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The map label for this gene is argD [H]

Identifier: 85859272

GI number: 85859272

Start: 1459138

End: 1460328

Strand: Direct

Name: argD [H]

Synonym: SYN_02155

Alternate gene names: 85859272

Gene position: 1459138-1460328 (Clockwise)

Preceding gene: 85859271

Following gene: 85859273

Centisome position: 45.89

GC content: 51.3

Gene sequence:

>1191_bases
ATGACAACAGAGGAACTGATTGCGCTTTCTGAAAAGAATATCATGGGAACCTATCGCCGTTTTCCTATTGTTCTGACCAG
GGGAGAAGGCGTTCGGGTCTGGGACAGAGATGGTAAAGAATATCTCGACTTTGTAGCCGGCATAGCGGTCTGCAGTCTGG
GGCATTCTCACCCGGCCGTGGTCGAGGCCATCAAACGGCAGGCCGAAACCCTCATGCATGTATCGAATCTCTATCATATC
GAGCCGCAGATTCACTTTGCCGACCAGCTCGTGAAGCATTCTTTCGCAGATAAGGTATTTTTCTGCAACAGCGGCGCTGA
AGCCAATGAAGGAGCAATCAAGCTTGCACGCAAATACGCTTTTGAAAACATGGAGCCCGGCCGCTGCGAGTTGATTACTA
TGAAAGATTCTTTTCATGGAAGAACATTGGCAACGATTACTGCTACGGGTCAGAAAAAGTTTCAGGTTGGTTTTGAGCCC
TTGCCGGAAGGGTTCAATTATGTCCCTTTCAACGACCTTGCTGCTCTGGAGGGGGCGGTGACGGAGCGGACATGCGGCGT
TCTCCTCGAACCCATTCAGGGAGAGGGCGGTGTTCGAATGCCTGACAGGCATTACCTGAGAAAAGTAAGGGAGTTATGCG
ATGACAGGGGCATTCTGATGATCCTCGACGAAGTGCAGGTCGGCATGGGACGCACCGGACATTTATTTGCTTATGAACAC
GATTCGGTGACACCGGATATCATGACACTGGCCAAGGCGTTGGGAAACGGCTTCCCAATTGGCGCCGTGCTGGCGACTGA
CCGGGTTGCATCCTCTTTCGTCCCGGGAAGCCATGCCTCCACCTTCGGAGGAAATCCACTCGCCATGGCTGCAGGACTTA
CCGTAATGGAAACTCTCCTTGAGGGAGATATCCTGGAGAATTGTCGGCGATCAGGGAGATACTTTCTTGAAAGTCTCGAA
AATTTAAAGAGGAAATATCCGTTTGTGAAGGAAGTCCGAGGACGGGGATTGATAATTGGAATGGAACTGACTGCTGAGGG
AACCGATATTGTCCGTTCCTGCATGGAAAAGGGGCTGCTGATCAACTGCACGAGCGGAAATGTTTTGCGCTTTATTCCGC
CGTTGATCATAACGGAAGCGGAAGTGGATCGGGCGGTTGAAATACTGGACAGGGCGATGGGAGAACGATGA

Upstream 100 bases:

>100_bases
ATTGGAACGGAACTCGTACTGTAATTACTTGCGGAAGGCGGTTCAAAGGACGGATTTCAAAAACTGGATAATGGAAACTC
GCCCTTGGGAGGGATAGGGA

Downstream 100 bases:

>100_bases
AAAAGGATCTGTTAAGCATCTATGATCTTGAAGCAGGAGATTTTAAGGCTATTTTTGAGAAAGCCCGGCATCTCAAGTCG
GTGCATGAGCAAGGGGTGGC

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MTTEELIALSEKNIMGTYRRFPIVLTRGEGVRVWDRDGKEYLDFVAGIAVCSLGHSHPAVVEAIKRQAETLMHVSNLYHI
EPQIHFADQLVKHSFADKVFFCNSGAEANEGAIKLARKYAFENMEPGRCELITMKDSFHGRTLATITATGQKKFQVGFEP
LPEGFNYVPFNDLAALEGAVTERTCGVLLEPIQGEGGVRMPDRHYLRKVRELCDDRGILMILDEVQVGMGRTGHLFAYEH
DSVTPDIMTLAKALGNGFPIGAVLATDRVASSFVPGSHASTFGGNPLAMAAGLTVMETLLEGDILENCRRSGRYFLESLE
NLKRKYPFVKEVRGRGLIIGMELTAEGTDIVRSCMEKGLLINCTSGNVLRFIPPLIITEAEVDRAVEILDRAMGER

Sequences:

>Translated_396_residues
MTTEELIALSEKNIMGTYRRFPIVLTRGEGVRVWDRDGKEYLDFVAGIAVCSLGHSHPAVVEAIKRQAETLMHVSNLYHI
EPQIHFADQLVKHSFADKVFFCNSGAEANEGAIKLARKYAFENMEPGRCELITMKDSFHGRTLATITATGQKKFQVGFEP
LPEGFNYVPFNDLAALEGAVTERTCGVLLEPIQGEGGVRMPDRHYLRKVRELCDDRGILMILDEVQVGMGRTGHLFAYEH
DSVTPDIMTLAKALGNGFPIGAVLATDRVASSFVPGSHASTFGGNPLAMAAGLTVMETLLEGDILENCRRSGRYFLESLE
NLKRKYPFVKEVRGRGLIIGMELTAEGTDIVRSCMEKGLLINCTSGNVLRFIPPLIITEAEVDRAVEILDRAMGER
>Mature_395_residues
TTEELIALSEKNIMGTYRRFPIVLTRGEGVRVWDRDGKEYLDFVAGIAVCSLGHSHPAVVEAIKRQAETLMHVSNLYHIE
PQIHFADQLVKHSFADKVFFCNSGAEANEGAIKLARKYAFENMEPGRCELITMKDSFHGRTLATITATGQKKFQVGFEPL
PEGFNYVPFNDLAALEGAVTERTCGVLLEPIQGEGGVRMPDRHYLRKVRELCDDRGILMILDEVQVGMGRTGHLFAYEHD
SVTPDIMTLAKALGNGFPIGAVLATDRVASSFVPGSHASTFGGNPLAMAAGLTVMETLLEGDILENCRRSGRYFLESLEN
LKRKYPFVKEVRGRGLIIGMELTAEGTDIVRSCMEKGLLINCTSGNVLRFIPPLIITEAEVDRAVEILDRAMGER

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=400, Percent_Identity=34.75, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI284507298, Length=299, Percent_Identity=37.4581939799331, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI13994255, Length=440, Percent_Identity=31.3636363636364, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI37574042, Length=449, Percent_Identity=29.6213808463252, Blast_Score=184, Evalue=9e-47,
Organism=Homo sapiens, GI226442705, Length=449, Percent_Identity=28.7305122494432, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI226442709, Length=394, Percent_Identity=30.4568527918782, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI24119277, Length=434, Percent_Identity=28.8018433179723, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI188536080, Length=402, Percent_Identity=23.8805970149254, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI38679950, Length=402, Percent_Identity=23.8805970149254, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI38679946, Length=402, Percent_Identity=23.8805970149254, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1789759, Length=392, Percent_Identity=43.1122448979592, Blast_Score=351, Evalue=5e-98,
Organism=Escherichia coli, GI1788044, Length=374, Percent_Identity=43.8502673796791, Blast_Score=342, Evalue=3e-95,
Organism=Escherichia coli, GI145693181, Length=378, Percent_Identity=38.3597883597884, Blast_Score=246, Evalue=1e-66,
Organism=Escherichia coli, GI1789016, Length=413, Percent_Identity=33.6561743341404, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1787560, Length=400, Percent_Identity=33.75, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1786991, Length=430, Percent_Identity=29.5348837209302, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1786349, Length=302, Percent_Identity=30.1324503311258, Blast_Score=125, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI25144271, Length=402, Percent_Identity=36.0696517412935, Blast_Score=275, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI32564660, Length=437, Percent_Identity=34.324942791762, Blast_Score=241, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI25144274, Length=291, Percent_Identity=37.4570446735395, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI71992977, Length=448, Percent_Identity=27.4553571428571, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI71981843, Length=175, Percent_Identity=31.4285714285714, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17541228, Length=438, Percent_Identity=25.1141552511416, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324432, Length=402, Percent_Identity=34.3283582089552, Blast_Score=261, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6323470, Length=421, Percent_Identity=31.8289786223278, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6321456, Length=425, Percent_Identity=26.5882352941176, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6324386, Length=482, Percent_Identity=25.3112033195021, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21357415, Length=384, Percent_Identity=36.1979166666667, Blast_Score=265, Evalue=5e-71,
Organism=Drosophila melanogaster, GI28574759, Length=439, Percent_Identity=31.6628701594533, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI161085790, Length=436, Percent_Identity=31.1926605504587, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI21356575, Length=455, Percent_Identity=28.5714285714286, Blast_Score=168, Evalue=6e-42,
Organism=Drosophila melanogaster, GI281366494, Length=425, Percent_Identity=24, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24667139, Length=425, Percent_Identity=24, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24667143, Length=425, Percent_Identity=24, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 43754; Mature: 43623

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEELIALSEKNIMGTYRRFPIVLTRGEGVRVWDRDGKEYLDFVAGIAVCSLGHSHPAV
CCHHHHHHHCCCCHHHHHCCCCEEEECCCCEEEECCCCHHHHHHHHHHHHHHCCCCCHHH
VEAIKRQAETLMHVSNLYHIEPQIHFADQLVKHSFADKVFFCNSGAEANEGAIKLARKYA
HHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHH
FENMEPGRCELITMKDSFHGRTLATITATGQKKFQVGFEPLPEGFNYVPFNDLAALEGAV
HCCCCCCCEEEEEEECCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHHH
TERTCGVLLEPIQGEGGVRMPDRHYLRKVRELCDDRGILMILDEVQVGMGRTGHLFAYEH
HHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECHHHCCCCCCCEEEEEC
DSVTPDIMTLAKALGNGFPIGAVLATDRVASSFVPGSHASTFGGNPLAMAAGLTVMETLL
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EGDILENCRRSGRYFLESLENLKRKYPFVKEVRGRGLIIGMELTAEGTDIVRSCMEKGLL
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEEEEEECCCCHHHHHHHHHCCEE
INCTSGNVLRFIPPLIITEAEVDRAVEILDRAMGER
EEECCCCCCEECCCHHEEHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTEELIALSEKNIMGTYRRFPIVLTRGEGVRVWDRDGKEYLDFVAGIAVCSLGHSHPAV
CHHHHHHHCCCCHHHHHCCCCEEEECCCCEEEECCCCHHHHHHHHHHHHHHCCCCCHHH
VEAIKRQAETLMHVSNLYHIEPQIHFADQLVKHSFADKVFFCNSGAEANEGAIKLARKYA
HHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHH
FENMEPGRCELITMKDSFHGRTLATITATGQKKFQVGFEPLPEGFNYVPFNDLAALEGAV
HCCCCCCCEEEEEEECCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHHH
TERTCGVLLEPIQGEGGVRMPDRHYLRKVRELCDDRGILMILDEVQVGMGRTGHLFAYEH
HHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECHHHCCCCCCCEEEEEC
DSVTPDIMTLAKALGNGFPIGAVLATDRVASSFVPGSHASTFGGNPLAMAAGLTVMETLL
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EGDILENCRRSGRYFLESLENLKRKYPFVKEVRGRGLIIGMELTAEGTDIVRSCMEKGLL
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEEEEEECCCCHHHHHHHHHCCEE
INCTSGNVLRFIPPLIITEAEVDRAVEILDRAMGER
EEECCCCCCEECCCHHEEHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]