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The map label for this gene is acdA [H]

Identifier: 85858226

GI number: 85858226

Start: 379482

End: 380627

Strand: Direct

Name: acdA [H]

Synonym: SYN_01146

Alternate gene names: 85858226

Gene position: 379482-380627 (Clockwise)

Preceding gene: 85858225

Following gene: 85858227

Centisome position: 11.94

GC content: 55.85

Gene sequence:

>1146_bases
ATGGATTTTTCATTGACCGCCGAACAGATCAGATTCAAGGAATCCGTCGTGGAGTTCGCGCGTCGCGCCCTTAAAAACGA
GGCGCTCGAACACGGCGACCCGCGGGAGTTTTACTGGGAAGGATGGCGCCGGTGCGCCGAATTCGGCATTCAGGGCATCG
CGATGCCCAAAGCTTACGGGGGCCTTGAACTGGATCTGCTGACCTGCGTTCTCATCATGCAGGGGCTTGGCTACGCGTGC
AGGGACGCCGGTTTGATCTTCTCCCTCAATACCCAGATCTGGACGTGTGAATGCCCCATCCTGAAATTTGGAACGGACGA
GCAGAAAGAAAAGTATCTGGGGCGACTGATCAGCGGCTCCATCGTCGGCGGCCACGCCATGACGGAACCGGATTCCGGCT
CCGATGCCTTCAGTATGAAGACCCGGGCGGTCAGGGACGGCGACAGGTACATTCTCAACGGGACGAAGATTTTTATCACC
AATGCCCCCATCGCCGATATCCTTCTCGTCTTCGCCGTAACGAACGAGCAGAAAAAATTCGGAGGCGTTTCCGCCTTCAT
CGTTGAAAAGGGATTTCCCGGATTCTCCGTGGGAAAGCCCTTCAGTCTCATGGGACTCAGGAGCTGCCCCATCGGGGAAG
TCATCCTGCAGGACTGCGAGGTTCCCGCCGAAAACAGACTCGGGAGCGAGGGAGCGGGCTCGGCCATTTTCAATTCCGAA
ATGGAGCAGGAAAGGAGCTGCCTGTTCGCCTCCCAGCTCGGCGCCATGGAAAAGATCCTGGAGGATTGTGTGCAGTACGC
GAAAGCGCGATCTCAGTTCGGGCAGCCCATCGGAGATTACCAGGCCGTATCCCATAAGATTGCGGACATGAGGGTCCGGA
TCGAACTGTCCCGGCTGATTCTCTATCAGGTGGCCTGGATGAAGGCTTCCGGGAAACGGGCGCCCGTCGAATCTTCCATT
GCCAAACTGTACGTCAGTGAAAGTTATGTTCAGACCTGCATGGATGCCCTTCAGATTCATGGCGCCTATGGTTATTCCAC
GGAGTTTCCCATCGAGAGGAATCTCCGTGATTCCATCGCCGGAAAAATCTATTCCGGAAGCTCCGAGATTCAGAGAAATA
TCCTGGCAAGCTTTCTGGGGTTATAG

Upstream 100 bases:

>100_bases
CCGCCTCAGGACGAGAAGGTTCAAACGACATCTGAAAGTTGCGTGTTGCAGGGATTATTCTGAATTCTTTCATTTTTCCT
GAGACAACGGGAGGGAAAAC

Downstream 100 bases:

>100_bases
CGGAGGGGATAAAGAATGCCGAACCACCTACTGCACCATCAACTGACCAATACGTCCTGGCGATGCCCGGAAAAAGAAGC
GGTCATCGCCGTTGATCGGT

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MDFSLTAEQIRFKESVVEFARRALKNEALEHGDPREFYWEGWRRCAEFGIQGIAMPKAYGGLELDLLTCVLIMQGLGYAC
RDAGLIFSLNTQIWTCECPILKFGTDEQKEKYLGRLISGSIVGGHAMTEPDSGSDAFSMKTRAVRDGDRYILNGTKIFIT
NAPIADILLVFAVTNEQKKFGGVSAFIVEKGFPGFSVGKPFSLMGLRSCPIGEVILQDCEVPAENRLGSEGAGSAIFNSE
MEQERSCLFASQLGAMEKILEDCVQYAKARSQFGQPIGDYQAVSHKIADMRVRIELSRLILYQVAWMKASGKRAPVESSI
AKLYVSESYVQTCMDALQIHGAYGYSTEFPIERNLRDSIAGKIYSGSSEIQRNILASFLGL

Sequences:

>Translated_381_residues
MDFSLTAEQIRFKESVVEFARRALKNEALEHGDPREFYWEGWRRCAEFGIQGIAMPKAYGGLELDLLTCVLIMQGLGYAC
RDAGLIFSLNTQIWTCECPILKFGTDEQKEKYLGRLISGSIVGGHAMTEPDSGSDAFSMKTRAVRDGDRYILNGTKIFIT
NAPIADILLVFAVTNEQKKFGGVSAFIVEKGFPGFSVGKPFSLMGLRSCPIGEVILQDCEVPAENRLGSEGAGSAIFNSE
MEQERSCLFASQLGAMEKILEDCVQYAKARSQFGQPIGDYQAVSHKIADMRVRIELSRLILYQVAWMKASGKRAPVESSI
AKLYVSESYVQTCMDALQIHGAYGYSTEFPIERNLRDSIAGKIYSGSSEIQRNILASFLGL
>Mature_381_residues
MDFSLTAEQIRFKESVVEFARRALKNEALEHGDPREFYWEGWRRCAEFGIQGIAMPKAYGGLELDLLTCVLIMQGLGYAC
RDAGLIFSLNTQIWTCECPILKFGTDEQKEKYLGRLISGSIVGGHAMTEPDSGSDAFSMKTRAVRDGDRYILNGTKIFIT
NAPIADILLVFAVTNEQKKFGGVSAFIVEKGFPGFSVGKPFSLMGLRSCPIGEVILQDCEVPAENRLGSEGAGSAIFNSE
MEQERSCLFASQLGAMEKILEDCVQYAKARSQFGQPIGDYQAVSHKIADMRVRIELSRLILYQVAWMKASGKRAPVESSI
AKLYVSESYVQTCMDALQIHGAYGYSTEFPIERNLRDSIAGKIYSGSSEIQRNILASFLGL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=37.0666666666667, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI226958414, Length=338, Percent_Identity=38.4615384615385, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI4557233, Length=337, Percent_Identity=35.9050445103858, Blast_Score=220, Evalue=1e-57,
Organism=Homo sapiens, GI4557231, Length=377, Percent_Identity=33.42175066313, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI187960098, Length=377, Percent_Identity=33.42175066313, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI4501859, Length=376, Percent_Identity=31.6489361702128, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI7656849, Length=376, Percent_Identity=32.9787234042553, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI4501857, Length=375, Percent_Identity=30.1333333333333, Blast_Score=194, Evalue=9e-50,
Organism=Homo sapiens, GI4557235, Length=387, Percent_Identity=33.3333333333333, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI76496475, Length=387, Percent_Identity=33.3333333333333, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI21361497, Length=362, Percent_Identity=32.0441988950276, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI4503943, Length=377, Percent_Identity=29.973474801061, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI7669494, Length=366, Percent_Identity=29.7814207650273, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI48976061, Length=288, Percent_Identity=27.4305555555556, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI211971008, Length=288, Percent_Identity=27.4305555555556, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI38505218, Length=303, Percent_Identity=26.0726072607261, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI87081958, Length=392, Percent_Identity=31.3775510204082, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1786223, Length=372, Percent_Identity=27.1505376344086, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI87081702, Length=368, Percent_Identity=25.2717391304348, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082384, Length=291, Percent_Identity=26.8041237113402, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=379, Percent_Identity=35.3562005277045, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17570075, Length=382, Percent_Identity=33.2460732984293, Blast_Score=221, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI17534899, Length=385, Percent_Identity=34.5454545454545, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17569725, Length=383, Percent_Identity=33.420365535248, Blast_Score=217, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI17508101, Length=377, Percent_Identity=32.3607427055703, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17506239, Length=375, Percent_Identity=30.6666666666667, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI71990804, Length=283, Percent_Identity=34.982332155477, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI71985184, Length=284, Percent_Identity=35.2112676056338, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17533517, Length=368, Percent_Identity=27.1739130434783, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71982178, Length=277, Percent_Identity=31.0469314079422, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17534353, Length=297, Percent_Identity=28.956228956229, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI71985192, Length=231, Percent_Identity=35.0649350649351, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17505929, Length=335, Percent_Identity=27.1641791044776, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17551932, Length=360, Percent_Identity=26.9444444444444, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=31.9502074688797, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI32563615, Length=232, Percent_Identity=30.1724137931034, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17562446, Length=276, Percent_Identity=26.4492753623188, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17531913, Length=176, Percent_Identity=27.8409090909091, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI86563383, Length=297, Percent_Identity=26.2626262626263, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI86563381, Length=297, Percent_Identity=26.2626262626263, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI21356377, Length=373, Percent_Identity=36.7292225201072, Blast_Score=245, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24660351, Length=377, Percent_Identity=34.4827586206897, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI21355753, Length=385, Percent_Identity=36.1038961038961, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24646207, Length=367, Percent_Identity=32.6975476839237, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI281363737, Length=386, Percent_Identity=33.6787564766839, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24666513, Length=372, Percent_Identity=29.5698924731183, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI19920834, Length=283, Percent_Identity=31.8021201413428, Blast_Score=128, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 42133; Mature: 42133

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSLTAEQIRFKESVVEFARRALKNEALEHGDPREFYWEGWRRCAEFGIQGIAMPKAYG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEECCCCCC
GLELDLLTCVLIMQGLGYACRDAGLIFSLNTQIWTCECPILKFGTDEQKEKYLGRLISGS
CCHHHHHHHHHHHHCCCHHHHCCCEEEEECCEEEEECCCCEECCCCHHHHHHHHHHHCCC
IVGGHAMTEPDSGSDAFSMKTRAVRDGDRYILNGTKIFITNAPIADILLVFAVTNEQKKF
EECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECEEEEEECCCHHHHHHHHHHCCCHHHH
GGVSAFIVEKGFPGFSVGKPFSLMGLRSCPIGEVILQDCEVPAENRLGSEGAGSAIFNSE
CCEEEEEEECCCCCCCCCCCCHHHCCCCCCHHHHHHHHCCCCHHHCCCCCCCCCHHHHHH
MEQERSCLFASQLGAMEKILEDCVQYAKARSQFGQPIGDYQAVSHKIADMRVRIELSRLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEHHHHHHH
LYQVAWMKASGKRAPVESSIAKLYVSESYVQTCMDALQIHGAYGYSTEFPIERNLRDSIA
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHC
GKIYSGSSEIQRNILASFLGL
CEEECCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDFSLTAEQIRFKESVVEFARRALKNEALEHGDPREFYWEGWRRCAEFGIQGIAMPKAYG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEECCCCCC
GLELDLLTCVLIMQGLGYACRDAGLIFSLNTQIWTCECPILKFGTDEQKEKYLGRLISGS
CCHHHHHHHHHHHHCCCHHHHCCCEEEEECCEEEEECCCCEECCCCHHHHHHHHHHHCCC
IVGGHAMTEPDSGSDAFSMKTRAVRDGDRYILNGTKIFITNAPIADILLVFAVTNEQKKF
EECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECEEEEEECCCHHHHHHHHHHCCCHHHH
GGVSAFIVEKGFPGFSVGKPFSLMGLRSCPIGEVILQDCEVPAENRLGSEGAGSAIFNSE
CCEEEEEEECCCCCCCCCCCCHHHCCCCCCHHHHHHHHCCCCHHHCCCCCCCCCHHHHHH
MEQERSCLFASQLGAMEKILEDCVQYAKARSQFGQPIGDYQAVSHKIADMRVRIELSRLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEHHHHHHH
LYQVAWMKASGKRAPVESSIAKLYVSESYVQTCMDALQIHGAYGYSTEFPIERNLRDSIA
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHC
GKIYSGSSEIQRNILASFLGL
CEEECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]