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The map label for this gene is merR [H]

Identifier: 85374821

GI number: 85374821

Start: 2024800

End: 2025195

Strand: Reverse

Name: merR [H]

Synonym: ELI_09970

Alternate gene names: 85374821

Gene position: 2025195-2024800 (Counterclockwise)

Preceding gene: 85374825

Following gene: 85374820

Centisome position: 66.35

GC content: 58.59

Gene sequence:

>396_bases
TTGGCTTTGAAAATTGGCGAAGTGGCGAAGCGGACCGGGTGTAACATCGAGACAATCCGGTATTACGAACGGATAGGCGT
TATCGATGCTCCGCCGAGAAGGGGCGCCTACCGCGACTATGGTCCTCACGACACGGAGCGCCTCCGCTTCATTCGGCGCG
CGCGCGAACTCGGATTTTCCCTCGAAGAGGTGCGGGCATTGCTTGACTTAACGCCAGGTCAGGAAGTGCGTTGCGATGAG
GTGCAATCGATCGCCGAACAGCACCTCGCAAACATCCGTGCGAAGCGGGCCGACCTTGAGCGTATGGAGAACGCTCTCGC
TAAACTGATCGAGCAATGTGGCACCACGAGCAATGATCGGTGCCCGGTATTGGAAAGCCTCGCGGGCGAAGGCTAG

Upstream 100 bases:

>100_bases
ATCCGTTCCACCATGTGCTGATGCCGCGCATCGATCGTCCTTTTGCAAACCTCGATTCGCACACCTATTTACAGTCTGTA
GCAACTACAGACTCAAGAGG

Downstream 100 bases:

>100_bases
CCCAGCGAATTCAAGCTACAGACCAACGGGTTTCCACCCAGCACTCAAAATTGGCGCAGCCTGCCGGATCAGAAAAGCAA
GCGGTCCGCTTTCGGGCACC

Product: heavy metal resistance transcriptional regulator Hmrr, MerR family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 131; Mature: 130

Protein sequence:

>131_residues
MALKIGEVAKRTGCNIETIRYYERIGVIDAPPRRGAYRDYGPHDTERLRFIRRARELGFSLEEVRALLDLTPGQEVRCDE
VQSIAEQHLANIRAKRADLERMENALAKLIEQCGTTSNDRCPVLESLAGEG

Sequences:

>Translated_131_residues
MALKIGEVAKRTGCNIETIRYYERIGVIDAPPRRGAYRDYGPHDTERLRFIRRARELGFSLEEVRALLDLTPGQEVRCDE
VQSIAEQHLANIRAKRADLERMENALAKLIEQCGTTSNDRCPVLESLAGEG
>Mature_130_residues
ALKIGEVAKRTGCNIETIRYYERIGVIDAPPRRGAYRDYGPHDTERLRFIRRARELGFSLEEVRALLDLTPGQEVRCDEV
QSIAEQHLANIRAKRADLERMENALAKLIEQCGTTSNDRCPVLESLAGEG

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=128, Percent_Identity=38.28125, Blast_Score=84, Evalue=2e-18,
Organism=Escherichia coli, GI1786695, Length=128, Percent_Identity=31.25, Blast_Score=69, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 14813; Mature: 14682

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALKIGEVAKRTGCNIETIRYYERIGVIDAPPRRGAYRDYGPHDTERLRFIRRARELGFS
CCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
LEEVRALLDLTPGQEVRCDEVQSIAEQHLANIRAKRADLERMENALAKLIEQCGTTSNDR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
CPVLESLAGEG
CHHHHHHCCCC
>Mature Secondary Structure 
ALKIGEVAKRTGCNIETIRYYERIGVIDAPPRRGAYRDYGPHDTERLRFIRRARELGFS
CCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
LEEVRALLDLTPGQEVRCDEVQSIAEQHLANIRAKRADLERMENALAKLIEQCGTTSNDR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
CPVLESLAGEG
CHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2666393 [H]