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The map label for this gene is hisN [H]

Identifier: 85375588

GI number: 85375588

Start: 2781089

End: 2781874

Strand: Direct

Name: hisN [H]

Synonym: ELI_13805

Alternate gene names: 85375588

Gene position: 2781089-2781874 (Clockwise)

Preceding gene: 85375585

Following gene: 85375589

Centisome position: 91.11

GC content: 66.67

Gene sequence:

>786_bases
ATGAATCTCGAAGCCGAACTGCTCGTCGCTCACCGCCTTGCCGATGCCGCGCGCGAGGAAATCCGTCCGCTCTTTCGTGC
CGCTTTCGAATCGGAGCGTAAGGGCGATGCCTCGCCCGTGACCGAAGCGGATCGCGCCGCCGAAGAATCCATGCGCCGCA
TTCTCAAGGCGGAATATCCGCAGGACGGCGTGATCGGGGAAGAATTCGGCAGCGAGCAGGGTCGCTCGGGCCGGCAATGG
GTGCTCGACCCCATCGACGGCACGATCAGCTTCATGGCGGGCCGCCCGATCTTCGGCACGCTGATCGCGCTGATGCAGGA
TGGATGGCCGGTGCTCGGCATCATCGACCAGCCGATCGCGGGGGAGCGCTGGGTCGGGCGCATCGGCGGGCCGACGACGC
TCAACGAGCGCCCGGTGCGCACCCGTACCTGCAAGAGCCTCGAAGAAGCGGTGCTGGCGACCAGCAGCCCGCATTATTTC
ACCTCCGACCAAGCCGAACCCTATATGGCGCTAGCGCAGAAGGTCGGCGGCAACGAGCGGCAGGGCATGATCGTCTATGG
CGGCGATTGCTACAATTACGGCCTGCTGGCGGGCGGGCATCTCGACATCGTGTGCGAAGCGGGCCTGTCGGTCTACGATT
ACGCCGCGCTGGTGCCGGTGGTCGAAGGCGCGGGCGGCACGGTGTCCGACTGGCAGGGCAACCCGCTCGACGCCGAAAGC
GACGGCACGATCATCGCGCTGGGCGATCCGGCGCGGCTGGAGGATGTGCTGGAGGCGATGGGCTGA

Upstream 100 bases:

>100_bases
CAGTGCGACCCGCATGTGCGAGAGATGTCATTGATTGGGGATTTCCGCAACACATCTCAAAGGCTTGACCCGCACTGGAT
AGCCGACCATCGCCACGCGC

Downstream 100 bases:

>100_bases
CAGGCCTGCCGCAGCTATCTCCGGAGAACCATCGCCCGCATTGCCCGTTGTCGGGATATGGGTAAGCGAACGATCTGCAT
CACCGGAGCGGGCAACGGTA

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MNLEAELLVAHRLADAAREEIRPLFRAAFESERKGDASPVTEADRAAEESMRRILKAEYPQDGVIGEEFGSEQGRSGRQW
VLDPIDGTISFMAGRPIFGTLIALMQDGWPVLGIIDQPIAGERWVGRIGGPTTLNERPVRTRTCKSLEEAVLATSSPHYF
TSDQAEPYMALAQKVGGNERQGMIVYGGDCYNYGLLAGGHLDIVCEAGLSVYDYAALVPVVEGAGGTVSDWQGNPLDAES
DGTIIALGDPARLEDVLEAMG

Sequences:

>Translated_261_residues
MNLEAELLVAHRLADAAREEIRPLFRAAFESERKGDASPVTEADRAAEESMRRILKAEYPQDGVIGEEFGSEQGRSGRQW
VLDPIDGTISFMAGRPIFGTLIALMQDGWPVLGIIDQPIAGERWVGRIGGPTTLNERPVRTRTCKSLEEAVLATSSPHYF
TSDQAEPYMALAQKVGGNERQGMIVYGGDCYNYGLLAGGHLDIVCEAGLSVYDYAALVPVVEGAGGTVSDWQGNPLDAES
DGTIIALGDPARLEDVLEAMG
>Mature_261_residues
MNLEAELLVAHRLADAAREEIRPLFRAAFESERKGDASPVTEADRAAEESMRRILKAEYPQDGVIGEEFGSEQGRSGRQW
VLDPIDGTISFMAGRPIFGTLIALMQDGWPVLGIIDQPIAGERWVGRIGGPTTLNERPVRTRTCKSLEEAVLATSSPHYF
TSDQAEPYMALAQKVGGNERQGMIVYGGDCYNYGLLAGGHLDIVCEAGLSVYDYAALVPVVEGAGGTVSDWQGNPLDAES
DGTIIALGDPARLEDVLEAMG

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=211, Percent_Identity=25.1184834123223, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI221625487, Length=211, Percent_Identity=25.1184834123223, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI7657236, Length=211, Percent_Identity=25.1184834123223, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1788882, Length=235, Percent_Identity=32.3404255319149, Blast_Score=98, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI193202570, Length=237, Percent_Identity=28.2700421940928, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI193202572, Length=234, Percent_Identity=27.3504273504274, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6320493, Length=237, Percent_Identity=25.7383966244726, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21357957, Length=233, Percent_Identity=27.0386266094421, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24664918, Length=221, Percent_Identity=25.7918552036199, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21357329, Length=221, Percent_Identity=27.6018099547511, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24664922, Length=230, Percent_Identity=27.3913043478261, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21357303, Length=224, Percent_Identity=27.6785714285714, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28113; Mature: 28113

Theoretical pI: Translated: 4.22; Mature: 4.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLEAELLVAHRLADAAREEIRPLFRAAFESERKGDASPVTEADRAAEESMRRILKAEYP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCC
QDGVIGEEFGSEQGRSGRQWVLDPIDGTISFMAGRPIFGTLIALMQDGWPVLGIIDQPIA
CCCCCHHHHCCCCCCCCCCEEECCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCC
GERWVGRIGGPTTLNERPVRTRTCKSLEEAVLATSSPHYFTSDQAEPYMALAQKVGGNER
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCC
QGMIVYGGDCYNYGLLAGGHLDIVCEAGLSVYDYAALVPVVEGAGGTVSDWQGNPLDAES
CCEEEECCCEECCCEEECCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
DGTIIALGDPARLEDVLEAMG
CCEEEEECCCHHHHHHHHHCC
>Mature Secondary Structure
MNLEAELLVAHRLADAAREEIRPLFRAAFESERKGDASPVTEADRAAEESMRRILKAEYP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCC
QDGVIGEEFGSEQGRSGRQWVLDPIDGTISFMAGRPIFGTLIALMQDGWPVLGIIDQPIA
CCCCCHHHHCCCCCCCCCCEEECCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCC
GERWVGRIGGPTTLNERPVRTRTCKSLEEAVLATSSPHYFTSDQAEPYMALAQKVGGNER
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCC
QGMIVYGGDCYNYGLLAGGHLDIVCEAGLSVYDYAALVPVVEGAGGTVSDWQGNPLDAES
CCEEEECCCEECCCEEECCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
DGTIIALGDPARLEDVLEAMG
CCEEEEECCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]