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The map label for this gene is hom [H]

Identifier: 85375582

GI number: 85375582

Start: 2774888

End: 2776204

Strand: Direct

Name: hom [H]

Synonym: ELI_13775

Alternate gene names: 85375582

Gene position: 2774888-2776204 (Clockwise)

Preceding gene: 85375581

Following gene: 85375584

Centisome position: 90.91

GC content: 69.93

Gene sequence:

>1317_bases
ATGAGCGGAACGAAAGCGCCCCTGCGGCTGGCCATAGCGGGCCTTGGCACGGTCGGGGCGGGCGTGCTGCGCCTCCTCAC
GGAGAACCGCGACCTCATCGAAGCGCGCGCCGGCCGCGCGATCGCAGTGACCGCCGTCAGCGCGCGCGACCGGTCGCGCG
ATCGCGGCGTCGACCTGTCCGCCTATGCCTGGCACGACGATATGGCCGAGCTGGCCGCGCGCGACGATATCGATGTCGTG
GTCGAACTGGTCGGGGGCGCGGACGGCCCGGCGCTGGCGCTCGCGCGGCAGGCGCTCGGTGCGGGCAAGGGCTTCGTGAC
GGCCAACAAGGCGATGATTGCGCATCACGGGCAGGAACTGGCGCAGGCAGCGGAGGAGCACGGCGCGGCTCTGCGGTTCG
AGGCTGCCGTGGCCGGCGGGATACCCGTGCTCAAGGGAGTGCGCGAAGGCGCGGCGGCCAACGCCATCGACCGGGTCTAT
GGCATCCTCAACGGCACCTGCAATTACATCCTGACCGCGATGGAAAGCACCGGCGCGGATTTCGGCGAGACACTGGCCGA
AGCGCAGGCAAAGGGCTTTGCCGAAGCCGATCCGGCGTTCGACATCGACGGGGTCGACGCCGCGCACAAGCTGGCAATCC
TTGCCGCGCTGTCCTTCGGGGCGGAGATCGACTTCGGCAGCGTCGAGATCGAAGGCATTCGCCGGGTCTGCGCCGCCGAC
ATCGCGCAGGCCGATGCGCTGGGCTATGTCGTGCGGCTGATCGGGGTGGCCGATATCGAGCAGAGCGAGAATGGCCCGCG
GCTGCTGCAGCGGGTGCGCCCCTGCCTCGTCGCCAAGGACCATCCGCTGGCACCGATCGACGGGCCGACCAATGCGGTCG
TCGCCGAGGGCAATTTCTCCGGTCGGCTGCTGTTCCAGGGCGCGGGCGCGGGCGACGGGCCGACGGCGAGCGCGGTCGTC
GCCGACCTGATCGACTTGGCGCGCGGCGATACCGGCGCGCCGTTCTCCGTTCCTGCGGCCCAGCTGGTCGCTATGCCCAA
GGCGGATTCGGGCGCGCGCGAAAGCCGCTCCTACATCCGCTTCATGGTCGCCGACCGGCCGGGCGTGCTGGCGGAGATTA
CTGCCGCGATGCGCGATGCCGGGGTCTCGATCCAGAGCCTGATTCAGGAAGGCGAGGCGAATGGCACGGAAGGCGTGCTG
GTGGCGATGGTCACGCATACCGGCCCGGTGCGCTGCGTGCGCGATGCGGTGGCGATGCTCGAAGGCTCGGAAAGCCTGGT
CGACGAACCACTGGTCATGCCGATCCTGCGCAGCTAG

Upstream 100 bases:

>100_bases
ATGTCGATCTCGCGACCGGCAAGCCGCAGCGCATACCCGACAGCGTGCGCGCGATGTTCGCCGGCTCGATCGAGGCTCAC
GCCGACGAGGCGTCGCCAGC

Downstream 100 bases:

>100_bases
CGGCGCTCAGCCGGCAGGCTTTTCGCCCTTGGCGATCTTGTCGGCATCGGAGCCGGGTGGCGCTTCGGGTAGAGCAGTGA
TGTCGAAAATATATGCGGGT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MSGTKAPLRLAIAGLGTVGAGVLRLLTENRDLIEARAGRAIAVTAVSARDRSRDRGVDLSAYAWHDDMAELAARDDIDVV
VELVGGADGPALALARQALGAGKGFVTANKAMIAHHGQELAQAAEEHGAALRFEAAVAGGIPVLKGVREGAAANAIDRVY
GILNGTCNYILTAMESTGADFGETLAEAQAKGFAEADPAFDIDGVDAAHKLAILAALSFGAEIDFGSVEIEGIRRVCAAD
IAQADALGYVVRLIGVADIEQSENGPRLLQRVRPCLVAKDHPLAPIDGPTNAVVAEGNFSGRLLFQGAGAGDGPTASAVV
ADLIDLARGDTGAPFSVPAAQLVAMPKADSGARESRSYIRFMVADRPGVLAEITAAMRDAGVSIQSLIQEGEANGTEGVL
VAMVTHTGPVRCVRDAVAMLEGSESLVDEPLVMPILRS

Sequences:

>Translated_438_residues
MSGTKAPLRLAIAGLGTVGAGVLRLLTENRDLIEARAGRAIAVTAVSARDRSRDRGVDLSAYAWHDDMAELAARDDIDVV
VELVGGADGPALALARQALGAGKGFVTANKAMIAHHGQELAQAAEEHGAALRFEAAVAGGIPVLKGVREGAAANAIDRVY
GILNGTCNYILTAMESTGADFGETLAEAQAKGFAEADPAFDIDGVDAAHKLAILAALSFGAEIDFGSVEIEGIRRVCAAD
IAQADALGYVVRLIGVADIEQSENGPRLLQRVRPCLVAKDHPLAPIDGPTNAVVAEGNFSGRLLFQGAGAGDGPTASAVV
ADLIDLARGDTGAPFSVPAAQLVAMPKADSGARESRSYIRFMVADRPGVLAEITAAMRDAGVSIQSLIQEGEANGTEGVL
VAMVTHTGPVRCVRDAVAMLEGSESLVDEPLVMPILRS
>Mature_437_residues
SGTKAPLRLAIAGLGTVGAGVLRLLTENRDLIEARAGRAIAVTAVSARDRSRDRGVDLSAYAWHDDMAELAARDDIDVVV
ELVGGADGPALALARQALGAGKGFVTANKAMIAHHGQELAQAAEEHGAALRFEAAVAGGIPVLKGVREGAAANAIDRVYG
ILNGTCNYILTAMESTGADFGETLAEAQAKGFAEADPAFDIDGVDAAHKLAILAALSFGAEIDFGSVEIEGIRRVCAADI
AQADALGYVVRLIGVADIEQSENGPRLLQRVRPCLVAKDHPLAPIDGPTNAVVAEGNFSGRLLFQGAGAGDGPTASAVVA
DLIDLARGDTGAPFSVPAAQLVAMPKADSGARESRSYIRFMVADRPGVLAEITAAMRDAGVSIQSLIQEGEANGTEGVLV
AMVTHTGPVRCVRDAVAMLEGSESLVDEPLVMPILRS

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=255, Percent_Identity=29.0196078431373, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1790376, Length=361, Percent_Identity=26.5927977839335, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 45053; Mature: 44921

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTKAPLRLAIAGLGTVGAGVLRLLTENRDLIEARAGRAIAVTAVSARDRSRDRGVDLS
CCCCCCCCEEEEHHCCHHHHHHHHHHHCCCHHHHHCCCCEEEEEEECCCCCCHHCCCCCE
AYAWHDDMAELAARDDIDVVVELVGGADGPALALARQALGAGKGFVTANKAMIAHHGQEL
EEECHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEECCHHHHHHHHHH
AQAAEEHGAALRFEAAVAGGIPVLKGVREGAAANAIDRVYGILNGTCNYILTAMESTGAD
HHHHHHCCCEEEEEHHHHCCCHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCH
FGETLAEAQAKGFAEADPAFDIDGVDAAHKLAILAALSFGAEIDFGSVEIEGIRRVCAAD
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHH
IAQADALGYVVRLIGVADIEQSENGPRLLQRVRPCLVAKDHPLAPIDGPTNAVVAEGNFS
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEECCCCCCCCCCCCCEEEECCCCC
GRLLFQGAGAGDGPTASAVVADLIDLARGDTGAPFSVPAAQLVAMPKADSGARESRSYIR
CEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHEECCCCCCCCHHHHHHEE
FMVADRPGVLAEITAAMRDAGVSIQSLIQEGEANGTEGVLVAMVTHTGPVRCVRDAVAML
EEECCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHH
EGSESLVDEPLVMPILRS
CCCHHHHCCCHHHHHHCC
>Mature Secondary Structure 
SGTKAPLRLAIAGLGTVGAGVLRLLTENRDLIEARAGRAIAVTAVSARDRSRDRGVDLS
CCCCCCCEEEEHHCCHHHHHHHHHHHCCCHHHHHCCCCEEEEEEECCCCCCHHCCCCCE
AYAWHDDMAELAARDDIDVVVELVGGADGPALALARQALGAGKGFVTANKAMIAHHGQEL
EEECHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEECCHHHHHHHHHH
AQAAEEHGAALRFEAAVAGGIPVLKGVREGAAANAIDRVYGILNGTCNYILTAMESTGAD
HHHHHHCCCEEEEEHHHHCCCHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCH
FGETLAEAQAKGFAEADPAFDIDGVDAAHKLAILAALSFGAEIDFGSVEIEGIRRVCAAD
HHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHH
IAQADALGYVVRLIGVADIEQSENGPRLLQRVRPCLVAKDHPLAPIDGPTNAVVAEGNFS
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEECCCCCCCCCCCCCEEEECCCCC
GRLLFQGAGAGDGPTASAVVADLIDLARGDTGAPFSVPAAQLVAMPKADSGARESRSYIR
CEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHEECCCCCCCCHHHHHHEE
FMVADRPGVLAEITAAMRDAGVSIQSLIQEGEANGTEGVLVAMVTHTGPVRCVRDAVAML
EEECCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHH
EGSESLVDEPLVMPILRS
CCCHHHHCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]