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The map label for this gene is wecC [H]

Identifier: 85858249

GI number: 85858249

Start: 408459

End: 410108

Strand: Direct

Name: wecC [H]

Synonym: SYN_01124

Alternate gene names: 85858249

Gene position: 408459-410108 (Clockwise)

Preceding gene: 85858248

Following gene: 85858251

Centisome position: 12.85

GC content: 58.18

Gene sequence:

>1650_bases
GTGAATCAATCCGATAAAACGTGGTCTGTCAGTCCTGGTGGTGAATCATTTCCTTTGCCTTTGCCGGAAGAGTACCCGGG
AGAATTCGAGCGACTTCAGCAGATCGTCCAGGAGCAGCGCAGCTTGGGCCGGGAGATTGTTGTCGTCATGGGGCTGGGTT
TTGTGGGGGCAGTGATGGCGGGGGTCGTGGCCGATTCGGTGGATCGCGATACCGGCAAACCGATGAAGTTCGTCATCGGG
ATGCAGCGCCCTTCGGTACGATCCTATTGGAAGATCCCCCTGTTCAACCGCGGAATCGCCCCCGTGGAGGCGGAAGATCC
GGAGGTCGTTCCGCTGATTGACCGCTGCGTCAACAAGAAAAAGACCCTGATGGCCACCTATACGGATGATGTCCTTTCCC
TGGCCGATGTTGTGGTCGTCGATGTCCAGTGCGACTATTTCAAGGAATGCCTGGGCAATGTCCGGGAAGGGCATGCGGAA
ATCGCCGCGCTGGAGGACAGCCTGCGCATCCTGGGGGAAAAGATCCGACCGGAATGCCTCGTCCTGATCGAAACGACGGT
TCCGCCGGGGACAACGGAATATATCGCCTATCCCATCATCAAGAAGGCCTTTGAAAAGCGCGGACTAAAGGATGCGGAGC
CTCTGCTGGGCCATTCCTTCGAGCGGGTCATGCCGGGCCGGGAGTATGTGGCCTCCATCCGGGATTTCTGGCGGGTCTGC
AGCGGGATCAACGATACCGCCAGAGAGCGGGTGCGGAAGTTCCTGTCGGATATACTGAATGTGGAAAAATATCCCCTGAC
CGTTCTGGACCGTCCCATCGAGAGCGAGACCTGCAAGATTGTGGAAAATTCCTACCGGGCGACCCTCCTGGCCTTCCTGG
ATGAATGGAGCCTGTTTGCAGAACGCAACGGCGTGGATCTGATCAAGGTGATCCAGGCGATCAAGGTCCGCCCCACCCAT
TCCAACATGATCTTTCCCGGACCCGGGATCGGCGGTTACTGCCTGCCCAAGGACGGCGGCCTGGGGGTCTGGTCCTACCG
GACCCTGATGGGATATGATGATGAAATCTTCAGGCTGACGCCCATGGCAATCGATATCAACGACACCCGGGCGCTTCACG
CCGCGGAGCTGGTGCGGGATGCCCTCAGGAACATGGGCAAGATCGTCGCGGCCTCGAAGATTGCCATTCTCGGGGCCTCA
TACCGGGAAGATGTGGGGGACACCCGCTACAGCGGCTCGGAGATCCTGGTCCGCAAGCTGACGGAAATGGGCGCTGAAAT
TTCCGTTCATGATCCTTATGTCCAGCACTGGTGGGAGTTTGAAAAACAGGAGAGCTATCCGGCAACCGGTCACTCCTGGT
CCCGATTCTTCCGCAATCAGGAAAGGCTCAGTGAACTCCGCATCAGCAAGGATCTGGGGGAGGCCCTGGATGGATCCGAT
GCCGCTGTCTTAGCCGTCCGTCACCAGCTCTACCTGAGCTTGACGCCGGATGATATCGTCCGCATGGCCGGTCGGCCGAT
TGCCGTGGTGGACTGTTTCGGGATTCTCTATGACGAGGGAATCCGGCGGTTTATTGAACTGGGATGCGAAGTCAAAGGCC
TGGGACGCGGCCACATCAGGCGGATCAAGGATCAGGTGCAAAAAAGATGA

Upstream 100 bases:

>100_bases
CATTAGAACCGCCTGGGACTGGGAACTGAAGTACCGGTCCCTTCTGAAAGGAAAGGTGTGAAACCCCTGACAATAAAACT
CATACAAGAAAGGAATCCAA

Downstream 100 bases:

>100_bases
GAAAATGCCGGTCGCTGACACCGCCTTTCCTTCCCTCCAATCAGGCAATCATCCCCAGTTGTTGCTGAAACAACGCCCTG
ATTCAATTCATCATTCCTCC

Product: UDP-glucose 6-dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MNQSDKTWSVSPGGESFPLPLPEEYPGEFERLQQIVQEQRSLGREIVVVMGLGFVGAVMAGVVADSVDRDTGKPMKFVIG
MQRPSVRSYWKIPLFNRGIAPVEAEDPEVVPLIDRCVNKKKTLMATYTDDVLSLADVVVVDVQCDYFKECLGNVREGHAE
IAALEDSLRILGEKIRPECLVLIETTVPPGTTEYIAYPIIKKAFEKRGLKDAEPLLGHSFERVMPGREYVASIRDFWRVC
SGINDTARERVRKFLSDILNVEKYPLTVLDRPIESETCKIVENSYRATLLAFLDEWSLFAERNGVDLIKVIQAIKVRPTH
SNMIFPGPGIGGYCLPKDGGLGVWSYRTLMGYDDEIFRLTPMAIDINDTRALHAAELVRDALRNMGKIVAASKIAILGAS
YREDVGDTRYSGSEILVRKLTEMGAEISVHDPYVQHWWEFEKQESYPATGHSWSRFFRNQERLSELRISKDLGEALDGSD
AAVLAVRHQLYLSLTPDDIVRMAGRPIAVVDCFGILYDEGIRRFIELGCEVKGLGRGHIRRIKDQVQKR

Sequences:

>Translated_549_residues
MNQSDKTWSVSPGGESFPLPLPEEYPGEFERLQQIVQEQRSLGREIVVVMGLGFVGAVMAGVVADSVDRDTGKPMKFVIG
MQRPSVRSYWKIPLFNRGIAPVEAEDPEVVPLIDRCVNKKKTLMATYTDDVLSLADVVVVDVQCDYFKECLGNVREGHAE
IAALEDSLRILGEKIRPECLVLIETTVPPGTTEYIAYPIIKKAFEKRGLKDAEPLLGHSFERVMPGREYVASIRDFWRVC
SGINDTARERVRKFLSDILNVEKYPLTVLDRPIESETCKIVENSYRATLLAFLDEWSLFAERNGVDLIKVIQAIKVRPTH
SNMIFPGPGIGGYCLPKDGGLGVWSYRTLMGYDDEIFRLTPMAIDINDTRALHAAELVRDALRNMGKIVAASKIAILGAS
YREDVGDTRYSGSEILVRKLTEMGAEISVHDPYVQHWWEFEKQESYPATGHSWSRFFRNQERLSELRISKDLGEALDGSD
AAVLAVRHQLYLSLTPDDIVRMAGRPIAVVDCFGILYDEGIRRFIELGCEVKGLGRGHIRRIKDQVQKR
>Mature_549_residues
MNQSDKTWSVSPGGESFPLPLPEEYPGEFERLQQIVQEQRSLGREIVVVMGLGFVGAVMAGVVADSVDRDTGKPMKFVIG
MQRPSVRSYWKIPLFNRGIAPVEAEDPEVVPLIDRCVNKKKTLMATYTDDVLSLADVVVVDVQCDYFKECLGNVREGHAE
IAALEDSLRILGEKIRPECLVLIETTVPPGTTEYIAYPIIKKAFEKRGLKDAEPLLGHSFERVMPGREYVASIRDFWRVC
SGINDTARERVRKFLSDILNVEKYPLTVLDRPIESETCKIVENSYRATLLAFLDEWSLFAERNGVDLIKVIQAIKVRPTH
SNMIFPGPGIGGYCLPKDGGLGVWSYRTLMGYDDEIFRLTPMAIDINDTRALHAAELVRDALRNMGKIVAASKIAILGAS
YREDVGDTRYSGSEILVRKLTEMGAEISVHDPYVQHWWEFEKQESYPATGHSWSRFFRNQERLSELRISKDLGEALDGSD
AAVLAVRHQLYLSLTPDDIVRMAGRPIAVVDCFGILYDEGIRRFIELGCEVKGLGRGHIRRIKDQVQKR

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=483, Percent_Identity=24.4306418219462, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI296040443, Length=265, Percent_Identity=27.5471698113208, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI296040438, Length=265, Percent_Identity=27.5471698113208, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI48994968, Length=344, Percent_Identity=23.8372093023256, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1788340, Length=314, Percent_Identity=21.656050955414, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 61800; Mature: 61800

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQSDKTWSVSPGGESFPLPLPEEYPGEFERLQQIVQEQRSLGREIVVVMGLGFVGAVMA
CCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHH
GVVADSVDRDTGKPMKFVIGMQRPSVRSYWKIPLFNRGIAPVEAEDPEVVPLIDRCVNKK
HHHHHHCCCCCCCCEEEEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCC
KTLMATYTDDVLSLADVVVVDVQCDYFKECLGNVREGHAEIAALEDSLRILGEKIRPECL
CEEEEEHHHHHHHHHHHHEEECCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCEEE
VLIETTVPPGTTEYIAYPIIKKAFEKRGLKDAEPLLGHSFERVMPGREYVASIRDFWRVC
EEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHCCCHHHHHHHHHHHHHH
SGINDTARERVRKFLSDILNVEKYPLTVLDRPIESETCKIVENSYRATLLAFLDEWSLFA
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ERNGVDLIKVIQAIKVRPTHSNMIFPGPGIGGYCLPKDGGLGVWSYRTLMGYDDEIFRLT
CCCCCHHHHHHHHHCCCCCCCCEEECCCCCCCEECCCCCCCCHHHHHHHHCCCCCEEEEE
PMAIDINDTRALHAAELVRDALRNMGKIVAASKIAILGASYREDVGDTRYSGSEILVRKL
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHCCCCCCCCHHHHHHHH
TEMGAEISVHDPYVQHWWEFEKQESYPATGHSWSRFFRNQERLSELRISKDLGEALDGSD
HHCCCEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AAVLAVRHQLYLSLTPDDIVRMAGRPIAVVDCFGILYDEGIRRFIELGCEVKGLGRGHIR
HHHHEEEEEEEEEECHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCEECCCHHHHH
RIKDQVQKR
HHHHHHHCC
>Mature Secondary Structure
MNQSDKTWSVSPGGESFPLPLPEEYPGEFERLQQIVQEQRSLGREIVVVMGLGFVGAVMA
CCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHH
GVVADSVDRDTGKPMKFVIGMQRPSVRSYWKIPLFNRGIAPVEAEDPEVVPLIDRCVNKK
HHHHHHCCCCCCCCEEEEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCC
KTLMATYTDDVLSLADVVVVDVQCDYFKECLGNVREGHAEIAALEDSLRILGEKIRPECL
CEEEEEHHHHHHHHHHHHEEECCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCEEE
VLIETTVPPGTTEYIAYPIIKKAFEKRGLKDAEPLLGHSFERVMPGREYVASIRDFWRVC
EEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHCCCHHHHHHHHHHHHHH
SGINDTARERVRKFLSDILNVEKYPLTVLDRPIESETCKIVENSYRATLLAFLDEWSLFA
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ERNGVDLIKVIQAIKVRPTHSNMIFPGPGIGGYCLPKDGGLGVWSYRTLMGYDDEIFRLT
CCCCCHHHHHHHHHCCCCCCCCEEECCCCCCCEECCCCCCCCHHHHHHHHCCCCCEEEEE
PMAIDINDTRALHAAELVRDALRNMGKIVAASKIAILGASYREDVGDTRYSGSEILVRKL
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHCCCCCCCCHHHHHHHH
TEMGAEISVHDPYVQHWWEFEKQESYPATGHSWSRFFRNQERLSELRISKDLGEALDGSD
HHCCCEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AAVLAVRHQLYLSLTPDDIVRMAGRPIAVVDCFGILYDEGIRRFIELGCEVKGLGRGHIR
HHHHEEEEEEEEEECHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCEECCCHHHHH
RIKDQVQKR
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]