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The map label for this gene is hflK [H]

Identifier: 85375093

GI number: 85375093

Start: 2291635

End: 2292747

Strand: Direct

Name: hflK [H]

Synonym: ELI_11330

Alternate gene names: 85375093

Gene position: 2291635-2292747 (Clockwise)

Preceding gene: 85375087

Following gene: 85375094

Centisome position: 75.08

GC content: 64.33

Gene sequence:

>1113_bases
ATGGCTGGCAAGAGTCCCTGGGGATCAGGTGGCGGCAAAGGCAGCAATGACGAAGGGTCCGGCGGCGACGACAGCACCAG
CGGCGATGTGCCGTCCTCCGAAGGTTCGAAGGGCCCGCGCAATCCGTGGCTCCCCCCTGGAAAGGACAGGGGCGAACCTC
GCCGTTCGGCCAGTATCGAGGATATCTTCAAGAACCGCGGCCCCGAAGGTCCGCGCCGCACCGGCGGCGGCGGCAAGGGG
CCGAATTTCCGCCTGCCCGAACGGCCCGGCGGCAAGAGCTGGTTTCCGTTGGCGCTCGGCGGCCTCGCGGCAGTCTGGAT
TCTCACGACCAGCGTGCACCAGGTGGCCCCGGCAGAGCAGGCGCTCGTTTCGTGGATCGGTGGCAAATATTCCCGGACGA
TGGATTCGGGCTTCCAGGTTACGCTCCCCTACCCGATCCAGTCGGTGGACAAGGAGAACGTGCAGGAAATCCGCTCCGAG
AAAATTCCGGCCGGTGACACGCAGAAGCTGATCCTGACAGGCGATCAGAACCTGGTCGATCTCAGCTATCTTATTCGCTG
GAATATCGGCGACCTCGCGCTTTTCCGCTATCGCCTGGCCGACCCCATCGAGACGGTCCGTGAAGCGGCGGAAACCGCGA
TGCGCCAGTCGGTGGCCGAACTGGAACTGGACACGGTCCTGTCGGGCGAAGGCCGCGCCGAGATCGAGCAGAATGTTCGC
GAGCGCATGCAGGCGATCCTCGATGCCTATCAGGCCGGGATCGTGGTGCAGGGTATCGAGATCGACAAGACCGATCCGCC
CGAAACCGTGGTCGACGCGTTCAAGGACGTTTCGGCGGCCGAGCAGGATGCGCAGGCCGAATTGAACCGCGCCCGCCGCT
ATGCCCAGCAGTTGCTCGCCCGCGCACAGGGCGATGCGGCCGCTTTCGACAAGATATACGCTGAATACCGGCTCGCGCCC
GATGTGACGCGTCGTCGCCTCTATTACGAGACAATGGAAAGCGTGCTGAGAGAAACCGACAAGACCGTGATCGAGGCCGA
CGGGGTTACGCCGTATCTGCCGCTCCCCGAAGTTCAGCGCCGCAACCGCGCGTCCCAGGCGGAGGGTCAGTAA

Upstream 100 bases:

>100_bases
AGCAATTTTGCGCCTGCCACCCCTGTTTTTCTGGGCGGGGCTACCTATAACGAGAAGCATGCAGAGTTTTGACAGGTTCC
GTAACCGGATCGGTCTCGCC

Downstream 100 bases:

>100_bases
TCATGGACAGCATCTGGCAGAATTATAAACTCCCGATCATCGCCATTATCGTGCTCGCGATCCTGGCCGCGATGAGCATC
GTCTTCGTCGGCGAAGACGA

Product: integral membrane proteinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MAGKSPWGSGGGKGSNDEGSGGDDSTSGDVPSSEGSKGPRNPWLPPGKDRGEPRRSASIEDIFKNRGPEGPRRTGGGGKG
PNFRLPERPGGKSWFPLALGGLAAVWILTTSVHQVAPAEQALVSWIGGKYSRTMDSGFQVTLPYPIQSVDKENVQEIRSE
KIPAGDTQKLILTGDQNLVDLSYLIRWNIGDLALFRYRLADPIETVREAAETAMRQSVAELELDTVLSGEGRAEIEQNVR
ERMQAILDAYQAGIVVQGIEIDKTDPPETVVDAFKDVSAAEQDAQAELNRARRYAQQLLARAQGDAAAFDKIYAEYRLAP
DVTRRRLYYETMESVLRETDKTVIEADGVTPYLPLPEVQRRNRASQAEGQ

Sequences:

>Translated_370_residues
MAGKSPWGSGGGKGSNDEGSGGDDSTSGDVPSSEGSKGPRNPWLPPGKDRGEPRRSASIEDIFKNRGPEGPRRTGGGGKG
PNFRLPERPGGKSWFPLALGGLAAVWILTTSVHQVAPAEQALVSWIGGKYSRTMDSGFQVTLPYPIQSVDKENVQEIRSE
KIPAGDTQKLILTGDQNLVDLSYLIRWNIGDLALFRYRLADPIETVREAAETAMRQSVAELELDTVLSGEGRAEIEQNVR
ERMQAILDAYQAGIVVQGIEIDKTDPPETVVDAFKDVSAAEQDAQAELNRARRYAQQLLARAQGDAAAFDKIYAEYRLAP
DVTRRRLYYETMESVLRETDKTVIEADGVTPYLPLPEVQRRNRASQAEGQ
>Mature_369_residues
AGKSPWGSGGGKGSNDEGSGGDDSTSGDVPSSEGSKGPRNPWLPPGKDRGEPRRSASIEDIFKNRGPEGPRRTGGGGKGP
NFRLPERPGGKSWFPLALGGLAAVWILTTSVHQVAPAEQALVSWIGGKYSRTMDSGFQVTLPYPIQSVDKENVQEIRSEK
IPAGDTQKLILTGDQNLVDLSYLIRWNIGDLALFRYRLADPIETVREAAETAMRQSVAELELDTVLSGEGRAEIEQNVRE
RMQAILDAYQAGIVVQGIEIDKTDPPETVVDAFKDVSAAEQDAQAELNRARRYAQQLLARAQGDAAAFDKIYAEYRLAPD
VTRRRLYYETMESVLRETDKTVIEADGVTPYLPLPEVQRRNRASQAEGQ

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=261, Percent_Identity=28.735632183908, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 40425; Mature: 40294

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGKSPWGSGGGKGSNDEGSGGDDSTSGDVPSSEGSKGPRNPWLPPGKDRGEPRRSASIE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHH
DIFKNRGPEGPRRTGGGGKGPNFRLPERPGGKSWFPLALGGLAAVWILTTSVHQVAPAEQ
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHH
ALVSWIGGKYSRTMDSGFQVTLPYPIQSVDKENVQEIRSEKIPAGDTQKLILTGDQNLVD
HHHHHHCCHHHHHHCCCCEEEECCCHHHCCHHHHHHHHHHCCCCCCCCEEEEECCCCCEE
LSYLIRWNIGDLALFRYRLADPIETVREAAETAMRQSVAELELDTVLSGEGRAEIEQNVR
HHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ERMQAILDAYQAGIVVQGIEIDKTDPPETVVDAFKDVSAAEQDAQAELNRARRYAQQLLA
HHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAQGDAAAFDKIYAEYRLAPDVTRRRLYYETMESVLRETDKTVIEADGVTPYLPLPEVQR
HHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHH
RNRASQAEGQ
HCCCCCCCCC
>Mature Secondary Structure 
AGKSPWGSGGGKGSNDEGSGGDDSTSGDVPSSEGSKGPRNPWLPPGKDRGEPRRSASIE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHH
DIFKNRGPEGPRRTGGGGKGPNFRLPERPGGKSWFPLALGGLAAVWILTTSVHQVAPAEQ
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHH
ALVSWIGGKYSRTMDSGFQVTLPYPIQSVDKENVQEIRSEKIPAGDTQKLILTGDQNLVD
HHHHHHCCHHHHHHCCCCEEEECCCHHHCCHHHHHHHHHHCCCCCCCCEEEEECCCCCEE
LSYLIRWNIGDLALFRYRLADPIETVREAAETAMRQSVAELELDTVLSGEGRAEIEQNVR
HHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ERMQAILDAYQAGIVVQGIEIDKTDPPETVVDAFKDVSAAEQDAQAELNRARRYAQQLLA
HHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAQGDAAAFDKIYAEYRLAPDVTRRRLYYETMESVLRETDKTVIEADGVTPYLPLPEVQR
HHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHH
RNRASQAEGQ
HCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]