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The map label for this gene is hisZ [H]

Identifier: 85373222

GI number: 85373222

Start: 439042

End: 440163

Strand: Direct

Name: hisZ [H]

Synonym: ELI_01975

Alternate gene names: 85373222

Gene position: 439042-440163 (Clockwise)

Preceding gene: 85373221

Following gene: 85373226

Centisome position: 14.38

GC content: 70.41

Gene sequence:

>1122_bases
ATGTATGGCCCCGCAATGACCGACACCGACGACCTGCTCCCCATCGGCCTCGAGGACCGCCTGCCCGCAGAGGCGCGCAA
GGCGACGCATGCCATGCGCGCGGCGCTGGGGGCGATGGACAGCCACGGTTACGACCGCGTGCGACCGCCGCTGATCGAAT
TCGAACGCTCGCTGGCAGGCCGCATGGACGGGGTGCAGACGCGCCGCCTGTTCCGCTTCGTCGATCCGGAAAGCCTGCGC
ACGCTGGCGCTGCGCAGCGACATGACCCCGCAGGTGGGGCGGATCGCCTCGACCGGGCTGGCCGATGCGCCGCGTCCGCT
GAGGCTCTGCTATGCGGGCGATGTCGCGACGATCACCGCCGACCAGCTCGATCCCGCGCGCCAGCGCCTGCAACTGGGCG
CGGAATTGATCGGGGCCGACACGGTGGCTGCTGCGAGCGAGATCGTGATGCTGGCGGTCGAAGCGGTCGAAGCGACGGGC
GCGCGCGGGATTTCGGTCGACTTCACGCTGCCGGACCTGGTCGACGTGTTGGCCGCGGATGCTTTCGCGCTGGCCGAAGA
CCGTATCGACGCCGTTCGCCGCGAACTCGATACCAAGGATGCCGGCGGCCTCGTCGCGGCGGGGGGCGAAGCCTATCTGC
CGCTGATCCATGCCGCCGGATCGCTTGGCGATGCGCTGGCTAAGCTGCGCGAACTCGACGGCGGCGGGACGCTCGCCACA
CGCATCGAGGCGCTTGAGACGATCGCCGATCGCATCGGCGCCCGCGCCCGCGTCACTCTCGATCCGACCGAACGTCATGG
CTTCGAATACCAGAGCTGGTTCGGCTTCACGATCTACGCCGACGGCGCGCGCGGCGCACTGGGGCGCGGCGGGACCTACT
GGATCAAAGGCAGCGACGAAGCCGCGACCGGATTTTCGCTCTATCTCGACGCCCTGCTGCCCGCGCTCGAAGGCCGCGAA
CCTGCCGCGACCGTGTTCCTGCCGCTGGGGCACGATCCATCGGTGGCGGCGCGGCTGCGCGAAGAGGCCTGGCGCACGGT
CGCCGCGCTCGAAGAGAGCGACGATCCGCGCGCGCTGGGCTGCTCGCACCGGCTCGACGGCAGCGAGCCGGTCGCGCTCT
AG

Upstream 100 bases:

>100_bases
CTTTCTGACCTTCCACGTCACCCCGTCGGAAGCTGGGGGCGGGCGGCATCGGGTCCGACTTGATTGAGAAAGATCCCAGC
TTCCGCTGGGATGACGAGGT

Downstream 100 bases:

>100_bases
CTGTTGAATTCGCCCGGGTTCGGGCCCATCCGGCCGTCGTCGCTGTCGAGATCGTCGATCCGCTTCATCTGCTCGTCGGT
CAGCTCGAAATCGAGCGCGG

Product: ATP phosphoribosyltransferase

Products: ATP; 5-phospho-alpha-D-ribose 1-diphosphate

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MYGPAMTDTDDLLPIGLEDRLPAEARKATHAMRAALGAMDSHGYDRVRPPLIEFERSLAGRMDGVQTRRLFRFVDPESLR
TLALRSDMTPQVGRIASTGLADAPRPLRLCYAGDVATITADQLDPARQRLQLGAELIGADTVAAASEIVMLAVEAVEATG
ARGISVDFTLPDLVDVLAADAFALAEDRIDAVRRELDTKDAGGLVAAGGEAYLPLIHAAGSLGDALAKLRELDGGGTLAT
RIEALETIADRIGARARVTLDPTERHGFEYQSWFGFTIYADGARGALGRGGTYWIKGSDEAATGFSLYLDALLPALEGRE
PAATVFLPLGHDPSVAARLREEAWRTVAALEESDDPRALGCSHRLDGSEPVAL

Sequences:

>Translated_373_residues
MYGPAMTDTDDLLPIGLEDRLPAEARKATHAMRAALGAMDSHGYDRVRPPLIEFERSLAGRMDGVQTRRLFRFVDPESLR
TLALRSDMTPQVGRIASTGLADAPRPLRLCYAGDVATITADQLDPARQRLQLGAELIGADTVAAASEIVMLAVEAVEATG
ARGISVDFTLPDLVDVLAADAFALAEDRIDAVRRELDTKDAGGLVAAGGEAYLPLIHAAGSLGDALAKLRELDGGGTLAT
RIEALETIADRIGARARVTLDPTERHGFEYQSWFGFTIYADGARGALGRGGTYWIKGSDEAATGFSLYLDALLPALEGRE
PAATVFLPLGHDPSVAARLREEAWRTVAALEESDDPRALGCSHRLDGSEPVAL
>Mature_373_residues
MYGPAMTDTDDLLPIGLEDRLPAEARKATHAMRAALGAMDSHGYDRVRPPLIEFERSLAGRMDGVQTRRLFRFVDPESLR
TLALRSDMTPQVGRIASTGLADAPRPLRLCYAGDVATITADQLDPARQRLQLGAELIGADTVAAASEIVMLAVEAVEATG
ARGISVDFTLPDLVDVLAADAFALAEDRIDAVRRELDTKDAGGLVAAGGEAYLPLIHAAGSLGDALAKLRELDGGGTLAT
RIEALETIADRIGARARVTLDPTERHGFEYQSWFGFTIYADGARGALGRGGTYWIKGSDEAATGFSLYLDALLPALEGRE
PAATVFLPLGHDPSVAARLREEAWRTVAALEESDDPRALGCSHRLDGSEPVAL

Specific function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine [H]

COG id: COG3705

COG function: function code E; ATP phosphoribosyltransferase involved in histidine biosynthesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004516 [H]

Pfam domain/function: PF00587 tRNA-synt_2b [H]

EC number: 2.4.2.17

Molecular weight: Translated: 39728; Mature: 39728

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYGPAMTDTDDLLPIGLEDRLPAEARKATHAMRAALGAMDSHGYDRVRPPLIEFERSLAG
CCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
RMDGVQTRRLFRFVDPESLRTLALRSDMTPQVGRIASTGLADAPRPLRLCYAGDVATITA
HHCCHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCEEEEEECCEEEEEH
DQLDPARQRLQLGAELIGADTVAAASEIVMLAVEAVEATGARGISVDFTLPDLVDVLAAD
HCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHH
AFALAEDRIDAVRRELDTKDAGGLVAAGGEAYLPLIHAAGSLGDALAKLRELDGGGTLAT
HHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHCCHHHHHHHHHHHCCCCCHHHH
RIEALETIADRIGARARVTLDPTERHGFEYQSWFGFTIYADGARGALGRGGTYWIKGSDE
HHHHHHHHHHHHCCCEEEEECCHHHCCCCCCCEEEEEEEECCCCCCCCCCCEEEEECCCC
AATGFSLYLDALLPALEGREPAATVFLPLGHDPSVAARLREEAWRTVAALEESDDPRALG
CCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
CSHRLDGSEPVAL
CCCCCCCCCCCCC
>Mature Secondary Structure
MYGPAMTDTDDLLPIGLEDRLPAEARKATHAMRAALGAMDSHGYDRVRPPLIEFERSLAG
CCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
RMDGVQTRRLFRFVDPESLRTLALRSDMTPQVGRIASTGLADAPRPLRLCYAGDVATITA
HHCCHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCEEEEEECCEEEEEH
DQLDPARQRLQLGAELIGADTVAAASEIVMLAVEAVEATGARGISVDFTLPDLVDVLAAD
HCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHH
AFALAEDRIDAVRRELDTKDAGGLVAAGGEAYLPLIHAAGSLGDALAKLRELDGGGTLAT
HHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHCCHHHHHHHHHHHCCCCCHHHH
RIEALETIADRIGARARVTLDPTERHGFEYQSWFGFTIYADGARGALGRGGTYWIKGSDE
HHHHHHHHHHHHCCCEEEEECCHHHCCCCCCCEEEEEEEECCCCCCCCCCCEEEEECCCC
AATGFSLYLDALLPALEGREPAATVFLPLGHDPSVAARLREEAWRTVAALEESDDPRALG
CCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
CSHRLDGSEPVAL
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 1-(5-phospho-D-ribosyl)-ATP; diphosphate

Specific reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA