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The map label for this gene is 85373024

Identifier: 85373024

GI number: 85373024

Start: 232503

End: 233741

Strand: Direct

Name: 85373024

Synonym: ELI_00985

Alternate gene names: NA

Gene position: 232503-233741 (Clockwise)

Preceding gene: 85373023

Following gene: 85373025

Centisome position: 7.62

GC content: 63.92

Gene sequence:

>1239_bases
ATGAGCGACATCTATATCGCCGGCGTTGGCATGACGCAGTTCGGTCGGCAACTCGACCGCAGCCTCAAGGACCTGTCGGC
GGACGCCTGTGCTCGGGCTTTCGCCGATGCCGGATGCGGCCGGGAGGACATCGAGGCGGTCTTCTTTGGCAACTGCGTGC
AGGGCCACATGGAAGGGCAGGACATGATCCGTGGCGAGCTCGTAGCACGCGCGGTTGGGATGCAGGGCGTGCCAGTTGTC
AACGTTGAGAATGCCTGCGCCACAGCCTCGACGGCGGTCGCGATGGCGACTGCTTATGTCCGGTCGGGTATGGCGGACAT
CGTGCTCGCGCTCGGCGCGGAGAAGATGTGCTCGCCTGACAAGGCCTTGATGTTCAGCGCTTTCGATGGGGCGTGGGACG
TGCACGAGACGGAGTGCAGCCGCGAGACACTGCTCGCTATGGGCCAAGGCGTTGAGGTGCCAGAAGGGTCGGTGTCAAAC
CAACCCTACAGCGTATTCATGGACATCTACGCTGCGATGTCGCGCGCCCATATGCGCACTTACGGATCAACGCAGGCGCA
GATCGCAGCGGTGTCAGCCAAAAACCACGTCCATTCGACGCACAACCCGCTCGCTCAATACCGCAAACCCTACACGGTAG
AGGCCGTGCTGGCCGCACCGCCAATCGTGTTTCCGCTGACACTGCCGATGTGCTCACCGATCAGTGACGGCGCTGCGGCT
GCGGTGATCTGCAACTCGGCAGGCTTGCGCAAGCTGGCGGTGTCTGACGACAGGGCAATCCGAGTACTTGCGTCGGTGCT
CCAGACCAGTGCCGAGCGCGACCCTTACGACTATGATCGGCACGTCACAAGGCTGGCGGCAATGCGCGCCTATGCGATGG
CGGGGCTCGGCCCGTTAGACGTCGACGTTGCGGAAGTGCACGACGCGACGGCGATGGGCGAGATCATCGAAATTGAGGCT
CTGGGCCTCGTGCCGCCTGGCGAGGGAGGGATTGCTGCTGAGCGTGGCGACACCGTCATTGGCGGCCGCATCCCCGTAAA
TCCGTCGGGCGGCCTCGAATGCAAAGGGCACCCGATCGGCGCGACGGGTCTCGGTCAGATCTACGAACTGGTGTCGCAAC
TGCGTGGCGATGCCGGCGCTCGCCAGATCGAGGGAGCGCGGGTCGCGGTAGCGCAGAATGGCGGCGGGGTTCTGGGCGTG
GAGGAAGCCGTCGTCGCAGTCACCATCCTTGGTCGTTAA

Upstream 100 bases:

>100_bases
GCCAGGAACTCGAGATCATCGGAGCCTATGCTGCCTCACACGATCTGCGCGAGGGACTAGCGGCGTTCGCAGAGAAGCGC
GAACCGGAGTTCAAAGGAAA

Downstream 100 bases:

>100_bases
GGAGCGGATAATATGGATTTTACACCCACTGACGAGCAGCGGATGGCAGTCGAGAGCATTCGGCGCTTCCTCGACGAAAA
GCTGGAGCCTGAAATTCGCG

Product: thiolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MSDIYIAGVGMTQFGRQLDRSLKDLSADACARAFADAGCGREDIEAVFFGNCVQGHMEGQDMIRGELVARAVGMQGVPVV
NVENACATASTAVAMATAYVRSGMADIVLALGAEKMCSPDKALMFSAFDGAWDVHETECSRETLLAMGQGVEVPEGSVSN
QPYSVFMDIYAAMSRAHMRTYGSTQAQIAAVSAKNHVHSTHNPLAQYRKPYTVEAVLAAPPIVFPLTLPMCSPISDGAAA
AVICNSAGLRKLAVSDDRAIRVLASVLQTSAERDPYDYDRHVTRLAAMRAYAMAGLGPLDVDVAEVHDATAMGEIIEIEA
LGLVPPGEGGIAAERGDTVIGGRIPVNPSGGLECKGHPIGATGLGQIYELVSQLRGDAGARQIEGARVAVAQNGGGVLGV
EEAVVAVTILGR

Sequences:

>Translated_412_residues
MSDIYIAGVGMTQFGRQLDRSLKDLSADACARAFADAGCGREDIEAVFFGNCVQGHMEGQDMIRGELVARAVGMQGVPVV
NVENACATASTAVAMATAYVRSGMADIVLALGAEKMCSPDKALMFSAFDGAWDVHETECSRETLLAMGQGVEVPEGSVSN
QPYSVFMDIYAAMSRAHMRTYGSTQAQIAAVSAKNHVHSTHNPLAQYRKPYTVEAVLAAPPIVFPLTLPMCSPISDGAAA
AVICNSAGLRKLAVSDDRAIRVLASVLQTSAERDPYDYDRHVTRLAAMRAYAMAGLGPLDVDVAEVHDATAMGEIIEIEA
LGLVPPGEGGIAAERGDTVIGGRIPVNPSGGLECKGHPIGATGLGQIYELVSQLRGDAGARQIEGARVAVAQNGGGVLGV
EEAVVAVTILGR
>Mature_411_residues
SDIYIAGVGMTQFGRQLDRSLKDLSADACARAFADAGCGREDIEAVFFGNCVQGHMEGQDMIRGELVARAVGMQGVPVVN
VENACATASTAVAMATAYVRSGMADIVLALGAEKMCSPDKALMFSAFDGAWDVHETECSRETLLAMGQGVEVPEGSVSNQ
PYSVFMDIYAAMSRAHMRTYGSTQAQIAAVSAKNHVHSTHNPLAQYRKPYTVEAVLAAPPIVFPLTLPMCSPISDGAAAA
VICNSAGLRKLAVSDDRAIRVLASVLQTSAERDPYDYDRHVTRLAAMRAYAMAGLGPLDVDVAEVHDATAMGEIIEIEAL
GLVPPGEGGIAAERGDTVIGGRIPVNPSGGLECKGHPIGATGLGQIYELVSQLRGDAGARQIEGARVAVAQNGGGVLGVE
EAVVAVTILGR

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=414, Percent_Identity=36.7149758454106, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI302344760, Length=414, Percent_Identity=35.7487922705314, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI302344767, Length=341, Percent_Identity=38.7096774193548, Blast_Score=212, Evalue=6e-55,
Organism=Homo sapiens, GI302344762, Length=414, Percent_Identity=33.5748792270531, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI55956775, Length=372, Percent_Identity=31.4516129032258, Blast_Score=151, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI17537653, Length=400, Percent_Identity=32.75, Blast_Score=208, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24585051, Length=414, Percent_Identity=37.43961352657, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI19921506, Length=416, Percent_Identity=36.5384615384615, Blast_Score=229, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: NA

Molecular weight: Translated: 42977; Mature: 42846

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIYIAGVGMTQFGRQLDRSLKDLSADACARAFADAGCGREDIEAVFFGNCVQGHMEGQ
CCCEEEEECCHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHEEEECCHHHCCCCCH
DMIRGELVARAVGMQGVPVVNVENACATASTAVAMATAYVRSGMADIVLALGAEKMCSPD
HHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHCCCC
KALMFSAFDGAWDVHETECSRETLLAMGQGVEVPEGSVSNQPYSVFMDIYAAMSRAHMRT
HHEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
YGSTQAQIAAVSAKNHVHSTHNPLAQYRKPYTVEAVLAAPPIVFPLTLPMCSPISDGAAA
CCCCCCEEEEEHHCCCCCCCCCHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCCCCCEE
AVICNSAGLRKLAVSDDRAIRVLASVLQTSAERDPYDYDRHVTRLAAMRAYAMAGLGPLD
EEEECCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
VDVAEVHDATAMGEIIEIEALGLVPPGEGGIAAERGDTVIGGRIPVNPSGGLECKGHPIG
CHHHHHHHHHHHCCEEEEEEEECCCCCCCCCEECCCCEEECCEEECCCCCCCEECCCCCC
ATGLGQIYELVSQLRGDAGARQIEGARVAVAQNGGGVLGVEEAVVAVTILGR
CCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEECCCEEEEEEEECC
>Mature Secondary Structure 
SDIYIAGVGMTQFGRQLDRSLKDLSADACARAFADAGCGREDIEAVFFGNCVQGHMEGQ
CCEEEEECCHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHEEEECCHHHCCCCCH
DMIRGELVARAVGMQGVPVVNVENACATASTAVAMATAYVRSGMADIVLALGAEKMCSPD
HHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHCCCC
KALMFSAFDGAWDVHETECSRETLLAMGQGVEVPEGSVSNQPYSVFMDIYAAMSRAHMRT
HHEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
YGSTQAQIAAVSAKNHVHSTHNPLAQYRKPYTVEAVLAAPPIVFPLTLPMCSPISDGAAA
CCCCCCEEEEEHHCCCCCCCCCHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCCCCCEE
AVICNSAGLRKLAVSDDRAIRVLASVLQTSAERDPYDYDRHVTRLAAMRAYAMAGLGPLD
EEEECCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
VDVAEVHDATAMGEIIEIEALGLVPPGEGGIAAERGDTVIGGRIPVNPSGGLECKGHPIG
CHHHHHHHHHHHCCEEEEEEEECCCCCCCCCEECCCCEEECCEEECCCCCCCEECCCCCC
ATGLGQIYELVSQLRGDAGARQIEGARVAVAQNGGGVLGVEEAVVAVTILGR
CCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEECCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]