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The map label for this gene is degP [H]

Identifier: 85375095

GI number: 85375095

Start: 2293749

End: 2295281

Strand: Direct

Name: degP [H]

Synonym: ELI_11340

Alternate gene names: 85375095

Gene position: 2293749-2295281 (Clockwise)

Preceding gene: 85375094

Following gene: 85375101

Centisome position: 75.15

GC content: 66.6

Gene sequence:

>1533_bases
GTGAAACCCGTGCGCTATGCTTATGGCCTGACCTCTGCGCTGCTGGTGGGCGGCGCGACCGTATCCCTCCTGACCGGCCA
GCCGGCCGGTGCCCAGGTGGCCCAGAACGACGACCGCGTGATGTCCAATGTCGTGCCGCGTGCCGGTGCGCCGGAAAGCT
TCGCCGAACTGACGGAGCAATTGCAGCCCGCCGTGGTCAATATCTCGACCCGGCAGCGGATCGAAGTGCAGAACCGCAAC
CCCTTCCAGGGCACGCCGTTTGCCGATCTTTTCAACCGCCGGGGCCAGCCGCAGCAGCCCCAGACGCGCGAGGCGCAGTC
GCTCGGTTCGGGTTTCTTCATCTCCGCCGACGGCTATGTCGTCACCAACAACCACGTGGTGGCTCCCAACGGACGCGGGA
CGGTCGAGGAAATCACCGTTACCCTGCCCGACGGGCGCGAATATGCGGCCGAACTGGTCGGGGCCGATGCGGCTTCCGAT
CTGGCCGTGCTCAAGGTCAGCCGTTCGGAGCCCTTCCCCTTCGTGCGCTTCGGCGACTCCAGCCAGGCCCGCGCTGGCGA
CTGGGTGATCGCGATCGGCAACCCGTTCGGCCTGGGCGGTACCGTCACCAGCGGCATCGTCTCCGCACAGCTGCGCAACA
CGGGCGGCGGCGCGTACGACCGCTATATCCAGACCGATGCCAGCATCAACCGAGGCAATTCGGGCGGCCCGCTGTTCGAC
ATGCAGGGCAATGTGATCGGCATCAACAATGCGATCTTCTCGCCATCGGGCGGCAGCGTCGGTATCGGCTTCGCCATCCC
GGCGGAAACCGCCGCCCCGATCGTGGCCCAGCTCCAGCGCGGCAACGCTATCGAGCGCGGCTATCTTGGCGTGCAGATCC
AGCAGGTCAGCGAAGATGTCGCCGACTCGCTCGGCCTGCCGAAGAACCGCGGCGAGATCGTGCAAACCGTGGTCGATGGC
GAGGCCGCCGACCGATCGGGTATTCGCGCGGGCGACGTCGTGCTCAAGATCGATGGCAAGGACGTAACGCCCGATCAGAC
GCTGTCCTTCCTCATCGCCAACATTTCGCCCGGCACCACCGTGCCGGTGGAGGTGTTCCGCGAAGGCTCGCGCCGCACGC
TCAATGTCACGGTGGGCAAGCGCCCGAGCGAAGAGGAACTCCGCCAGTCGCAGATATTCTCGCAGGACGAAGACGAAGAT
CCCGATGCTGCGCCCGAGATGGACGACAGCGAAATGCTCGCCGACAAGCTCGGTCTTGGTGTCATTCCGGTGACGCCCGA
AATCGCGCGCCAGCTCGGTGTCGCGGCCGATACGCGCGGGCTCGCCATCGCCGTGGTCGATCCGAATTCGGACGCCGCGC
GCAAGGGCCTGCGCCGCCGGGACATCATCCTGTCGGCGAATTACGAGCCGGTCGAAAGCGTCGAAGATCTCGAGGCGATC
GTCCAGCAGGCCGAGGAGGCCGGTCGCAGCTCTGTCCTGCTGCGCTTCCGCCGCGGCGGGCAGACGGCCTTCCGCGCAGT
GCGCTTCCGCTAA

Upstream 100 bases:

>100_bases
CAGCGCCCGCGCGCTGAACACGGAAATCGACCCGGACCTGAAACCGGAACACCTTTCGGTGCGTATCTGCACCAGACGAA
ACGAAAAGGAACGAGAGGAC

Downstream 100 bases:

>100_bases
CAGATTGCACCGAGCAAAAAAGAGCCCCGTCGGAGCGATCCGGCGGGGCTTTTTCTATCGGTTCTGCGAATTTGTGCCGG
GCGGCGGCTGGGGCCTTTGC

Product: trypsin-like serine protease

Products: NA

Alternate protein names: Antigen htrA [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MKPVRYAYGLTSALLVGGATVSLLTGQPAGAQVAQNDDRVMSNVVPRAGAPESFAELTEQLQPAVVNISTRQRIEVQNRN
PFQGTPFADLFNRRGQPQQPQTREAQSLGSGFFISADGYVVTNNHVVAPNGRGTVEEITVTLPDGREYAAELVGADAASD
LAVLKVSRSEPFPFVRFGDSSQARAGDWVIAIGNPFGLGGTVTSGIVSAQLRNTGGGAYDRYIQTDASINRGNSGGPLFD
MQGNVIGINNAIFSPSGGSVGIGFAIPAETAAPIVAQLQRGNAIERGYLGVQIQQVSEDVADSLGLPKNRGEIVQTVVDG
EAADRSGIRAGDVVLKIDGKDVTPDQTLSFLIANISPGTTVPVEVFREGSRRTLNVTVGKRPSEEELRQSQIFSQDEDED
PDAAPEMDDSEMLADKLGLGVIPVTPEIARQLGVAADTRGLAIAVVDPNSDAARKGLRRRDIILSANYEPVESVEDLEAI
VQQAEEAGRSSVLLRFRRGGQTAFRAVRFR

Sequences:

>Translated_510_residues
MKPVRYAYGLTSALLVGGATVSLLTGQPAGAQVAQNDDRVMSNVVPRAGAPESFAELTEQLQPAVVNISTRQRIEVQNRN
PFQGTPFADLFNRRGQPQQPQTREAQSLGSGFFISADGYVVTNNHVVAPNGRGTVEEITVTLPDGREYAAELVGADAASD
LAVLKVSRSEPFPFVRFGDSSQARAGDWVIAIGNPFGLGGTVTSGIVSAQLRNTGGGAYDRYIQTDASINRGNSGGPLFD
MQGNVIGINNAIFSPSGGSVGIGFAIPAETAAPIVAQLQRGNAIERGYLGVQIQQVSEDVADSLGLPKNRGEIVQTVVDG
EAADRSGIRAGDVVLKIDGKDVTPDQTLSFLIANISPGTTVPVEVFREGSRRTLNVTVGKRPSEEELRQSQIFSQDEDED
PDAAPEMDDSEMLADKLGLGVIPVTPEIARQLGVAADTRGLAIAVVDPNSDAARKGLRRRDIILSANYEPVESVEDLEAI
VQQAEEAGRSSVLLRFRRGGQTAFRAVRFR
>Mature_510_residues
MKPVRYAYGLTSALLVGGATVSLLTGQPAGAQVAQNDDRVMSNVVPRAGAPESFAELTEQLQPAVVNISTRQRIEVQNRN
PFQGTPFADLFNRRGQPQQPQTREAQSLGSGFFISADGYVVTNNHVVAPNGRGTVEEITVTLPDGREYAAELVGADAASD
LAVLKVSRSEPFPFVRFGDSSQARAGDWVIAIGNPFGLGGTVTSGIVSAQLRNTGGGAYDRYIQTDASINRGNSGGPLFD
MQGNVIGINNAIFSPSGGSVGIGFAIPAETAAPIVAQLQRGNAIERGYLGVQIQQVSEDVADSLGLPKNRGEIVQTVVDG
EAADRSGIRAGDVVLKIDGKDVTPDQTLSFLIANISPGTTVPVEVFREGSRRTLNVTVGKRPSEEELRQSQIFSQDEDED
PDAAPEMDDSEMLADKLGLGVIPVTPEIARQLGVAADTRGLAIAVVDPNSDAARKGLRRRDIILSANYEPVESVEDLEAI
VQQAEEAGRSSVLLRFRRGGQTAFRAVRFR

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI24308541, Length=307, Percent_Identity=33.5504885993485, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI22129776, Length=320, Percent_Identity=33.4375, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI4506141, Length=321, Percent_Identity=32.7102803738318, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI7019477, Length=301, Percent_Identity=34.8837209302326, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1786356, Length=476, Percent_Identity=32.7731092436975, Blast_Score=228, Evalue=6e-61,
Organism=Escherichia coli, GI1789629, Length=467, Percent_Identity=34.9036402569593, Blast_Score=228, Evalue=1e-60,
Organism=Escherichia coli, GI1789630, Length=303, Percent_Identity=36.6336633663366, Blast_Score=171, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24646839, Length=256, Percent_Identity=34.375, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 54151; Mature: 54151

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPVRYAYGLTSALLVGGATVSLLTGQPAGAQVAQNDDRVMSNVVPRAGAPESFAELTEQ
CCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHH
LQPAVVNISTRQRIEVQNRNPFQGTPFADLFNRRGQPQQPQTREAQSLGSGFFISADGYV
CCCEEEEECCCEEEEECCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHCCCCEEEECCCEE
VTNNHVVAPNGRGTVEEITVTLPDGREYAAELVGADAASDLAVLKVSRSEPFPFVRFGDS
EECCEEECCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEECCC
SQARAGDWVIAIGNPFGLGGTVTSGIVSAQLRNTGGGAYDRYIQTDASINRGNSGGPLFD
CCCCCCCEEEEECCCCCCCCHHHHHHHEEEHHCCCCCHHHHEEECCCCCCCCCCCCCEEE
MQGNVIGINNAIFSPSGGSVGIGFAIPAETAAPIVAQLQRGNAIERGYLGVQIQQVSEDV
CCCCEEEECCEEECCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHH
ADSLGLPKNRGEIVQTVVDGEAADRSGIRAGDVVLKIDGKDVTPDQTLSFLIANISPGTT
HHHCCCCCCCCHHHHHHHCCCCCCCCCCEECCEEEEECCCCCCHHHEEEEEEEECCCCCC
VPVEVFREGSRRTLNVTVGKRPSEEELRQSQIFSQDEDEDPDAAPEMDDSEMLADKLGLG
CHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCC
VIPVTPEIARQLGVAADTRGLAIAVVDPNSDAARKGLRRRDIILSANYEPVESVEDLEAI
EEECCHHHHHHHCCCCCCCCEEEEEECCCCHHHHHCCCCCEEEEECCCCHHHHHHHHHHH
VQQAEEAGRSSVLLRFRRGGQTAFRAVRFR
HHHHHHCCCCEEEEEECCCCHHHHHEEECC
>Mature Secondary Structure
MKPVRYAYGLTSALLVGGATVSLLTGQPAGAQVAQNDDRVMSNVVPRAGAPESFAELTEQ
CCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHH
LQPAVVNISTRQRIEVQNRNPFQGTPFADLFNRRGQPQQPQTREAQSLGSGFFISADGYV
CCCEEEEECCCEEEEECCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHCCCCEEEECCCEE
VTNNHVVAPNGRGTVEEITVTLPDGREYAAELVGADAASDLAVLKVSRSEPFPFVRFGDS
EECCEEECCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEECCC
SQARAGDWVIAIGNPFGLGGTVTSGIVSAQLRNTGGGAYDRYIQTDASINRGNSGGPLFD
CCCCCCCEEEEECCCCCCCCHHHHHHHEEEHHCCCCCHHHHEEECCCCCCCCCCCCCEEE
MQGNVIGINNAIFSPSGGSVGIGFAIPAETAAPIVAQLQRGNAIERGYLGVQIQQVSEDV
CCCCEEEECCEEECCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHH
ADSLGLPKNRGEIVQTVVDGEAADRSGIRAGDVVLKIDGKDVTPDQTLSFLIANISPGTT
HHHCCCCCCCCHHHHHHHCCCCCCCCCCEECCEEEEECCCCCCHHHEEEEEEEECCCCCC
VPVEVFREGSRRTLNVTVGKRPSEEELRQSQIFSQDEDEDPDAAPEMDDSEMLADKLGLG
CHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCC
VIPVTPEIARQLGVAADTRGLAIAVVDPNSDAARKGLRRRDIILSANYEPVESVEDLEAI
EEECCHHHHHHHCCCCCCCCEEEEEECCCCHHHHHCCCCCEEEEECCCCHHHHHHHHHHH
VQQAEEAGRSSVLLRFRRGGQTAFRAVRFR
HHHHHHCCCCEEEEEECCCCHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8027347 [H]