>Mature Secondary Structure 
TRCRILPIVPKLQTKLKVKEVIRNMKIILLGAPGAGKGTVAKLLTEYDGSVQISTGDIL
CCCEEEECCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEHHHHH
RAAVKEGTELGREAKGYMDRGDLVPDALIMRMMETRLQQPDCANGFILDGFPRTIPQAEA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCHHHH
LKKLLEKLNIRLNFVVNLEVPRDVILDRLTTRRTCSNPDCQEIYNIKSNPPLPDGRCKKC
HHHHHHHHCCEEEEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCHHHHC
GSPTIQRDDETEEAILNRLETYNEKTAPLIGFYEREGLLKTFSSVSSAETVEAVKKALKE
CCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
C
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA