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The map label for this gene is hdrA [H]

Identifier: 85859240

GI number: 85859240

Start: 1421194

End: 1424013

Strand: Direct

Name: hdrA [H]

Synonym: SYN_03215

Alternate gene names: 85859240

Gene position: 1421194-1424013 (Clockwise)

Preceding gene: 85859239

Following gene: 85859241

Centisome position: 44.7

GC content: 58.87

Gene sequence:

>2820_bases
GTGGATCGTGTAGCCGGGGAGGTGGGAGATTTCAAGGTCACACTGACGAAAAAACCCAGATACATCATCGAGGACAAGTG
CTCGGGCTGTACTACCTGCGTGGAGTACTGTCCGGTCGTCTATCCCGATGTCTACAATCAGGAGATATCAAAGAACAAGG
CGGTTCATGTGTACTTCGCCCAGGCCATTCCCCTGGTGACATACATCGATGAGAGCTGCCTTTACCTGAAGGAGGACAAG
TGCCGGATCTGCGAAGCCGTGTGCAAGCAGGACGCCATCGACTTCAGTCAGGTTCCCGAGCAGATGGAGGTCAATGTGGG
GGCCATCATCCTGTCGGCAGGTCTTGAGCCGTTCGATCCCCGGCTGAGCAAGGAATACCATTACGGGGAGTTTGCCAACG
TGGTCACCGGCATGGACTTCGAGCGGCTGCTGTGCGCCACCGGTCCCTATGGGGGCGAGATCCTGCGCGCCTCCGACCTG
AAGCATCCCCATAAAATCGCGTGGCTTTCCTGTGTCGGCTCCCGACGGGTGACCGAGGGCGAGAACAGCTACTGCTCCAT
GGTCTGCTGCACCTACAGTCAGAAGCATGCCATCCTGACGAAGGATCACGACCCCGATGCGGAGTGCACGATCTTCCATA
ACGATGTGCGTTCCTATGGGAAGGATTTCGAGCGCTACGTCGACCGGACGGAGGCCCTTCCCGGGATCCGGTTCATTCGC
AGCTATGTGTCCATCGTTCGAGAGGACCCAGTCACGAAGAATGTTTTCGTCCGGTATTCCACGCCTGATGAAGGGGTCAA
GGAAGAAGAATTCGACATGGTGGTTCTGTCGGTCGGTCTGGCTCCTCCGCTGGAGGTGAAGGCGATGGCGGAGAAGTTCG
GCATCGAGTTGAACGAACATAATTTCTGCAAGGTCGATCCCCGCAATTCGTTGCAGACCAGCCGGCCCGGGATTTTTGTC
AGTGGAGGCTTCCAGGGGCCGCTGGATATTCCCGAGTCGGTTTTCGGCGCCAGCGGGGCCGGCTCCCAGTGCGGCGAGCT
TCTGGACTACCGGCGGGGGAACCTGTCCAGGGAAAGGGTTTATCCCGAGGAAAAGGATGTTTCCGGGGAAGAGCCGAAGA
TCGCCGTCTTCGTCTGCCATTGCGGCGCGAACATCGGCCGGATCGTCAACGTCCCCGAGGTCGTGGAGTACGCCCTGACG
CTGCCCAACGTGGTCTACGCGCAGGAGCAGCTCTTCTCCTGCGCGACGAACTCCGCCCAGGAGATCACCGACATGACCCG
GGAGAAGGGGATCAACCGCGTGATCGTCGCCGCCTGCTCGCCGCGAACCCTGGAGAACCTGTTCCGGGATACCGTTCGCG
AGGCGGGGATCAACCAGTATTATTATGAAATGCCCAACATCCGGGAGCACAACTCCTGGGTTCACGCGAAGGAAAAAGAA
GAAGCGACCCAGAAGGCCAAGGATCTCCTCCGGATGTCCGTGGCTCGTGCTCGTCGTCTGCAGGCCCTGCAGGAATTTGA
CCTGCCGGTGAACAACAATGCGCTCATCGTCGGCGGCGGTGTTGCCGGCATGGTTTGCGCCCTTTCCATCGCCGAACAGG
GTCATGAGGTCTACCTCCTGGAGAAGGAGAAGGAGTTGGGCGGAAACGCCAGAAGGATTCACACCACGCTGGAAGGGATG
GATGTCCAGGCCTACCTGAAAGACCTGATCCAGAAGGTCTACGGGAATCAGCTGATTCATGTCTACACCGGGGCCACCAT
CACGGAGGCGACGGGTTATATCGGCAATTTCGTCACCAGGGTGACTTCGGAAAGAGGTCCCGCGGAGATCAAACACGGGG
CCGCCGTCATCGCCATCGGCGCCGAGGAATACAAGCCCACGGAATACCTTTACGGGCAGGACGAGCGGGTGATGACCCAG
TTGGAGCTGGAAGAAAAGATTGCCCGGGGCGACGAAGCGGTCATCAATGGCGAGAGCCTGGTGATGATCCAGTGTGTGGG
CTGCCGGAACGAAGACCGGAACTACTGTTCCCGGATCTGCTGCAGTCATGCGGTCAAGAATGCCCTGAAGCTCAAGGAGA
AGAATCCCGCGAAGGATATCTACATCCTCTTCCGGGATATGAGGACTTACGGGTTTGCCGAGGATTATTACCGGCAGGCT
TCGGAGAATGATGTCAAGTTTATCCGCTATGAGCCGGAGACCGCCCCCGAGGTGGAAGCCGTTGTGGAGGAAGGGAAGCC
GGTGCTGCGGGTGAGTGTTCTCGATCCGATTCTGGGTCAGGGTCTTGCCCTGGATGCGGATCACCTTGTTCTGTCGGCCG
CGGTGCTTCCCTCGGAAGCGACCAGGGAAGTGGCGAATCAGTTCAAGGTGACATTGAGCCTGGACGGCTTCTTCAAGGAA
GCCCATGTGAAGCTGCGTCCGGTGGAATTTGCGACGGACGGTGTTTTCCTCTGTGGGCTGGCTCAATATCCCAAGCACAT
CAATGAGACGATCAACCAGGCGTATGGTGCGGCGGGCCGGGTCATCACCCTTCTGTCCCGCGACACGGTCACCGCCTCGG
GTTCCGTCTGCGAGGTGGATGAGAAGAGGTGCATGGGCTGCGGGGCTTGCGCGTCGGTCTGTACTTACGGGGCCATCGAA
ATGCGCGAGACCAAGCAGGGCCGGAAAGCGACCATGAATCCCGTTCTCTGCAAGGGGGATGGTCTGTGCAACGCCATGTG
TCCGACCGGAGCGATTTCCCTGAGGCACTATACCGAGGATGAACTCCTGGCCCAGATAGACGCGATCGTACCGGAGCAGG
TGTCGGTCGAAGTCGACTGA

Upstream 100 bases:

>100_bases
CAAGACCTTCCCCACCAATGACTGCTCCATGTGAATTCTCGCACCTAAACTGGTCGAGGTCGGCCGGCATCCGAATATCG
AGGTCCTGACTTACACGGAA

Downstream 100 bases:

>100_bases
GAAGGAAGCAGGAACAAAGAAGAACTTAGGAAGGAGAGAAGAATGGCTGATCTTAGATTTAAGCCCCGGATCATCGGTTT
CGTGTGCCACTGGTGAGCAT

Product: heterodisulfide reductase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 939; Mature: 939

Protein sequence:

>939_residues
MDRVAGEVGDFKVTLTKKPRYIIEDKCSGCTTCVEYCPVVYPDVYNQEISKNKAVHVYFAQAIPLVTYIDESCLYLKEDK
CRICEAVCKQDAIDFSQVPEQMEVNVGAIILSAGLEPFDPRLSKEYHYGEFANVVTGMDFERLLCATGPYGGEILRASDL
KHPHKIAWLSCVGSRRVTEGENSYCSMVCCTYSQKHAILTKDHDPDAECTIFHNDVRSYGKDFERYVDRTEALPGIRFIR
SYVSIVREDPVTKNVFVRYSTPDEGVKEEEFDMVVLSVGLAPPLEVKAMAEKFGIELNEHNFCKVDPRNSLQTSRPGIFV
SGGFQGPLDIPESVFGASGAGSQCGELLDYRRGNLSRERVYPEEKDVSGEEPKIAVFVCHCGANIGRIVNVPEVVEYALT
LPNVVYAQEQLFSCATNSAQEITDMTREKGINRVIVAACSPRTLENLFRDTVREAGINQYYYEMPNIREHNSWVHAKEKE
EATQKAKDLLRMSVARARRLQALQEFDLPVNNNALIVGGGVAGMVCALSIAEQGHEVYLLEKEKELGGNARRIHTTLEGM
DVQAYLKDLIQKVYGNQLIHVYTGATITEATGYIGNFVTRVTSERGPAEIKHGAAVIAIGAEEYKPTEYLYGQDERVMTQ
LELEEKIARGDEAVINGESLVMIQCVGCRNEDRNYCSRICCSHAVKNALKLKEKNPAKDIYILFRDMRTYGFAEDYYRQA
SENDVKFIRYEPETAPEVEAVVEEGKPVLRVSVLDPILGQGLALDADHLVLSAAVLPSEATREVANQFKVTLSLDGFFKE
AHVKLRPVEFATDGVFLCGLAQYPKHINETINQAYGAAGRVITLLSRDTVTASGSVCEVDEKRCMGCGACASVCTYGAIE
MRETKQGRKATMNPVLCKGDGLCNAMCPTGAISLRHYTEDELLAQIDAIVPEQVSVEVD

Sequences:

>Translated_939_residues
MDRVAGEVGDFKVTLTKKPRYIIEDKCSGCTTCVEYCPVVYPDVYNQEISKNKAVHVYFAQAIPLVTYIDESCLYLKEDK
CRICEAVCKQDAIDFSQVPEQMEVNVGAIILSAGLEPFDPRLSKEYHYGEFANVVTGMDFERLLCATGPYGGEILRASDL
KHPHKIAWLSCVGSRRVTEGENSYCSMVCCTYSQKHAILTKDHDPDAECTIFHNDVRSYGKDFERYVDRTEALPGIRFIR
SYVSIVREDPVTKNVFVRYSTPDEGVKEEEFDMVVLSVGLAPPLEVKAMAEKFGIELNEHNFCKVDPRNSLQTSRPGIFV
SGGFQGPLDIPESVFGASGAGSQCGELLDYRRGNLSRERVYPEEKDVSGEEPKIAVFVCHCGANIGRIVNVPEVVEYALT
LPNVVYAQEQLFSCATNSAQEITDMTREKGINRVIVAACSPRTLENLFRDTVREAGINQYYYEMPNIREHNSWVHAKEKE
EATQKAKDLLRMSVARARRLQALQEFDLPVNNNALIVGGGVAGMVCALSIAEQGHEVYLLEKEKELGGNARRIHTTLEGM
DVQAYLKDLIQKVYGNQLIHVYTGATITEATGYIGNFVTRVTSERGPAEIKHGAAVIAIGAEEYKPTEYLYGQDERVMTQ
LELEEKIARGDEAVINGESLVMIQCVGCRNEDRNYCSRICCSHAVKNALKLKEKNPAKDIYILFRDMRTYGFAEDYYRQA
SENDVKFIRYEPETAPEVEAVVEEGKPVLRVSVLDPILGQGLALDADHLVLSAAVLPSEATREVANQFKVTLSLDGFFKE
AHVKLRPVEFATDGVFLCGLAQYPKHINETINQAYGAAGRVITLLSRDTVTASGSVCEVDEKRCMGCGACASVCTYGAIE
MRETKQGRKATMNPVLCKGDGLCNAMCPTGAISLRHYTEDELLAQIDAIVPEQVSVEVD
>Mature_939_residues
MDRVAGEVGDFKVTLTKKPRYIIEDKCSGCTTCVEYCPVVYPDVYNQEISKNKAVHVYFAQAIPLVTYIDESCLYLKEDK
CRICEAVCKQDAIDFSQVPEQMEVNVGAIILSAGLEPFDPRLSKEYHYGEFANVVTGMDFERLLCATGPYGGEILRASDL
KHPHKIAWLSCVGSRRVTEGENSYCSMVCCTYSQKHAILTKDHDPDAECTIFHNDVRSYGKDFERYVDRTEALPGIRFIR
SYVSIVREDPVTKNVFVRYSTPDEGVKEEEFDMVVLSVGLAPPLEVKAMAEKFGIELNEHNFCKVDPRNSLQTSRPGIFV
SGGFQGPLDIPESVFGASGAGSQCGELLDYRRGNLSRERVYPEEKDVSGEEPKIAVFVCHCGANIGRIVNVPEVVEYALT
LPNVVYAQEQLFSCATNSAQEITDMTREKGINRVIVAACSPRTLENLFRDTVREAGINQYYYEMPNIREHNSWVHAKEKE
EATQKAKDLLRMSVARARRLQALQEFDLPVNNNALIVGGGVAGMVCALSIAEQGHEVYLLEKEKELGGNARRIHTTLEGM
DVQAYLKDLIQKVYGNQLIHVYTGATITEATGYIGNFVTRVTSERGPAEIKHGAAVIAIGAEEYKPTEYLYGQDERVMTQ
LELEEKIARGDEAVINGESLVMIQCVGCRNEDRNYCSRICCSHAVKNALKLKEKNPAKDIYILFRDMRTYGFAEDYYRQA
SENDVKFIRYEPETAPEVEAVVEEGKPVLRVSVLDPILGQGLALDADHLVLSAAVLPSEATREVANQFKVTLSLDGFFKE
AHVKLRPVEFATDGVFLCGLAQYPKHINETINQAYGAAGRVITLLSRDTVTASGSVCEVDEKRCMGCGACASVCTYGAIE
MRETKQGRKATMNPVLCKGDGLCNAMCPTGAISLRHYTEDELLAQIDAIVPEQVSVEVD

Specific function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). May act as the catalytic subunit [H]

COG id: COG1148

COG function: function code C; Heterodisulfide reductase, subunit A and related polyferredoxins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR003953 [H]

Pfam domain/function: PF00890 FAD_binding_2 [H]

EC number: =1.8.98.1 [H]

Molecular weight: Translated: 104314; Mature: 104314

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRVAGEVGDFKVTLTKKPRYIIEDKCSGCTTCVEYCPVVYPDVYNQEISKNKAVHVYFA
CCCCCCCCCCEEEEEECCCCEEECCCCCCHHHHHHHCCCCCCCHHHHHHCCCCEEEEEEH
QAIPLVTYIDESCLYLKEDKCRICEAVCKQDAIDFSQVPEQMEVNVGAIILSAGLEPFDP
HHCCCHHHCCCCCEEEECCHHHHHHHHHHHCCCCHHHCCHHHCCCCCEEEEECCCCCCCC
RLSKEYHYGEFANVVTGMDFERLLCATGPYGGEILRASDLKHPHKIAWLSCVGSRRVTEG
CCCCCCCCCHHHHHHCCCCHHHHHHHCCCCCCCEEECCCCCCCCCEEEEEECCCCCCCCC
ENSYCSMVCCTYSQKHAILTKDHDPDAECTIFHNDVRSYGKDFERYVDRTEALPGIRFIR
CCCEEEEEEEECCCCCEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHH
SYVSIVREDPVTKNVFVRYSTPDEGVKEEEFDMVVLSVGLAPPLEVKAMAEKFGIELNEH
HHHHHHHCCCCCCEEEEEECCCCCCCCCHHHCEEEEEECCCCCHHHHHHHHHHCCEECCC
NFCKVDPRNSLQTSRPGIFVSGGFQGPLDIPESVFGASGAGSQCGELLDYRRGNLSRERV
CEEEECCCCCCCCCCCCEEEECCCCCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCCHHHC
YPEEKDVSGEEPKIAVFVCHCGANIGRIVNVPEVVEYALTLPNVVYAQEQLFSCATNSAQ
CCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCHH
EITDMTREKGINRVIVAACSPRTLENLFRDTVREAGINQYYYEMPNIREHNSWVHAKEKE
HHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCHHHH
EATQKAKDLLRMSVARARRLQALQEFDLPVNNNALIVGGGVAGMVCALSIAEQGHEVYLL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEE
EKEKELGGNARRIHTTLEGMDVQAYLKDLIQKVYGNQLIHVYTGATITEATGYIGNFVTR
ECHHHCCCCCEEEEEHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHH
VTSERGPAEIKHGAAVIAIGAEEYKPTEYLYGQDERVMTQLELEEKIARGDEAVINGESL
HHCCCCCCHHCCCEEEEEECCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCE
VMIQCVGCRNEDRNYCSRICCSHAVKNALKLKEKNPAKDIYILFRDMRTYGFAEDYYRQA
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHCCHHHHHHCC
SENDVKFIRYEPETAPEVEAVVEEGKPVLRVSVLDPILGQGLALDADHLVLSAAVLPSEA
CCCCCEEEEECCCCCHHHHHHHHCCCCEEEEEEHHHHHCCCCEECCHHHHHHHHHCCCHH
TREVANQFKVTLSLDGFFKEAHVKLRPVEFATDGVFLCGLAQYPKHINETINQAYGAAGR
HHHHHHHEEEEEEECCHHHCCCEEEEEEEEECCCEEEECHHHHHHHHHHHHHHHHCCCCC
VITLLSRDTVTASGSVCEVDEKRCMGCGACASVCTYGAIEMRETKQGRKATMNPVLCKGD
EEEEEECCCEECCCCEEECCHHHCCCCHHHHHHHHCCCEEEHHHCCCCCCCCCCEEECCC
GLCNAMCPTGAISLRHYTEDELLAQIDAIVPEQVSVEVD
CCCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure
MDRVAGEVGDFKVTLTKKPRYIIEDKCSGCTTCVEYCPVVYPDVYNQEISKNKAVHVYFA
CCCCCCCCCCEEEEEECCCCEEECCCCCCHHHHHHHCCCCCCCHHHHHHCCCCEEEEEEH
QAIPLVTYIDESCLYLKEDKCRICEAVCKQDAIDFSQVPEQMEVNVGAIILSAGLEPFDP
HHCCCHHHCCCCCEEEECCHHHHHHHHHHHCCCCHHHCCHHHCCCCCEEEEECCCCCCCC
RLSKEYHYGEFANVVTGMDFERLLCATGPYGGEILRASDLKHPHKIAWLSCVGSRRVTEG
CCCCCCCCCHHHHHHCCCCHHHHHHHCCCCCCCEEECCCCCCCCCEEEEEECCCCCCCCC
ENSYCSMVCCTYSQKHAILTKDHDPDAECTIFHNDVRSYGKDFERYVDRTEALPGIRFIR
CCCEEEEEEEECCCCCEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHH
SYVSIVREDPVTKNVFVRYSTPDEGVKEEEFDMVVLSVGLAPPLEVKAMAEKFGIELNEH
HHHHHHHCCCCCCEEEEEECCCCCCCCCHHHCEEEEEECCCCCHHHHHHHHHHCCEECCC
NFCKVDPRNSLQTSRPGIFVSGGFQGPLDIPESVFGASGAGSQCGELLDYRRGNLSRERV
CEEEECCCCCCCCCCCCEEEECCCCCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCCHHHC
YPEEKDVSGEEPKIAVFVCHCGANIGRIVNVPEVVEYALTLPNVVYAQEQLFSCATNSAQ
CCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCHH
EITDMTREKGINRVIVAACSPRTLENLFRDTVREAGINQYYYEMPNIREHNSWVHAKEKE
HHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCHHHH
EATQKAKDLLRMSVARARRLQALQEFDLPVNNNALIVGGGVAGMVCALSIAEQGHEVYLL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEE
EKEKELGGNARRIHTTLEGMDVQAYLKDLIQKVYGNQLIHVYTGATITEATGYIGNFVTR
ECHHHCCCCCEEEEEHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHH
VTSERGPAEIKHGAAVIAIGAEEYKPTEYLYGQDERVMTQLELEEKIARGDEAVINGESL
HHCCCCCCHHCCCEEEEEECCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCE
VMIQCVGCRNEDRNYCSRICCSHAVKNALKLKEKNPAKDIYILFRDMRTYGFAEDYYRQA
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHCCHHHHHHCC
SENDVKFIRYEPETAPEVEAVVEEGKPVLRVSVLDPILGQGLALDADHLVLSAAVLPSEA
CCCCCEEEEECCCCCHHHHHHHHCCCCEEEEEEHHHHHCCCCEECCHHHHHHHHHCCCHH
TREVANQFKVTLSLDGFFKEAHVKLRPVEFATDGVFLCGLAQYPKHINETINQAYGAAGR
HHHHHHHEEEEEEECCHHHCCCEEEEEEEEECCCEEEECHHHHHHHHHHHHHHHHCCCCC
VITLLSRDTVTASGSVCEVDEKRCMGCGACASVCTYGAIEMRETKQGRKATMNPVLCKGD
EEEEEECCCEECCCCEEECCHHHCCCCHHHHHHHHCCCEEEHHHCCCCCCCCCCEEECCC
GLCNAMCPTGAISLRHYTEDELLAQIDAIVPEQVSVEVD
CCCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]