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The map label for this gene is kefC [H]

Identifier: 85374059

GI number: 85374059

Start: 1275825

End: 1277678

Strand: Direct

Name: kefC [H]

Synonym: ELI_06160

Alternate gene names: 85374059

Gene position: 1275825-1277678 (Clockwise)

Preceding gene: 85374058

Following gene: 85374065

Centisome position: 41.8

GC content: 61.38

Gene sequence:

>1854_bases
ATGGGCGACTTCCTGATGTTGGCATTCAGCCTGCTCGTCGCAGGCGTGATCGCCGTGCCGCTGGCGACGCGGTTCGGGCT
GGGCACCGTCCTAGGCTATTTGCTCGCCGGCATGGCACTCAGCCCGCTGCTGGGCATTCTCGAAGTCAATGTCGAGCAGA
TGCAGCAGTTTGCCGAATTCGGCGTCGTCATGATGCTTTTCATCATCGGCCTCGAGCTGGAGCCTCGGCGTCTGTGGGAC
ATGCGCAGGCGGCTCATCGGGTTCGGAGGCGGGCAGGTCGTCATCACGACGGTCCTGCTGGCCGGGATTGCCTATTTCAG
CGGTAATGCATGGCAAACGGCGGTGGCGATCGGCATGATCCTCGCGCTTTCGTCGACAGCGATCGTGTTGCAGACGCTGG
AAGAAAAGAAGCTGATGCGCACGCAAGGTGGCGAAGCGAGCTTCTCCGTGTTGCTGGTCCAGGATGTTGCGGTCATTCCC
ATGCTGGCTCTATTGCCGTTGCTGGCGATACCGGAGCTGACCGGGGCCGGAGCACACGGCGGGGAGGGAGTCCACGGGCA
CGGCGGGCTCAATCTGCTGGCAGGCCTGCCGGCCTGGCTTGCGGGGCTGGCAACGGTTGGGGCGGTGGGGCTTGTCGTCT
TTATCGGCGTCTTTCTCACCCGACCGGTATTCCGGATGATCGCCGATCTGCGGCTGCGCGAGATGTTTACTGCCGCAGCC
CTCATGTTCGTCATCGGGATCGCCTTGTTGATGACGCTGGTCGGGCTCTCACCCGCCCTCGGCGCGTTTATCGCGGGCGT
GGTCTTAGCCAACAGCGAGTTCCGCCACGAGCTCGAAGCCGACATCAACCCCTTCAAGAGCCTGCTGCTCGGCTTGTTTT
TCATAACAGTGGGCGCGGGGATCGACTTTGCCCTCGTCTCCGAACGCTTCGGCGAAGTGCTGTTCTGGACCGCGCTCGTC
ATCGGCGCGAAAATGCTGGTGCTGTTTGGTATCGGCAAGGCGTTCCACCTGATGGGGCAGGATCGCTGGCTGTTCTCGCT
CGGGTTGGCGCAGGCCGGTGAGTTCGGCTTCGTGCTGATCGCTTTCGCGACGGGAAATGCCGTTTTGAGCAGAGAATTGG
CCGATTTGCTGCTGCTCGTCGTCGCCTTCTCGATGTTGGTCACGCCGCTGCTGTTTATATTCTACGAGAAAGTCATCGTG
CCGCGATATTCCGCAGGCGAAGAGCGCGAGGCGGACGCGATCGAGGAAAACAACAGTATTATCCTCGCCGGGCGCGGGCG
CATCGGTGGTATCATCGATCGCATGCTCGATGCCGCCGGCTACAAGACGACCGTTATCGACTACGATTCCCGGCACATCG
CCAACATGGAGAAGTTCGGCAACAAGGCCTATTTCGGCGATGCGACGCGGCCGGACTTGCTCGCTAGCGCAGGAATCGCG
CAGGCGAAGTTGCTGATCGTCGCGCTGGACGAAAAAGACCAGATCGACCGATTGGTTTCGCACGTCTTGGAGAATTATCC
AGATGTCCACGTGCTGGCCCGCGCGATCGACCGCGACCATGTGTTCAAGCTGTGGGCGCTGGGCTGCCGCGACATTATCC
GCGAAACCTATGACGGGGCCGTGCGTATGGGCCGCTCGGCATTCGAGGCTATGGGTCACGACCGGCAGGCGGCGCAGGCC
ATGGCCGATGCCTGGGAGGAAATGGACCGCAGTTCGATGATCGAAGTGGCGGACGTCTACAAGGTCGACGTGCCGGCATG
GGAGAACGACGAACTTATCGCGCGCGTGCGGAAGCTGCGCGAAGAGTGGGACCCCAAACTCAGCGATCAGATGGACCAGA
TCATGAAGCGTTAA

Upstream 100 bases:

>100_bases
CAAGAGTAAGGATGCCGCCGGCAGCGTCGTCAATCCCGGCCCCAAAAACAGCGACGCTTCCGACGATTGACCAAAGCCCG
TGAGCCGCTAAGCCGGATTC

Downstream 100 bases:

>100_bases
AGACGCGCTGTGGCGGACAGGGTATTTCCAACCGAGTTCCCCCAGGAAGCCGCGCTTGCCTTGAAACAGACCGCGATCAA
GTCGCTCACTCCCACGCATG

Product: TrkA family protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 617; Mature: 616

Protein sequence:

>617_residues
MGDFLMLAFSLLVAGVIAVPLATRFGLGTVLGYLLAGMALSPLLGILEVNVEQMQQFAEFGVVMMLFIIGLELEPRRLWD
MRRRLIGFGGGQVVITTVLLAGIAYFSGNAWQTAVAIGMILALSSTAIVLQTLEEKKLMRTQGGEASFSVLLVQDVAVIP
MLALLPLLAIPELTGAGAHGGEGVHGHGGLNLLAGLPAWLAGLATVGAVGLVVFIGVFLTRPVFRMIADLRLREMFTAAA
LMFVIGIALLMTLVGLSPALGAFIAGVVLANSEFRHELEADINPFKSLLLGLFFITVGAGIDFALVSERFGEVLFWTALV
IGAKMLVLFGIGKAFHLMGQDRWLFSLGLAQAGEFGFVLIAFATGNAVLSRELADLLLLVVAFSMLVTPLLFIFYEKVIV
PRYSAGEEREADAIEENNSIILAGRGRIGGIIDRMLDAAGYKTTVIDYDSRHIANMEKFGNKAYFGDATRPDLLASAGIA
QAKLLIVALDEKDQIDRLVSHVLENYPDVHVLARAIDRDHVFKLWALGCRDIIRETYDGAVRMGRSAFEAMGHDRQAAQA
MADAWEEMDRSSMIEVADVYKVDVPAWENDELIARVRKLREEWDPKLSDQMDQIMKR

Sequences:

>Translated_617_residues
MGDFLMLAFSLLVAGVIAVPLATRFGLGTVLGYLLAGMALSPLLGILEVNVEQMQQFAEFGVVMMLFIIGLELEPRRLWD
MRRRLIGFGGGQVVITTVLLAGIAYFSGNAWQTAVAIGMILALSSTAIVLQTLEEKKLMRTQGGEASFSVLLVQDVAVIP
MLALLPLLAIPELTGAGAHGGEGVHGHGGLNLLAGLPAWLAGLATVGAVGLVVFIGVFLTRPVFRMIADLRLREMFTAAA
LMFVIGIALLMTLVGLSPALGAFIAGVVLANSEFRHELEADINPFKSLLLGLFFITVGAGIDFALVSERFGEVLFWTALV
IGAKMLVLFGIGKAFHLMGQDRWLFSLGLAQAGEFGFVLIAFATGNAVLSRELADLLLLVVAFSMLVTPLLFIFYEKVIV
PRYSAGEEREADAIEENNSIILAGRGRIGGIIDRMLDAAGYKTTVIDYDSRHIANMEKFGNKAYFGDATRPDLLASAGIA
QAKLLIVALDEKDQIDRLVSHVLENYPDVHVLARAIDRDHVFKLWALGCRDIIRETYDGAVRMGRSAFEAMGHDRQAAQA
MADAWEEMDRSSMIEVADVYKVDVPAWENDELIARVRKLREEWDPKLSDQMDQIMKR
>Mature_616_residues
GDFLMLAFSLLVAGVIAVPLATRFGLGTVLGYLLAGMALSPLLGILEVNVEQMQQFAEFGVVMMLFIIGLELEPRRLWDM
RRRLIGFGGGQVVITTVLLAGIAYFSGNAWQTAVAIGMILALSSTAIVLQTLEEKKLMRTQGGEASFSVLLVQDVAVIPM
LALLPLLAIPELTGAGAHGGEGVHGHGGLNLLAGLPAWLAGLATVGAVGLVVFIGVFLTRPVFRMIADLRLREMFTAAAL
MFVIGIALLMTLVGLSPALGAFIAGVVLANSEFRHELEADINPFKSLLLGLFFITVGAGIDFALVSERFGEVLFWTALVI
GAKMLVLFGIGKAFHLMGQDRWLFSLGLAQAGEFGFVLIAFATGNAVLSRELADLLLLVVAFSMLVTPLLFIFYEKVIVP
RYSAGEEREADAIEENNSIILAGRGRIGGIIDRMLDAAGYKTTVIDYDSRHIANMEKFGNKAYFGDATRPDLLASAGIAQ
AKLLIVALDEKDQIDRLVSHVLENYPDVHVLARAIDRDHVFKLWALGCRDIIRETYDGAVRMGRSAFEAMGHDRQAAQAM
ADAWEEMDRSSMIEVADVYKVDVPAWENDELIARVRKLREEWDPKLSDQMDQIMKR

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=406, Percent_Identity=27.3399014778325, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1786232, Length=588, Percent_Identity=42.5170068027211, Blast_Score=400, Evalue=1e-112,
Organism=Escherichia coli, GI1789749, Length=615, Percent_Identity=38.5365853658537, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1786685, Length=522, Percent_Identity=26.2452107279693, Blast_Score=150, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 67143; Mature: 67012

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDFLMLAFSLLVAGVIAVPLATRFGLGTVLGYLLAGMALSPLLGILEVNVEQMQQFAEF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
GVVMMLFIIGLELEPRRLWDMRRRLIGFGGGQVVITTVLLAGIAYFSGNAWQTAVAIGMI
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LALSSTAIVLQTLEEKKLMRTQGGEASFSVLLVQDVAVIPMLALLPLLAIPELTGAGAHG
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GEGVHGHGGLNLLAGLPAWLAGLATVGAVGLVVFIGVFLTRPVFRMIADLRLREMFTAAA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMFVIGIALLMTLVGLSPALGAFIAGVVLANSEFRHELEADINPFKSLLLGLFFITVGAG
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
IDFALVSERFGEVLFWTALVIGAKMLVLFGIGKAFHLMGQDRWLFSLGLAQAGEFGFVLI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHCCCCCCEEEE
AFATGNAVLSRELADLLLLVVAFSMLVTPLLFIFYEKVIVPRYSAGEEREADAIEENNSI
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCE
ILAGRGRIGGIIDRMLDAAGYKTTVIDYDSRHIANMEKFGNKAYFGDATRPDLLASAGIA
EEEECCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCCHHHHHCCCH
QAKLLIVALDEKDQIDRLVSHVLENYPDVHVLARAIDRDHVFKLWALGCRDIIRETYDGA
HEEEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
VRMGRSAFEAMGHDRQAAQAMADAWEEMDRSSMIEVADVYKVDVPAWENDELIARVRKLR
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHH
EEWDPKLSDQMDQIMKR
HHHCCCHHHHHHHHHCC
>Mature Secondary Structure 
GDFLMLAFSLLVAGVIAVPLATRFGLGTVLGYLLAGMALSPLLGILEVNVEQMQQFAEF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
GVVMMLFIIGLELEPRRLWDMRRRLIGFGGGQVVITTVLLAGIAYFSGNAWQTAVAIGMI
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LALSSTAIVLQTLEEKKLMRTQGGEASFSVLLVQDVAVIPMLALLPLLAIPELTGAGAHG
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GEGVHGHGGLNLLAGLPAWLAGLATVGAVGLVVFIGVFLTRPVFRMIADLRLREMFTAAA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMFVIGIALLMTLVGLSPALGAFIAGVVLANSEFRHELEADINPFKSLLLGLFFITVGAG
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
IDFALVSERFGEVLFWTALVIGAKMLVLFGIGKAFHLMGQDRWLFSLGLAQAGEFGFVLI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHCCCCCCEEEE
AFATGNAVLSRELADLLLLVVAFSMLVTPLLFIFYEKVIVPRYSAGEEREADAIEENNSI
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCE
ILAGRGRIGGIIDRMLDAAGYKTTVIDYDSRHIANMEKFGNKAYFGDATRPDLLASAGIA
EEEECCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCCHHHHHCCCH
QAKLLIVALDEKDQIDRLVSHVLENYPDVHVLARAIDRDHVFKLWALGCRDIIRETYDGA
HEEEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
VRMGRSAFEAMGHDRQAAQAMADAWEEMDRSSMIEVADVYKVDVPAWENDELIARVRKLR
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHH
EEWDPKLSDQMDQIMKR
HHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA