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The map label for this gene is ahpC [H]

Identifier: 85374917

GI number: 85374917

Start: 2119991

End: 2120557

Strand: Direct

Name: ahpC [H]

Synonym: ELI_10450

Alternate gene names: 85374917

Gene position: 2119991-2120557 (Clockwise)

Preceding gene: 85374916

Following gene: 85374918

Centisome position: 69.45

GC content: 61.73

Gene sequence:

>567_bases
ATGGGTATCATCGGAAGCACCATCAAACCCTTCAAGGCGACCGCATTCAAGGCCGGCGAAGACTTTTGCGACGTCACCGA
CGAGGACGTGAAGGGCAAGTGGGCCGTGTTCTTCTTCTATCCGGCCGACTTCACCTTCGTGTGCCCGACCGAGCTGGAAG
ACCTCGGCGAGAAGTATGCGATGCTGCAGGACATGGACGTCGAAGTCTATGCCGTCAGCACCGACACGCATTTCAGCCAC
AAGGCCTGGCACGACACCAGCGAGCGCATCGGCAAGCTGACCTTCCCGTTCCTCGGCGACCAGAATCACCAACTCGCGCG
CAATTTCGACGTGCTGCGCGAAGGCGTCGGCCTCGCCGATCGCGCCACCTTCGTGGTCGATCCGGACGGCGTGATCCAGC
TGGTCGAGCAGACCTGCGAAGGCGTCGGCCGCAATGCCAACGAGCTGACCCGCAAGATCAAGGCGGCCCAGTATGTCCGC
GCCAACCCCGGCCAGGTTTGTCCGGCCGCATGGGAAGAAGGCAGCGAAACTCTCGCACCGTCGCTCGATCTCGTCGGCAA
GATTTAA

Upstream 100 bases:

>100_bases
TTGAGTTTTTCGATTTTCGGAATCGAAACACTCCGCTTTGCTGCGCCGCATCAATTCCTATGTGCAGCGCACCAATTTCA
TCCCACACAACGGAGACATC

Downstream 100 bases:

>100_bases
GCGCCGACACCCCCTGACCGCCGCGCGCCTGTCCTCCGGCGCGGGCGGCCTGAAGGCCCGGGGCGATCCTCCCCCTCCCT
CCCCGTCCCGGGCCTTCCCC

Product: alkyl hydroperoxide reductase (small subunit)

Products: NA

Alternate protein names: Alkyl hydroperoxide reductase protein C22; General stress protein 22; Peroxiredoxin; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MGIIGSTIKPFKATAFKAGEDFCDVTDEDVKGKWAVFFFYPADFTFVCPTELEDLGEKYAMLQDMDVEVYAVSTDTHFSH
KAWHDTSERIGKLTFPFLGDQNHQLARNFDVLREGVGLADRATFVVDPDGVIQLVEQTCEGVGRNANELTRKIKAAQYVR
ANPGQVCPAAWEEGSETLAPSLDLVGKI

Sequences:

>Translated_188_residues
MGIIGSTIKPFKATAFKAGEDFCDVTDEDVKGKWAVFFFYPADFTFVCPTELEDLGEKYAMLQDMDVEVYAVSTDTHFSH
KAWHDTSERIGKLTFPFLGDQNHQLARNFDVLREGVGLADRATFVVDPDGVIQLVEQTCEGVGRNANELTRKIKAAQYVR
ANPGQVCPAAWEEGSETLAPSLDLVGKI
>Mature_187_residues
GIIGSTIKPFKATAFKAGEDFCDVTDEDVKGKWAVFFFYPADFTFVCPTELEDLGEKYAMLQDMDVEVYAVSTDTHFSHK
AWHDTSERIGKLTFPFLGDQNHQLARNFDVLREGVGLADRATFVVDPDGVIQLVEQTCEGVGRNANELTRKIKAAQYVRA
NPGQVCPAAWEEGSETLAPSLDLVGKI

Specific function: Directly reduces organic hydroperoxides in its reduced dithiol form [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32483377, Length=181, Percent_Identity=45.8563535911602, Blast_Score=154, Evalue=4e-38,
Organism=Homo sapiens, GI5802974, Length=174, Percent_Identity=45.9770114942529, Blast_Score=153, Evalue=9e-38,
Organism=Homo sapiens, GI4505591, Length=182, Percent_Identity=35.7142857142857, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI32455266, Length=182, Percent_Identity=35.7142857142857, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI32455264, Length=182, Percent_Identity=35.7142857142857, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI32189392, Length=183, Percent_Identity=39.344262295082, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI5453549, Length=181, Percent_Identity=38.6740331491713, Blast_Score=134, Evalue=7e-32,
Organism=Homo sapiens, GI33188454, Length=86, Percent_Identity=43.0232558139535, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI4758638, Length=157, Percent_Identity=28.6624203821656, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1786822, Length=188, Percent_Identity=63.8297872340426, Blast_Score=259, Evalue=8e-71,
Organism=Caenorhabditis elegans, GI17554494, Length=182, Percent_Identity=42.3076923076923, Blast_Score=142, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI32565831, Length=182, Percent_Identity=40.1098901098901, Blast_Score=142, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI193204376, Length=182, Percent_Identity=40.1098901098901, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320661, Length=176, Percent_Identity=36.3636363636364, Blast_Score=119, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323613, Length=176, Percent_Identity=36.9318181818182, Blast_Score=116, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319407, Length=158, Percent_Identity=29.746835443038, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI17738015, Length=167, Percent_Identity=39.5209580838323, Blast_Score=137, Evalue=3e-33,
Organism=Drosophila melanogaster, GI21357347, Length=153, Percent_Identity=39.8692810457516, Blast_Score=130, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24656348, Length=183, Percent_Identity=33.879781420765, Blast_Score=126, Evalue=9e-30,
Organism=Drosophila melanogaster, GI17864676, Length=183, Percent_Identity=33.879781420765, Blast_Score=126, Evalue=9e-30,
Organism=Drosophila melanogaster, GI17157991, Length=171, Percent_Identity=38.0116959064327, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24641739, Length=171, Percent_Identity=38.0116959064327, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24581278, Length=183, Percent_Identity=32.2404371584699, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17975518, Length=186, Percent_Identity=27.9569892473118, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24652436, Length=186, Percent_Identity=27.9569892473118, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24652434, Length=186, Percent_Identity=27.9569892473118, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017559
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 20815; Mature: 20683

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIIGSTIKPFKATAFKAGEDFCDVTDEDVKGKWAVFFFYPADFTFVCPTELEDLGEKYA
CCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCEEEECCHHHHHHHHHHH
MLQDMDVEVYAVSTDTHFSHKAWHDTSERIGKLTFPFLGDQNHQLARNFDVLREGVGLAD
HHHCCCEEEEEEECCCCCCCHHHCCHHHHHCCEECCCCCCCCCHHHHHHHHHHHCCCCCC
RATFVVDPDGVIQLVEQTCEGVGRNANELTRKIKAAQYVRANPGQVCPAAWEEGSETLAP
CEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCC
SLDLVGKI
CHHHHCCC
>Mature Secondary Structure 
GIIGSTIKPFKATAFKAGEDFCDVTDEDVKGKWAVFFFYPADFTFVCPTELEDLGEKYA
CCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCEEEECCHHHHHHHHHHH
MLQDMDVEVYAVSTDTHFSHKAWHDTSERIGKLTFPFLGDQNHQLARNFDVLREGVGLAD
HHHCCCEEEEEEECCCCCCCHHHCCHHHHHCCEECCCCCCCCCHHHHHHHHHHHCCCCCC
RATFVVDPDGVIQLVEQTCEGVGRNANELTRKIKAAQYVRANPGQVCPAAWEEGSETLAP
CEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCC
SLDLVGKI
CHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8180695; 8012595 [H]