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The map label for this gene is kynU [H]

Identifier: 85375657

GI number: 85375657

Start: 2841521

End: 2842870

Strand: Direct

Name: kynU [H]

Synonym: ELI_14150

Alternate gene names: 85375657

Gene position: 2841521-2842870 (Clockwise)

Preceding gene: 85375656

Following gene: 85375660

Centisome position: 93.09

GC content: 65.63

Gene sequence:

>1350_bases
ATGCTGGATAAAGCGCGCGAACTCGATGCGGCGGACGAGCTGGCGCATTTTCGCGACCGCTTCGAAATTCCGGAAGGCGT
AATCTATCTCGATGGCAATTCCCTCGGCGCGCTGCCCAAGGCGACGCCTGCGCGGCTGGAGCAGGTCATGCGCGGCGAAT
GGGGCAAGGGGCTGATCCGAAGCTGGAACGATGCCGACTGGATCACCCTGCCGCAGCGCGTTGGCGGCAAGATCGCGCCG
CTGATCGGGGCGCATCCGCATGAGGTAATCGTCGCCGACAGCGTTTCGGTGAACCTGTTCAAGCTCATCAGCGCCGCGTT
GAAGATGCGGCCCGGCAGAAAGGTGATCCTCAGCGAACCGGGCAATTTCCCGACCGATCTTTACATGATCCAGGGGTTGG
AAAGTCAGGGCCTCGCCACCCAGCGACTGGCCGAGCGCGAGGCGATCATAGACGCGCTGGATGAGGACGTGGCGCTCCTG
CTGCTGACCCATGTGCATTACAAGTCCGGCGCGATGTTCGACATGGCGGCGCTGACTGAGGCCGCGCATGACGCAGGCGC
GCTGGTGTTGTGGGACCTGTCGCATACCGGCGGCGCGCTGCCGGTCGATCTGAACGGGTGCGGGGCGGATTTTGCGGTCG
GTTGCGGCTACAAATATCTGAACGGCGGACCCGGCGCCCCGGCCTACGCCTTCGTCGCTGAGCGGCATCACGAGGCGCTC
GAACAGCCGCTCTCCGGCTGGATGGGCCACGCCGCGCCGTTTGCCTTTACGGACGACTACAGCCCCGCACCGGGCGTCGA
TCGCCTGCTGTGCGGCACCGCGCCGATCCTGTCGGTCAGCGCGCTGGAAGTGGGCGTGGACCTGATCGCCGAGATCGGCG
TCGATCACCTCTGGGCCAAGTCCCGCGCGCTCAGCGAGTTCTTGCTGGAATGTCTGGCAGAAGCGGGTGTCATCAATACG
CCCTCTCTCCTTCAGGGGAGAGGGAGGAGCCGCGAAGCGGCGGAGGGCGTGGGGGATGCCCAGACGGAAACTTCGGCACG
TGACGCCCCCGCCCCCGAACCCCCTCCCCTGAAGGAGAGGGGGAGTTTGGCGCTTGTCAGCCCGATCGACCCGATGCAGC
GCGGCAGCCAACTCTCCTTCCGCCACCAAGAAGCCTACGCCCTGTGCCAGGCCCTGATCGCCCGCGGCATCATCGGCGAC
TTCCGCGCTCCCGATATCCTGCGCCTCGGCTTCGCGCCGGCCTACCTACGCTTCAAAGACATGGCGCGCACGGCGGAGGA
ATTGGCGGATATTCTGGCGAAAGGTGCGTGGGATACGGCCGAGTTCAAGCAGCGTGCGGCGGTGACTTAG

Upstream 100 bases:

>100_bases
GATGACGTGCCGGAGGGACGGTATGAGCTGCTTGCGCTGCCGCTCAAGATTGTCGACGGCGATGCCGGGCTGTGCCGGGC
GATCCTGCGGGAGTTGCCCG

Downstream 100 bases:

>100_bases
TCGATTTTCCAACCGCAGGTTTCAGATAATTCCTGGAATGCCTGGCGGGCGCCAGTAGTGTCGAAAATAGCGGTCATAGG
CGCTTCATTATAGGGCACAG

Product: kynureninase, putative

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MLDKARELDAADELAHFRDRFEIPEGVIYLDGNSLGALPKATPARLEQVMRGEWGKGLIRSWNDADWITLPQRVGGKIAP
LIGAHPHEVIVADSVSVNLFKLISAALKMRPGRKVILSEPGNFPTDLYMIQGLESQGLATQRLAEREAIIDALDEDVALL
LLTHVHYKSGAMFDMAALTEAAHDAGALVLWDLSHTGGALPVDLNGCGADFAVGCGYKYLNGGPGAPAYAFVAERHHEAL
EQPLSGWMGHAAPFAFTDDYSPAPGVDRLLCGTAPILSVSALEVGVDLIAEIGVDHLWAKSRALSEFLLECLAEAGVINT
PSLLQGRGRSREAAEGVGDAQTETSARDAPAPEPPPLKERGSLALVSPIDPMQRGSQLSFRHQEAYALCQALIARGIIGD
FRAPDILRLGFAPAYLRFKDMARTAEELADILAKGAWDTAEFKQRAAVT

Sequences:

>Translated_449_residues
MLDKARELDAADELAHFRDRFEIPEGVIYLDGNSLGALPKATPARLEQVMRGEWGKGLIRSWNDADWITLPQRVGGKIAP
LIGAHPHEVIVADSVSVNLFKLISAALKMRPGRKVILSEPGNFPTDLYMIQGLESQGLATQRLAEREAIIDALDEDVALL
LLTHVHYKSGAMFDMAALTEAAHDAGALVLWDLSHTGGALPVDLNGCGADFAVGCGYKYLNGGPGAPAYAFVAERHHEAL
EQPLSGWMGHAAPFAFTDDYSPAPGVDRLLCGTAPILSVSALEVGVDLIAEIGVDHLWAKSRALSEFLLECLAEAGVINT
PSLLQGRGRSREAAEGVGDAQTETSARDAPAPEPPPLKERGSLALVSPIDPMQRGSQLSFRHQEAYALCQALIARGIIGD
FRAPDILRLGFAPAYLRFKDMARTAEELADILAKGAWDTAEFKQRAAVT
>Mature_449_residues
MLDKARELDAADELAHFRDRFEIPEGVIYLDGNSLGALPKATPARLEQVMRGEWGKGLIRSWNDADWITLPQRVGGKIAP
LIGAHPHEVIVADSVSVNLFKLISAALKMRPGRKVILSEPGNFPTDLYMIQGLESQGLATQRLAEREAIIDALDEDVALL
LLTHVHYKSGAMFDMAALTEAAHDAGALVLWDLSHTGGALPVDLNGCGADFAVGCGYKYLNGGPGAPAYAFVAERHHEAL
EQPLSGWMGHAAPFAFTDDYSPAPGVDRLLCGTAPILSVSALEVGVDLIAEIGVDHLWAKSRALSEFLLECLAEAGVINT
PSLLQGRGRSREAAEGVGDAQTETSARDAPAPEPPPLKERGSLALVSPIDPMQRGSQLSFRHQEAYALCQALIARGIIGD
FRAPDILRLGFAPAYLRFKDMARTAEELADILAKGAWDTAEFKQRAAVT

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=477, Percent_Identity=28.0922431865828, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI74101437, Length=266, Percent_Identity=32.3308270676692, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17550466, Length=467, Percent_Identity=25.4817987152034, Blast_Score=132, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6323261, Length=486, Percent_Identity=27.3662551440329, Blast_Score=147, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 48220; Mature: 48220

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKARELDAADELAHFRDRFEIPEGVIYLDGNSLGALPKATPARLEQVMRGEWGKGLIR
CCCCHHHCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHCCCCCCHHHC
SWNDADWITLPQRVGGKIAPLIGAHPHEVIVADSVSVNLFKLISAALKMRPGRKVILSEP
CCCCCCCEECHHHHCCCCCHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECC
GNFPTDLYMIQGLESQGLATQRLAEREAIIDALDEDVALLLLTHVHYKSGAMFDMAALTE
CCCCCHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AAHDAGALVLWDLSHTGGALPVDLNGCGADFAVGCGYKYLNGGPGAPAYAFVAERHHEAL
HHCCCCEEEEEEECCCCCCCEEECCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
EQPLSGWMGHAAPFAFTDDYSPAPGVDRLLCGTAPILSVSALEVGVDLIAEIGVDHLWAK
HHHHHHHHCCCCCCEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHH
SRALSEFLLECLAEAGVINTPSLLQGRGRSREAAEGVGDAQTETSARDAPAPEPPPLKER
HHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
GSLALVSPIDPMQRGSQLSFRHQEAYALCQALIARGIIGDFRAPDILRLGFAPAYLRFKD
CCEEEECCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHH
MARTAEELADILAKGAWDTAEFKQRAAVT
HHHHHHHHHHHHHCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MLDKARELDAADELAHFRDRFEIPEGVIYLDGNSLGALPKATPARLEQVMRGEWGKGLIR
CCCCHHHCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHCCCCCCHHHC
SWNDADWITLPQRVGGKIAPLIGAHPHEVIVADSVSVNLFKLISAALKMRPGRKVILSEP
CCCCCCCEECHHHHCCCCCHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECC
GNFPTDLYMIQGLESQGLATQRLAEREAIIDALDEDVALLLLTHVHYKSGAMFDMAALTE
CCCCCHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AAHDAGALVLWDLSHTGGALPVDLNGCGADFAVGCGYKYLNGGPGAPAYAFVAERHHEAL
HHCCCCEEEEEEECCCCCCCEEECCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
EQPLSGWMGHAAPFAFTDDYSPAPGVDRLLCGTAPILSVSALEVGVDLIAEIGVDHLWAK
HHHHHHHHCCCCCCEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHH
SRALSEFLLECLAEAGVINTPSLLQGRGRSREAAEGVGDAQTETSARDAPAPEPPPLKER
HHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
GSLALVSPIDPMQRGSQLSFRHQEAYALCQALIARGIIGDFRAPDILRLGFAPAYLRFKD
CCEEEECCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHH
MARTAEELADILAKGAWDTAEFKQRAAVT
HHHHHHHHHHHHHCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA