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The map label for this gene is msrA [H]

Identifier: 85375085

GI number: 85375085

Start: 2282939

End: 2283481

Strand: Direct

Name: msrA [H]

Synonym: ELI_11290

Alternate gene names: 85375085

Gene position: 2282939-2283481 (Clockwise)

Preceding gene: 85375067

Following gene: 85375087

Centisome position: 74.79

GC content: 62.25

Gene sequence:

>543_bases
GTGAGCAATTTGCAGCAAGCGATCATCGCCGGCGGGTGCTTCTGGTGCACCGAGGCCGTGTTCAAGGATGTGATCGGCGT
GACCGAAGTCGAGAGTGGCTATATCGGCGGCCACGTCGCCGACCCGACCTACAAGGAGGTTTGCAGCGGCACTACCGGCC
ATGCCGAGGGCATCCGCGTGACCTTCGATCCCGACGTGGTGAGCCTGCCGGAAATCTACGACATGTTTCTCGGCACGCAC
GACCCGACGCAGCTTAATCGCCAGGGCAACGATGTCGGCACGCAATACCGCAGCGCGATCTTCCCGCTCGACGATGAACA
GCGCCAGGAAGCCGAGGCCGCCATCGCGCGCTGGAACGAGAGCAACGGAGGCACTGCGGTGACGACGATCGAGGGCCCGG
CCGAGTGGTATCCGGCAGAAGACTATCACCAGGACTATTGGGACGGCGAAGGCCAGCGCAATCCCTATTGCCAGGCGACC
ATTCCGCCCAAGCTGATGAAGCTGCGCAAGAGCTTCGCCAAATATGTGAAGGACGACGCCTGA

Upstream 100 bases:

>100_bases
TTGGAAACTCCCCCGGGAATCGAAATGTAGTCATGCGATGTAGGCGAAACGGATGACATTGGCGATTCGATCCCCATTTC
ATGCCCGAAGGAGAATGCGA

Downstream 100 bases:

>100_bases
TTCGCCGGCCGTTGCGCCGGGGGCCACAGAAGTCAGAAACTCGGCTTCGGCCCCATCAACCTGGAGACATGGACCGCATG
GACCACTGTCCAGGGCCGAA

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MSNLQQAIIAGGCFWCTEAVFKDVIGVTEVESGYIGGHVADPTYKEVCSGTTGHAEGIRVTFDPDVVSLPEIYDMFLGTH
DPTQLNRQGNDVGTQYRSAIFPLDDEQRQEAEAAIARWNESNGGTAVTTIEGPAEWYPAEDYHQDYWDGEGQRNPYCQAT
IPPKLMKLRKSFAKYVKDDA

Sequences:

>Translated_180_residues
MSNLQQAIIAGGCFWCTEAVFKDVIGVTEVESGYIGGHVADPTYKEVCSGTTGHAEGIRVTFDPDVVSLPEIYDMFLGTH
DPTQLNRQGNDVGTQYRSAIFPLDDEQRQEAEAAIARWNESNGGTAVTTIEGPAEWYPAEDYHQDYWDGEGQRNPYCQAT
IPPKLMKLRKSFAKYVKDDA
>Mature_179_residues
SNLQQAIIAGGCFWCTEAVFKDVIGVTEVESGYIGGHVADPTYKEVCSGTTGHAEGIRVTFDPDVVSLPEIYDMFLGTHD
PTQLNRQGNDVGTQYRSAIFPLDDEQRQEAEAAIARWNESNGGTAVTTIEGPAEWYPAEDYHQDYWDGEGQRNPYCQATI
PPKLMKLRKSFAKYVKDDA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=159, Percent_Identity=43.3962264150943, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI208609995, Length=159, Percent_Identity=43.3962264150943, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI208609993, Length=112, Percent_Identity=42.8571428571429, Blast_Score=83, Evalue=1e-16,
Organism=Escherichia coli, GI1790665, Length=157, Percent_Identity=43.9490445859873, Blast_Score=132, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17533973, Length=147, Percent_Identity=33.3333333333333, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=152, Percent_Identity=36.8421052631579, Blast_Score=105, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24664627, Length=165, Percent_Identity=32.1212121212121, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI45553131, Length=160, Percent_Identity=32.5, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24664631, Length=165, Percent_Identity=31.5151515151515, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 19960; Mature: 19829

Theoretical pI: Translated: 4.27; Mature: 4.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLQQAIIAGGCFWCTEAVFKDVIGVTEVESGYIGGHVADPTYKEVCSGTTGHAEGIRV
CCHHHHHHHHCHHHHHHHHHHHHHHCHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEE
TFDPDVVSLPEIYDMFLGTHDPTQLNRQGNDVGTQYRSAIFPLDDEQRQEAEAAIARWNE
EECCCCCCHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
SNGGTAVTTIEGPAEWYPAEDYHQDYWDGEGQRNPYCQATIPPKLMKLRKSFAKYVKDDA
CCCCEEEEEECCCCCCCCCCHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SNLQQAIIAGGCFWCTEAVFKDVIGVTEVESGYIGGHVADPTYKEVCSGTTGHAEGIRV
CHHHHHHHHCHHHHHHHHHHHHHHCHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEE
TFDPDVVSLPEIYDMFLGTHDPTQLNRQGNDVGTQYRSAIFPLDDEQRQEAEAAIARWNE
EECCCCCCHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
SNGGTAVTTIEGPAEWYPAEDYHQDYWDGEGQRNPYCQATIPPKLMKLRKSFAKYVKDDA
CCCCEEEEEECCCCCCCCCCHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA