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The map label for this gene is fabG [C]

Identifier: 85373282

GI number: 85373282

Start: 493958

End: 494887

Strand: Direct

Name: fabG [C]

Synonym: ELI_02275

Alternate gene names: 85373282

Gene position: 493958-494887 (Clockwise)

Preceding gene: 85373281

Following gene: 85373284

Centisome position: 16.18

GC content: 62.9

Gene sequence:

>930_bases
ATGAGCGCTTTCGCCTATTCCGACATTCCCGACCAGTCCGGCAAGACCGCCATCGTAACCGGTGCCAATACCGGATTGGG
CTATTGTATCGCCGAAGCGCTGGCCCGCAGCAAAGCCAAGGTGCTGCTCGCCTGTCGCAGCGAAGACAAGGCGCGCGAAG
CGATGGATCGCATCGCCGAAGCCGTGCTGGGTGCGGACACCGAATTTCTCGAACTCGATCTGCAGGACATGGACTCGATC
CGTGGCGCGGCAAAAGCAGCGCAAAGTCAAGCGCGGCTCGATATTCTCGTCAACAATGCCGGCATCATGGTCCCGCCCTT
GAAGCTGGCGATGGGCGTCGAATCGCAATTTGCCACCAACCACTTGGGCCATTTCGCCCTGACGGGTCTGTTGCTCGACA
AGCTGGCGCAAAATGGCGGTGCCCGGATCGTCAATCAGTCCAGCATCGCGCATCGCGGCGCGAAGATCGGTTTCGACAAT
CTCGACGGGGCCAAAGGATATTCGCGCCAGCGCTTCTACGGACAGAGCAAGCTTGCCAACCTGCTCTTTACCTTCGAACT
CGACCGGCGTTTGCGGGCGGCGCAATCGCCGGTTTCGGCCTATGCCGCACACCCCGGTATCGCCGAGACCGAGCTCATGC
GCCATCTCGGCCCGCTGGCGTTGATGGGCAAAGTCGTCGGTGTGTTTCTCAACAGCGCCAAGGACGGAGCCTTGCCCGCG
CTTCAGGCAGCGACATGGCCCGATGCCGAGCCGGGCGGCTATTACGGGCCCTACGGCCTCGGCGAGATCAGTGGTCCGCG
ATCCGGGCGGGCGATCGCCAGCCGCACCGCGCGCGATCCCCTGCTGGCTGCGCGTTTGTGGGAGATTTCGGTCGAATTGA
CCGGGGTAGACCCCGGCCTCCCGGCCGACGACGTCGAGCAGGATATTTGA

Upstream 100 bases:

>100_bases
GTTACGGAACCGCGCAGCACCTCGAAGCGCTAAGACTGCATGGACCGACGCCGCTGCACCGCCGCAGCTTTGCGCCGGTC
GCGCAGCAGGAGCTATTTCG

Downstream 100 bases:

>100_bases
GCGCTACGCTACACAGGCGTCGGTCAGGCCAGAAGCCTGCGCGCATGATCCGCGATGAGCTGTGCGATCTCGGCATAGGT
CTCGCTTAACGCCGTGCGCT

Product: putative oxidoreductase protein

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MSAFAYSDIPDQSGKTAIVTGANTGLGYCIAEALARSKAKVLLACRSEDKAREAMDRIAEAVLGADTEFLELDLQDMDSI
RGAAKAAQSQARLDILVNNAGIMVPPLKLAMGVESQFATNHLGHFALTGLLLDKLAQNGGARIVNQSSIAHRGAKIGFDN
LDGAKGYSRQRFYGQSKLANLLFTFELDRRLRAAQSPVSAYAAHPGIAETELMRHLGPLALMGKVVGVFLNSAKDGALPA
LQAATWPDAEPGGYYGPYGLGEISGPRSGRAIASRTARDPLLAARLWEISVELTGVDPGLPADDVEQDI

Sequences:

>Translated_309_residues
MSAFAYSDIPDQSGKTAIVTGANTGLGYCIAEALARSKAKVLLACRSEDKAREAMDRIAEAVLGADTEFLELDLQDMDSI
RGAAKAAQSQARLDILVNNAGIMVPPLKLAMGVESQFATNHLGHFALTGLLLDKLAQNGGARIVNQSSIAHRGAKIGFDN
LDGAKGYSRQRFYGQSKLANLLFTFELDRRLRAAQSPVSAYAAHPGIAETELMRHLGPLALMGKVVGVFLNSAKDGALPA
LQAATWPDAEPGGYYGPYGLGEISGPRSGRAIASRTARDPLLAARLWEISVELTGVDPGLPADDVEQDI
>Mature_308_residues
SAFAYSDIPDQSGKTAIVTGANTGLGYCIAEALARSKAKVLLACRSEDKAREAMDRIAEAVLGADTEFLELDLQDMDSIR
GAAKAAQSQARLDILVNNAGIMVPPLKLAMGVESQFATNHLGHFALTGLLLDKLAQNGGARIVNQSSIAHRGAKIGFDNL
DGAKGYSRQRFYGQSKLANLLFTFELDRRLRAAQSPVSAYAAHPGIAETELMRHLGPLALMGKVVGVFLNSAKDGALPAL
QAATWPDAEPGGYYGPYGLGEISGPRSGRAIASRTARDPLLAARLWEISVELTGVDPGLPADDVEQDI

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI186928839, Length=287, Percent_Identity=40.418118466899, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI166795268, Length=294, Percent_Identity=39.1156462585034, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI225579078, Length=294, Percent_Identity=40.1360544217687, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI193804850, Length=297, Percent_Identity=36.7003367003367, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI10190746, Length=304, Percent_Identity=36.5131578947368, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI7706523, Length=296, Percent_Identity=34.7972972972973, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI146231950, Length=308, Percent_Identity=36.6883116883117, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI19923931, Length=258, Percent_Identity=38.7596899224806, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1787335, Length=207, Percent_Identity=30.4347826086957, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17558006, Length=258, Percent_Identity=35.6589147286822, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71992402, Length=298, Percent_Identity=29.5302013422819, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17532791, Length=291, Percent_Identity=28.1786941580756, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17532805, Length=299, Percent_Identity=28.4280936454849, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI72001364, Length=221, Percent_Identity=34.3891402714932, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI193207620, Length=301, Percent_Identity=27.5747508305648, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17505416, Length=219, Percent_Identity=31.9634703196347, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17535059, Length=308, Percent_Identity=27.9220779220779, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI32565532, Length=207, Percent_Identity=31.4009661835749, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324820, Length=283, Percent_Identity=30.3886925795053, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28573296, Length=261, Percent_Identity=40.9961685823755, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24586328, Length=299, Percent_Identity=35.4515050167224, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI161076371, Length=255, Percent_Identity=38.0392156862745, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI22024069, Length=305, Percent_Identity=36.0655737704918, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI19921754, Length=307, Percent_Identity=36.1563517915309, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI45554248, Length=266, Percent_Identity=39.8496240601504, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24640117, Length=266, Percent_Identity=39.8496240601504, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI45553409, Length=298, Percent_Identity=31.2080536912752, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24647948, Length=298, Percent_Identity=31.2080536912752, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI20129347, Length=311, Percent_Identity=30.5466237942122, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24647946, Length=298, Percent_Identity=31.2080536912752, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24656154, Length=297, Percent_Identity=33.6700336700337, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI19922628, Length=297, Percent_Identity=33.6700336700337, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24647931, Length=310, Percent_Identity=30.6451612903226, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 32719; Mature: 32587

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAFAYSDIPDQSGKTAIVTGANTGLGYCIAEALARSKAKVLLACRSEDKAREAMDRIAE
CCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHH
AVLGADTEFLELDLQDMDSIRGAAKAAQSQARLDILVNNAGIMVPPLKLAMGVESQFATN
HHHCCCCHHEEECHHHHHHHHHHHHHHHHHCEEEEEECCCCEEECCHHHHHCCCHHHHHH
HLGHFALTGLLLDKLAQNGGARIVNQSSIAHRGAKIGFDNLDGAKGYSRQRFYGQSKLAN
HHHHHHHHHHHHHHHHCCCCCEEEECHHHHHCCCCCCCCCCCCCCCCCHHHHHCHHHHHH
LLFTFELDRRLRAAQSPVSAYAAHPGIAETELMRHLGPLALMGKVVGVFLNSAKDGALPA
HHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCH
LQAATWPDAEPGGYYGPYGLGEISGPRSGRAIASRTARDPLLAARLWEISVELTGVDPGL
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHEEEEEEEEECCCCCC
PADDVEQDI
CHHHHCCCC
>Mature Secondary Structure 
SAFAYSDIPDQSGKTAIVTGANTGLGYCIAEALARSKAKVLLACRSEDKAREAMDRIAE
CCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHH
AVLGADTEFLELDLQDMDSIRGAAKAAQSQARLDILVNNAGIMVPPLKLAMGVESQFATN
HHHCCCCHHEEECHHHHHHHHHHHHHHHHHCEEEEEECCCCEEECCHHHHHCCCHHHHHH
HLGHFALTGLLLDKLAQNGGARIVNQSSIAHRGAKIGFDNLDGAKGYSRQRFYGQSKLAN
HHHHHHHHHHHHHHHHCCCCCEEEECHHHHHCCCCCCCCCCCCCCCCCHHHHHCHHHHHH
LLFTFELDRRLRAAQSPVSAYAAHPGIAETELMRHLGPLALMGKVVGVFLNSAKDGALPA
HHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCH
LQAATWPDAEPGGYYGPYGLGEISGPRSGRAIASRTARDPLLAARLWEISVELTGVDPGL
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHEEEEEEEEECCCCCC
PADDVEQDI
CHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8383668 [H]