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The map label for this gene is murC [H]

Identifier: 85374297

GI number: 85374297

Start: 1527459

End: 1528889

Strand: Direct

Name: murC [H]

Synonym: ELI_07350

Alternate gene names: 85374297

Gene position: 1527459-1528889 (Clockwise)

Preceding gene: 85374291

Following gene: 85374299

Centisome position: 50.04

GC content: 65.48

Gene sequence:

>1431_bases
ATGACCGACCTTCCCGATCCGACCGAGCACCTCACTGCGCGCCCGTGGTTCTTCTGCGGTATCGGCGGATCCGGGATGCA
GCCGCTGGCAGCAATCCTCAAAGGGCGCGGAGCCGAAGTCGCGGGATCGGATCGCAGCTTCGACCAGGGCCGAACGCCTG
AGAAATTCGCCGCTCTAGAGCGGCAGGGCTTCGAGCTCTTCCCCCAAGACGGGAGTGGCATCACGCGCGAGGAGCAGGTG
CTGGTGGCGAGCGCGGCGGTCGAGGACAGCGTGCCCGAAGTCGTCCGCGCCAAGGAGCTCGGCCTTCCCCGCCTCACCCG
CGCCGATCTCAACGCAGCCCTGTTCAACTCCGCCGAGACAGGCGTCGCCATCGCCGGGACCAGCGGCAAATCCACCGTCA
CCGGGATGCTCGGCTGGATCCTGCACCACGCTGGCCGCGAGCCGACCATCATGAATGGCGCGGTGATGAAGAACTTCGTC
AGCGAAGGCCGCCCCTTCGCCAGCGCCGTGATAGGCGGCGTAGACCTTTATGTGTCCGAGGTAGACGAGAGCGACGGTTC
CATCGCGCTCTACCAGCCCAAAGTCGGCCTGCTGCTCAATGTCAGTCTCGATCACAAGAGCATGGAGGAGCTGCGCACGC
TGTTCGGCGACTATGTCGAAGCGTCGGACATCGCGGTGATCAATGCAGATGACGACGAGGCGATCCAGTTGGAAGGCCGC
GCCGACGATGCGATTACTTTCGCGATCTACGACAAGGGCGCGAGCATCGGGGTGGTGGATGGCAGCCGTGCCGATGGGCC
GGTCCGCCAGGCCGCGACCGTGATCGACCGGCGCGACGACAGCGAACATGCGCTGGTGCTGCACATGCCGGGGCGGCACA
ATCTATCCAATGCCTTGGCAGCAATCGCCGGTGCCAGCGCTGCGGGCGTGCAAGTCGCGGATGCCGTTGCGGCTTTGGCG
GAGTTCAAGGGCCTCGCTCGCCGCTTCGATATCATCGGCACCAGCGCCTCGGGCATTACCGTGATCGACGATTTCGGCCA
CAACCCGGAGAAATGCCGCGCCACTTTGCGCACGCTCAAGGCGCATCCGGGCCGCGTGCTCGCCTTCTTCCAGCCGCATG
GCTACGGCCCGCTGCGGCAGATGGGCGCTGAACTGGCGGAGACCTTTGCCTACGAACTCGACGCCGACGACATCACCCTG
CTGTGCGACCCGGTTTATTTCGGCGGAACCGTCGACCGCAGCCAAGGCAGCGAGCGGATCGTCGACCTGATCGCGCAGGC
GGGTGGACAGGCCATCCACATCAATACCCGCGAAGGCTGCGGCGACTGGCTTGTCGCCAATGCGCAGCCGGGCGACCGGA
TCGTGGTGATGGGCGCGCGTGACGACACGCTGACCGAATTTGCGTCGAGCATTCTCGCGCGACTGGACTAG

Upstream 100 bases:

>100_bases
AGGCGGGAATCCAGCTTTTATTCGACTGCTCCACAAAAGTAAGCTGGATCCCCGCCTGCGCGGGGATGACGAGAAAGCGA
ACTACCGCTAATCCGGGGCC

Downstream 100 bases:

>100_bases
ATTGCGGCCGCTCCGGCTTTCTCGCGCTCCACCGCCCGCATATACGCCTCCCGCGCCGTCAGGCGCTCGCGATAGGCCTT
GAGGTTCTCCGGAACGCCTT

Product: hypothetical protein

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MTDLPDPTEHLTARPWFFCGIGGSGMQPLAAILKGRGAEVAGSDRSFDQGRTPEKFAALERQGFELFPQDGSGITREEQV
LVASAAVEDSVPEVVRAKELGLPRLTRADLNAALFNSAETGVAIAGTSGKSTVTGMLGWILHHAGREPTIMNGAVMKNFV
SEGRPFASAVIGGVDLYVSEVDESDGSIALYQPKVGLLLNVSLDHKSMEELRTLFGDYVEASDIAVINADDDEAIQLEGR
ADDAITFAIYDKGASIGVVDGSRADGPVRQAATVIDRRDDSEHALVLHMPGRHNLSNALAAIAGASAAGVQVADAVAALA
EFKGLARRFDIIGTSASGITVIDDFGHNPEKCRATLRTLKAHPGRVLAFFQPHGYGPLRQMGAELAETFAYELDADDITL
LCDPVYFGGTVDRSQGSERIVDLIAQAGGQAIHINTREGCGDWLVANAQPGDRIVVMGARDDTLTEFASSILARLD

Sequences:

>Translated_476_residues
MTDLPDPTEHLTARPWFFCGIGGSGMQPLAAILKGRGAEVAGSDRSFDQGRTPEKFAALERQGFELFPQDGSGITREEQV
LVASAAVEDSVPEVVRAKELGLPRLTRADLNAALFNSAETGVAIAGTSGKSTVTGMLGWILHHAGREPTIMNGAVMKNFV
SEGRPFASAVIGGVDLYVSEVDESDGSIALYQPKVGLLLNVSLDHKSMEELRTLFGDYVEASDIAVINADDDEAIQLEGR
ADDAITFAIYDKGASIGVVDGSRADGPVRQAATVIDRRDDSEHALVLHMPGRHNLSNALAAIAGASAAGVQVADAVAALA
EFKGLARRFDIIGTSASGITVIDDFGHNPEKCRATLRTLKAHPGRVLAFFQPHGYGPLRQMGAELAETFAYELDADDITL
LCDPVYFGGTVDRSQGSERIVDLIAQAGGQAIHINTREGCGDWLVANAQPGDRIVVMGARDDTLTEFASSILARLD
>Mature_475_residues
TDLPDPTEHLTARPWFFCGIGGSGMQPLAAILKGRGAEVAGSDRSFDQGRTPEKFAALERQGFELFPQDGSGITREEQVL
VASAAVEDSVPEVVRAKELGLPRLTRADLNAALFNSAETGVAIAGTSGKSTVTGMLGWILHHAGREPTIMNGAVMKNFVS
EGRPFASAVIGGVDLYVSEVDESDGSIALYQPKVGLLLNVSLDHKSMEELRTLFGDYVEASDIAVINADDDEAIQLEGRA
DDAITFAIYDKGASIGVVDGSRADGPVRQAATVIDRRDDSEHALVLHMPGRHNLSNALAAIAGASAAGVQVADAVAALAE
FKGLARRFDIIGTSASGITVIDDFGHNPEKCRATLRTLKAHPGRVLAFFQPHGYGPLRQMGAELAETFAYELDADDITLL
CDPVYFGGTVDRSQGSERIVDLIAQAGGQAIHINTREGCGDWLVANAQPGDRIVVMGARDDTLTEFASSILARLD

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1790680, Length=459, Percent_Identity=28.1045751633987, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1786279, Length=336, Percent_Identity=33.0357142857143, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 50441; Mature: 50310

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLPDPTEHLTARPWFFCGIGGSGMQPLAAILKGRGAEVAGSDRSFDQGRTPEKFAALE
CCCCCCCHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHHH
RQGFELFPQDGSGITREEQVLVASAAVEDSVPEVVRAKELGLPRLTRADLNAALFNSAET
HCCCEECCCCCCCCCCHHHEEEEHHHHHCCHHHHHHHHHCCCCCCHHHHCHHHHHCCCCC
GVAIAGTSGKSTVTGMLGWILHHAGREPTIMNGAVMKNFVSEGRPFASAVIGGVDLYVSE
CEEEECCCCCHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHCCCCHHHHHHCCCEEEEEE
VDESDGSIALYQPKVGLLLNVSLDHKSMEELRTLFGDYVEASDIAVINADDDEAIQLEGR
CCCCCCCEEEECCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEECC
ADDAITFAIYDKGASIGVVDGSRADGPVRQAATVIDRRDDSEHALVLHMPGRHNLSNALA
CCCEEEEEEEECCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHH
AIAGASAAGVQVADAVAALAEFKGLARRFDIIGTSASGITVIDDFGHNPEKCRATLRTLK
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCHHHHHHHHHHHH
AHPGRVLAFFQPHGYGPLRQMGAELAETFAYELDADDITLLCDPVYFGGTVDRSQGSERI
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHEECCCCCEEEEECCEEECCCCCCCCCHHHH
VDLIAQAGGQAIHINTREGCGDWLVANAQPGDRIVVMGARDDTLTEFASSILARLD
HHHHHHCCCCEEEEECCCCCCCEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDLPDPTEHLTARPWFFCGIGGSGMQPLAAILKGRGAEVAGSDRSFDQGRTPEKFAALE
CCCCCCHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHHH
RQGFELFPQDGSGITREEQVLVASAAVEDSVPEVVRAKELGLPRLTRADLNAALFNSAET
HCCCEECCCCCCCCCCHHHEEEEHHHHHCCHHHHHHHHHCCCCCCHHHHCHHHHHCCCCC
GVAIAGTSGKSTVTGMLGWILHHAGREPTIMNGAVMKNFVSEGRPFASAVIGGVDLYVSE
CEEEECCCCCHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHCCCCHHHHHHCCCEEEEEE
VDESDGSIALYQPKVGLLLNVSLDHKSMEELRTLFGDYVEASDIAVINADDDEAIQLEGR
CCCCCCCEEEECCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEECC
ADDAITFAIYDKGASIGVVDGSRADGPVRQAATVIDRRDDSEHALVLHMPGRHNLSNALA
CCCEEEEEEEECCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHH
AIAGASAAGVQVADAVAALAEFKGLARRFDIIGTSASGITVIDDFGHNPEKCRATLRTLK
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCHHHHHHHHHHHH
AHPGRVLAFFQPHGYGPLRQMGAELAETFAYELDADDITLLCDPVYFGGTVDRSQGSERI
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHEECCCCCEEEEECCEEECCCCCCCCCHHHH
VDLIAQAGGQAIHINTREGCGDWLVANAQPGDRIVVMGARDDTLTEFASSILARLD
HHHHHHCCCCEEEEECCCCCCCEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA