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The map label for this gene is acdA [H]

Identifier: 85374832

GI number: 85374832

Start: 2033513

End: 2034661

Strand: Direct

Name: acdA [H]

Synonym: ELI_10025

Alternate gene names: 85374832

Gene position: 2033513-2034661 (Clockwise)

Preceding gene: 85374831

Following gene: 85374833

Centisome position: 66.62

GC content: 62.92

Gene sequence:

>1149_bases
ATGACTGGACAATTCGCTCTCACAGACGACCAACTGGCCATCCAGGAGATGGCGCAGCGCTTCACCGCCGACAACATTAC
GCCCCATGCTGCGGAATGGGACGAGCAGCACCATTTCCCCAAGGACGTAATCAAGCAGACCGCCGAGCTCGGCTTCGGTG
CGATCTATGTCAGCGAGGAATCGGGCGGGATCGGCCTCGGCCGCCTCGAAGCGGCGCTTATCATGGAAGCCATGGCCTAT
GGCTGCCCGACGACCAGCGCCTTCATCTCGATCCACAACATGGCGGCGTGGATGATCGACCAGTTCGGCGGACAGGGCGT
CAAGGACAAGTACCTTCCCGACCTCGTCACGATGGAAAAGATCGCCAGCTATTGCCTGACCGAGCCGGGCAGCGGTTCGG
ACGCTGCGGGTCTCAAGACCAGCGCGGTGCTGGACGGCGATCATTACGTCCTCAACGGCACCAAGCAGTTCATTTCCGGC
GGCGGCGTGAACGACGTCTATGTCACCATGGTTCGCACGTCCGATCACAAGACCAAGGGCATCACCTGCCTCGTGATCGA
CAAGGACACGCCGGGCGTCAGCTTCGGCGCGCCGGAAAAGAAGCTCGGCTGGAACGCCAGCCCGACAGCGCAGGTCATTC
TCGAAGATGCCCGCGTGCCGGTCGAGAACCGCGTCGGCGACGAGGGCGAAGGCTTCCGCTTCGCCATGATGGGTCTCGAT
GGCGGCCGGCTGAACATTGGCGCATGCTCGCTCGGCGGCGCACAGCGTTGCCTCGACGAAGCGGTCGCCTACACCAAGGA
ACGCCAGCAATTCGACCAGCCCGTGGCCGATTTCCAGAACACGCAGTTCATGTTGGCCGACATGGCGACCGACCTCGAGG
CGGCGCGTGCGCTGCTTTATCTTGCCGCGGCCAAGGTGACGGAGAACGCGCCCGACAAGTCGCGCTTCTCCGCCATGGCC
AAGCGGTTGGCGACCGACAATGGCAGCAAGATCGTCAACGACGCGCTGCAATTGTTCGGCGGCTACGGCTACCTCAAGGA
CTATCCGATCGAGCGGTTCTGGCGTGACCTGCGCGTCCATTCGATCCTCGAAGGCACCAACCAGGTCATGCGCATGATCG
TGGGCCGCGACCTGCTGCGACAGGGGTGA

Upstream 100 bases:

>100_bases
CGACCGGAATGGAAAGTGGAAATCGAGGCCGAAGCAATCCTCGATTGAACCGACGCGCACCCCCTTCCCTCGACTCTCTC
GCGGCGCTAAGCCCCGCGCC

Downstream 100 bases:

>100_bases
GCGAAATGACCGACCAAGTCCTGATCCACAAACACGGCCGCGTCGGCCATATCTCGCTCAACCGGCCGAAGGCACTCCAC
GCGCTGACGCTAGAGATGTG

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MTGQFALTDDQLAIQEMAQRFTADNITPHAAEWDEQHHFPKDVIKQTAELGFGAIYVSEESGGIGLGRLEAALIMEAMAY
GCPTTSAFISIHNMAAWMIDQFGGQGVKDKYLPDLVTMEKIASYCLTEPGSGSDAAGLKTSAVLDGDHYVLNGTKQFISG
GGVNDVYVTMVRTSDHKTKGITCLVIDKDTPGVSFGAPEKKLGWNASPTAQVILEDARVPVENRVGDEGEGFRFAMMGLD
GGRLNIGACSLGGAQRCLDEAVAYTKERQQFDQPVADFQNTQFMLADMATDLEAARALLYLAAAKVTENAPDKSRFSAMA
KRLATDNGSKIVNDALQLFGGYGYLKDYPIERFWRDLRVHSILEGTNQVMRMIVGRDLLRQG

Sequences:

>Translated_382_residues
MTGQFALTDDQLAIQEMAQRFTADNITPHAAEWDEQHHFPKDVIKQTAELGFGAIYVSEESGGIGLGRLEAALIMEAMAY
GCPTTSAFISIHNMAAWMIDQFGGQGVKDKYLPDLVTMEKIASYCLTEPGSGSDAAGLKTSAVLDGDHYVLNGTKQFISG
GGVNDVYVTMVRTSDHKTKGITCLVIDKDTPGVSFGAPEKKLGWNASPTAQVILEDARVPVENRVGDEGEGFRFAMMGLD
GGRLNIGACSLGGAQRCLDEAVAYTKERQQFDQPVADFQNTQFMLADMATDLEAARALLYLAAAKVTENAPDKSRFSAMA
KRLATDNGSKIVNDALQLFGGYGYLKDYPIERFWRDLRVHSILEGTNQVMRMIVGRDLLRQG
>Mature_381_residues
TGQFALTDDQLAIQEMAQRFTADNITPHAAEWDEQHHFPKDVIKQTAELGFGAIYVSEESGGIGLGRLEAALIMEAMAYG
CPTTSAFISIHNMAAWMIDQFGGQGVKDKYLPDLVTMEKIASYCLTEPGSGSDAAGLKTSAVLDGDHYVLNGTKQFISGG
GVNDVYVTMVRTSDHKTKGITCLVIDKDTPGVSFGAPEKKLGWNASPTAQVILEDARVPVENRVGDEGEGFRFAMMGLDG
GRLNIGACSLGGAQRCLDEAVAYTKERQQFDQPVADFQNTQFMLADMATDLEAARALLYLAAAKVTENAPDKSRFSAMAK
RLATDNGSKIVNDALQLFGGYGYLKDYPIERFWRDLRVHSILEGTNQVMRMIVGRDLLRQG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7656849, Length=375, Percent_Identity=52.8, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI4557231, Length=377, Percent_Identity=36.8700265251989, Blast_Score=260, Evalue=1e-69,
Organism=Homo sapiens, GI187960098, Length=377, Percent_Identity=36.8700265251989, Blast_Score=260, Evalue=1e-69,
Organism=Homo sapiens, GI4557233, Length=362, Percent_Identity=38.6740331491713, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=36.3636363636364, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI21361497, Length=350, Percent_Identity=34.8571428571429, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=32.4468085106383, Blast_Score=211, Evalue=9e-55,
Organism=Homo sapiens, GI76496475, Length=391, Percent_Identity=32.7365728900256, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI4557235, Length=391, Percent_Identity=32.7365728900256, Blast_Score=205, Evalue=4e-53,
Organism=Homo sapiens, GI226958414, Length=336, Percent_Identity=33.9285714285714, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI4501857, Length=375, Percent_Identity=30.6666666666667, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI4503943, Length=384, Percent_Identity=27.0833333333333, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI7669494, Length=363, Percent_Identity=26.9972451790634, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI211971008, Length=341, Percent_Identity=29.3255131964809, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI48976061, Length=341, Percent_Identity=29.3255131964809, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI38505218, Length=282, Percent_Identity=26.9503546099291, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786223, Length=380, Percent_Identity=28.9473684210526, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI87081958, Length=381, Percent_Identity=27.8215223097113, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI87082384, Length=270, Percent_Identity=27.4074074074074, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081702, Length=372, Percent_Identity=23.3870967741935, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17533517, Length=370, Percent_Identity=49.1891891891892, Blast_Score=396, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17534899, Length=381, Percent_Identity=41.7322834645669, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=39.8416886543536, Blast_Score=284, Evalue=6e-77,
Organism=Caenorhabditis elegans, GI17570075, Length=379, Percent_Identity=36.4116094986807, Blast_Score=261, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17508101, Length=365, Percent_Identity=36.7123287671233, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17506239, Length=365, Percent_Identity=35.8904109589041, Blast_Score=240, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI71985184, Length=349, Percent_Identity=35.5300859598854, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17538396, Length=385, Percent_Identity=31.6883116883117, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI71990804, Length=317, Percent_Identity=35.6466876971609, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17551932, Length=375, Percent_Identity=31.2, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17505929, Length=375, Percent_Identity=31.7333333333333, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI32563615, Length=227, Percent_Identity=39.2070484581498, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=31.7518248175182, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI71985192, Length=281, Percent_Identity=35.9430604982206, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17534353, Length=376, Percent_Identity=29.5212765957447, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17531909, Length=233, Percent_Identity=30.0429184549356, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17562446, Length=353, Percent_Identity=24.929178470255, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI86563381, Length=273, Percent_Identity=29.6703296703297, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI86563383, Length=273, Percent_Identity=29.6703296703297, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17531913, Length=168, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=39.4179894179894, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI21356377, Length=378, Percent_Identity=35.7142857142857, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24666513, Length=372, Percent_Identity=35.2150537634409, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24646207, Length=381, Percent_Identity=36.2204724409449, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI281363737, Length=339, Percent_Identity=34.8082595870207, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=31.496062992126, Blast_Score=187, Evalue=7e-48,
Organism=Drosophila melanogaster, GI19920834, Length=379, Percent_Identity=26.9129287598945, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 41561; Mature: 41429

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGQFALTDDQLAIQEMAQRFTADNITPHAAEWDEQHHFPKDVIKQTAELGFGAIYVSEE
CCCCEECCCHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCHHHHHHHHHHCCCEEEEEECC
SGGIGLGRLEAALIMEAMAYGCPTTSAFISIHNMAAWMIDQFGGQGVKDKYLPDLVTMEK
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHCCHHHHHHH
IASYCLTEPGSGSDAAGLKTSAVLDGDHYVLNGTKQFISGGGVNDVYVTMVRTSDHKTKG
HHHHHCCCCCCCCCCCCCCEEEEECCCEEEECCHHHHHCCCCCCCEEEEEEECCCCCCCC
ITCLVIDKDTPGVSFGAPEKKLGWNASPTAQVILEDARVPVENRVGDEGEGFRFAMMGLD
EEEEEEECCCCCCCCCCCCHHCCCCCCCHHHHHHHCCCCCHHHCCCCCCCCEEEEEEECC
GGRLNIGACSLGGAQRCLDEAVAYTKERQQFDQPVADFQNTQFMLADMATDLEAARALLY
CCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCHHHHHCCCEEEEHHHHHHHHHHHHHHH
LAAAKVTENAPDKSRFSAMAKRLATDNGSKIVNDALQLFGGYGYLKDYPIERFWRDLRVH
HHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
SILEGTNQVMRMIVGRDLLRQG
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TGQFALTDDQLAIQEMAQRFTADNITPHAAEWDEQHHFPKDVIKQTAELGFGAIYVSEE
CCCEECCCHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCHHHHHHHHHHCCCEEEEEECC
SGGIGLGRLEAALIMEAMAYGCPTTSAFISIHNMAAWMIDQFGGQGVKDKYLPDLVTMEK
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHCCHHHHHHH
IASYCLTEPGSGSDAAGLKTSAVLDGDHYVLNGTKQFISGGGVNDVYVTMVRTSDHKTKG
HHHHHCCCCCCCCCCCCCCEEEEECCCEEEECCHHHHHCCCCCCCEEEEEEECCCCCCCC
ITCLVIDKDTPGVSFGAPEKKLGWNASPTAQVILEDARVPVENRVGDEGEGFRFAMMGLD
EEEEEEECCCCCCCCCCCCHHCCCCCCCHHHHHHHCCCCCHHHCCCCCCCCEEEEEEECC
GGRLNIGACSLGGAQRCLDEAVAYTKERQQFDQPVADFQNTQFMLADMATDLEAARALLY
CCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCHHHHHCCCEEEEHHHHHHHHHHHHHHH
LAAAKVTENAPDKSRFSAMAKRLATDNGSKIVNDALQLFGGYGYLKDYPIERFWRDLRVH
HHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
SILEGTNQVMRMIVGRDLLRQG
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]