Click here to switch to the map view.

The map label for this gene is folP-A [H]

Identifier: 85373288

GI number: 85373288

Start: 501668

End: 502792

Strand: Direct

Name: folP-A [H]

Synonym: ELI_02305

Alternate gene names: 85373288

Gene position: 501668-502792 (Clockwise)

Preceding gene: 85373286

Following gene: 85373289

Centisome position: 16.44

GC content: 68.09

Gene sequence:

>1125_bases
ATGACCGAGACCGTCTACATCCGCCCCATCGGCTTTGTGCCGGGTCCGCAGGCGGAGGAGGGGGATGCGATCCGGTTGGC
GGGGAGCATGGTCTATGCGCATCGCTTTGCGGTGATCCTGCGCCGGGATGGCCAAGTGGCGGAGCGTTGGACCTGCTCGC
CCGAGCATATCGCGCAGGTGCTGGGCGAGCTGCCCGACAGCGTCGGGGCGGAGGCGGAGACGCAGTGGGCCAATCTCACC
ATCACGCATCCGCCGCTGTCGCTGGGCGAGCGCACGGTGCGGCTCGACCAGCCGCAGGTGATGGGCATCCTCAATGTCAC
GCCCGACAGTTTTTCCGACGGCGGCAAGTTCCTCGGTGCTGATGGTTCTTGGCCCGAAGCCGGCAAGGCGCAGGCTGCGG
CGATGCTGGAGGCGGGCGCGTCGATCATCGACATCGGCGGCGAGAGCACGCGGCCCGGTGCCGAGGTGGTGATCGAAGAC
CACGAGATCGAACGCGTGCTGCCCGCAGTCGAATATTGCGCCGCGATGGGCGCGGCGATCAGCGTGGACACCCGCCGCGC
CGGGGTGATGGCGGCGGCGCTCGATGCGGGGGCGAGCATCGTCAACGATGTTTCGGGCCTGCAATATGATCCGCGCAGCG
CCGAACTGGTCGCCGCACGCGGGTGCCCGGTGATCCTGATGCATGCGCCGGGAAGCGGGCAGGACCTGCATGAAGGCGGG
GACTACGAAAGCGTAGTGTTCGACGTGTTCGACCAGCTCAAGGCGCGGCGCGATACGGCGGTGGCGGCGGGGATTTCGGC
GGATAGGATCATGCTCGATCCCGGGCTGGGCTTCGGCAAGAAGCTGTCGGACAACACCGCGCTGATCAACGCGCTGCCGC
TGTTCCACGCACTCGGCCACCCGATCCTGCTCGGCGCGAGCCGCAAGAGGATGATCGGGGCGCTGAGCAACGAAGCGCCG
GTCGAGCAGCGGCTTGGCGGTTCTATCGCGCTGGCGGTGGCGGGGATGGATGCCGGGGCGCATATGCTGCGGGTCCACGA
TGTCGCGGAGACGGTGCAGGCGCGCAATGTGTGGCGCGGCCTGCGGGATGCGGCGCTGACCGACTTTAGCGACCTGGCGA
TGTGA

Upstream 100 bases:

>100_bases
TCCGCACGCCGAAAGGCGAAATGCACCCTCCAGCTTTTTTGCTTCAGGACCGTGTTCCATGTGTTCCATCCTGTTGGATT
GCGCGAGGTAAGCCTTCGAT

Downstream 100 bases:

>100_bases
TGATGAAATCTCCGAACACCCGATGCCGTTCGTGCTGAGCTTGTCGAAGCACTGTCCTTCTTCTGGCAAGCGCGGCACCA
GAAGAAAGTACGGCCCTTCG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MTETVYIRPIGFVPGPQAEEGDAIRLAGSMVYAHRFAVILRRDGQVAERWTCSPEHIAQVLGELPDSVGAEAETQWANLT
ITHPPLSLGERTVRLDQPQVMGILNVTPDSFSDGGKFLGADGSWPEAGKAQAAAMLEAGASIIDIGGESTRPGAEVVIED
HEIERVLPAVEYCAAMGAAISVDTRRAGVMAAALDAGASIVNDVSGLQYDPRSAELVAARGCPVILMHAPGSGQDLHEGG
DYESVVFDVFDQLKARRDTAVAAGISADRIMLDPGLGFGKKLSDNTALINALPLFHALGHPILLGASRKRMIGALSNEAP
VEQRLGGSIALAVAGMDAGAHMLRVHDVAETVQARNVWRGLRDAALTDFSDLAM

Sequences:

>Translated_374_residues
MTETVYIRPIGFVPGPQAEEGDAIRLAGSMVYAHRFAVILRRDGQVAERWTCSPEHIAQVLGELPDSVGAEAETQWANLT
ITHPPLSLGERTVRLDQPQVMGILNVTPDSFSDGGKFLGADGSWPEAGKAQAAAMLEAGASIIDIGGESTRPGAEVVIED
HEIERVLPAVEYCAAMGAAISVDTRRAGVMAAALDAGASIVNDVSGLQYDPRSAELVAARGCPVILMHAPGSGQDLHEGG
DYESVVFDVFDQLKARRDTAVAAGISADRIMLDPGLGFGKKLSDNTALINALPLFHALGHPILLGASRKRMIGALSNEAP
VEQRLGGSIALAVAGMDAGAHMLRVHDVAETVQARNVWRGLRDAALTDFSDLAM
>Mature_373_residues
TETVYIRPIGFVPGPQAEEGDAIRLAGSMVYAHRFAVILRRDGQVAERWTCSPEHIAQVLGELPDSVGAEAETQWANLTI
THPPLSLGERTVRLDQPQVMGILNVTPDSFSDGGKFLGADGSWPEAGKAQAAAMLEAGASIIDIGGESTRPGAEVVIEDH
EIERVLPAVEYCAAMGAAISVDTRRAGVMAAALDAGASIVNDVSGLQYDPRSAELVAARGCPVILMHAPGSGQDLHEGGD
YESVVFDVFDQLKARRDTAVAAGISADRIMLDPGLGFGKKLSDNTALINALPLFHALGHPILLGASRKRMIGALSNEAPV
EQRLGGSIALAVAGMDAGAHMLRVHDVAETVQARNVWRGLRDAALTDFSDLAM

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=267, Percent_Identity=46.0674157303371, Blast_Score=205, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6324073, Length=319, Percent_Identity=27.2727272727273, Blast_Score=117, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 39396; Mature: 39265

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETVYIRPIGFVPGPQAEEGDAIRLAGSMVYAHRFAVILRRDGQVAERWTCSPEHIAQV
CCCEEEEEEECCCCCCCCCCCCEEEEHHHHHHHHHEEEEEECCCCHHHHCCCCHHHHHHH
LGELPDSVGAEAETQWANLTITHPPLSLGERTVRLDQPQVMGILNVTPDSFSDGGKFLGA
HHHCCHHCCCCCCCCEEEEEEECCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCEECC
DGSWPEAGKAQAAAMLEAGASIIDIGGESTRPGAEVVIEDHEIERVLPAVEYCAAMGAAI
CCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCEE
SVDTRRAGVMAAALDAGASIVNDVSGLQYDPRSAELVAARGCPVILMHAPGSGQDLHEGG
EECCHHHHHHHHHHHHCHHHHHHHHCCEECCCCCEEEEECCCCEEEEECCCCCCCCCCCC
DYESVVFDVFDQLKARRDTAVAAGISADRIMLDPGLGFGKKLSDNTALINALPLFHALGH
CHHHHHHHHHHHHHHHHHHHHEECCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCC
PILLGASRKRMIGALSNEAPVEQRLGGSIALAVAGMDAGAHMLRVHDVAETVQARNVWRG
CEEECCCHHHHHHHCCCCCCHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
LRDAALTDFSDLAM
HHHHHHCCHHHHCC
>Mature Secondary Structure 
TETVYIRPIGFVPGPQAEEGDAIRLAGSMVYAHRFAVILRRDGQVAERWTCSPEHIAQV
CCEEEEEEECCCCCCCCCCCCEEEEHHHHHHHHHEEEEEECCCCHHHHCCCCHHHHHHH
LGELPDSVGAEAETQWANLTITHPPLSLGERTVRLDQPQVMGILNVTPDSFSDGGKFLGA
HHHCCHHCCCCCCCCEEEEEEECCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCEECC
DGSWPEAGKAQAAAMLEAGASIIDIGGESTRPGAEVVIEDHEIERVLPAVEYCAAMGAAI
CCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCEE
SVDTRRAGVMAAALDAGASIVNDVSGLQYDPRSAELVAARGCPVILMHAPGSGQDLHEGG
EECCHHHHHHHHHHHHCHHHHHHHHCCEECCCCCEEEEECCCCEEEEECCCCCCCCCCCC
DYESVVFDVFDQLKARRDTAVAAGISADRIMLDPGLGFGKKLSDNTALINALPLFHALGH
CHHHHHHHHHHHHHHHHHHHHEECCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCC
PILLGASRKRMIGALSNEAPVEQRLGGSIALAVAGMDAGAHMLRVHDVAETVQARNVWRG
CEEECCCHHHHHHHCCCCCCHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
LRDAALTDFSDLAM
HHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]