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The map label for this gene is acbB [H]

Identifier: 85373200

GI number: 85373200

Start: 419330

End: 420238

Strand: Direct

Name: acbB [H]

Synonym: ELI_01865

Alternate gene names: 85373200

Gene position: 419330-420238 (Clockwise)

Preceding gene: 85373199

Following gene: 85373210

Centisome position: 13.74

GC content: 66.78

Gene sequence:

>909_bases
GTGACTATCGCGATAACAGGGGGAACGGGCTTCGTCGGACAGGCGCTGATCGACCTTGCCGAGCGCAAGGGGGTGAAGCT
GCGCTCGCTGGCGCGGCGCATCCCCGAAGACAGGCGCGGGGTCGACTGGGTGCAGGGGGACCTAGCCGATCCGGCTGCGC
TCGCGAAGCTTGTCGACGGCGCCGACGCAGTCATCCACATCGCCGGTCAGGTACGCGCGCGCAATCCGGGCGAGTTCGAA
GCGGCCAACGTCACCGGCACGCTCAATGTCATCGAGGCAGCACTGGATGCGCATGTCCCGCGTTTCGTCTTCGTGTCGTC
GCTCGCCGCGCGCGAGCCTGCGCTGTCGGCCTATGGTGCGTCGAAACTACGCGCCGAAAAGCTGGTCGCTGCGAGCGGCC
TCGACTGGACCATCGTCCGACCGCCTGCCGTTTATGGCCCGCGCGATGGCGAAATGCTCGACCTGTTCGAAATGGCGACG
ATGAATGTCGTGCCGATGCCGAAGCAGGGCCATGCCTCGCTCATCCACGTCGGCGATCTTGCGCGCCTGTTGCTGGCCGT
CCTTCCGTCGGGCGAAGCGACGACCGGCCGCATATTCGAACCCGACGACGGCAAGCAGGGCGGCTGGGAGCATCGCGAAC
TGGCGCTCGCGATCGGCTGGGCGGTCGGCAAACGGCCTTTCGTCCCGCGGCTATCCAAGGGTATGCTGGCCTTTGCTGCG
AAACTGGACGGGCTGCTCCGCCGCGACGAGGCCAAGCTGACGCCCGACCGCGTCGGCTATATGTGCCACCCCGACTGGGT
GTCCGACCCCGCGGCCAGACCGCCCCGGGAGCTGTGGCAACCCAAGATTCCGACCCGCGAGGGTCTGAAGGCCTCCGCCA
AATGGTACCGGGACAACAAGTGGTTGTAA

Upstream 100 bases:

>100_bases
CGGCAAGCGCGAGGGTGATCAGGCCGCCATCCTGGGCTATGCCCCGCGCGCAGCAGTGATCCACCGCGATCACATGGTCA
TGCTTTGACAGGGTGATGCA

Downstream 100 bases:

>100_bases
GGCGTCAGAACGCCGGATCGTAGCCGGGGGGCAAATCGCCGTCGTCGCTGCCCGGCATGTGGATGCCGCATTCGGTTTTG
TCCCAGCCCCTCCAGCGGCC

Product: nucleoside-diphosphate-sugar epimerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MTIAITGGTGFVGQALIDLAERKGVKLRSLARRIPEDRRGVDWVQGDLADPAALAKLVDGADAVIHIAGQVRARNPGEFE
AANVTGTLNVIEAALDAHVPRFVFVSSLAAREPALSAYGASKLRAEKLVAASGLDWTIVRPPAVYGPRDGEMLDLFEMAT
MNVVPMPKQGHASLIHVGDLARLLLAVLPSGEATTGRIFEPDDGKQGGWEHRELALAIGWAVGKRPFVPRLSKGMLAFAA
KLDGLLRRDEAKLTPDRVGYMCHPDWVSDPAARPPRELWQPKIPTREGLKASAKWYRDNKWL

Sequences:

>Translated_302_residues
MTIAITGGTGFVGQALIDLAERKGVKLRSLARRIPEDRRGVDWVQGDLADPAALAKLVDGADAVIHIAGQVRARNPGEFE
AANVTGTLNVIEAALDAHVPRFVFVSSLAAREPALSAYGASKLRAEKLVAASGLDWTIVRPPAVYGPRDGEMLDLFEMAT
MNVVPMPKQGHASLIHVGDLARLLLAVLPSGEATTGRIFEPDDGKQGGWEHRELALAIGWAVGKRPFVPRLSKGMLAFAA
KLDGLLRRDEAKLTPDRVGYMCHPDWVSDPAARPPRELWQPKIPTREGLKASAKWYRDNKWL
>Mature_301_residues
TIAITGGTGFVGQALIDLAERKGVKLRSLARRIPEDRRGVDWVQGDLADPAALAKLVDGADAVIHIAGQVRARNPGEFEA
ANVTGTLNVIEAALDAHVPRFVFVSSLAAREPALSAYGASKLRAEKLVAASGLDWTIVRPPAVYGPRDGEMLDLFEMATM
NVVPMPKQGHASLIHVGDLARLLLAVLPSGEATTGRIFEPDDGKQGGWEHRELALAIGWAVGKRPFVPRLSKGMLAFAAK
LDGLLRRDEAKLTPDRVGYMCHPDWVSDPAARPPRELWQPKIPTREGLKASAKWYRDNKWL

Specific function: Probably involved in the biosynthesis of the acarviose moiety of the alpha-glucosidase inhibitor acarbose. Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4- hexulose via a three-step process involving oxidation, dehydration and re

COG id: COG0702

COG function: function code MG; Predicted nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 32781; Mature: 32650

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIAITGGTGFVGQALIDLAERKGVKLRSLARRIPEDRRGVDWVQGDLADPAALAKLVDG
CEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHCC
ADAVIHIAGQVRARNPGEFEAANVTGTLNVIEAALDAHVPRFVFVSSLAAREPALSAYGA
CCEEEEEECEEECCCCCCEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHCH
SKLRAEKLVAASGLDWTIVRPPAVYGPRDGEMLDLFEMATMNVVPMPKQGHASLIHVGDL
HHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHCCEECCCCCCCCCEEEHHHH
ARLLLAVLPSGEATTGRIFEPDDGKQGGWEHRELALAIGWAVGKRPFVPRLSKGMLAFAA
HHHHHHHCCCCCCCCCCEECCCCCCCCCCCHHHEEEEEEHHHCCCCCCCHHHHHHHHHHH
KLDGLLRRDEAKLTPDRVGYMCHPDWVSDPAARPPRELWQPKIPTREGLKASAKWYRDNK
HHHHHHHCCCCCCCHHHCCEEECCCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHCCCC
WL
CC
>Mature Secondary Structure 
TIAITGGTGFVGQALIDLAERKGVKLRSLARRIPEDRRGVDWVQGDLADPAALAKLVDG
EEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHCC
ADAVIHIAGQVRARNPGEFEAANVTGTLNVIEAALDAHVPRFVFVSSLAAREPALSAYGA
CCEEEEEECEEECCCCCCEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHCH
SKLRAEKLVAASGLDWTIVRPPAVYGPRDGEMLDLFEMATMNVVPMPKQGHASLIHVGDL
HHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHCCEECCCCCCCCCEEEHHHH
ARLLLAVLPSGEATTGRIFEPDDGKQGGWEHRELALAIGWAVGKRPFVPRLSKGMLAFAA
HHHHHHHCCCCCCCCCCEECCCCCCCCCCCHHHEEEEEEHHHCCCCCCCHHHHHHHHHHH
KLDGLLRRDEAKLTPDRVGYMCHPDWVSDPAARPPRELWQPKIPTREGLKASAKWYRDNK
HHHHHHHCCCCCCCHHHCCEEECCCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHCCCC
WL
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10196166 [H]