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The map label for this gene is mtnP [H]

Identifier: 85373125

GI number: 85373125

Start: 342977

End: 343846

Strand: Direct

Name: mtnP [H]

Synonym: ELI_01490

Alternate gene names: 85373125

Gene position: 342977-343846 (Clockwise)

Preceding gene: 85373124

Following gene: 85373126

Centisome position: 11.24

GC content: 64.83

Gene sequence:

>870_bases
ATGAGCAATTGGCATATCGGCGTCCTTGGCGGATCGGGTCTGTACGAGGGGATCGCGCTGGAAGAACAGCAGGAGATCGA
GGTTTCCTCACCGTTCGGCGCACCTTCCGGCCCGGTCACTACCGGGCGAATCGGCGATGTGCGGCTGACCTTTCTTGCAC
GCCACGGGGCCGGGCACCGCCTGTCGCCCGACAGCGTCAATTATCGCGCCAATGTGGATGTGATGAAGCGCTGCGGGGTG
ACGGACCTGCTCGCGATCAGCGCGATCGGGAGCCTGCGCGAGGAGCTGGCACCCGGCAGTTTCGTGGCCGTCGACCAGTT
CATCGATCGCACGCTGGGCAGCAGACCGTCCAGCTTCTTCGGCGTAGGGCTGGTGGGGCATGTCGCGCTCTCCGATCCGG
TCTGCACAAGACTGTCGGGCCTCGCCGCCGACGCTGCCGAAGCGGCGGGCGCAACTGTGCATCGCGGCGGGACCTATTTG
GCAATGGAGGGTCCGCAATTCTCGACCCGCGCCGAAAGCCGCATGTACCGCGCGTGGGGCGGAGACGTCATCGGGATGAC
GGGCATGCCCGAGGCCAAGCTCGCGCGCGAAGCGGAGCTGCCGTACGCCATGCTCGCCATGGTCACCGATTACGACAGCT
GGCGCGATGACCAGGCGGGCGTAGAGACGGTCGATATCCTCAAGGTTCTGCAGGCCAATGCGGATATGGCAAGAAAGACC
ATGTTACAGCTGGTCTCGTCGTTACCCGCTACGCGCGAGCCAAGTCCGCATGACACCGCACTCGAATATGCGATCTTGAC
CACGCCGGAGCAGCGCGATCCGGTGCTCGTCGCCAAGCTCGATGCCGTAGCCGGACGGGTGCTGGGGTAA

Upstream 100 bases:

>100_bases
CTCGAGAAGCGCGAACCGAACTATCCCGGCAAGGTCAGCGAAGACATGCCGGACTTCTATCCCTGGTGGGACCAGCCCGA
ATACAAGTGAGATCGCACAC

Downstream 100 bases:

>100_bases
AGCAAGCCTGCGCTTGCCAAGTGGATGGTTTCGTTGGAAACTAGTGTCATGGCCAGCGACATGACTCATGCCCCGGTCCT
TGCGGACTTTCTGCCCTACC

Product: methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MSNWHIGVLGGSGLYEGIALEEQQEIEVSSPFGAPSGPVTTGRIGDVRLTFLARHGAGHRLSPDSVNYRANVDVMKRCGV
TDLLAISAIGSLREELAPGSFVAVDQFIDRTLGSRPSSFFGVGLVGHVALSDPVCTRLSGLAADAAEAAGATVHRGGTYL
AMEGPQFSTRAESRMYRAWGGDVIGMTGMPEAKLAREAELPYAMLAMVTDYDSWRDDQAGVETVDILKVLQANADMARKT
MLQLVSSLPATREPSPHDTALEYAILTTPEQRDPVLVAKLDAVAGRVLG

Sequences:

>Translated_289_residues
MSNWHIGVLGGSGLYEGIALEEQQEIEVSSPFGAPSGPVTTGRIGDVRLTFLARHGAGHRLSPDSVNYRANVDVMKRCGV
TDLLAISAIGSLREELAPGSFVAVDQFIDRTLGSRPSSFFGVGLVGHVALSDPVCTRLSGLAADAAEAAGATVHRGGTYL
AMEGPQFSTRAESRMYRAWGGDVIGMTGMPEAKLAREAELPYAMLAMVTDYDSWRDDQAGVETVDILKVLQANADMARKT
MLQLVSSLPATREPSPHDTALEYAILTTPEQRDPVLVAKLDAVAGRVLG
>Mature_288_residues
SNWHIGVLGGSGLYEGIALEEQQEIEVSSPFGAPSGPVTTGRIGDVRLTFLARHGAGHRLSPDSVNYRANVDVMKRCGVT
DLLAISAIGSLREELAPGSFVAVDQFIDRTLGSRPSSFFGVGLVGHVALSDPVCTRLSGLAADAAEAAGATVHRGGTYLA
MEGPQFSTRAESRMYRAWGGDVIGMTGMPEAKLAREAELPYAMLAMVTDYDSWRDDQAGVETVDILKVLQANADMARKTM
LQLVSSLPATREPSPHDTALEYAILTTPEQRDPVLVAKLDAVAGRVLG

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=251, Percent_Identity=41.8326693227092, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71980569, Length=248, Percent_Identity=36.6935483870968, Blast_Score=167, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6323045, Length=263, Percent_Identity=38.7832699619772, Blast_Score=182, Evalue=5e-47,
Organism=Drosophila melanogaster, GI20130079, Length=247, Percent_Identity=39.2712550607287, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI221459247, Length=251, Percent_Identity=36.2549800796813, Blast_Score=172, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 30698; Mature: 30567

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNWHIGVLGGSGLYEGIALEEQQEIEVSSPFGAPSGPVTTGRIGDVRLTFLARHGAGHR
CCCEEEEEEECCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCC
LSPDSVNYRANVDVMKRCGVTDLLAISAIGSLREELAPGSFVAVDQFIDRTLGSRPSSFF
CCCCCCCEEECHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCCEE
GVGLVGHVALSDPVCTRLSGLAADAAEAAGATVHRGGTYLAMEGPQFSTRAESRMYRAWG
EHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEECCCEEEEECCCCCCHHHHHHHHHHCC
GDVIGMTGMPEAKLAREAELPYAMLAMVTDYDSWRDDQAGVETVDILKVLQANADMARKT
CCEEECCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHH
MLQLVSSLPATREPSPHDTALEYAILTTPEQRDPVLVAKLDAVAGRVLG
HHHHHHHCCCCCCCCCCCHHEEEEEEECCCCCCCEEEEEHHHHHHHCCC
>Mature Secondary Structure 
SNWHIGVLGGSGLYEGIALEEQQEIEVSSPFGAPSGPVTTGRIGDVRLTFLARHGAGHR
CCEEEEEEECCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCC
LSPDSVNYRANVDVMKRCGVTDLLAISAIGSLREELAPGSFVAVDQFIDRTLGSRPSSFF
CCCCCCCEEECHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCCEE
GVGLVGHVALSDPVCTRLSGLAADAAEAAGATVHRGGTYLAMEGPQFSTRAESRMYRAWG
EHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEECCCEEEEECCCCCCHHHHHHHHHHCC
GDVIGMTGMPEAKLAREAELPYAMLAMVTDYDSWRDDQAGVETVDILKVLQANADMARKT
CCEEECCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHH
MLQLVSSLPATREPSPHDTALEYAILTTPEQRDPVLVAKLDAVAGRVLG
HHHHHHHCCCCCCCCCCCHHEEEEEEECCCCCCCEEEEEHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA