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The map label for this gene is murB

Identifier: 85373188

GI number: 85373188

Start: 405632

End: 406603

Strand: Direct

Name: murB

Synonym: ELI_01805

Alternate gene names: 85373188

Gene position: 405632-406603 (Clockwise)

Preceding gene: 85373187

Following gene: 85373189

Centisome position: 13.29

GC content: 66.05

Gene sequence:

>972_bases
ATGAACACGATCCAGCCAGACGACTGGGCGATGCACGATACCGGTGCCGCGCCGACGGCCGAAGTCGAAGGCGCGGTTGC
CGCGCCTGTGCCGATCGAGGGCATTCGCGGCAAGCTGACCAACCAGGCTCCGCTCGCCAAGCTCGTCTGGTTCAAGAGCG
GCGGCGCGGCGGACTGGCTGTTCGAGCCCGCCGATCTCGACGATCTCAAGACCTTTCTCGCGCGGCTCGATGGCGACCTG
CCTGTCATGGCGCTTGGCCTCGGTTCCAACCTCATCATCCGCGATGGCGGGGTGCCGGGCGTGGTGATCAAGCTCGGCAA
GGCCTTTGCGTCGGTCGAAACGCATGATGACTACACCGTCACATGCGGTGCGGGCGCCCACGGCGTGCTGGTGGCATCGA
CCGCGCGCGATGCCGGTATCGCGGGTTTGGAATTCATGCGCGGCATTCCCGGCACGATCGGCGGTTTCGTCCGCATGAAC
GCCGGGGCCTATGGCCGCGAGACGCGGGACGTGCTGATCGACTGCGACGTGGTATTGCCGGGCGGGAGCTTTGTCACGCT
GCCGGTGGCCGACCTGCAATACACCTATCGCCATTCGGCATTGCCCGACGGCGCGGTGGTCGTGTCCGCCCGCCTGCAGG
GCGAACCGGGCGATCCCGAAATAATCGGTGCCGAGATGGAACGCGTCGCCGAAGCGCGCGAGCAATCGCAGCCGGTGCGG
ACCAAGACGGGCGGCTCCACCTTCAAGAACCCGCCGGGCAAGAAAGCATGGGAGCTGGTCGATGCCGCCGGATGTCGCGG
TCTCACGATGGGCGGCGCGCAGGTGAGCGAGAAGCACACCAATTTTCTCATCAACGTCGACGGGGCGACCAGCGCCGACA
TCGAAGGATTGGGCGAAGAAGTGAAGCGCCGGGTCTATGCGCATTCGGGCGTCGAGCTCGAATGGGAAATCCAGCGGGTG
GGACGCCCGTGA

Upstream 100 bases:

>100_bases
GCGAGATCGAGGAAGGCGACGTGGTCGTCTGCCTTGGCGCCGGGGATATCACCAAATGGGCTGCCGGCCTCGCCGATGCG
ATAGCGCAGGAGCGAGGCGC

Downstream 100 bases:

>100_bases
GCCTCGACCGTAAACTCCACGTCGTCGTCCTGATGGGCGGCTGGGCGAACGAGCGCGAAGTCTCGCTGATGAGCGGCGAG
GGTGTCGCCAAGGCGCTCGA

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MNTIQPDDWAMHDTGAAPTAEVEGAVAAPVPIEGIRGKLTNQAPLAKLVWFKSGGAADWLFEPADLDDLKTFLARLDGDL
PVMALGLGSNLIIRDGGVPGVVIKLGKAFASVETHDDYTVTCGAGAHGVLVASTARDAGIAGLEFMRGIPGTIGGFVRMN
AGAYGRETRDVLIDCDVVLPGGSFVTLPVADLQYTYRHSALPDGAVVVSARLQGEPGDPEIIGAEMERVAEAREQSQPVR
TKTGGSTFKNPPGKKAWELVDAAGCRGLTMGGAQVSEKHTNFLINVDGATSADIEGLGEEVKRRVYAHSGVELEWEIQRV
GRP

Sequences:

>Translated_323_residues
MNTIQPDDWAMHDTGAAPTAEVEGAVAAPVPIEGIRGKLTNQAPLAKLVWFKSGGAADWLFEPADLDDLKTFLARLDGDL
PVMALGLGSNLIIRDGGVPGVVIKLGKAFASVETHDDYTVTCGAGAHGVLVASTARDAGIAGLEFMRGIPGTIGGFVRMN
AGAYGRETRDVLIDCDVVLPGGSFVTLPVADLQYTYRHSALPDGAVVVSARLQGEPGDPEIIGAEMERVAEAREQSQPVR
TKTGGSTFKNPPGKKAWELVDAAGCRGLTMGGAQVSEKHTNFLINVDGATSADIEGLGEEVKRRVYAHSGVELEWEIQRV
GRP
>Mature_323_residues
MNTIQPDDWAMHDTGAAPTAEVEGAVAAPVPIEGIRGKLTNQAPLAKLVWFKSGGAADWLFEPADLDDLKTFLARLDGDL
PVMALGLGSNLIIRDGGVPGVVIKLGKAFASVETHDDYTVTCGAGAHGVLVASTARDAGIAGLEFMRGIPGTIGGFVRMN
AGAYGRETRDVLIDCDVVLPGGSFVTLPVADLQYTYRHSALPDGAVVVSARLQGEPGDPEIIGAEMERVAEAREQSQPVR
TKTGGSTFKNPPGKKAWELVDAAGCRGLTMGGAQVSEKHTNFLINVDGATSADIEGLGEEVKRRVYAHSGVELEWEIQRV
GRP

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_ERYLH (Q2NCY8)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_457250.1
- ProteinModelPortal:   Q2NCY8
- SMR:   Q2NCY8
- STRING:   Q2NCY8
- GeneID:   3868846
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_01805
- NMPDR:   fig|314225.3.peg.2728
- eggNOG:   COG0812
- HOGENOM:   HBG686573
- OMA:   SKKHAGF
- ProtClustDB:   PRK13905
- BioCyc:   ELIT314225:ELI_01805-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 33982; Mature: 33982

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 197-197 ACT_SITE 246-246 ACT_SITE 316-316

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTIQPDDWAMHDTGAAPTAEVEGAVAAPVPIEGIRGKLTNQAPLAKLVWFKSGGAADWL
CCCCCCCCCEECCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCE
FEPADLDDLKTFLARLDGDLPVMALGLGSNLIIRDGGVPGVVIKLGKAFASVETHDDYTV
ECCCCHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCEEEEEHHHHHHCEECCCCEEE
TCGAGAHGVLVASTARDAGIAGLEFMRGIPGTIGGFVRMNAGAYGRETRDVLIDCDVVLP
EECCCCCCEEEEECCCCCCCHHHHHHCCCCCCCCCEEEECCCCCCCCCCEEEEEEEEEEC
GGSFVTLPVADLQYTYRHSALPDGAVVVSARLQGEPGDPEIIGAEMERVAEAREQSQPVR
CCCEEEEEHHHCEEEHHHCCCCCCEEEEEEEECCCCCCCCEECHHHHHHHHHHHHCCCCE
TKTGGSTFKNPPGKKAWELVDAAGCRGLTMGGAQVSEKHTNFLINVDGATSADIEGLGEE
ECCCCCCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEECCCCCCCHHHHHHH
VKRRVYAHSGVELEWEIQRVGRP
HHHHHHHCCCCEEEEEHEECCCC
>Mature Secondary Structure
MNTIQPDDWAMHDTGAAPTAEVEGAVAAPVPIEGIRGKLTNQAPLAKLVWFKSGGAADWL
CCCCCCCCCEECCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCE
FEPADLDDLKTFLARLDGDLPVMALGLGSNLIIRDGGVPGVVIKLGKAFASVETHDDYTV
ECCCCHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCEEEEEHHHHHHCEECCCCEEE
TCGAGAHGVLVASTARDAGIAGLEFMRGIPGTIGGFVRMNAGAYGRETRDVLIDCDVVLP
EECCCCCCEEEEECCCCCCCHHHHHHCCCCCCCCCEEEECCCCCCCCCCEEEEEEEEEEC
GGSFVTLPVADLQYTYRHSALPDGAVVVSARLQGEPGDPEIIGAEMERVAEAREQSQPVR
CCCEEEEEHHHCEEEHHHCCCCCCEEEEEEEECCCCCCCCEECHHHHHHHHHHHHCCCCE
TKTGGSTFKNPPGKKAWELVDAAGCRGLTMGGAQVSEKHTNFLINVDGATSADIEGLGEE
ECCCCCCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEECCCCCCCHHHHHHH
VKRRVYAHSGVELEWEIQRVGRP
HHHHHHHCCCCEEEEEHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA