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The map label for this gene is nhaA2

Identifier: 85373284

GI number: 85373284

Start: 496215

End: 497423

Strand: Direct

Name: nhaA2

Synonym: ELI_02285

Alternate gene names: 85373284

Gene position: 496215-497423 (Clockwise)

Preceding gene: 85373282

Following gene: 85373285

Centisome position: 16.26

GC content: 64.02

Gene sequence:

>1209_bases
ATGTTTTACACCGCCGCTACGGCCCTGCGCGACTTCTTGAAACAGGAGAGCGCCGGGGGCATCGTGTTGATGTTTGCGGC
TGTGCTGGCGTTGATCTTCGCCAATACTGCGCTGGCCGATACCTACTTCTCGGTGCTGGCGACCGAGATCGCGGTGACAG
TCGGCGGCGGCGGCATCGAGAAGCCTGCGCTGTTGTGGATCAACGATGGTCTGATGGCGGTCTTTTTCTTTCTCGTCGGA
CTGGAAGTGAAGCGCGAAGTGCTGACGGGCCAGCTGTCGAGCTGGAAGCAGGCCTCGTTGCCGCTGATCGCGGCGTTCGG
CGGCATCGTGCTGCCCGCGCTGGTGTTCTACGGTATCAATTCGGGCACTCCGGAAAATCTCTCCGGCTGGGCGATCCCGG
CGGCGACCGATATCGCCTTCGCGCTGGGCATACTGGCGCTTCTCGGCAAGCGCGTGCCGGTCGCGCTCAAGGCGCTGTTG
CTCGCCATCGCGGTGATCGACGACATCGCCGCCATCGCCATCATCGCGATCTTTTACACGCCGGGTGTCGAGCTCGCGAT
GTTGGGGGCTGCGGCAATCACGCTATTGATCCTGAGCGCCTTCGGGCGGGCCAAGGCCGGCTCCAGCATCCCCTATATCG
TGCTTGGGATCGTGCTGTGGTACTTCGTCCTCAAGTCGGGCGTCCATGCCACCTTGGCCGGTGTCGCGCTGGCGATGACG
GTCCCGCTGATCGATCGCAAGGGCAACCACATGCTCGAACATATGGAGCATGCGCTGCACAGCTGGGTCGCCTTCCTGGT
CGTGCCGATCTTCGCGCTCGCCAACGCCGGGGTCTCGTTCGAAGGCGTGGAACTGTCCGCCCTGTTCGCACCGTTGCCGC
TTGGCATCGCGCTCGGCCTAATCGTCGGCAAGCAGGTCGGTATCTTCGGCTTTGCCTGGCTCGCGGTCAAAACGGGCTTC
GCGCAGCTACCGTCCAGCGTCGGCTGGTTACAGGTCTGGGGCCTGTCGCTGGTCGCCGGTATCGGCTTCACCATGAGCCT
GTTCATCGGCAACCTCGCCTTCGCCGATCCGGCGCAGATCAATGCCGTCAAGATCGGCGTGCTGTCGGGCTCGCTCATCG
CCGCGCTGGTCGGTATCGCGATCCTCGTCCTCGGCGCGAAGGCGCCTGCCGCGAAGTCGGCTGACGAGCGGGTGCAAGCT
CCGGCATGA

Upstream 100 bases:

>100_bases
ACCCTTCCCATCCCCCCCCCCTCGTTCGCGTGCCGCCCCCTTTTTCGCTATGCGCGCGTTAACGCACTGACCGATCTCCT
GAGAAAGACGGAGCAACCCG

Downstream 100 bases:

>100_bases
CCACAGCAATACTGGCAATCATCGGCGGGCTCATCGCGCTCGCCATCGGCGGCGAGTTGCTGGTGCGCGGCGCGGTCGCG
CTGGCGCGGCGGCTCGGCAT

Product: putative Na+/H+ antiporter protein

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA 2

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MFYTAATALRDFLKQESAGGIVLMFAAVLALIFANTALADTYFSVLATEIAVTVGGGGIEKPALLWINDGLMAVFFFLVG
LEVKREVLTGQLSSWKQASLPLIAAFGGIVLPALVFYGINSGTPENLSGWAIPAATDIAFALGILALLGKRVPVALKALL
LAIAVIDDIAAIAIIAIFYTPGVELAMLGAAAITLLILSAFGRAKAGSSIPYIVLGIVLWYFVLKSGVHATLAGVALAMT
VPLIDRKGNHMLEHMEHALHSWVAFLVVPIFALANAGVSFEGVELSALFAPLPLGIALGLIVGKQVGIFGFAWLAVKTGF
AQLPSSVGWLQVWGLSLVAGIGFTMSLFIGNLAFADPAQINAVKIGVLSGSLIAALVGIAILVLGAKAPAAKSADERVQA
PA

Sequences:

>Translated_402_residues
MFYTAATALRDFLKQESAGGIVLMFAAVLALIFANTALADTYFSVLATEIAVTVGGGGIEKPALLWINDGLMAVFFFLVG
LEVKREVLTGQLSSWKQASLPLIAAFGGIVLPALVFYGINSGTPENLSGWAIPAATDIAFALGILALLGKRVPVALKALL
LAIAVIDDIAAIAIIAIFYTPGVELAMLGAAAITLLILSAFGRAKAGSSIPYIVLGIVLWYFVLKSGVHATLAGVALAMT
VPLIDRKGNHMLEHMEHALHSWVAFLVVPIFALANAGVSFEGVELSALFAPLPLGIALGLIVGKQVGIFGFAWLAVKTGF
AQLPSSVGWLQVWGLSLVAGIGFTMSLFIGNLAFADPAQINAVKIGVLSGSLIAALVGIAILVLGAKAPAAKSADERVQA
PA
>Mature_402_residues
MFYTAATALRDFLKQESAGGIVLMFAAVLALIFANTALADTYFSVLATEIAVTVGGGGIEKPALLWINDGLMAVFFFLVG
LEVKREVLTGQLSSWKQASLPLIAAFGGIVLPALVFYGINSGTPENLSGWAIPAATDIAFALGILALLGKRVPVALKALL
LAIAVIDDIAAIAIIAIFYTPGVELAMLGAAAITLLILSAFGRAKAGSSIPYIVLGIVLWYFVLKSGVHATLAGVALAMT
VPLIDRKGNHMLEHMEHALHSWVAFLVVPIFALANAGVSFEGVELSALFAPLPLGIALGLIVGKQVGIFGFAWLAVKTGF
AQLPSSVGWLQVWGLSLVAGIGFTMSLFIGNLAFADPAQINAVKIGVLSGSLIAALVGIAILVLGAKAPAAKSADERVQA
PA

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=373, Percent_Identity=50.9383378016086, Blast_Score=327, Evalue=6e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA2_ERYLH (Q2NCP2)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_457346.1
- ProteinModelPortal:   Q2NCP2
- SMR:   Q2NCP2
- STRING:   Q2NCP2
- GeneID:   3869119
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_02285
- NMPDR:   fig|314225.3.peg.2630
- eggNOG:   COG3004
- HOGENOM:   HBG665619
- OMA:   YFALRDL
- PhylomeDB:   Q2NCP2
- BioCyc:   ELIT314225:ELI_02285-MONOMER
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 41570; Mature: 41570

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x134ebc0c)-; HASH(0x1398fabc)-; HASH(0x12fc1680)-; HASH(0x1398ecb8)-; HASH(0x13992f3c)-; HASH(0x1398eec8)-; HASH(0x1399146c)-; HASH(0x139913f4)-; HASH(0x1398fc6c)-; HASH(0x13986bf4)-; HASH(0x1398e1cc)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYTAATALRDFLKQESAGGIVLMFAAVLALIFANTALADTYFSVLATEIAVTVGGGGIE
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
KPALLWINDGLMAVFFFLVGLEVKREVLTGQLSSWKQASLPLIAAFGGIVLPALVFYGIN
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHHHHHCCC
SGTPENLSGWAIPAATDIAFALGILALLGKRVPVALKALLLAIAVIDDIAAIAIIAIFYT
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PGVELAMLGAAAITLLILSAFGRAKAGSSIPYIVLGIVLWYFVLKSGVHATLAGVALAMT
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VPLIDRKGNHMLEHMEHALHSWVAFLVVPIFALANAGVSFEGVELSALFAPLPLGIALGL
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
IVGKQVGIFGFAWLAVKTGFAQLPSSVGWLQVWGLSLVAGIGFTMSLFIGNLAFADPAQI
HHHCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
NAVKIGVLSGSLIAALVGIAILVLGAKAPAAKSADERVQAPA
CEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCH
>Mature Secondary Structure
MFYTAATALRDFLKQESAGGIVLMFAAVLALIFANTALADTYFSVLATEIAVTVGGGGIE
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
KPALLWINDGLMAVFFFLVGLEVKREVLTGQLSSWKQASLPLIAAFGGIVLPALVFYGIN
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHHHHHCCC
SGTPENLSGWAIPAATDIAFALGILALLGKRVPVALKALLLAIAVIDDIAAIAIIAIFYT
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PGVELAMLGAAAITLLILSAFGRAKAGSSIPYIVLGIVLWYFVLKSGVHATLAGVALAMT
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VPLIDRKGNHMLEHMEHALHSWVAFLVVPIFALANAGVSFEGVELSALFAPLPLGIALGL
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
IVGKQVGIFGFAWLAVKTGFAQLPSSVGWLQVWGLSLVAGIGFTMSLFIGNLAFADPAQI
HHHCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
NAVKIGVLSGSLIAALVGIAILVLGAKAPAAKSADERVQAPA
CEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA