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The map label for this gene is acdA [H]

Identifier: 85374748

GI number: 85374748

Start: 1956525

End: 1957703

Strand: Reverse

Name: acdA [H]

Synonym: ELI_09605

Alternate gene names: 85374748

Gene position: 1957703-1956525 (Counterclockwise)

Preceding gene: 85374754

Following gene: 85374747

Centisome position: 64.14

GC content: 62.51

Gene sequence:

>1179_bases
ATGTCCGATCTAGAGAGCTTCCGCAGCGAGACCCGCGCCTGGCTGGAAGCCAATTGCCCCGCCGAGATGCGCGAGCCTGT
TCGCGACGATGCCGATGTCTATTGGGGCGGCCGCAACGCCACCTTCAAGAACGATGCGCAGAAAGCCTGGTTCGAGGCCT
GCCGCGACAAGGGCTACACTGTCCCCGCCTGGCCCAAGGAGTATGGCGGGGCAGGGCTATCGCCCGCAGAGGCCAAGGTG
CTGCGCGAGGAAATGGCTGCCATCGGCGCACGCCCGCCGCTTTCCAGCTTCGGCATCTGGATGCTCGGCCCGGCGCTGCT
GCATTTCGGCACCGAAGGTCAGAAGCAGCGTTTCCTGAACGAGATCGCACGCGGTGAAATCCGCTGGTGCCAGGGTTATT
CCGAACCGGGCAGCGGCTCCGACCTCGTCAGTCTGCAGACCTATGGCGAGGACAAGGACGATCACTGGGTCGTCAACGGC
CAGAAGGTCTGGACCTCCTATGCCGACAAGGCCGACTGGATCTTCTGCCTCGTTCGCACGGACAAGAACGACAAGTATCG
CGGCATCACCTTCATGCTGTTCGACATGGCCAGCGAAGGCGTTTCGACCAAGCCGATCCTGCTGATCAGCGGTTCGAGCC
CCTTCTGCGAGACGTTCTTCGATGATGTCTCGGTGCCCAAGAGCTATGGAGAGGATGTTCCGGCCTATGTCGGCGAAGTG
AACCGCGGCTGGGACGTCGCCAAGTACCTGCTTGGCCATGAGCGCGAAATGATCTCGGGTGCCGACGGCGGCAATACGGC
CACCATCGGCGCCGCGATGAGCCGCAATGCCGGCGAGCTCGATCCGATCATGCGCGCAGAGCTGGCGATGTTCGACGTGG
ATGCCTTGGCCTATGCCGCAATGGGCGAGAAATTCCTCGACGAGATCAAGGTTGGCAAAGCGCACCCGGCACAGCCCAAC
ATGATGAAATATGCCGGGACCGAGCTCAACAAGCGTCGCCACGAGCTGATCATGAGCGCGGGCGGTTCGACTGCGCTCGA
ATGGGAAAGCGAAGAGACCAGCGGCGGCAAGCCTGCGCGCAACTGGCTCCGCACCAAGGCCAACAGCATCGAGGGCGGCA
CCAGCGAAGTGATGCTCAACGTCATTTCGAAGCGGATTCTCGAGCTGCCGGGCGGCTAG

Upstream 100 bases:

>100_bases
GACGCTACGGCATGGCTACGGAACAACGTCGGCCTTGCAGGGGAACGCAGAATCCCCCTAACGTTAGCGTCAAGTTCGAG
ACTATGAGAGGAGTCGGAAC

Downstream 100 bases:

>100_bases
GACGAGAACAAGCGCGTCACCCCAGCGAAAGCTGGGGTCTCGTGCCGCTTGGTCGGGTTAGTAACGGCCAGATCCCAGCT
TGCGCTGGGATGACGACATA

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MSDLESFRSETRAWLEANCPAEMREPVRDDADVYWGGRNATFKNDAQKAWFEACRDKGYTVPAWPKEYGGAGLSPAEAKV
LREEMAAIGARPPLSSFGIWMLGPALLHFGTEGQKQRFLNEIARGEIRWCQGYSEPGSGSDLVSLQTYGEDKDDHWVVNG
QKVWTSYADKADWIFCLVRTDKNDKYRGITFMLFDMASEGVSTKPILLISGSSPFCETFFDDVSVPKSYGEDVPAYVGEV
NRGWDVAKYLLGHEREMISGADGGNTATIGAAMSRNAGELDPIMRAELAMFDVDALAYAAMGEKFLDEIKVGKAHPAQPN
MMKYAGTELNKRRHELIMSAGGSTALEWESEETSGGKPARNWLRTKANSIEGGTSEVMLNVISKRILELPGG

Sequences:

>Translated_392_residues
MSDLESFRSETRAWLEANCPAEMREPVRDDADVYWGGRNATFKNDAQKAWFEACRDKGYTVPAWPKEYGGAGLSPAEAKV
LREEMAAIGARPPLSSFGIWMLGPALLHFGTEGQKQRFLNEIARGEIRWCQGYSEPGSGSDLVSLQTYGEDKDDHWVVNG
QKVWTSYADKADWIFCLVRTDKNDKYRGITFMLFDMASEGVSTKPILLISGSSPFCETFFDDVSVPKSYGEDVPAYVGEV
NRGWDVAKYLLGHEREMISGADGGNTATIGAAMSRNAGELDPIMRAELAMFDVDALAYAAMGEKFLDEIKVGKAHPAQPN
MMKYAGTELNKRRHELIMSAGGSTALEWESEETSGGKPARNWLRTKANSIEGGTSEVMLNVISKRILELPGG
>Mature_391_residues
SDLESFRSETRAWLEANCPAEMREPVRDDADVYWGGRNATFKNDAQKAWFEACRDKGYTVPAWPKEYGGAGLSPAEAKVL
REEMAAIGARPPLSSFGIWMLGPALLHFGTEGQKQRFLNEIARGEIRWCQGYSEPGSGSDLVSLQTYGEDKDDHWVVNGQ
KVWTSYADKADWIFCLVRTDKNDKYRGITFMLFDMASEGVSTKPILLISGSSPFCETFFDDVSVPKSYGEDVPAYVGEVN
RGWDVAKYLLGHEREMISGADGGNTATIGAAMSRNAGELDPIMRAELAMFDVDALAYAAMGEKFLDEIKVGKAHPAQPNM
MKYAGTELNKRRHELIMSAGGSTALEWESEETSGGKPARNWLRTKANSIEGGTSEVMLNVISKRILELPGG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=229, Percent_Identity=29.2576419213974, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI226958414, Length=202, Percent_Identity=30.6930693069307, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI4557233, Length=344, Percent_Identity=26.1627906976744, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI4501859, Length=353, Percent_Identity=26.3456090651558, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI187960098, Length=170, Percent_Identity=28.2352941176471, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI4557231, Length=170, Percent_Identity=28.2352941176471, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI76496475, Length=269, Percent_Identity=27.8810408921933, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI4557235, Length=269, Percent_Identity=27.8810408921933, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI4501857, Length=334, Percent_Identity=23.3532934131737, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508101, Length=426, Percent_Identity=24.4131455399061, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17505929, Length=199, Percent_Identity=30.6532663316583, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17506239, Length=217, Percent_Identity=31.3364055299539, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI32563615, Length=217, Percent_Identity=31.3364055299539, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17551932, Length=185, Percent_Identity=31.3513513513514, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71990804, Length=232, Percent_Identity=28.448275862069, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17538396, Length=220, Percent_Identity=28.1818181818182, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17534899, Length=175, Percent_Identity=29.1428571428571, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17569725, Length=153, Percent_Identity=28.7581699346405, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71982178, Length=211, Percent_Identity=28.436018957346, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17570075, Length=213, Percent_Identity=25.8215962441315, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356377, Length=259, Percent_Identity=31.6602316602317, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24666513, Length=220, Percent_Identity=30, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21355753, Length=200, Percent_Identity=31.5, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646207, Length=166, Percent_Identity=31.9277108433735, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24660351, Length=170, Percent_Identity=30, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 43248; Mature: 43117

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLESFRSETRAWLEANCPAEMREPVRDDADVYWGGRNATFKNDAQKAWFEACRDKGYT
CCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCC
VPAWPKEYGGAGLSPAEAKVLREEMAAIGARPPLSSFGIWMLGPALLHFGTEGQKQRFLN
CCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHCCCCHHHHHHHH
EIARGEIRWCQGYSEPGSGSDLVSLQTYGEDKDDHWVVNGQKVWTSYADKADWIFCLVRT
HHHCCCEEECCCCCCCCCCCCEEEEEECCCCCCCEEEECCHHHHHHHCCCCCEEEEEEEE
DKNDKYRGITFMLFDMASEGVSTKPILLISGSSPFCETFFDDVSVPKSYGEDVPAYVGEV
CCCCCCCCEEEEEEEHHCCCCCCCCEEEEECCCCHHHHHHHHCCCCHHHCCCCCHHHHCC
NRGWDVAKYLLGHEREMISGADGGNTATIGAAMSRNAGELDPIMRAELAMFDVDALAYAA
CCCHHHHHHHHCCCHHHHCCCCCCCCEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
MGEKFLDEIKVGKAHPAQPNMMKYAGTELNKRRHELIMSAGGSTALEWESEETSGGKPAR
HHHHHHHHHHCCCCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHH
NWLRTKANSIEGGTSEVMLNVISKRILELPGG
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SDLESFRSETRAWLEANCPAEMREPVRDDADVYWGGRNATFKNDAQKAWFEACRDKGYT
CHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCC
VPAWPKEYGGAGLSPAEAKVLREEMAAIGARPPLSSFGIWMLGPALLHFGTEGQKQRFLN
CCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHCCCCHHHHHHHH
EIARGEIRWCQGYSEPGSGSDLVSLQTYGEDKDDHWVVNGQKVWTSYADKADWIFCLVRT
HHHCCCEEECCCCCCCCCCCCEEEEEECCCCCCCEEEECCHHHHHHHCCCCCEEEEEEEE
DKNDKYRGITFMLFDMASEGVSTKPILLISGSSPFCETFFDDVSVPKSYGEDVPAYVGEV
CCCCCCCCEEEEEEEHHCCCCCCCCEEEEECCCCHHHHHHHHCCCCHHHCCCCCHHHHCC
NRGWDVAKYLLGHEREMISGADGGNTATIGAAMSRNAGELDPIMRAELAMFDVDALAYAA
CCCHHHHHHHHCCCHHHHCCCCCCCCEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
MGEKFLDEIKVGKAHPAQPNMMKYAGTELNKRRHELIMSAGGSTALEWESEETSGGKPAR
HHHHHHHHHHCCCCCCCCCCHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHH
NWLRTKANSIEGGTSEVMLNVISKRILELPGG
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]